P L Fidel

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi Immunity to Candida
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, USA
    Oral Dis 8:69-75. 2002
  2. pmc Efficacy of D0870 treatment of experimental Candida vaginitis
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans 70112 1393, USA
    Antimicrob Agents Chemother 41:1455-9. 1997
  3. pmc Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Clin Microbiol Rev 12:80-96. 1999
  4. pmc Analysis of vaginal cell populations during experimental vaginal candidiasis
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana, USA
    Infect Immun 67:3135-40. 1999
  5. pmc Effects of reproductive hormones on experimental vaginal candidiasis
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Infect Immun 68:651-7. 2000
  6. ncbi Host defense against oropharyngeal and vaginal candidiasis: Site-specific differences
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, LA, USA
    Rev Iberoam Micol 16:8-15. 1999
  7. ncbi Salivary cytokine profiles in the immunocompetent individual with Candida-associated denture stomatitis
    J E Leigh
    Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70119, USA
    Oral Microbiol Immunol 17:311-4. 2002
  8. ncbi Candida-specific systemic cell-mediated immune reactivities in human immunodeficiency virus-positive persons with mucosal candidiasis
    J E Leigh
    Department of General Dentistry, Louisiana State University School of Dentistry, New Orleans, LA, USA
    J Infect Dis 183:277-285. 2001
  9. ncbi Candida-induced oral epithelial cell responses
    E A Lilly
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center and School of Dentistry, New Orleans, LA, USA
    Mycopathologia 162:25-32. 2006
  10. ncbi Influence of periodontal disease on Th1/Th2-type cytokines in saliva of HIV-positive individuals
    S Vastardis
    Department of Periodontics, Louisiana State University School of Dentistry, New Orleans, LA 70119, USA
    Oral Microbiol Immunol 18:88-91. 2003

