Martin Feelisch

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo
    Martin Feelisch
    Department of Molecular and Cellular Physiology, LSU Health Sciences Centers, Shreveport, Louisiana 71130, USA
    FASEB J 16:1775-85. 2002
  2. pmc Nitroxyl gets to the heart of the matter
    Martin Feelisch
    Louisiana State University Health Sciences Center, Department of Molecular and Cellular Physiology, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 100:4978-80. 2003
  3. pmc Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    Nathan S Bryan
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 101:4308-13. 2004
  4. pmc Chemical nature of nitric oxide storage forms in rat vascular tissue
    Juan Rodriguez
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Proc Natl Acad Sci U S A 100:336-41. 2003
  5. ncbi request reprint Concomitant presence of N-nitroso and S-nitroso proteins in human plasma
    Tienush Rassaf
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 33:1590-6. 2002
  6. ncbi request reprint Performance of diamino fluorophores for the localization of sources and targets of nitric oxide
    Juan Rodriguez
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 38:356-68. 2005
  7. pmc Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions
    Mahesh S Joshi
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 70012, USA
    Proc Natl Acad Sci U S A 99:10341-6. 2002
  8. ncbi request reprint Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules
    Wolfgang H Cerwinka
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Heart Circ Physiol 282:H1111-7. 2002
  9. doi request reprint Isotope tracing enhancement of chemiluminescence assays for nitric oxide research
    Julia Cornelius
    Department of Physics, Centenary College of Louisiana, Shreveport, LA 71134, USA
    Biol Chem 390:181-9. 2009
  10. ncbi request reprint Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 36:413-22. 2004

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo
    Martin Feelisch
    Department of Molecular and Cellular Physiology, LSU Health Sciences Centers, Shreveport, Louisiana 71130, USA
    FASEB J 16:1775-85. 2002
    ....
  2. pmc Nitroxyl gets to the heart of the matter
    Martin Feelisch
    Louisiana State University Health Sciences Center, Department of Molecular and Cellular Physiology, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 100:4978-80. 2003
  3. pmc Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    Nathan S Bryan
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 101:4308-13. 2004
    ..The findings also raise the intriguing possibility that N-nitrosation is directly involved in the modulation of protein function...
  4. pmc Chemical nature of nitric oxide storage forms in rat vascular tissue
    Juan Rodriguez
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport 71130, USA
    Proc Natl Acad Sci U S A 100:336-41. 2003
    ..We conclude that intravascular nitroso species and nitrite both have the potential to release physiologically relevant quantities of NO independent of enzymatic control by NO synthase...
  5. ncbi request reprint Concomitant presence of N-nitroso and S-nitroso proteins in human plasma
    Tienush Rassaf
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 33:1590-6. 2002
    ..Our findings may not only have important implications for the transport of NO in vivo, but also for cardiovascular disease diagnostics and the risk assessment of nitrosamine-related carcinogenesis in man...
  6. ncbi request reprint Performance of diamino fluorophores for the localization of sources and targets of nitric oxide
    Juan Rodriguez
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Free Radic Biol Med 38:356-68. 2005
    ....
  7. pmc Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions
    Mahesh S Joshi
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA 70012, USA
    Proc Natl Acad Sci U S A 99:10341-6. 2002
    ..We conclude that the reaction of NO with hemoglobin under normoxic conditions results in consumption, rather than conservation, of NO...
  8. ncbi request reprint Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules
    Wolfgang H Cerwinka
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Am J Physiol Heart Circ Physiol 282:H1111-7. 2002
    ..These findings indicate that 1) eNOS-derived NO attenuates endotoxin-induced P/E adhesion and 2) sGC is responsible for the antiadhesive action of NO...
  9. doi request reprint Isotope tracing enhancement of chemiluminescence assays for nitric oxide research
    Julia Cornelius
    Department of Physics, Centenary College of Louisiana, Shreveport, LA 71134, USA
    Biol Chem 390:181-9. 2009
    ....
