NICHOLAS GOEDERS

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. doi request reprint The combination of metyrapone and oxazepam for the treatment of cocaine and other drug addictions
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, Louisiana, USA Electronic address
    Adv Pharmacol 69:419-79. 2014
  2. pmc Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Psychopharmacology (Berl) 223:17-25. 2012
  3. pmc Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Pharmacol Biochem Behav 91:181-9. 2008
  4. ncbi request reprint The impact of stress on addiction
    Nick E Goeders
    Department of Pharmacology and Therapeutics, LSU Health Sciences Center, Shreveport, LA 71130 3932, USA
    Eur Neuropsychopharmacol 13:435-41. 2003
  5. ncbi request reprint Lapses and reinstatement of heroin seeking in rats: comment on Leri and Stewart (2002)
    Nick E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Exp Clin Psychopharmacol 10:356-8; discussion 364-6. 2002
  6. doi request reprint Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, P O Box 33932, 1501 Kings Highway, Shreveport, LA 71130, USA
    Psychopharmacology (Berl) 201:581-8. 2009
  7. ncbi request reprint Stress and cocaine addiction
    Nick E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71139 3932, USA
    J Pharmacol Exp Ther 301:785-9. 2002
  8. ncbi request reprint Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats
    Nick E Goeders
    Department of Psychiatry, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Psychopharmacology (Berl) 161:222-32. 2002
  9. ncbi request reprint The HPA axis and cocaine reinforcement
    Nick E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, PO Box 33932, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Psychoneuroendocrinology 27:13-33. 2002
  10. ncbi request reprint Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats
    N E Goeders
    Departments of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuropsychopharmacology 23:577-86. 2000

Research Grants

Collaborators

Detail Information

Publications20

  1. doi request reprint The combination of metyrapone and oxazepam for the treatment of cocaine and other drug addictions
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, Louisiana, USA Electronic address
    Adv Pharmacol 69:419-79. 2014
    ..Additional research will be necessary to confirm this hypothesis and may lead to the development of improved and specific pharmacotherapies for the treatment of psychomotor stimulant use. ..
  2. pmc Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Psychopharmacology (Berl) 223:17-25. 2012
    ....
  3. pmc Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Pharmacol Biochem Behav 91:181-9. 2008
    ....
  4. ncbi request reprint The impact of stress on addiction
    Nick E Goeders
    Department of Pharmacology and Therapeutics, LSU Health Sciences Center, Shreveport, LA 71130 3932, USA
    Eur Neuropsychopharmacol 13:435-41. 2003
    ..Stress reduction, either alone or in combination with pharmacotherapies targeting the HPA axis may prove beneficial in reducing cravings and promoting abstinence in individuals seeking treatment for addiction...
  5. ncbi request reprint Lapses and reinstatement of heroin seeking in rats: comment on Leri and Stewart (2002)
    Nick E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport 71130 3932, USA
    Exp Clin Psychopharmacol 10:356-8; discussion 364-6. 2002
    ..Future research should attempt to replicate these experiments taking these considerations into account...
  6. doi request reprint Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats
    Nicholas E Goeders
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, P O Box 33932, 1501 Kings Highway, Shreveport, LA 71130, USA
    Psychopharmacology (Berl) 201:581-8. 2009
    ..We have previously reported that pretreatment with benzodiazepines reduces intravenous cocaine self-administration in rats...
  7. ncbi request reprint Stress and cocaine addiction
    Nick E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71139 3932, USA
    J Pharmacol Exp Ther 301:785-9. 2002
    ..Stress reduction, either alone or in combination with pharmacotherapies targeting the HPA axis may prove beneficial in reducing cravings and promoting abstinence in individuals seeking treatment for cocaine addiction...
  8. ncbi request reprint Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats
    Nick E Goeders
    Department of Psychiatry, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Psychopharmacology (Berl) 161:222-32. 2002
    ....
  9. ncbi request reprint The HPA axis and cocaine reinforcement
    Nick E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, PO Box 33932, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Psychoneuroendocrinology 27:13-33. 2002
    ..Continued investigations into how stress and the subsequent activation of the HPA axis affect cocaine self-administration will likely result in the identification of more effective and efficient treatment for cocaine addiction...
  10. ncbi request reprint Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats
    N E Goeders
    Departments of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuropsychopharmacology 23:577-86. 2000
    ..These data are discussed in terms of the role for CRH in the neurobehavioral effects of cocaine...
  11. ncbi request reprint Effects of CP-154,526 on responding during extinction from cocaine self-administration in rats
    O Gurkovskaya
    Departments of Pharmacology and Therapeutics and Psychiatry, Louisiana State University Health Sciences Center, 1501 Kings Highway, PO Box 33932, Shreveport, LA 71130-3932, USA
    Eur J Pharmacol 432:53-6. 2001
    ..Pretreatment with CP-154,526 (20 mg/kg, i.p.) decreased responding on the cocaine-associated lever during extinction, suggesting an involvement of CRH1 receptors in cue-induced craving...
  12. ncbi request reprint CP-154,526, a CRF type-1 receptor antagonist, attenuates the cue-and methamphetamine-induced reinstatement of extinguished methamphetamine-seeking behavior in rats
    M C Moffett
    Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Psychopharmacology (Berl) 190:171-80. 2007
    ..Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapse..
  13. ncbi request reprint Effects of saline substitution on responding and plasma corticosterone in rats trained to self-administer different doses of cocaine
    R L Peltier
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    J Pharmacol Exp Ther 299:114-20. 2001
    ..These data are discussed in terms of the potential difficulties involved in interpreting the effects of compounds intended to reduce drug reinforcement...
  14. ncbi request reprint Ketoconazole reduces low dose cocaine self-administration in rats
    N E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Drug Alcohol Depend 53:67-77. 1998
    ..These data suggest the potential utility of ketoconazole or related drugs as adjuncts in the treatment of cocaine abuse and further underscore the role for corticosterone in cocaine reinforcement...
  15. ncbi request reprint Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats
    N E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Brain Res 722:145-52. 1996
    ..These data suggest that corticosterone is not only important, but may also be necessary for both the acquisition and maintenance of cocaine reinforcement in rats...
  16. ncbi request reprint Neither non-contingent electric footshock nor administered corticosterone facilitate the acquisition of methamphetamine self-administration
    M C Moffett
    Department of Pharmacology and Therapeutics, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Pharmacol Biochem Behav 80:333-9. 2005
    ....
  17. ncbi request reprint Pretreatment with corticosterone attenuates the nucleus accumbens dopamine response but not the stimulant response to cocaine in rats
    J D Steketee
    Departments of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Behav Pharmacol 13:593-601. 2002
    ....
  18. ncbi request reprint A neuroendocrine role in cocaine reinforcement
    N E Goeders
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130, USA
    Psychoneuroendocrinology 22:237-59. 1997
    ..In particular, the medial prefrontal cortex appears to be at least one brain region where dopamine and adrenocorticosteroids may interact to affect cocaine reinforcement...
  19. ncbi request reprint Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration
    S I Dworkin
    Department of Psychiatry, Louisiana State University School of Medicine, Shreveport 71130
    Pharmacol Biochem Behav 30:1051-7. 1988
    ..Like so many other manipulations, the magnitude of the effect that a neurotoxin lesion can exert on behavior may depend on the specific procedures that are used to maintain responding...
  20. ncbi request reprint Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications
    Yasuyoshi Iso
    Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    J Med Chem 49:1080-100. 2006
    ..Two compounds 19 and 59 exhibited functional activity as mGluR5 antagonists that are 490 and 230 times, respectively, better than that of MTEP...