Collaborators

Detail Information

Publications33

  1. ncbi Immunity to Candida
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, USA
    Oral Dis 8:69-75. 2002
    ..Taken together, these data suggest that immunity to Candida is site-specific, compartmentalized and involves innate and/or acquired mechanisms from systemic and/or local sources...
  2. pmc Efficacy of D0870 treatment of experimental Candida vaginitis
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans 70112 1393, USA
    Antimicrob Agents Chemother 41:1455-9. 1997
    ..glabrata vaginitis, D0870 was superior to fluconazole in the treatment of experimental C. albicans vaginitis caused by isolates that were either susceptible or resistant to fluconazole...
  3. pmc Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Clin Microbiol Rev 12:80-96. 1999
    ..glabrata infections with comparisons to C. albicans as a means of contrasting the two species commonly observed and emphasizing the many recognized differences...
  4. pmc Analysis of vaginal cell populations during experimental vaginal candidiasis
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, Louisiana, USA
    Infect Immun 67:3135-40. 1999
    ....
  5. pmc Effects of reproductive hormones on experimental vaginal candidiasis
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Infect Immun 68:651-7. 2000
    ..albicans. These results suggest that estrogen, but not progesterone, is an important factor in hormone-associated susceptibility to C. albicans vaginitis...
  6. ncbi Host defense against oropharyngeal and vaginal candidiasis: Site-specific differences
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Medical Center, New Orleans, LA, USA
    Rev Iberoam Micol 16:8-15. 1999
    ..Thus, current evidence suggests that VVC, unlike OPC, may not represent a strict opportunistic infection...
  7. ncbi Salivary cytokine profiles in the immunocompetent individual with Candida-associated denture stomatitis
    J E Leigh
    Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70119, USA
    Oral Microbiol Immunol 17:311-4. 2002
    ..These results suggest that a local Th cytokine dichotomy in saliva is not associated with susceptibility to denture stomatitis in immunocompetent persons...
  8. ncbi Candida-specific systemic cell-mediated immune reactivities in human immunodeficiency virus-positive persons with mucosal candidiasis
    J E Leigh
    Department of General Dentistry, Louisiana State University School of Dentistry, New Orleans, LA, USA
    J Infect Dis 183:277-285. 2001
    ....
  9. ncbi Candida-induced oral epithelial cell responses
    E A Lilly
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center and School of Dentistry, New Orleans, LA, USA
    Mycopathologia 162:25-32. 2006
    ....
  10. ncbi Influence of periodontal disease on Th1/Th2-type cytokines in saliva of HIV-positive individuals
    S Vastardis
    Department of Periodontics, Louisiana State University School of Dentistry, New Orleans, LA 70119, USA
    Oral Microbiol Immunol 18:88-91. 2003
    ..Thus, the lack of salivary influences by periodontitis eliminates periodontal disease as a variable in interpretations regarding correlates of local cytokines during oral manifestations of HIV...
  11. pmc Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis
    F L Wormley
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Infect Immun 69:7162-4. 2001
    ..Results showed that T-cell receptor delta-chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for gamma/delta T cells in Candida vaginitis...
  12. ncbi Growth inhibition of Candida albicans by human vaginal epithelial cells
    M M Barousse
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Infect Dis 184:1489-93. 2001
    ..These results are further evidence that vaginal epithelial cells provide an innate host resistance mechanism against Candida and that reduced activity may contribute to RVVC...
  13. pmc CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis
    K Quimby
    Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA, USA
    Oral Dis 18:153-61. 2012
    ..Objective:  To conduct a longitudinal study of tissue CD8(+) T-cells and E-cadherin expression before, during, and after the episodes of OPC...
  14. ncbi Chemokine receptor expression in HIV-positive persons with oropharyngeal candidiasis
    E A Lilly
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center and School of Dentistry, New Orleans, LA 70119, USA
    Oral Dis 12:493-9. 2006
    ..The purpose of this study was to examine chemokine receptors present in the OPC lesions for a potential role in susceptibility to infection...
  15. pmc Oral and vaginal epithelial cell anti-Candida activity is acid labile and does not require live epithelial cells
    J Yano
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, 70112, USA
    Oral Microbiol Immunol 20:199-205. 2005
    ..The mechanism of action includes a requirement for cell contact with no role for soluble factors, and a putative role for carbohydrates based on the sensitivity of the activity to periodic acid...
  16. ncbi Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed Candida albicans and the mucosal adjuvant LT(R192G)
    L Cárdenas-Freytag
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Med Mycol 40:291-9. 2002
    ..These results suggest that mucosal vaccination can afford partial protection against vulvovaginal candidiasis, but the precise immune mechanisms responsible for protection are complex and as yet, not well understood...
  17. pmc Annexin-A1 identified as the oral epithelial cell anti-Candida effector moiety
    E A Lilly
    Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center and School of Dentistry, New Orleans, LA 70119, USA
