A J Dunn

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi HPA axis activation and neurochemical responses to bacterial translocation from the gastrointestinal tract
    Adrian J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Ann N Y Acad Sci 992:21-9. 2003
  2. ncbi Cytokine activation of the HPA axis
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Ann N Y Acad Sci 917:608-17. 2000
  3. ncbi Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Ann N Y Acad Sci 1018:25-34. 2004
  4. ncbi Cytokines as mediators of depression: what can we learn from animal studies?
    Adrian J Dunn
    Department of Pharmacology, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Neurosci Biobehav Rev 29:891-909. 2005
  5. ncbi The reductions in sweetened milk intake induced by interleukin-1 and endotoxin are not prevented by chronic antidepressant treatment
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuroimmunomodulation 9:163-9. 2001
  6. pmc Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, LSU Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Pharmacol Biochem Behav 81:688-93. 2005
  7. pmc Reduced ingestion of sweetened milk induced by interleukin-1 and lipopolysaccharide is associated with induction of cyclooxygenase-2 in brain endothelia
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuroimmunomodulation 13:96-104. 2006
  8. ncbi Effects of the IL-1 receptor antagonist on the IL-1- and endotoxin-induced activation of the HPA axis and cerebral biogenic amines in mice
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport, LA 71130 3932, USA
    Neuroimmunomodulation 7:36-45. 2000
  9. ncbi Behavioral responses to stress are intact in CRF-deficient mice
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport, LA 71130 3932, USA
    Brain Res 845:14-20. 1999
  10. ncbi The role of cytokines in infection-related behavior
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71103, USA
    Ann N Y Acad Sci 840:577-85. 1998

