NICOLAS GUILLERMO BAZAN

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism
    Walter J Lukiw
    LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8D, New Orleans, Louisiana, 70112 2272, USA
    Cell Mol Neurobiol 25:475-83. 2005
  2. ncbi request reprint Lipid signaling: sleep, synaptic plasticity, and neuroprotection
    Chu Chen
    Neuroscience Center of Excellence and Department of Ophthamology, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Prostaglandins Other Lipid Mediat 77:65-76. 2005
  3. pmc A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
    Walter J Lukiw
    Louisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Clin Invest 115:2774-83. 2005
  4. ncbi request reprint Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:9858-70. 2005
  5. pmc Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1
    Nicolas G Bazan
    Louisiana State University Health Sciences Center, Neuroscience Center of Excellence and Department of Ophthalmology, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Adv Exp Med Biol 613:39-44. 2008
  6. pmc Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARĪ³-mediated mechanisms in Alzheimer's disease models
    Yuhai Zhao
    School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e15816. 2011
  7. pmc Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1
    Jorgelina M Calandria
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 287:23726-39. 2012
  8. pmc Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse
    Kristopher G Sheets
    Department of Ophthalmology and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Mol Vis 16:320-9. 2010
  9. pmc Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats
    Tiffany N Eady
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 7:e46151. 2012
  10. pmc Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1
    Kristopher G Sheets
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, LA, USA
    Mol Vis 19:1747-59. 2013

Research Grants

  1. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2010
  2. RPE Messengers, Transcription & Photoreceptor Renewal
    Nicolas Bazan; Fiscal Year: 2005
  3. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    Nicolas Bazan; Fiscal Year: 2005
  4. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2005
  5. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2005
  6. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    Nicolas Bazan; Fiscal Year: 2004
  7. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2004
  8. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2004
  9. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2003
  10. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2003

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism
    Walter J Lukiw
    LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8D, New Orleans, Louisiana, 70112 2272, USA
    Cell Mol Neurobiol 25:475-83. 2005
    ..2. In this short review, recent experimental evidence for these associations is further discussed below...
  2. ncbi request reprint Lipid signaling: sleep, synaptic plasticity, and neuroprotection
    Chu Chen
    Neuroscience Center of Excellence and Department of Ophthamology, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Prostaglandins Other Lipid Mediat 77:65-76. 2005
    ....
  3. pmc A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
    Walter J Lukiw
    Louisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Clin Invest 115:2774-83. 2005
    ..These results indicate that NPD1 promotes brain cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity...
  4. ncbi request reprint Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:9858-70. 2005
    ..Our results suggest that PGE2 synthesized by postsynaptically localized COX-2 functions as a retrograde messenger in hippocampal synaptic signaling via a presynaptic EP2 receptor...
  5. pmc Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1
    Nicolas G Bazan
    Louisiana State University Health Sciences Center, Neuroscience Center of Excellence and Department of Ophthalmology, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Adv Exp Med Biol 613:39-44. 2008
    ..Also, neurotrophins are regulators of NPD1 synthesis and of its polarized apical efflux from RPE cells. Therefore, NPD1 may elicit autocrine and paracrine bioactivity in cells located in the proximity of the interphotoreceptor matrix...
  6. pmc Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARĪ³-mediated mechanisms in Alzheimer's disease models
    Yuhai Zhao
    School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e15816. 2011
    ....
  7. pmc Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1
    Jorgelina M Calandria
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 287:23726-39. 2012
    ....
  8. pmc Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse
    Kristopher G Sheets
    Department of Ophthalmology and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Mol Vis 16:320-9. 2010
    ..Specifically, this was assessed by clinically grading laser-induced lesions, measuring leakage area, and volumetrically quantifying vascular endothelial cell proliferation...
  9. pmc Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats
    Tiffany N Eady
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 7:e46151. 2012
    ..We hypothesize that DHA elicits neuroprotection by inducing AKT/p70S6K phosphorylation, which in turn leads to cell survival and protects against ischemic stroke in young and aged rats...
  10. pmc Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1
    Kristopher G Sheets
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, LA, USA
    Mol Vis 19:1747-59. 2013
    ..We also examined the effect of NPD1 on the recruitment and activation of microglia surrounding CNV lesions...
  11. pmc Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window
    Tiffany N Eady
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, 70112, USA
    Exp Transl Stroke Med 4:19. 2012
    ..abstract:..
  12. pmc The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival
    N G Bazan
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Prostaglandins Leukot Essent Fatty Acids 88:127-9. 2013
    ..Therefore, mechanisms and mediators such as NPD1 that curtail consequences of these events are of interest as leads in the search for novel preventive and or therapeutic approaches...