  10. ncbi request reprint Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 36:413-22. 2004
    ..In addition, we attempt to give a recommendation as to the most appropriate analytical technique and sample processing procedures for the reliable quantification of either species...
  11. ncbi request reprint Plasma nitroso compounds are decreased in patients with endothelial dysfunction
    Christian Heiss
    Department of Cardiology, Pneumology, and Vascular Medicine, RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 47:573-9. 2006
    ..We investigated whether plasma nitros(yl)ated species (RXNOs) that mediate systemic nitric oxide (NO) bioactivity are depleted in individuals with cardiovascular risk factors and endothelial dysfunction...
  12. ncbi request reprint The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling
    Sonia Donzelli
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Antioxid Redox Signal 8:1363-71. 2006
    ..In this review, we discuss the biochemistry of such reactions in the context of their pharmacologic and biologic implications...
  13. ncbi request reprint Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm
    David A Wink
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm B3 B69, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 285:H2264-76. 2003
    ..This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo...
  14. ncbi request reprint N-Nitroso products from the reaction of indoles with Angeli's salt
    Fabienne Peyrot
    Institut de Chimie des Substances Naturelles, C N R S, Avenue de la Terrasse, F 91198, Gif sur Yvette, France
    Chem Res Toxicol 19:58-67. 2006
    ..It is intriguing to speculate that the particular efficiency of nitroxyl to form N-nitroso species in the heart may account for the positive inotropic effects observed with AS earlier...
  15. ncbi request reprint Nitrosative stress in an animal model of necrotizing enterocolitis
    Ruben Zamora
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 39:1428-37. 2005
    ..Whether nitrite plays a protective or deleterious role remains to be investigated...
  16. ncbi request reprint Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism
    DAVID JOURD'HEUIL
    Center for Cardiovascular Sciences, Albany Medical College, 47 New Scotland Avenue MC8, Albany, NY 12208, USA
    J Biol Chem 278:15720-6. 2003
    ..Nitrosothiol formation in vivo depends not only on the availability of .NO and O2 but also on the degree of oxidative stress by affecting the steady-state concentration of thiyl radicals...
  17. ncbi request reprint Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS
    Katrina M Miranda
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, MD 20892, USA
    J Inorg Biochem 93:52-60. 2003
    ....
  18. ncbi request reprint Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood
    Tienush Rassaf
    Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
    Circ Res 91:470-7. 2002
    ..These findings demonstrate that in humans the pharmacological delivery of NO solutions results in the transport and delivery of NO as RSNOs along the vascular tree...
  19. ncbi request reprint Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
    Petra Kleinbongard
    Division of Cardiology, Pulmonary Diseases and Angiology, Department of Medicine, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Free Radic Biol Med 40:295-302. 2006
    ..Future studies are necessary to identify the prognostic relevance of plasma nitrite determination in patients suffering from cardiovascular disease...
  20. ncbi request reprint Cardioprotective effects of vegetables: is nitrate the answer?
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet 171 77, Stockholm, Sweden
    Nitric Oxide 15:359-62. 2006
    ....
  21. ncbi request reprint Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Arterioscler Thromb Vasc Biol 26:1517-23. 2006
    ..We reported previously that systemic genetic overexpression of eNOS attenuates MI-R injury. The purpose of the current study was to investigate tissue-specific genetic overexpression of the human eNOS gene...
  22. ncbi request reprint Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment
    Xunde Wang
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 281:26994-7002. 2006
    ....
  23. ncbi request reprint Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury
    Mark R Duranski
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 291:H2980-6. 2006
    ..These results suggest that hepatic protection in eNOS-TG mice may be mediated in part by NO signaling via the sGC-cGMP pathway and is independent of HO-1 signal transduction pathways...