Collaborators

Detail Information

Publications39

  1. ncbi HPA axis activation and neurochemical responses to bacterial translocation from the gastrointestinal tract
    Adrian J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Ann N Y Acad Sci 992:21-9. 2003
    ..However, the above experiments suggest that this is not the mechanism by which restraint activates these systems...
  2. ncbi Cytokine activation of the HPA axis
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Ann N Y Acad Sci 917:608-17. 2000
    ..Manipulation of noradrenergic, but not serotonergic systems alters the IL-1-induced HPA activation, suggesting the involvement of NA. However, brain NA does not appear to be essential for HPA activation in mice...
  3. ncbi Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Ann N Y Acad Sci 1018:25-34. 2004
    ..Further investigations are necessary to establish the validity or otherwise of the feed-forward hypothesis...
  4. ncbi Cytokines as mediators of depression: what can we learn from animal studies?
    Adrian J Dunn
    Department of Pharmacology, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Neurosci Biobehav Rev 29:891-909. 2005
    ..It is concluded that immune activation and cytokines may be involved in depressive symptoms in some patients. However, cytokines do not appear to be essential mediators of depressive illness...
  5. ncbi The reductions in sweetened milk intake induced by interleukin-1 and endotoxin are not prevented by chronic antidepressant treatment
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuroimmunomodulation 9:163-9. 2001
    ..These results indicate that chronic treatment with antidepressants does not significantly alter the responses to IL-1 or LPS in the mouse sweetened milk model of sickness behavior...
  6. pmc Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, LSU Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Pharmacol Biochem Behav 81:688-93. 2005
    ..Thus the results obtained in these two animal tests commonly used to test antidepressant properties do not provide strong support for an IL-1 hypothesis of depression...
  7. pmc Reduced ingestion of sweetened milk induced by interleukin-1 and lipopolysaccharide is associated with induction of cyclooxygenase-2 in brain endothelia
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuroimmunomodulation 13:96-104. 2006
    ..These effects of IL-1 and LPS have been shown to be sensitive to inhibitors of cyclooxygenase (COX)...
  8. ncbi Effects of the IL-1 receptor antagonist on the IL-1- and endotoxin-induced activation of the HPA axis and cerebral biogenic amines in mice
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport, LA 71130 3932, USA
    Neuroimmunomodulation 7:36-45. 2000
    ..However, IL-1 within the CNS may contribute to the responses to intraperitoneal IL-1, but not to intraperitoneal LPS or intravenous IL-1...
  9. ncbi Behavioral responses to stress are intact in CRF-deficient mice
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport, LA 71130 3932, USA
    Brain Res 845:14-20. 1999
    ..Alternatively, the natural modulator of behavior may not be CRF, but some other molecule that can act on receptors sensitive to CRF. Thus, redundant CNS mechanisms appear to be involved in stress-related behaviors...
  10. ncbi The role of cytokines in infection-related behavior
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71103, USA
    Ann N Y Acad Sci 840:577-85. 1998
    ..Our results suggest that while IL-1 may play an important role in the responses to infection, IL-6 does not. Moreover, IL-1 cannot be the only factor contributing to the altered behavior of LPS-injected or influenza virus-infected mice...
  11. ncbi Cyclooxygenase 1 is not essential for hypophagic responses to interleukin-1 and endotoxin in mice
    A H Swiergiel
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, P.O. Box 33932, Shreveport, LA 71130-3932, USA
    Pharmacol Biochem Behav 69:659-63. 2001
    ..The results from COX2ko mice are consistent with the involvement of COX2 in the IL-1-induced depression of milk intake, but other mechanisms may effect decreases in sweetened milk intake...
  12. ncbi CRF-deficient mice respond like wild-type mice to hypophagic stimuli
    A H Swiergiel
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Pharmacol Biochem Behav 64:59-64. 1999
    ..These results suggest that CRF is not essential for the reduction in sweetened milk intake that occurs following restraint, LPS, IL-1, or d-fenfluramine administration to mice...
  13. ncbi The role of cerebral noradrenergic systems in the Fos response to interleukin-1
    A H Swiergiel
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Brain Res Bull 41:61-4. 1996
    ..By contrast with previous experiments is rats, the IL-1-induced increase in plasma corticosterone was not significantly altered by the 6-OHDA pretreatment in mice...
  14. ncbi The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra)
    A H Swiergiel
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Brain Res 776:96-104. 1997
    ..The results suggest that IL-1 contributes to sickness behavior induced by LPS and influenza virus infection, but it is not the only factor involved...
  15. ncbi The role of CRH in behavioral responses to stress
    G N Smagin
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Peptides 22:713-24. 2001
    ..This review summarizes recent findings with respect to components of the CRH system and their role in stress-induced behavioral responses...
  16. ncbi Peripheral interleukin-6 administration increases extracellular concentrations of serotonin and the evoked release of serotonin in the rat striatum
    J Zhang
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, PO Box 33932, Shreveport, LA 71130-3932, USA
    Neurochem Int 38:303-8. 2001
    ..These results indicate that the increases in brain concentrations of 5-HIAA observed in earlier studies indeed reflect increased synaptic release of 5-HT...
  17. ncbi Footshock-induced changes in brain catecholamines and indoleamines are not mediated by CRF or ACTH
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University, Medical Center, Shreveport 71130 3932, USA
    Neurochem Int 37:61-9. 2000
    ..These results suggest that CRF and its receptors, and ACTH and other pituitary hormones, are not involved in the catecholamine and serotonin responses to a brief period of footshock...
  18. ncbi Brain catecholaminergic and tryptophan responses to restraint are attenuated by nitric oxide synthase inhibition
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport 71130, USA
    Neurochem Int 33:551-7. 1998
    ..The attenuation of the restraint-related effects on the catecholamines most probably reflects a contribution to the CNS responses from peripheral vascular changes which are likely to be limited by the inhibition of NOS...
  19. pmc Effects of interleukin-1beta and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests
    Artur H Swiergiel
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, P O Box 33932, Louisiana, USA
    Pharmacol Biochem Behav 86:651-9. 2007
    ..Nevertheless, because infections, endotoxins, and the ensuing cytokines cause alterations in CNS norepinephrine and serotonin, they may contribute to emotionality, and perhaps to anxiety...
  20. ncbi Effects of chronic footshock, restraint and corticotropin-releasing factor on freezing, ultrasonic vocalization and forced swim behavior in rats
