Research Topics
Genomes and Genes | Kyle I HappelSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
Research Grants
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Publications
Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharideKyle I Happel
Louisiana State University Health Sciences Center, Alcohol Research Center, Section of Pulmonary Critical Care, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
Alcohol 41:325-33. 2007..These results implicate acute ethanol intoxication as a significant inhibitor of lymphocyte chemoattractant expression during pulmonary inflammation...
Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infectionKyle I Happel
Section of Pulmonary Critical Care Medicine, Lousiana State University Health Sciences Center, New Orleans, Louisiana, USA
Alcohol Clin Exp Res 30:1200-7. 2006..We investigated the effect of acute alcohol intoxication on the IL-23 response to this infection...- Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungsKyle I Happel
Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, Suite 3205, 1901 Perdido St, New Orleans, LA 70112, USA
Infect Immun 73:5782-8. 2005..Overall, our data show that transient IL-23 gene delivery in the lung is well tolerated, and they provide the initial demonstration that this factor controls mycobacterial growth while augmenting early pulmonary T-cell immunity... - Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniaeKyle I Happel
Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Exp Med 202:761-9. 2005..pneumoniae, the former of which is required for IFN-gamma expression and the latter of which is required for IL-17 production... - Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitmentLee J Quinton
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Alcohol Clin Exp Res 29:1198-205. 2005.... - Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infectionKyle I Happel
Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Gene Therapy Program, and Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
J Immunol 170:4432-6. 2003..These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8(+) T cell IL-17 production... - Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxicationJames E Walker
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Alcohol Clin Exp Res 33:357-65. 2009..The effect of acute alcohol intoxication on AE2 cell expression of LIX is unknown... - Alcohol abuse, immunosuppression, and pulmonary infectionPing Zhang
Department of Medicine, Section of Pulmonary CCM, Louisiana State University Health Sciences Center, New Orleans, Louisiana, LA 70112, USA
Curr Drug Abuse Rev 1:56-67. 2008..Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed... 
The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharideLisa Gamble
Departments of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Shock 31:212-7. 2009..If impaired, this may be one mechanism underlying the increased mortality observed in patients with liver disease who develop pneumonia...- Acute alcohol intoxication inhibits the lineage- c-kit+ Sca-1+ cell response to Escherichia coli bacteremiaPing Zhang
Department of Medicine, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Immunol 182:1568-76. 2009..These data show that alcohol inhibits the hematopoietic precursor cell response to bacteremia, which may serve as one mechanism underlying the impaired host defense in alcohol abusers with severe bacterial infections... - The impact of alcohol on BCG-induced immunity against Mycobacterium tuberculosisElizabeth Porretta
Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Alcohol Clin Exp Res 36:310-7. 2012..This study evaluates chronic alcohol consumption in a murine model of vaccination with Mycobacterium bovis Bacille Calmette-Guèrin (BCG) and subsequent pulmonary infection with virulent Mycobacterium tuberculosis... - Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitmentLee J Quinton
Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112
Am J Physiol Lung Cell Mol Physiol 286:L465-72. 2004..Our results show that CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus... - Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infectionXiaowen L Rudner
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Infect Immun 75:3055-61. 2007..In IL-23p19-/- mice infected with P. carinii, there were fewer effector CD4(+) T cells in the lung tissue. Collectively, these studies indicate that the IL-23-IL-17 axis participates in host defense against P. carinii... - RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ Jan Hoek
Department of The University of Massachusetts Medical Center (GS and PM, Department of Medicine, Worcester, MA 01605-2324, USA
Alcohol Clin Exp Res 29:1735-43. 2005..The new techniques and ideas presented will be helpful in future studies in this area of research, and should result in some exciting avenues of study... - Focus on: alcohol and the immune systemPatricia E Molina
Comprehensive Alcohol Research Center and Alcohol and Drug Abuse Center of Excellence at the Louisiana State University Health Sciences Center, New Orleans, Louisiana
Alcohol Res Health 33:97-108. 2010..Some of these mechanisms are directly related to the pathology found in people with infections such as HIV/AIDS, tuberculosis, hepatitis, and pneumonia who continue to use and abuse alcohol... - Alcohol, immunosuppression, and the lungKyle I Happel
Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
Proc Am Thorac Soc 2:428-32. 2005..This article reviews some of the key mechanisms of pulmonary host defense that are negatively impacted in the setting of alcohol abuse... - Pulmonary host defenses and alcoholPing Zhang
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Front Biosci 7:d1314-30. 2002..Immunotherapy to improve or enhance pulmonary host defense function in conjunction with aggressive antimicrobial regimens may provide a new approach in the management of infections in these patients... - The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathwayJunko Yano
Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
PLoS ONE 7:e46311. 2012.... - The lung in sepsis: fueling the fireKyle I Happel
Section of Pulmonary/Critical Care Medicine, Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Am J Med Sci 328:230-7. 2004..This article discusses the lung's response to sepsis, from the standpoint of organ dysfunction related to sepsis as well as its participation in the generation and maintenance of the systemic inflammatory state... - Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in miceCraig M Patterson
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Respir Res 13:40. 2012..There is limited work describing FP effects on host defenses against bacterial pneumonia...
Research Grants
- Alcohol, Pulmonary Cytokines, and Host DefenseKyle Happel; Fiscal Year: 2007..The didactic program and basic research experiences in this mentored proposal are designed to catalyze the applicant's development into an independent investigator in the field of alcoholism and pulmonary host defenses. ..