Chu Chen

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurochem 102:1966-77. 2007
  2. pmc Endocannabinoids differentially modulate synaptic plasticity in rat hippocampal CA1 pyramidal neurons
    Jian Yi Xu
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 5:e10306. 2010
  3. ncbi request reprint Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurophysiol 87:2851-7. 2002
  4. pmc Cyclooxygenase-2 in synaptic signaling
    Hongwei Yang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Curr Pharm Des 14:1443-51. 2008
  5. ncbi request reprint Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 340:435-40. 2006
  6. ncbi request reprint Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons
    Chu Chen
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Neurophysiol 93:929-41. 2005
  7. ncbi request reprint ZD7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cell synapses
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Eur J Neurosci 19:643-9. 2004
  8. ncbi request reprint Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT2 receptor
    Chu Chen
    Neuroscience Center of Excellence, School of Medicine, LSU Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Neuroreport 14:743-7. 2003
  9. pmc Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor
    Hongwei Yang
    Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA
    J Neurochem 108:295-304. 2009
  10. pmc Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo Delta9-THC exposure-impaired hippocampal synaptic plasticity
    Ni Fan
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurochem 112:691-702. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurochem 102:1966-77. 2007
    ..Our results suggest that the COX-2 oxidative metabolism of endocannabinoids is an important mechanism contributing to the inflammation-induced neurodegeneration...
  2. pmc Endocannabinoids differentially modulate synaptic plasticity in rat hippocampal CA1 pyramidal neurons
    Jian Yi Xu
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 5:e10306. 2010
    ..However, little information is available on whether and how eCBs modulate glutamatergic synaptic transmission and plasticity at PP synapses...
  3. ncbi request reprint Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurophysiol 87:2851-7. 2002
    ..Our results indicate that COX-2-generated PGE2 regulates membrane excitability and long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses...
  4. pmc Cyclooxygenase-2 in synaptic signaling
    Hongwei Yang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Curr Pharm Des 14:1443-51. 2008
    ..Thus, elucidation of COX-2 in synaptic signaling may provide a mechanistic basis for designing new drugs aimed at preventing, treating or alleviating neuroinflammation-associated neurological disorders...
  5. ncbi request reprint Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 340:435-40. 2006
    ..The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity...
  6. ncbi request reprint Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons
    Chu Chen
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Neurophysiol 93:929-41. 2005
    ....
  7. ncbi request reprint ZD7288 inhibits postsynaptic glutamate receptor-mediated responses at hippocampal perforant path-granule cell synapses
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Eur J Neurosci 19:643-9. 2004
    ..The results suggest that ZD7288-induced reduction of synaptic transmission may result from its inhibition of the postsynaptic glutamate receptors on dentate granule neurons...
  8. ncbi request reprint Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT2 receptor
    Chu Chen
    Neuroscience Center of Excellence, School of Medicine, LSU Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Neuroreport 14:743-7. 2003
    ..The results suggest that APAP-induced modification of synaptic plasticity at hippocampal lateral perforant path-dentate granule cell synapses may be mediated by a presynaptic 5-HT(2) receptor...
  9. pmc Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor
    Hongwei Yang
    Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA
    J Neurochem 108:295-304. 2009
    ..Our results show that hippocampal long-term synaptic plasticity is impaired in mice deficient in the EP2, suggesting that PGE2-EP2 signaling is important for hippocampal long-term synaptic plasticity and cognitive function...
  10. pmc Reduced expression of glutamate receptors and phosphorylation of CREB are responsible for in vivo Delta9-THC exposure-impaired hippocampal synaptic plasticity
    Ni Fan
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurochem 112:691-702. 2010
    ..Our results suggest that reduced expression and function of the GluR subunits and phosphorylation of CREB may underlie the impaired long-term synaptic plasticity induced by repeated in vivo exposure to Delta9-THC...
  11. ncbi request reprint Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:9858-70. 2005
    ..Our results suggest that PGE2 synthesized by postsynaptically localized COX-2 functions as a retrograde messenger in hippocampal synaptic signaling via a presynaptic EP2 receptor...
  12. pmc Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ
    Huizhi Du
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Br J Pharmacol 163:1533-49. 2011
    ....
  13. pmc Δ(9)-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling
    Rongqing Chen
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Cell 155:1154-65. 2013
    ..These results suggest that the applicability of medical marijuana would be broadened by concurrent inhibition of COX-2. ..
  14. pmc Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease
    Rongqing Chen
