Research Topics
Species | P L FidelSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Publications
Immunity to CandidaP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, USA
Oral Dis 8:69-75. 2002..Taken together, these data suggest that immunity to Candida is site-specific, compartmentalized and involves innate and/or acquired mechanisms from systemic and/or local sources...
Efficacy of D0870 treatment of experimental Candida vaginitisP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans 70112 1393, USA
Antimicrob Agents Chemother 41:1455-9. 1997..glabrata vaginitis, D0870 was superior to fluconazole in the treatment of experimental C. albicans vaginitis caused by isolates that were either susceptible or resistant to fluconazole...
Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicansP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
Clin Microbiol Rev 12:80-96. 1999..glabrata infections with comparisons to C. albicans as a means of contrasting the two species commonly observed and emphasizing the many recognized differences...
Analysis of vaginal cell populations during experimental vaginal candidiasisP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana, USA
Infect Immun 67:3135-40. 1999....
Effects of reproductive hormones on experimental vaginal candidiasisP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Infect Immun 68:651-7. 2000..albicans. These results suggest that estrogen, but not progesterone, is an important factor in hormone-associated susceptibility to C. albicans vaginitis...
Host defense against oropharyngeal and vaginal candidiasis: Site-specific differencesP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, LA, USA
Rev Iberoam Micol 16:8-15. 1999..Thus, current evidence suggests that VVC, unlike OPC, may not represent a strict opportunistic infection...
Salivary cytokine profiles in the immunocompetent individual with Candida-associated denture stomatitisJ E Leigh
Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70119, USA
Oral Microbiol Immunol 17:311-4. 2002..These results suggest that a local Th cytokine dichotomy in saliva is not associated with susceptibility to denture stomatitis in immunocompetent persons...
Candida-specific systemic cell-mediated immune reactivities in human immunodeficiency virus-positive persons with mucosal candidiasisJ E Leigh
Department of General Dentistry, Louisiana State University School of Dentistry, New Orleans, LA, USA
J Infect Dis 183:277-285. 2001....
Candida-induced oral epithelial cell responsesE A Lilly
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center and School of Dentistry, New Orleans, LA, USA
Mycopathologia 162:25-32. 2006....
Influence of periodontal disease on Th1/Th2-type cytokines in saliva of HIV-positive individualsS Vastardis
Department of Periodontics, Louisiana State University School of Dentistry, New Orleans, LA 70119, USA
Oral Microbiol Immunol 18:88-91. 2003..Thus, the lack of salivary influences by periodontitis eliminates periodontal disease as a variable in interpretations regarding correlates of local cytokines during oral manifestations of HIV...
Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitisF L Wormley
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Infect Immun 69:7162-4. 2001..Results showed that T-cell receptor delta-chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for gamma/delta T cells in Candida vaginitis...
Growth inhibition of Candida albicans by human vaginal epithelial cellsM M Barousse
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Infect Dis 184:1489-93. 2001..These results are further evidence that vaginal epithelial cells provide an innate host resistance mechanism against Candida and that reduced activity may contribute to RVVC...
CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasisK Quimby
Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA, USA
Oral Dis 18:153-61. 2012..Objective: To conduct a longitudinal study of tissue CD8(+) T-cells and E-cadherin expression before, during, and after the episodes of OPC...
Chemokine receptor expression in HIV-positive persons with oropharyngeal candidiasisE A Lilly
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center and School of Dentistry, New Orleans, LA 70119, USA
Oral Dis 12:493-9. 2006..CONCLUSION: Tissue-associated chemokine receptor expression does not appear to contribute to the dysfunction in cellular migration associated with susceptibility to OPC...
Oral and vaginal epithelial cell anti-Candida activity is acid labile and does not require live epithelial cellsJ Yano
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, 70112, USA
Oral Microbiol Immunol 20:199-205. 2005..CONCLUSION: These results suggest that antifungal activity is dependent on contact by intact, but not necessarily live, epithelial cells through an acid-labile mechanism...
Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed Candida albicans and the mucosal adjuvant LT(R192G)L Cárdenas-Freytag
Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Med Mycol 40:291-9. 2002..These results suggest that mucosal vaccination can afford partial protection against vulvovaginal candidiasis, but the precise immune mechanisms responsible for protection are complex and as yet, not well understood...
Annexin-A1 identified as the oral epithelial cell anti-Candida effector moietyE A Lilly
Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center and School of Dentistry, New Orleans, LA 70119, USA
Mol Oral Microbiol 25:293-304. 2010..Taken together, these results indicate that Annexin-A1 is a strong candidate for the epithelial cell anti-Candida effector protein...