  24. pmc Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in Arabidopsis
    Ung Lee
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    Plant Cell 20:786-802. 2008
    ..An NO-overproducing mutant is also defective in thermotolerance. Together, our results expand the importance of GSNOR-regulated NO homeostasis to abiotic stress and plant development...
  25. doi request reprint Therapeutic uses of inorganic nitrite and nitrate: from the past to the future
    Anthony R Butler
    Bute Medical School, University of St Andrews, St Andrews, Fife, KY16 9ST, Scotland
    Circulation 117:2151-9. 2008
    ....
  26. pmc Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury
    Yasuko Nagasaka
    Anesthesia Center for Critical Care Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 109:675-82. 2008
    ..Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood...
  27. ncbi request reprint The emerging biology of the nitrite anion
    Mark T Gladwin
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 1:308-14. 2005
    ..A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics...
  28. ncbi request reprint Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Chem Biol 1:290-7. 2005
    ..Thus, nitrite homeostasis may be of great importance to NO biology...
  29. ncbi request reprint Direct biochemical evidence for eNOS stimulation by bradykinin in the human forearm vasculature
    Thomas Lauer
    Heinrich Heine Universitat Dusseldorf, Medizinische Klinik und Poliklinik B, Klinik fur Kardiologie, Pneumologie, Angiologie, Moorenstrasse 5, D 40225 Dusseldorf
    Basic Res Cardiol 98:84-9. 2003
    ..Therefore, the present study was designed to test the hypothesis that in the human forearm vasculature eNOS stimulation significantly contributes to BK-induced vasodilation...
  30. ncbi request reprint Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems
    Douglas D Thomas
    Tumor Biology Section, Radiation Biology Branch, National Institutes of Health National Cancer Institute, Bethesda, Maryland 20892, USA
    Methods Enzymol 359:84-105. 2002
  31. ncbi request reprint NO adducts in mammalian red blood cells: too much or too little?
    Tienush Rassaf
    Nat Med 9:481-2; author reply 482-3. 2003
  32. pmc A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
    Katrina M Miranda
    Radiation Biology Branch, Building 10, Room B3 B69, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9196-201. 2003
    ..The orthogonality of HNO and NO may be due to differential reactivity toward metals and thiols and in the cardiovascular system, may ultimately be driven by respective alteration of cAMP and cGMP levels...
  33. ncbi request reprint Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
    Petra Kleinbongard
    Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 35:790-6. 2003
    ..These results provide evidence for a uniform constitutive vascular NOS-activity across mammalian species...
  34. ncbi request reprint Thiols enhance NO formation from nitrate photolysis
    Andre Dejam
    Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 35:1551-9. 2003
    ..This may lead to substantial overestimation of the latter when photolysis-based methodologies are used for their determination. Whether this novel reaction channel also has in vivo relevance remains to be investigated...
  35. ncbi request reprint The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
    Lisa A Ridnour
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Biol Chem 385:1-10. 2004
    ....
  36. ncbi request reprint Bound NO in human red blood cells: fact or artifact?
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Nitric Oxide 10:221-8. 2004
    ....
  37. pmc Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]
    Ling Tao
    Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:11471-6. 2004
    ..In the case of hTrx, these effects are further potentiated by S-nitrosation, but this posttranslational modification is not essential for protection...
  38. pmc Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo
    David R Janero
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 101:16958-63. 2004
    ..These findings provide insight into the global in vivo metabolism of GTN at pharmacologically relevant doses and offer an additional experimental paradigm for the NObonomic analysis of NO-donor metabolism and signaling...
  39. pmc Evidence for in vivo transport of bioactive nitric oxide in human plasma
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Clin Invest 109:1241-8. 2002
    ..Our results suggest that NO can be transported in bioactive form for significant distances along the vascular bed. Both free NO and plasma nitroso species contribute to the dilation of the downstream vasculature...
  40. ncbi request reprint Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Orbassano, Italy
    Free Radic Biol Med 34:33-43. 2003
    ....