Research Topics
| NICOLAS GUILLERMO BAZANSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Publications
Alzheimer's disease--a dysfunction in cholesterol and lipid metabolismWalter J Lukiw
LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8D, New Orleans, Louisiana, 70112 2272, USA
Cell Mol Neurobiol 25:475-83. 2005..2. In this short review, recent experimental evidence for these associations is further discussed below...- Lipid signaling: sleep, synaptic plasticity, and neuroprotectionChu Chen
Neuroscience Center of Excellence and Department of Ophthamology, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Prostaglandins Other Lipid Mediat 77:65-76. 2005.... 
A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer diseaseWalter J Lukiw
Louisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
J Clin Invest 115:2774-83. 2005..These results indicate that NPD1 promotes brain cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity...- Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptorNan Sang
Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Neurosci 25:9858-70. 2005..Our results suggest that PGE2 synthesized by postsynaptically localized COX-2 functions as a retrograde messenger in hippocampal synaptic signaling via a presynaptic EP2 receptor... - Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1Nicolas G Bazan
Louisiana State University Health Sciences Center, Neuroscience Center of Excellence and Department of Ophthalmology, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Adv Exp Med Biol 613:39-44. 2008..Also, neurotrophins are regulators of NPD1 synthesis and of its polarized apical efflux from RPE cells. Therefore, NPD1 may elicit autocrine and paracrine bioactivity in cells located in the proximity of the interphotoreceptor matrix... - The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survivalN G Bazan
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Prostaglandins Leukot Essent Fatty Acids 88:127-9. 2013..Therefore, mechanisms and mediators such as NPD1 that curtail consequences of these events are of interest as leads in the search for novel preventive and or therapeutic approaches... - Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1Nicolas G Bazan
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Mol Neurobiol 46:221-6. 2012..This overview discusses the potent neuroprotective and inflammation-modulating bioactivity of NPD1. This lipid mediator represents an early response to neurodegenerations, aiming to restore homeostasis... - Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental strokeNicolas G Bazan
Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Exp Neurol 236:122-30. 2012..In addition, administration of synthetic AT-NPD1, in either its sodium salt or as the methyl ester, was able to attenuate cerebral ischemic injury which leads to a novel approach for pharmaceutical intervention and clinical translation... - What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesisNicolas G Bazan
Neuroscience Center of Excellence, Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Prog Brain Res 135:175-85. 2002..We discuss mechanisms through which lipid messengers, such as AA and PAF, may turn into injury mediators participating in seizure-induced brain damage... - The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signalingNicolas G Bazan
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans 70112, USA
Cell Mol Neurobiol 26:901-13. 2006..The specificity and potency of this novel docosanoid (neuroprotectin D1) indicate a potentially important target for therapeutic intervention... - Lipid signaling in neural plasticity, brain repair, and neuroprotectionNicolas G Bazan
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Mol Neurobiol 32:89-103. 2005.... - Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1Nicolas G Bazan
Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, Neuroscience Center of Excellence, New Orleans, LA 70112, USA
J Lipid Res 51:2018-31. 2010..It also describes the role of neurotrophins as agonists of NPD1 synthesis and how photoreceptor phagocytosis induces refractoriness to oxidative stress in RPE cells, with concomitant NPD1 synthesis... - Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stressNicolas G Bazan
LSU Neuroscience Center and Department of Opthamology, Louisiana State University Health Sciences Center School of Medicine, New Orleans 70112, USA
Brain Pathol 15:159-66. 2005.... - Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factorNicolas G Bazan
Louisiana State University Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
J Lipid Res 44:2221-33. 2003.... - Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protectionNicolas G Bazan
Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Prostaglandins Leukot Essent Fatty Acids 81:205-11. 2009.... - Synaptic signaling by lipids in the life and death of neuronsNicolas G Bazan
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, LA, USA
Mol Neurobiol 31:219-30. 2005.... - Prostaglandins and other lipid mediators in Alzheimer's diseaseNicolas G Bazan
Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA
