Research Topics
| Martin FeelischSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Detail Information
Publications
Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivoMartin Feelisch
Department of Molecular and Cellular Physiology, LSU Health Sciences Centers, Shreveport, Louisiana 71130, USA
FASEB J 16:1775-85. 2002....
Nitroxyl gets to the heart of the matterMartin Feelisch
Louisiana State University Health Sciences Center, Department of Molecular and Cellular Physiology, 1501 Kings Highway, Shreveport, LA 71130, USA
Proc Natl Acad Sci U S A 100:4978-80. 2003- Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivoNathan S Bryan
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Proc Natl Acad Sci U S A 101:4308-13. 2004..The findings also raise the intriguing possibility that N-nitrosation is directly involved in the modulation of protein function... - Chemical nature of nitric oxide storage forms in rat vascular tissueJuan Rodriguez
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
Proc Natl Acad Sci U S A 100:336-41. 2003..We conclude that intravascular nitroso species and nitrite both have the potential to release physiologically relevant quantities of NO independent of enzymatic control by NO synthase... - Concomitant presence of N-nitroso and S-nitroso proteins in human plasmaTienush Rassaf
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
Free Radic Biol Med 33:1590-6. 2002..Our findings may not only have important implications for the transport of NO in vivo, but also for cardiovascular disease diagnostics and the risk assessment of nitrosamine-related carcinogenesis in man... - Performance of diamino fluorophores for the localization of sources and targets of nitric oxideJuan Rodriguez
Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130, USA
Free Radic Biol Med 38:356-68. 2005.... - Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditionsMahesh S Joshi
Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 70012, USA
Proc Natl Acad Sci U S A 99:10341-6. 2002..We conclude that the reaction of NO with hemoglobin under normoxic conditions results in consumption, rather than conservation, of NO... - Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venulesWolfgang H Cerwinka
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, USA
Am J Physiol Heart Circ Physiol 282:H1111-7. 2002..These findings indicate that 1) eNOS-derived NO attenuates endotoxin-induced P/E adhesion and 2) sGC is responsible for the antiadhesive action of NO... 
Isotope tracing enhancement of chemiluminescence assays for nitric oxide researchJulia Cornelius
Department of Physics, Centenary College of Louisiana, Shreveport, LA 71134, USA
Biol Chem 390:181-9. 2009....- Circulating NO pool: assessment of nitrite and nitroso species in blood and tissuesTienush Rassaf
Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich-Heine-University, Duesseldorf, Germany
Free Radic Biol Med 36:413-22. 2004..In addition, we attempt to give a recommendation as to the most appropriate analytical technique and sample processing procedures for the reliable quantification of either species... - Plasma nitroso compounds are decreased in patients with endothelial dysfunctionChristian Heiss
Department of Cardiology, Pneumology, and Vascular Medicine, RWTH Aachen, Aachen, Germany
J Am Coll Cardiol 47:573-9. 2006.... - The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signalingSonia Donzelli
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Antioxid Redox Signal 8:1363-71. 2006..In this review, we discuss the biochemistry of such reactions in the context of their pharmacologic and biologic implications... - Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigmDavid A Wink
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm B3 B69, Bethesda, MD 20892, USA
Am J Physiol Heart Circ Physiol 285:H2264-76. 2003..This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo... - N-Nitroso products from the reaction of indoles with Angeli's saltFabienne Peyrot
Institut de Chimie des Substances Naturelles, C. N. R. S, Avenue de la Terrasse, F-91198, Gif-sur-Yvette, France
Chem Res Toxicol 19:58-67. 2006..It is intriguing to speculate that the particular efficiency of nitroxyl to form N-nitroso species in the heart may account for the positive inotropic effects observed with AS earlier... - Nitrosative stress in an animal model of necrotizing enterocolitisRuben Zamora
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Free Radic Biol Med 39:1428-37. 2005..Whether nitrite plays a protective or deleterious role remains to be investigated... - Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanismDAVID JOURD'HEUIL
Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC8, Albany, NY 12208, USA
J Biol Chem 278:15720-6. 2003..Nitrosothiol formation in vivo depends not only on the availability of .NO and O2 but also on the degree of oxidative stress by affecting the steady-state concentration of thiyl radicals... - Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOSKatrina M Miranda
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3-B69, Bethesda, MD 20892, USA
J Inorg Biochem 93:52-60. 2003.... - Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human bloodTienush Rassaf
Department of Medicine, Heinrich-Heine-University, , Germany
Circ Res 91:470-7. 2002..These findings demonstrate that in humans the pharmacological delivery of NO solutions results in the transport and delivery of NO as RSNOs along the vascular tree... - Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humansPetra Kleinbongard
Division of Cardiology, Pulmonary Diseases and Angiology, Department of Medicine, Heinrich Heine University, , Germany
Free Radic Biol Med 40:295-302. 2006..Future studies are necessary to identify the prognostic relevance of plasma nitrite determination in patients suffering from cardiovascular disease... - Cardioprotective effects of vegetables: is nitrate the answer?Jon O Lundberg