Analysis of the CD4 protein on human vaginal T lymphocytesP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
Am J Reprod Immunol 45:200-4. 2001..Recently, we observed as well that the N-terminus of the CD4 protein on murine vaginal T lymphocytes is atypically expressed compared to its systemic counterpart, and that the atypical expression extends to the mRNA level...
Candida-host interactions in HIV disease: relationships in oropharyngeal candidiasisP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
Adv Dent Res 19:80-4. 2006..The status and efficiency of local host defenses when blood CD4+ T-cells are not available appear to play a role in protection against or susceptibility to OPC...
Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasisF L Wormley
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-1393, USA
Infect Immun 69:5072-9. 2001....
Lack of evidence for local immune activity in oral hairy leukoplakia and oral wart lesionsE A Lilly
Department of Microbiology, Immunology, and Parasitology, Section of Infectious Disease, Lousiana State University Health Sciences Center and School of Dentistry, New Orleans, LA 70119, USA
Oral Microbiol Immunol 20:154-62. 2005....
Vaginal yeast colonisation, prevalence of vaginitis, and associated local immunity in adolescentsM M Barousse
Department of Microbiology, Immunology, and Parasitology, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
Sex Transm Infect 80:48-53. 2004..Despite several factors predictive for VVC, symptomatic VVC was low compared to STIs...
Local immune responsiveness following intravaginal challenge with Candida antigen in adult women at different stages of the menstrual cycleP L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Med Mycol 41:97-109. 2003..albicans...
Potential role for a carbohydrate moiety in anti-Candida activity of human oral epithelial cellsC Steele
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Infect Immun 69:7091-9. 2001..These results suggest that oral epithelial cell-mediated anti-Candida activity occurs exclusively with viable epithelial cells through contact with C. albicans by an as-yet-undefined carbohydrate moiety...
Candida-host interactions in HIV disease: implications for oropharyngeal candidiasisP L Fidel
Department of Oral and Craniofacial Biology, Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA
Adv Dent Res 23:45-9. 2011..Oral epithelial cells concomitantly function through annexin A1 to keep Candida in a commensal state but can easily be overwhelmed, thereby contributing to susceptibility to OPC...
Immunopathogenesis of recurrent vulvovaginal candidiasisP L Fidel
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Clin Microbiol Rev 9:335-48. 1996....
Evidence for a unique expression of CD4 on murine vaginal CD4+ cellsF L Wormley
Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
Immunology 100:300-8. 2000....
Inhibitory effects of whole and parotid saliva on immunomodulatorsK L Wozniak
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Oral Microbiol Immunol 17:100-7. 2002..These results suggest that absolute concentrations of cytokines/chemokines may not be fully detectable in saliva. Therefore, the diagnostic value of any cytokine/chemokine is questionable and should be evaluated independently as such...
Fabrication of a multi-applicable removable intraoral denture system for rodent researchH Lee
Department of Prosthodontics, LSU Health Sciences Center School of Dentistry, New Orleans, LA, USA
J Oral Rehabil 38:686-90. 2011..The removable portion is advantageous for longitudinal analyses and charging/discharging of biomaterials...
(B1) Candida and mycotic infectionsM M Coogan
Division of Oral Microbiology, School of Dentistry, University of the Witwatersrand, Private Bag X6, Wits 2050, Johannesburg, South Africa
Adv Dent Res 19:130-8. 2006..Thus, perinatal retroviral therapy should be combined with the treatment of oral thrush to prevent the post-natal acquisition of HIV...
Fungal infections associated with HIV infectionL P Samaranayake
Faculty of Dentistry, The University of Hong Kong, Hong Kong
Oral Dis 8:151-60. 2002..Additionally, the lesser-known regional variations in the disease manifestations and therapeutic approaches were stark. Further work is direly needed to address these issues...
The host cytokine responses and protective immunity in oropharyngeal candidiasisA Dongari-Bagtzoglou
School of Dental Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030 1710, USA
J Dent Res 84:966-77. 2005..Identification of such cytokines with the ability to enhance anti-fungal activities of immune effector cells may have therapeutic implications in the treatment of this oral infection in the severely immunocompromised host...
Chlamydia trachomatis infection does not enhance local cellular immunity against concurrent Candida vaginal infectionK A Kelly
Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California, USA
Infect Immun 69:3451-4. 2001..Together, these results suggest that host responses to these genital tract infections are independent and not influenced by the presence of the other...