Prostaglandins Other Lipid Mediat 68:197-210. 2002..This review addresses some current ideas concerning how brain PLA2 and brain PGs are early and key players in acute neural trauma and in brain-cell damage associated with chronic neurodegenerative diseases such as AD... - Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's diseaseNicolas G Bazan
Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
J Lipid Res 50:S400-5. 2009..Thus, NPD1 elicits potent cell-protective, anti-inflammatory, prosurvival repair signaling... - Brain response to injury and neurodegeneration: endogenous neuroprotective signalingNicolas G Bazan
LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, 2020 Gravier Street, Suite D, New Orleans, Louisiana 70112, USA
Ann N Y Acad Sci 1053:137-47. 2005..The specificity and potency of NPD1 indicate a potential target for therapeutic intervention for stroke, age-related macular degeneration, spinal cord injury, and other neuroinflammatory or neurodegenerative diseases... - Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptorsNicolas G Bazan
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, LA 70112, USA
Trends Neurosci 29:263-71. 2006..This enhanced understanding of the molecular basis of endogenous anti-inflammatory and neuroprotective signaling in the RPE presents an opportunity for the development of therapies for retinal degenerative diseases... - Omega-3 fatty acids, pro-inflammatory signaling and neuroprotectionNicolas G Bazan
Louisiana State University Health Sciences Center, Neuroscience Center of Excellence, New Orleans, Louisiana 70112, USA
Curr Opin Clin Nutr Metab Care 10:136-41. 2007..To summarize recent findings that docosahexaenoate (DHA) is the precursor of stereospecific derivatives with anti-inflammatory and cytoprotective properties... - Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrityNicolas G Bazan
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA
Mol Neurobiol 44:216-22. 2011..Therefore, this approach offers emerging targets for prevention, pharmaceutical intervention, and clinical translation involving DHA-mediated signaling... - Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseasesNicolas G Bazan
Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Annu Rev Nutr 31:321-51. 2011..DHA signalolipidomics in the nervous system offers emerging targets for pharmaceutical intervention and clinical translation... - Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor LectureNicolas G Bazan
Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Invest Ophthalmol Vis Sci 48:4866-81; biography 4864-5. 2007 - Prevention of experimental diffuse lamellar keratitis using a novel platelet-activating factor receptor antagonistSalomon Esquenazi
Department of Ophthalmology and Neuroscience Center of Excellence, LSU Health Science Center, Louisiana State University School of Medicine, 2020 Gravier Street 3rd Floor, Suite B, New Orleans, LA 70112, USA
J Cataract Refract Surg 30:884-91. 2004.... - Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survivalPeimin Zhu
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
J Neurosci Res 77:525-31. 2004..This study suggests that PAF-receptor antagonists may be useful for neuroprotection. A similar effect might also be obtained with group I mGluR agonists, probably by way of a different underlying mechanism... - Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neuronsCarmel M McDermott
Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70115, USA
J Neurosci 23:9687-95. 2003..Together these data suggest that failure to acquire adequate sleep produces several molecular and cellular level alterations that profoundly inhibit hippocampal functioning... - Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortexBin Tu
Louisiana State University Health Sciences Center, Neuroscience Center of Excellence, New Orleans, LA 70112, USA
Exp Neurol 179:167-75. 2003..Moreover the COX-2 selective inhibitor nimesulide attenuated kindling development. We conclude that neuronal COX-2 gene induction and cPLA(2) activation are key signaling events in epileptogenesis... - A novel platelet activating factor receptor antagonist reduces cell infiltration and expression of inflammatory mediators in mice exposed to desiccating conditions after PRKSalomon Esquenazi
LSU Eye Center and Neuroscience Center, LSU Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA
Clin Dev Immunol 2009:138513. 2009..To study the contribution of a novel PAF receptor antagonist LAU-0901 in the modulation of the increased inflammatory response in mice exposed to dessicating conditions (DE) after PRK... - Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cellsNicolas G Bazan
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
J Biol Chem 277:30359-67. 2002.... - Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in cultureMiriam Kolko
Louisiana State University Health Sciences Center Neuroscience Center of Excellence, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Neurosci Lett 338:164-8. 2003..We conclude that sPLA(2)-OS2 activates a neuronal signaling cascade that includes activation of cPLA(2), arachidonic acid release, PAF production, and induction of COX-2... - Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cellsJian Guo Cui
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Neurochem Res 29:1731-7. 2004.... - Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signalingPranab K Mukherjee
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
