Kyle I Happel

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. pmc Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in mice
    Craig M Patterson
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Respir Res 13:40. 2012
  2. ncbi request reprint Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection
    Kyle I Happel
    Section of Pulmonary Critical Care Medicine, Lousiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Alcohol Clin Exp Res 30:1200-7. 2006
  3. pmc Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide
    Kyle I Happel
    Louisiana State University Health Sciences Center, Alcohol Research Center, Section of Pulmonary Critical Care, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
    Alcohol 41:325-33. 2007
  4. pmc Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs
    Kyle I Happel
    Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, Suite 3205, 1901 Perdido St, New Orleans, LA 70112, USA
    Infect Immun 73:5782-8. 2005
  5. pmc Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Exp Med 202:761-9. 2005
  6. ncbi request reprint Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 29:1198-205. 2005
  7. pmc Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication
    James E Walker
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 33:357-65. 2009
  8. pmc Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Gene Therapy Program, and Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Immunol 170:4432-6. 2003
  9. ncbi request reprint Alcohol abuse, immunosuppression, and pulmonary infection
    Ping Zhang
    Department of Medicine, Section of Pulmonary CCM, Louisiana State University Health Sciences Center, New Orleans, Louisiana, LA 70112, USA
    Curr Drug Abuse Rev 1:56-67. 2008
  10. doi request reprint The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide
    Lisa Gamble
    Departments of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Shock 31:212-7. 2009