  13. pmc Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1
    Nicolas G Bazan
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Mol Neurobiol 46:221-6. 2012
    ..This overview discusses the potent neuroprotective and inflammation-modulating bioactivity of NPD1. This lipid mediator represents an early response to neurodegenerations, aiming to restore homeostasis...
  14. pmc Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke
    Nicolas G Bazan
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Neurol 236:122-30. 2012
    ..In addition, administration of synthetic AT-NPD1, in either its sodium salt or as the methyl ester, was able to attenuate cerebral ischemic injury which leads to a novel approach for pharmaceutical intervention and clinical translation...
  15. pmc Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease
    Nicolas G Bazan
    Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Lipid Res 50:S400-5. 2009
    ..Thus, NPD1 elicits potent cell-protective, anti-inflammatory, prosurvival repair signaling...
  16. ncbi request reprint Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture
    Nicolas G Bazan
    Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 48:4866-81; biography 4864-5. 2007
  17. ncbi request reprint Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection
    Nicolas G Bazan
    Louisiana State University Health Sciences Center, Neuroscience Center of Excellence, New Orleans, Louisiana 70112, USA
    Curr Opin Clin Nutr Metab Care 10:136-41. 2007
    ..To summarize recent findings that docosahexaenoate (DHA) is the precursor of stereospecific derivatives with anti-inflammatory and cytoprotective properties...
  18. ncbi request reprint Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress
    Nicolas G Bazan
    LSU Neuroscience Center and Department of Opthamology, Louisiana State University Health Sciences Center School of Medicine, New Orleans 70112, USA
    Brain Pathol 15:159-66. 2005
    ....
  19. ncbi request reprint Synaptic signaling by lipids in the life and death of neurons
    Nicolas G Bazan
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, LA, USA
    Mol Neurobiol 31:219-30. 2005
    ....
  20. ncbi request reprint The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling
    Nicolas G Bazan
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans 70112, USA
    Cell Mol Neurobiol 26:901-13. 2006
    ..The specificity and potency of this novel docosanoid (neuroprotectin D1) indicate a potentially important target for therapeutic intervention...
  21. ncbi request reprint Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
    Nicolas G Bazan
    LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, LA 70112, USA
    Trends Neurosci 29:263-71. 2006
    ..This enhanced understanding of the molecular basis of endogenous anti-inflammatory and neuroprotective signaling in the RPE presents an opportunity for the development of therapies for retinal degenerative diseases...
  22. ncbi request reprint Lipid signaling in neural plasticity, brain repair, and neuroprotection
    Nicolas G Bazan
    LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Mol Neurobiol 32:89-103. 2005
    ....
  23. ncbi request reprint Brain response to injury and neurodegeneration: endogenous neuroprotective signaling
    Nicolas G Bazan
    LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, 2020 Gravier Street, Suite D, New Orleans, Louisiana 70112, USA
    Ann N Y Acad Sci 1053:137-47. 2005
    ..The specificity and potency of NPD1 indicate a potential target for therapeutic intervention for stroke, age-related macular degeneration, spinal cord injury, and other neuroinflammatory or neurodegenerative diseases...
  24. ncbi request reprint Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor
    Nicolas G Bazan
    Louisiana State University Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Lipid Res 44:2221-33. 2003
    ....
  25. pmc Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1
    Nicolas G Bazan
    Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, Neuroscience Center of Excellence, New Orleans, LA 70112, USA
    J Lipid Res 51:2018-31. 2010
    ..It also describes the role of neurotrophins as agonists of NPD1 synthesis and how photoreceptor phagocytosis induces refractoriness to oxidative stress in RPE cells, with concomitant NPD1 synthesis...
  26. ncbi request reprint Prostaglandins and other lipid mediators in Alzheimer's disease
    Nicolas G Bazan
    Department of Ophthalmology, LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Prostaglandins Other Lipid Mediat 68:197-210. 2002
    ..This review addresses some current ideas concerning how brain PLA2 and brain PGs are early and key players in acute neural trauma and in brain-cell damage associated with chronic neurodegenerative diseases such as AD...
  27. ncbi request reprint What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis
    Nicolas G Bazan
    Neuroscience Center of Excellence, Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Prog Brain Res 135:175-85. 2002
    ..We discuss mechanisms through which lipid messengers, such as AA and PAF, may turn into injury mediators participating in seizure-induced brain damage...
  28. pmc Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection
    Nicolas G Bazan
    Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Prostaglandins Leukot Essent Fatty Acids 81:205-11. 2009
    ....