Department of Physiology and Pharmacology, Karolinska Institutet 171 77, Stockholm, Sweden
Nitric Oxide 15:359-62. 2006.... - Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injuryJohn W Elrod
Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Arterioscler Thromb Vasc Biol 26:1517-23. 2006..We reported previously that systemic genetic overexpression of eNOS attenuates MI-R injury. The purpose of the current study was to investigate tissue-specific genetic overexpression of the human eNOS gene... - Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatmentXunde Wang
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 281:26994-7002. 2006.... - Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injuryMark R Duranski
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Am J Physiol Heart Circ Physiol 291:H2980-6. 2006..These results suggest that hepatic protection in eNOS-TG mice may be mediated in part by NO signaling via the sGC-cGMP pathway and is independent of HO-1 signal transduction pathways... - Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in ArabidopsisUng Lee
Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
Plant Cell 20:786-802. 2008..An NO-overproducing mutant is also defective in thermotolerance. Together, our results expand the importance of GSNOR-regulated NO homeostasis to abiotic stress and plant development... - Therapeutic uses of inorganic nitrite and nitrate: from the past to the futureAnthony R Butler
Bute Medical School, University of St Andrews, St Andrews, Fife, KY16 9ST, Scotland
Circulation 117:2151-9. 2008.... - Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injuryYasuko Nagasaka
Anesthesia Center for Critical Care Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Anesthesiology 109:675-82. 2008..Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood... - The emerging biology of the nitrite anionMark T Gladwin
Vascular Medicine Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA
Nat Chem Biol 1:308-14. 2005..A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics... - Nitrite is a signaling molecule and regulator of gene expression in mammalian tissuesNathan S Bryan
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Nat Chem Biol 1:290-7. 2005..Thus, nitrite homeostasis may be of great importance to NO biology... - Direct biochemical evidence for eNOS stimulation by bradykinin in the human forearm vasculatureThomas Lauer
, Medizinische Klinik und Poliklinik B, , Pneumologie, Angiologie, Moorenstrasse 5,
Basic Res Cardiol 98:84-9. 2003..CONCLUSIONS: These data provide direct biochemical evidence for the involvement of eNOS in bradykinin-induced vasodilation of forearm resistance vessels in humans... - Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systemsDouglas D Thomas
Tumor Biology Section, Radiation Biology Branch, National Institutes of Health/National Cancer Institute, Bethesda, Maryland 20892, USA
Methods Enzymol 359:84-105. 2002 - NO adducts in mammalian red blood cells: too much or too little?Tienush Rassaf
Nat Med 9:481-2; author reply 482-3. 2003 - A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular systemKatrina M Miranda
Radiation Biology Branch, Building 10, Room B3 B69, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:9196-201. 2003..The orthogonality of HNO and NO may be due to differential reactivity toward metals and thiols and in the cardiovascular system, may ultimately be driven by respective alteration of cAMP and cGMP levels... - Plasma nitrite reflects constitutive nitric oxide synthase activity in mammalsPetra Kleinbongard
Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich-Heine-University, Duesseldorf, Germany
Free Radic Biol Med 35:790-6. 2003..These results provide evidence for a uniform constitutive vascular NOS-activity across mammalian species... - Thiols enhance NO formation from nitrate photolysisAndre Dejam
Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich Heine University, Duesseldorf, Germany
Free Radic Biol Med 35:1551-9. 2003..This may lead to substantial overestimation of the latter when photolysis-based methodologies are used for their determination. Whether this novel reaction channel also has in vivo relevance remains to be investigated... - The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situationsLisa A Ridnour
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Biol Chem 385:1-10. 2004.... - Bound NO in human red blood cells: fact or artifact?Nathan S Bryan
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Nitric Oxide 10:221-8. 2004.... - Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]Ling Tao
Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 101:11471-6. 2004..In the case of hTrx, these effects are further potentiated by S-nitrosation, but this posttranslational modification is not essential for protection... - Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivoDavid R Janero
Whitaker Cardiovascular Institute, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
Proc Natl Acad Sci U S A 101:16958-63. 2004..These findings provide insight into the global in vivo metabolism of GTN at pharmacologically relevant doses and offer an additional experimental paradigm for the NObonomic analysis of NO-donor metabolism and signaling... - Evidence for in vivo transport of bioactive nitric oxide in human plasmaTienush Rassaf
Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, , , Germany
J Clin Invest 109:1241-8. 2002..Our results suggest that NO can be transported in bioactive form for significant distances along the vascular bed. Both free NO and plasma nitroso species contribute to the dilation of the downstream vasculature... - Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioningPasquale Pagliaro
Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Orbassano, Italy
Free Radic Biol Med 34:33-43. 2003....