    Mol Oral Microbiol 25:293-304. 2010
    ..Taken together, these results indicate that Annexin-A1 is a strong candidate for the epithelial cell anti-Candida effector protein...
  18. ncbi Analysis of the CD4 protein on human vaginal T lymphocytes
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Am J Reprod Immunol 45:200-4. 2001
    ..Recently, we observed as well that the N-terminus of the CD4 protein on murine vaginal T lymphocytes is atypically expressed compared to its systemic counterpart, and that the atypical expression extends to the mRNA level...
  19. ncbi Candida-host interactions in HIV disease: relationships in oropharyngeal candidiasis
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
    Adv Dent Res 19:80-4. 2006
    ..The status and efficiency of local host defenses when blood CD4+ T-cells are not available appear to play a role in protection against or susceptibility to OPC...
  20. pmc Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis
    F L Wormley
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-1393, USA
    Infect Immun 69:5072-9. 2001
    ....
  21. ncbi Lack of evidence for local immune activity in oral hairy leukoplakia and oral wart lesions
    E A Lilly
    Department of Microbiology, Immunology, and Parasitology, Section of Infectious Disease, Lousiana State University Health Sciences Center and School of Dentistry, New Orleans, LA 70119, USA
    Oral Microbiol Immunol 20:154-62. 2005
    ..The present study evaluated tissue-associated proinflammatory and T-helper cytokine and chemokine mRNA expression and the presence of T cells in each lesion...
  22. pmc Vaginal yeast colonisation, prevalence of vaginitis, and associated local immunity in adolescents
    M M Barousse
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
    Sex Transm Infect 80:48-53. 2004
    ....
  23. ncbi Local immune responsiveness following intravaginal challenge with Candida antigen in adult women at different stages of the menstrual cycle
    P L Fidel
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Med Mycol 41:97-109. 2003
    ..albicans...
  24. pmc Potential role for a carbohydrate moiety in anti-Candida activity of human oral epithelial cells
    C Steele
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Infect Immun 69:7091-9. 2001
    ..These results suggest that oral epithelial cell-mediated anti-Candida activity occurs exclusively with viable epithelial cells through contact with C. albicans by an as-yet-undefined carbohydrate moiety...
  25. pmc Candida-host interactions in HIV disease: implications for oropharyngeal candidiasis
    P L Fidel
    Department of Oral and Craniofacial Biology, Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA
    Adv Dent Res 23:45-9. 2011
    ..Oral epithelial cells concomitantly function through annexin A1 to keep Candida in a commensal state but can easily be overwhelmed, thereby contributing to susceptibility to OPC...
  26. pmc Immunopathogenesis of recurrent vulvovaginal candidiasis
    P L Fidel
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Microbiol Rev 9:335-48. 1996
    ....
  27. pmc Evidence for a unique expression of CD4 on murine vaginal CD4+ cells
    F L Wormley
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
    Immunology 100:300-8. 2000
    ....
  28. ncbi Inhibitory effects of whole and parotid saliva on immunomodulators
    K L Wozniak
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Oral Microbiol Immunol 17:100-7. 2002
    ..These results suggest that absolute concentrations of cytokines/chemokines may not be fully detectable in saliva. Therefore, the diagnostic value of any cytokine/chemokine is questionable and should be evaluated independently as such...
  29. pmc Fabrication of a multi-applicable removable intraoral denture system for rodent research
    H Lee
    Department of Prosthodontics, LSU Health Sciences Center School of Dentistry, New Orleans, LA, USA
    J Oral Rehabil 38:686-90. 2011
    ..The removable portion is advantageous for longitudinal analyses and charging/discharging of biomaterials...
  30. ncbi (B1) Candida and mycotic infections
    M M Coogan
    Division of Oral Microbiology, School of Dentistry, University of the Witwatersrand, Private Bag X6, Wits 2050, Johannesburg, South Africa
    Adv Dent Res 19:130-8. 2006
    ..Thus, perinatal retroviral therapy should be combined with the treatment of oral thrush to prevent the post-natal acquisition of HIV...
  31. ncbi Fungal infections associated with HIV infection
    L P Samaranayake
    Faculty of Dentistry, The University of Hong Kong, Hong Kong
    Oral Dis 8:151-60. 2002
    ..Additionally, the lesser-known regional variations in the disease manifestations and therapeutic approaches were stark. Further work is direly needed to address these issues...
  32. ncbi The host cytokine responses and protective immunity in oropharyngeal candidiasis
    A Dongari-Bagtzoglou
    School of Dental Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut, 263 Farmington Ave, Farmington, CT 06030 1710, USA
    J Dent Res 84:966-77. 2005
    ..Identification of such cytokines with the ability to enhance anti-fungal activities of immune effector cells may have therapeutic implications in the treatment of this oral infection in the severely immunocompromised host...
  33. pmc Chlamydia trachomatis infection does not enhance local cellular immunity against concurrent Candida vaginal infection
    K A Kelly
    Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California, USA
    Infect Immun 69:3451-4. 2001
    ..Together, these results suggest that host responses to these genital tract infections are independent and not influenced by the presence of the other...