    Artur H Swiergiel
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Behav Brain Res 183:178-87. 2007
    ..On the other hand, the enhancement of conditioned freezing by CFS, and of conditioned USV's by CRF in CFS rats, indicates more complex effects...
  21. ncbi Effects of chronic and acute stressors and CRF on depression-like behavior in mice
    Artur H Swiergiel
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Behav Brain Res 186:32-40. 2008
    ..Acute footshock activated brain dopamine, norepinephrine and serotonin metabolism, and increased tryptophan concentrations in the brain. In CFS mice, these responses were attenuated, significantly for hypothalamic NE...
  22. doi Effects of chlordiazepoxide on footshock- and corticotropin-releasing factor-induced increases in cortical and hypothalamic norepinephrine secretion in rats
    Artur H Swiergiel
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neurochem Int 52:1220-5. 2008
    ..CDP may exert a direct inhibitory effect on the noradrenergic neurons, alter the input to LC noradrenergic neurons, or alter the ability of CRF to activate the LC noradrenergic system...
  23. pmc Effect of subdiaphragmatic vagotomy on the noradrenergic and HPA axis activation induced by intraperitoneal interleukin-1 administration in rats
    Marek Wieczorek
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, PO Box 33932, Shreveport, LA 71130 3932, USA
    Brain Res 1101:73-84. 2006
    ..However, IL-1beta can also exert direct effects on IL-1 receptors on cerebral blood vessels, activating cyclooxygenases and hence synthesis of prostaglandins which in turn can affect body temperature, behavior and HPA axis activation...
  24. pmc Feeding, exploratory, anxiety- and depression-related behaviors are not altered in interleukin-6-deficient male mice
    Artur H Swiergiel
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, 71130 3932, USA
    Behav Brain Res 171:94-108. 2006
    ..It is concluded that the lack of IL-6 is not associated with substantial alterations in several different mouse behaviors, and in the responses to restraint, IL-1beta, IL-6 and LPS...
  25. pmc Relationships among the behavioral, noradrenergic, and pituitary-adrenal responses to interleukin-1 and the effects of indomethacin
    Marek Wieczorek
    Department of Neurophysiology, University of Lodz, Poland
    Brain Behav Immun 20:477-87. 2006
    ..These results suggest that hypothalamic NE is involved in the IL-1-induced HPA axis activation, but that this is not the only mechanism by which the HPA axis is activated by intraperitoneally injected IL-1...
  26. pmc The role of corticotropin-releasing factor and noradrenaline in stress-related responses, and the inter-relationships between the two systems
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    Eur J Pharmacol 583:186-93. 2008
    ..The possible abnormalities of these two systems in depressive illness are also discussed...
  27. pmc Physiological and behavioral responses to interleukin-1beta and LPS in vagotomized mice
    Marek Wieczorek
    Laboratory of Neurophysiology, University of Lodz, 66 Rewolucji 1905 r st, 90 222 Lódź, Poland
    Physiol Behav 85:500-11. 2005
    ..Overall the results indicate that the various responses to peripheral IL-1 and LPS involve multiple mechanisms including vagal afferents, and that there are species differences in the relative importance of the various mechanisms...
  28. ncbi Effects of interleukin-1beta on food-maintained behavior in the mouse
    Susan J Larson
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Brain Behav Immun 16:398-410. 2002
    ..These findings suggest that motivational factors may be capable of attenuating some of the behavioral effects of these agents...
  29. ncbi Distinct roles for cyclooxygenases 1 and 2 in interleukin-1-induced behavioral changes
    Artur H Swiergiel
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    J Pharmacol Exp Ther 302:1031-6. 2002
    ....
  30. ncbi Hippocampal noradrenergic responses to CRF injected into the locus coeruleus of unanesthetized rats
    Vitaliy S Palamarchouk
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Brain Res 950:31-8. 2002
    ..The large differences in the responses to glutamate and CRF suggest that the effects of CRF are not exerted directly on receptors on LC neurons, and more likely reflect indirect actions on other cells in this region...
  31. ncbi Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan
    Natalie R Lenard
    Department of Pharmacology and Therapeutics, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    J Pharmacol Exp Ther 305:653-9. 2003
    ..We conclude that activation of either beta(2)- or beta(3)-adrenergic receptors, but not beta(1)-adrenergic receptors, increases mouse brain tryptophan content...
  32. ncbi Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms
    Charles S Cleeland
    Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer 97:2919-25. 2003
    ..These symptoms include pain, wasting, fatigue, cognitive impairment, anxiety, and depression, many of which co-occur. There is growing recognition that at least some of these symptoms may share common biologic mechanisms...
  33. ncbi Interleukin-6 access to the axis
    Adrian J Dunn
    Endocrinology 145:3578-9. 2004
  34. ncbi Increased insulin is not required for beta2-adrenoceptor-induced increases in mouse brain tryptophan
    Natalie R Lenard
    Department of Pharmacology and Therapeutics and School of Graduate Studies, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Eur J Pharmacol 497:105-10. 2004
    ..These results suggest that beta(2)-adrenoceptor agonists increase brain tryptophan by a mechanism that does not involve changes in insulin...
  35. ncbi Potential role for nonesterified fatty acids in beta-adrenoceptor-induced increases in brain tryptophan
    Natalie R Lenard
    Department of Pharmacology and Therapeutics and School of Graduate Studies, Louisiana State University Health Sciences Center, 1501 Kings Highway Shreveport, LA 71130 3932, USA
    Neurochem Int 46:179-87. 2005
    ..Nonetheless, beta3-adrenergic agonists appear to increase brain tryptophan by a mechanism that may depend partially on elevations of plasma NEFAs...
  36. pmc Possible dopaminergic stimulation of locus coeruleus alpha1-adrenoceptors involved in behavioral activation
    Yan Lin
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Synapse 62:516-23. 2008
    ..These results indicate that DA is a candidate as an endogenous agonist for behaviorally activating LC alpha(1)-receptors and may play a role in the activation of this nucleus by novel surroundings...
  37. ncbi A cytokine-based neuroimmunologic mechanism of cancer-related symptoms
    Bang Ning Lee
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neuroimmunomodulation 11:279-92. 2004
    ..These concepts open exciting new avenues for translational research in the pathophysiology and treatment of cancer-related symptoms...
  38. ncbi Mechanisms by which cytokines signal the brain
    Adrian J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Int Rev Neurobiol 52:43-65. 2002
  39. ncbi Mechanisms and significance of the increased brain uptake of tryptophan
    Natalie R Lenard
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Neurochem Res 30:1543-8. 2005
    ..The mechanisms involved in the increases observed in brain tryptophan are discussed, as well as their possible biological significance...