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in mice
    Craig M Patterson
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Respir Res 13:40. 2012
    ..There is limited work describing FP effects on host defenses against bacterial pneumonia...
  2. ncbi request reprint Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection
    Kyle I Happel
    Section of Pulmonary Critical Care Medicine, Lousiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Alcohol Clin Exp Res 30:1200-7. 2006
    ..We investigated the effect of acute alcohol intoxication on the IL-23 response to this infection...
  3. pmc Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide
    Kyle I Happel
    Louisiana State University Health Sciences Center, Alcohol Research Center, Section of Pulmonary Critical Care, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
    Alcohol 41:325-33. 2007
    ..These results implicate acute ethanol intoxication as a significant inhibitor of lymphocyte chemoattractant expression during pulmonary inflammation...
  4. pmc Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs
    Kyle I Happel
    Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, Suite 3205, 1901 Perdido St, New Orleans, LA 70112, USA
    Infect Immun 73:5782-8. 2005
    ..Overall, our data show that transient IL-23 gene delivery in the lung is well tolerated, and they provide the initial demonstration that this factor controls mycobacterial growth while augmenting early pulmonary T-cell immunity...
  5. pmc Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Exp Med 202:761-9. 2005
    ..pneumoniae, the former of which is required for IFN-gamma expression and the latter of which is required for IL-17 production...
  6. ncbi request reprint Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 29:1198-205. 2005
    ..Here we hypothesized that exogenous chemokine administration would mitigate the suppressive effect of alcohol on neutrophil recruitment into the lung...
  7. pmc Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication
    James E Walker
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 33:357-65. 2009
    ..The effect of acute alcohol intoxication on AE2 cell expression of LIX is unknown...
  8. pmc Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Gene Therapy Program, and Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Immunol 170:4432-6. 2003
    ..These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8(+) T cell IL-17 production...
  9. ncbi request reprint Alcohol abuse, immunosuppression, and pulmonary infection
    Ping Zhang
    Department of Medicine, Section of Pulmonary CCM, Louisiana State University Health Sciences Center, New Orleans, Louisiana, LA 70112, USA
    Curr Drug Abuse Rev 1:56-67. 2008
    ..Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed...
  10. doi request reprint The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide
    Lisa Gamble
    Departments of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Shock 31:212-7. 2009
    ..If impaired, this may be one mechanism underlying the increased mortality observed in patients with liver disease who develop pneumonia...
  11. pmc The impact of alcohol on BCG-induced immunity against Mycobacterium tuberculosis
    Elizabeth Porretta
    Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Alcohol Clin Exp Res 36:310-7. 2012
    ..This study evaluates chronic alcohol consumption in a murine model of vaccination with Mycobacterium bovis Bacille Calmette-Guèrin (BCG) and subsequent pulmonary infection with virulent Mycobacterium tuberculosis...
  12. pmc Acute alcohol intoxication inhibits the lineage- c-kit+ Sca-1+ cell response to Escherichia coli bacteremia
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 182:1568-76. 2009
    ..These data show that alcohol inhibits the hematopoietic precursor cell response to bacteremia, which may serve as one mechanism underlying the impaired host defense in alcohol abusers with severe bacterial infections...
  13. pmc Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection
    Xiaowen L Rudner
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Infect Immun 75:3055-61. 2007
    ..In IL-23p19-/- mice infected with P. carinii, there were fewer effector CD4(+) T cells in the lung tissue. Collectively, these studies indicate that the IL-23-IL-17 axis participates in host defense against P. carinii...
  14. ncbi request reprint Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112
    Am J Physiol Lung Cell Mol Physiol 286:L465-72. 2004
    ..Our results show that CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus...
  15. pmc The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway
    Junko Yano
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    PLoS ONE 7:e46311. 2012
    ....
  16. ncbi request reprint Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption
    Howard C Becker
    Comprehensive Alcohol Research Center and Alcohol and Drug Abuse Center of Excellence at the Louisiana State University Health Sciences Center, New Orleans, Louisiana
    Alcohol Res 34:448-58. 2012
    ..e., corticosteroids), neuromodulators known as neuroactive steroids, CRF, the neurotransmitter norepinephrine, and other stress-related molecules...
  17. ncbi request reprint RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ
    Jan Hoek
    Department of The University of Massachusetts Medical Center GS and PM, Department of Medicine, Worcester, MA 01605 2324, USA
    Alcohol Clin Exp Res 29:1735-43. 2005
    ..The new techniques and ideas presented will be helpful in future studies in this area of research, and should result in some exciting avenues of study...
  18. pmc Effect of bacterial pneumonia on lung simian immunodeficiency virus (SIV) replication in alcohol consuming SIV-infected rhesus macaques
    Steve Nelson
    Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 37:969-77. 2013
    ....
  19. ncbi request reprint Focus on: alcohol and the immune system
    Patricia E Molina
    Comprehensive Alcohol Research Center and Alcohol and Drug Abuse Center of Excellence at the Louisiana State University Health Sciences Center, New Orleans, Louisiana
    Alcohol Res Health 33:97-108. 2010
    ..Some of these mechanisms are directly related to the pathology found in people with infections such as HIV/AIDS, tuberculosis, hepatitis, and pneumonia who continue to use and abuse alcohol...
  20. ncbi request reprint Alcohol, immunosuppression, and the lung
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
    Proc Am Thorac Soc 2:428-32. 2005
    ..This article reviews some of the key mechanisms of pulmonary host defense that are negatively impacted in the setting of alcohol abuse...
  21. ncbi request reprint Pulmonary host defenses and alcohol
    Ping Zhang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Front Biosci 7:d1314-30. 2002
    ..Immunotherapy to improve or enhance pulmonary host defense function in conjunction with aggressive antimicrobial regimens may provide a new approach in the management of infections in these patients...
  22. ncbi request reprint The lung in sepsis: fueling the fire
    Kyle I Happel
    Section of Pulmonary Critical Care Medicine, Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Med Sci 328:230-7. 2004
    ..This article discusses the lung's response to sepsis, from the standpoint of organ dysfunction related to sepsis as well as its participation in the generation and maintenance of the systemic inflammatory state...

Research Grants2

  1. Alcohol, Pulmonary Cytokines, and Host Defense
    Kyle Happel; Fiscal Year: 2007
    ..The didactic program and basic research experiences in this mentored proposal are designed to catalyze the applicant's development into an independent investigator in the field of alcoholism and pulmonary host defenses. ..