Proc Natl Acad Sci U S A 104:13152-7. 2007..Taken together, these findings imply NPD1 may elicit autocrine actions on RPE cells and paracrine bioactivity in cells located in the proximity of the interphotoreceptor matrix... - Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cellsDayanand D Deo
Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Biol Chem 279:3497-508. 2004..Clearly, PAF-mediated signaling in differentiated endothelial cells is critical to endothelial cell functions, including cell migration and proteolytic activation of MMP2... - Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albuminElena B Rodriguez de Turco
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA
J Neurochem 83:515-24. 2002.... - Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signalingVittorio Colangelo
Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-2272, USA
J Neurosci Res 70:462-73. 2002.... - Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondriaM Soledad Cortina
Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Exp Eye Res 81:742-50. 2005..Thus, DNA-repair enzymes such as polymerase gamma and 8-oxoguanine-DNA-glycosylase may provide novel pharmacologic targets to promote DNA repair and rescue photoreceptors in retinal degenerative diseases... - Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptorsPeimin Zhu
Neuroscience Center, School of Medicine, LSU Health Sciences Center, New Orleans, Louisiana
J Neurosci Res 81:817-26. 2005.... - Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expressionVictor L Marcheselli
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Biol Chem 278:43807-17. 2003..These results challenge the view that docosahexaenoate only participates in brain damage and demonstrate that this fatty acid is also the endogenous precursor to a neuroprotective signaling response to ischemia-reperfusion... - PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosisZahra Faghiri
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA
Exp Eye Res 90:718-25. 2010.... - Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonistJiucheng He
Department of Ophthalmology and Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA
Arch Ophthalmol 124:70-8. 2006..Clinical Relevance The inhibition of PAF action by LAU0901 could be important in the immediate and intermediate treatment of chemical injuries to preserve the integrity of the cornea... - Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesisAlberto Musto
LSU Neuroscience Center of Excellence, Louisiana State University School of Medicine, Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, U.S.A
Epilepsia 47:267-76. 2006.... - Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHAM Soledad Cortina
Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 51:804-10. 2010.... - Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerationsNicolas G Bazan
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Adv Exp Med Biol 572:531-40. 2006..This new survival signaling is potentially of interest in the understanding of the pathophysiology of retinal degenerations and in exploration of new therapeutic modalities... - Secreted phospholipase A2 potentiates glutamate-induced calcium increase and cell death in primary neuronal culturesMark A DeCoster
Neuroscience Center, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA
J Neurosci Res 67:634-45. 2002..These results indicate that sPLA2 affects neuronal responses to both nontoxic (0.1-10 microM) and toxic (=25 microM) concentrations of glutamate, implicating this enzyme in neuronal functions in pathology... - Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epitheliumZahra Faghiri
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 47:397-404. 2006..These signaling events may be critical during RPE responses to oxidative stress, inflammation, and retinal degenerations, when PAF production is enhanced... - Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidationLisa A Teather
Neuroscience Center of Excellence, Louisiana State University Health Center, New Orleans, LA 70112, USA
Learn Mem 9:41-7. 2002..These findings indicate that COX-2 is a required biochemical component mediating the consolidation of hippocampal-dependent memory... - Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migrationT William Axelrad
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
FASEB J 18:568-70. 2004..6:1, approximating the hypothesized ideal ratio of 2:1 necessary for the conversion of proMMP2 to MMP2. Our data support the involvement of PAF in vascular endothelial cell migration and invasion... - Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stressPranab K Mukherjee
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
Proc Natl Acad Sci U S A 101:8491-6. 2004..Because both RPE and photoreceptor cells die in retinal degenerations, our findings contribute to the understanding of retinal cell survival signaling and potentially to the development of new therapeutic strategies... - Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activityPaulo Ottino
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Mol Vis 10:341-50. 2004..These molecular changes in EC could, in part, contribute to the angiogenic response that occurs in the development of ischemic retinopathies and choroidal neovascularization... - Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptorsMiriam Kolko