    Neuroscience Center of Excellence, Louisiana State University Health New Orleans Sciences Center, New Orleans, LA 70112, USA
    Cell Rep 2:1329-39. 2012
    ....
  15. pmc PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Physiol 572:735-45. 2006
    ....
  16. ncbi request reprint Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons
    Carmel M McDermott
    Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70115, USA
    J Neurosci 23:9687-95. 2003
    ..Together these data suggest that failure to acquire adequate sleep produces several molecular and cellular level alterations that profoundly inhibit hippocampal functioning...
  17. pmc COX-2 oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticity
    Hongwei Yang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Mol Cell Neurosci 37:682-95. 2008
    ..Our results indicate that COX-2 oxidative metabolism of eCBs is an important signaling pathway in modulation of synaptic transmission and plasticity...
  18. pmc Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids
    Jian Yi Xu
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    J Physiol 590:2305-15. 2012
    ....
  19. ncbi request reprint Lipid signaling: sleep, synaptic plasticity, and neuroprotection
    Chu Chen
    Neuroscience Center of Excellence and Department of Ophthamology, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Prostaglandins Other Lipid Mediat 77:65-76. 2005
    ....
  20. pmc Neurodevelopmental role for VGLUT2 in pyramidal neuron plasticity, dendritic refinement, and in spatial learning
    Hongbo He
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 32:15886-901. 2012
    ....
  21. pmc Long-term potentiation at hippocampal perforant path-dentate astrocyte synapses
    Xiong Zhang
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, 70112, USA
    Biochem Biophys Res Commun 383:326-30. 2009
    ..Our results suggest that astrocytes in the hippocampal dentate gyrus are able to undergo plasticity in response to presynaptic inputs...
  22. pmc Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation
    Jian Zhang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 283:22601-11. 2008
    ....
  23. pmc SNAT2 amino acid transporter is regulated by amino acids of the SLC6 gamma-aminobutyric acid transporter subfamily in neocortical neurons and may play no role in delivering glutamine for glutamatergic transmission
    Sukhjeevan Grewal
    Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 284:11224-36. 2009
    ..Our data revealed that SNAT2 expression is constitutively low in neurons under physiological conditions but potently induced, together with the taurine transporter TauT, in response to depletion of neutral amino acids...
  24. ncbi request reprint Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors
    Peimin Zhu
    Neuroscience Center, School of Medicine, LSU Health Sciences Center, New Orleans, Louisiana
    J Neurosci Res 81:817-26. 2005
    ....
  25. ncbi request reprint beta-Amyloid increases dendritic Ca2+ influx by inhibiting the A-type K+ current in hippocampal CA1 pyramidal neurons
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 338:1913-9. 2005
    ..This may be a component of the events that cause synaptic failure and initiate neuronal degenerative processes in the hippocampus...
  26. ncbi request reprint Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain
    Jian Guo Cui
    Neuroscience Center of Excellence, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 350:358-63. 2006
    ..Acetaminophen only induced 6.8+/-1.0% inhibition. The results suggest SCP-1 possesses anti-nociceptive activity in the rat model involving calcium channel blocking properties...
  27. ncbi request reprint Lipid signaling and synaptic plasticity
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    Neuroscientist 12:425-34. 2006
    ..Thus, in the present review article, the authors will mainly discuss COX-2 regulation of prostaglandin signaling in modulation of hippocampal synaptic transmission and plasticity...
  28. ncbi request reprint Homeostatic scaling of vesicular glutamate and GABA transporter expression in rat neocortical circuits
    Stephanie De Gois
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:7121-33. 2005
    ....
  29. ncbi request reprint Marijuana use and risk of oral squamous cell carcinoma
    Karin A Rosenblatt
    Department of Community Health, University of Illinois at Urbana Champaign, Champaign, Illinois, USA
    Cancer Res 64:4049-54. 2004
    ..Marijuana use was not associated with OSCC risk in this large, population-based study...
  30. ncbi request reprint Inflammation and endometrial cancer: a hypothesis
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 516A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Cancer Epidemiol Biomarkers Prev 14:2840-7. 2005
    ..A proinflammatory milieu can also directly increase estrogen production. Hence, inflammation may work in conjunction with or in addition to estrogen exposure in the development of endometrial cancer...

Research Grants8

  1. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2010
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..
  2. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2009
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..
  3. Pilot--Cyclooxygenases in neuronal synaptic plasticity
    Chu Chen; Fiscal Year: 2002
    ..abstract_text> ..
  4. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2007
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..
  5. Endocannabinoids in COX-2-Mediated Synaptic Modification and Neurotoxicity
    Chu Chen; Fiscal Year: 2009
    ..The outcome from the proposed project will also provide new targets for designing drugs aimed at treating or alleviating COX-2-mediated degenerative diseases. ..