Research Grants23

  1. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 1992
    ....
  2. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2003
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  3. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2003
    ..abstract_text> ..
  4. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2004
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  5. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2004
    ..abstract_text> ..
  6. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2005
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  7. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2005
    ..abstract_text> ..
  8. STRESS AND THE NEUROBIOLOGY OF DRUG AND ALCOHOL DEPENDE
    NICHOLAS GOEDERS; Fiscal Year: 2004
    ..The primary goal of this Training Program is to provide students and young scientists with comprehensive guidance in stress and drug abuse research. ..
  9. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2006
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  10. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2007
    ..The experiments described in this revised application were designed with these stipulations in mind, taking into consideration the recommendations of the reviewers of the previous submission. ..
  11. Neurochemistry of Cocaine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2002
    ..These results will also provide evidence of the role that is played by steroid hormones in shaping the functional activity of the brain. ..
  12. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2002
    ..abstract_text> ..
  13. DETERMINANTS OF DRUG EFFECTS ON DRUG MAINTAINED BEHAVIOR
    NICHOLAS GOEDERS; Fiscal Year: 2001
    ..abstract_text> ..
  14. ENVIRONMENTAL INFLUENCES ON COCAINE SELF ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 1999
    ....
  15. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 1990
    ....
  16. ENVIRONMENTAL INFLUENCES ON COCAINE SELF-ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 1991
    ....
  17. ENVIRONMENTAL INFLUENCES ON COCAINE SELF ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2000
    ....
  18. Role for the HPA Axis in Methamphetamine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2001
    ..abstract_text> ..
  19. ENVIRONMENTAL INFLUENCES ON COCAINE SELF ADMINISTRATION
    NICHOLAS GOEDERS; Fiscal Year: 2001
    ....
  20. Cocaine addiction medication EMB-001
    Nicholas E Goeders; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This proposal is focused on the development of EMB-001, a novel combination drug product for the treatment of cocaine addiction. The goal of the work is to advance EMB-001 through a Phase 1 clinical trial. ..