Lousiana State University Health Sciences Center, Neuroscience Center of Excellence and Department of Opthalmology, New Orleans, LA 70112, USA
Neuroreport 13:1963-6. 2002..Systemic administration of MK-801 to rats that had sPLA injected into the right striatum significantly decreased neuronal cell death. We conclude that glutamatergic synaptic activity modulates sPLA -induced neuronal cell death... - Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cellsXiang Ma
Department of Ophthalmology, Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 45:2915-21. 2004..The current study was conducted to investigate the direct effect of PAF on corneal neovascularization and on the expression of angiogenic growth factors in vascular endothelial cells... - Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesisGuru Dutt Sharma
Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
J Biol Chem 280:7917-24. 2005.... - Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neuronsShi Di
Division of Neurobiology, Tulane University, New Orleans, Louisiana 70118-5698, USA
Endocrinology 146:4292-301. 2005.... - Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1Jorgelina M Calandria
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
J Biol Chem 284:17877-82. 2009..These results demonstrate that 15-lipoxygenase-1 is activated by oxidative stress in ARPE-19 cells and that NPD1 is part of an early survival signaling in RPE cells... - Mapping the entire human corneal nerve architectureJiucheng He
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA
Exp Eye Res 91:513-23. 2010..Our study reveals that aging decreases the number of central epithelial nerve terminals, and increases the presence of irregular anomalies beneath the basal layer... - Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemiaLudmila Belayev
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Stroke 40:3121-6. 2009..This study was conducted to assess whether DHA would show neuroprotective efficacy when systemically administered in different doses after middle cerebral artery occlusion (MCAo) in rats... - LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemiaLudmila Belayev
Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Exp Neurol 214:253-8. 2008..Thus, this PAF receptor antagonist exhibits potent and sustained neuroprotection that may be of value for the design of stroke therapies... 
Agrin downregulation induced by nerve injury contributes to neuropathic painJian Guo Cui
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
J Neurosci 30:15286-97. 2010..In conclusion, 50 kDa agrin modulates neuropathic pain through NR1 phosphorylation in GABA neurons. This mechanism may open new approaches for treating not only neuropathic pain, but also epilepsy, tremors, and spasticity...- A2E selectively induces cox-2 in ARPE-19 and human neural cellsWalter J Lukiw
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, 70112, USA
Curr Eye Res 31:259-63. 2006.... - Expression and location of mRNAs encoding multiple forms of secretory phospholipase A2 in the rat retinaMiriam Kolko
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Neurosci Res 77:517-24. 2004..We suggest that these enzymes are themselves intercellular signaling modulators of retinal cell function and perhaps also of retinal degeneration... - Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neuronsChu Chen
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Neurophysiol 93:929-41. 2005.... - Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomySalomon Esquenazi
Department of Ophthalmology and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Cataract Refract Surg 31:1632-9. 2005..To evaluate in a rabbit model the differences in cellular and matrix stromal response in low and high attempted corrections between photorefractive keratectomy (PRK) and laser-assisted subepithelial keratectomy (LASEK)... - Deafness and retinal degeneration in a novel USH1C knock-in mouse modelJennifer J Lentz
Department of Genetics, LSU Health Sciences Center, New Orleans, Louisiana, USA
Dev Neurobiol 70:253-67. 2010..This knock-in mouse reproduces the dual sensory loss of human Usher I, providing a novel resource to study the disease mechanism and the development of therapies... - Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleusShi Di
Department of Cell and Molecular Biology, 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118-5698, USA
J Physiol 569:751-60. 2005..This activity-dependent regulation of excitatory synaptic input by endocannabinoids may play a role in determining spiking patterns characteristic of magnocellular neurones under stimulated conditions... - Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampusCarmel M McDermott
Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70115, USA
J Physiol 570:553-65. 2006..This synaptic alteration may underlie the cognitive deficits seen following sleep deprivation and could represent a target for future intervention studies... - Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairmentsChu Chen
Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Biochem Biophys Res Commun 340:435-40. 2006..The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity... - Wound-healing response and refractive regression after conductive keratoplastySalomon Esquenazi
LSU Eye Center, LSU Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
J Cataract Refract Surg 32:480-6. 2006..To characterize the histological changes that occur after conductive keratoplasty (CK) using a rabbit model... - Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanismDayanand D Deo
Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Biol Chem 277:21237-45. 2002..Taken together, these findings suggest the production of PAF is important for bFGF-mediated signaling and that a dual kinase mechanism is involved in the PAF-mediated signal transduction cascade... - Comparative in vivo high-resolution confocal microscopy of corneal epithelium, sub-basal nerves and stromal cells in mice with and without dry eye after photorefractive keratectomySalomon Esquenazi
LSU Eye Center and Neuroscience Center, LSU Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
Clin Experiment Ophthalmol 35:545-9. 2007.... - Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT2 receptorChu Chen
Neuroscience Center of Excellence, School of Medicine, LSU Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
Neuroreport 14:743-7. 2003..The results suggest that APAP-induced modification of synaptic plasticity at hippocampal lateral perforant path-dentate granule cell synapses may be mediated by a presynaptic 5-HT(2) receptor... - Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxiaWalter J Lukiw
Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Invest Ophthalmol Vis Sci 44:4163-70. 2003..Effects of the carboxamide CGP43182 were tested on COX-2 and VEGF activation and prostaglandin (PG)E(2) release... - Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosisWalter J Lukiw
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
Mol Neurobiol 42:10-6. 2010.... - Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticityChu Chen
Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Neurophysiol 87:2851-7. 2002..Our results indicate that COX-2-generated PGE2 regulates membrane excitability and long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses... - LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the ratLudmila Belayev
Neuroscience Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
Brain Res 1253:184-90. 2009..3 +/- 4.6% vs. 46.0 +/- 10.3%, respectively). These results establish that LAU-0901 confers enduring ischemic neuroprotection... - Docosahexaenoic acid and the aging brainWalter J Lukiw
Department of Ophthalmology, LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Nutr 138:2510-4. 2008.... - Use of autologous serum in corneal epithelial defects post-lamellar surgerySalomon Esquenazi
Department of Ophthalmology and Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, LA 70112, USA
Cornea 24:992-7. 2005..To evaluate the efficacy of an autologous serum treatment of post-LASIK (laser in situ keratomileusis) corneal epithelial defects in a rabbit model... - DNA damage and repair in light-induced photoreceptor degenerationWilliam C Gordon
Louisiana State University Health Sciences Center, Department of Ophthalmology and Neuroscience Center, New Orleans 70112, USA
Invest Ophthalmol Vis Sci 43:3511-21. 2002..These events may provide useful drug targets to promote photoreceptor survival in various forms of retinal degeneration... - Secretory phospholipase A(2) induces delayed neuronal COX-2 expression compared with glutamateMiriam Kolko
Laboratory of Neuropathology, University of Copenhagen, Copenhagen, Denmark
J Neurosci Res 69:169-77. 2002..We conclude that sPLA(2) may modulate neuronal COX-2 expression through mechanisms that differ from those of glutamate-induced COX-2 expression... - Glutamate signalling and secretory phospholipase A2 modulate the release of arachidonic acid from neuronal membranesElena B Rodriguez de Turco
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
J Neurosci Res 68:558-67. 2002.... - Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathwaysDavid S Gelinas
Department of Pharmacology, University of Montreal, Montreal QC, Canada
Br J Pharmacol 137:1021-30. 2002..5. In conclusion, VEGF induces an immediate cGMP synthesis through the PLC-Ca2+/CaM pathway, and that the induction of delayed cGMP synthesis implies Akt and PKC activity... - DNA repair in photoreceptor survivalM Soledad Cortina
Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Mol Neurobiol 28:111-22. 2003.... - Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid releaseRenato Malcher-Lopes
Neuroscience Program, Tulane University, New Orleans, Louisiana 70118, USA
J Neurosci 26:6643-50. 2006.... - Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segmentsMiriam Kolko
Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark
Invest Ophthalmol Vis Sci 48:1401-9. 2007..To identify intracellular phospholipases A(2) (PLA(2)) in the human retina and to explore the role of these enzymes in human retinal pigment epithelium (RPE) phagocytosis of photoreceptor outer segments (POS)... - Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cellsMerete Boedker
Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Neurosci Lett 380:176-80. 2005.... - Survival signalling in Alzheimer's diseaseW J Lukiw
Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112 2272, USA or
Biochem Soc Trans 34:1277-82. 2006....
Research Grants
- Neuroprotection Lipid Signaling in Ischemia ReperfusionNICOLAS GUILLERMO BAZAN; Fiscal Year: 2010..These findings have the potential to open a new translational avenue for clinical therapies of cerebrovascular diseases. ..
- Phospholipid and Arachidonic Acid Signaling in EpilepsyNicolas Bazan; Fiscal Year: 2005..This work is expected to provide new insights into neuronal signaling in epileptogenesis, to uncover novel molecular pathways in seizure-induced neuronal injury and define events for neuroprotective pharmacological interventions. ..
- MENTORING NEUROSCIENCE IN LOUISIANANicolas Bazan; Fiscal Year: 2006..The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana. ..
- RPE Messengers, Transcription & Photoreceptor RenewalNicolas Bazan; Fiscal Year: 2009..This will include defining the mechanism of prosaposin gene induction in RPE cytoprotection, making use of LAU-0901. We aim for a better understanding of AMD and to contribute to the development of effective therapies. ..
- Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance NeuroscienceNicolas Bazan; Fiscal Year: 2009..abstract_text> ..
- Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance NeuroscienceNICOLAS GUILLERMO BAZAN; Fiscal Year: 2010..We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana. ..
- RPE Messengers, Transcription & Photoreceptor RenewalNicolas Bazan; Fiscal Year: 2009..This will include defining the mechanism of prosaposin gene induction in RPE cytoprotection, making use of LAU-0901. We aim for a better understanding of AMD and to contribute to the development of effective therapies. ..
- Neuroprotection Lipid Signaling in Ischemia ReperfusionNicolas Bazan; Fiscal Year: 2009....
- Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance NeuroscienceNicolas Bazan; Fiscal Year: 2009..We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana. ..
- Phospholipid and Arachidonic Acid Signaling in EpilepsyNicolas Bazan; Fiscal Year: 2007..abstract_text> ..
- Neuroprotection Lipid Signaling in Ischemia ReperfusionNicolas Bazan; Fiscal Year: 2007....
- Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance NeuroscienceNicolas Bazan; Fiscal Year: 2007..We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana. ..
- RPE MESSENGERS, TRANSCRIPTION AND PHOTORECEPTOR RENEWALNicolas Bazan; Fiscal Year: 1999....
- PHOSPHOLIPIDS AND ARACHIDONIC ACID AND EPNicolas Bazan; Fiscal Year: 2000....
- ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSYNicolas Bazan; Fiscal Year: 1993....
- LEUKOTRIENES AND PROSTAGLANDINS IN PHOTORECEPTOR RENEWALNicolas Bazan; Fiscal Year: 1991..The results obtained will define the involvement of the arachidonic acid cascade and the inositol lipid cycle in the modulation of the interactions between visual cells and retinal pigment epithelium...