  29. pmc Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity
    Nicolas G Bazan
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA, 70112, USA
    Mol Neurobiol 44:216-22. 2011
    ..Therefore, this approach offers emerging targets for prevention, pharmaceutical intervention, and clinical translation involving DHA-mediated signaling...
  30. pmc Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases
    Nicolas G Bazan
    Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Annu Rev Nutr 31:321-51. 2011
    ..DHA signalolipidomics in the nervous system offers emerging targets for pharmaceutical intervention and clinical translation...
  31. ncbi request reprint Prevention of experimental diffuse lamellar keratitis using a novel platelet-activating factor receptor antagonist
    Salomon Esquenazi
    Department of Ophthalmology and Neuroscience Center of Excellence, LSU Health Science Center, Louisiana State University School of Medicine, 2020 Gravier Street 3rd Floor, Suite B, New Orleans, LA 70112, USA
    J Cataract Refract Surg 30:884-91. 2004
    ..To determine whether a novel platelet-activating factor (PAF) antagonist prevents experimentally induced diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK)...
  32. ncbi request reprint Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex
    Bin Tu
    Louisiana State University Health Sciences Center, Neuroscience Center of Excellence, New Orleans, LA 70112, USA
    Exp Neurol 179:167-75. 2003
    ..Moreover the COX-2 selective inhibitor nimesulide attenuated kindling development. We conclude that neuronal COX-2 gene induction and cPLA(2) activation are key signaling events in epileptogenesis...
  33. ncbi request reprint Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons
    Carmel M McDermott
    Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70115, USA
    J Neurosci 23:9687-95. 2003
    ..Together these data suggest that failure to acquire adequate sleep produces several molecular and cellular level alterations that profoundly inhibit hippocampal functioning...
  34. ncbi request reprint Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival
    Peimin Zhu
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
    J Neurosci Res 77:525-31. 2004
    ..This study suggests that PAF-receptor antagonists may be useful for neuroprotection. A similar effect might also be obtained with group I mGluR agonists, probably by way of a different underlying mechanism...
  35. ncbi request reprint Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells
    Nicolas G Bazan
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
    J Biol Chem 277:30359-67. 2002
    ....
  36. ncbi request reprint Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture
    Miriam Kolko
    Louisiana State University Health Sciences Center Neuroscience Center of Excellence, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Neurosci Lett 338:164-8. 2003
    ..We conclude that sPLA(2)-OS2 activates a neuronal signaling cascade that includes activation of cPLA(2), arachidonic acid release, PAF production, and induction of COX-2...
  37. pmc A novel platelet activating factor receptor antagonist reduces cell infiltration and expression of inflammatory mediators in mice exposed to desiccating conditions after PRK
    Salomon Esquenazi
    LSU Eye Center and Neuroscience Center, LSU Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA
    Clin Dev Immunol 2009:138513. 2009
    ..To study the contribution of a novel PAF receptor antagonist LAU-0901 in the modulation of the increased inflammatory response in mice exposed to dessicating conditions (DE) after PRK...
  38. ncbi request reprint Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells
    Dayanand D Deo
    Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 279:3497-508. 2004
    ..Clearly, PAF-mediated signaling in differentiated endothelial cells is critical to endothelial cell functions, including cell migration and proteolytic activation of MMP2...
  39. ncbi request reprint Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells
    Jian Guo Cui
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Neurochem Res 29:1731-7. 2004
    ....
  40. pmc Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling
    Pranab K Mukherjee
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 104:13152-7. 2007
    ..Taken together, these findings imply NPD1 may elicit autocrine actions on RPE cells and paracrine bioactivity in cells located in the proximity of the interphotoreceptor matrix...
  41. ncbi request reprint Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis
    Alberto Musto
    LSU Neuroscience Center of Excellence, Louisiana State University School of Medicine, Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, U S A
    Epilepsia 47:267-76. 2006
    ..We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis...
  42. ncbi request reprint Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist
    Jiucheng He
    Department of Ophthalmology and Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    Arch Ophthalmol 124:70-8. 2006
    ..To evaluate the effect of LAU0901 (2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester), a novel platelet-activating factor (PAF) receptor antagonist, on a rabbit model of severe corneal alkali injury...
  43. ncbi request reprint Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations
    Nicolas G Bazan
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Adv Exp Med Biol 572:531-40. 2006
    ..This new survival signaling is potentially of interest in the understanding of the pathophysiology of retinal degenerations and in exploration of new therapeutic modalities...
  44. pmc PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis
    Zahra Faghiri
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    Exp Eye Res 90:718-25. 2010
    ....
  45. ncbi request reprint Secreted phospholipase A2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures
    Mark A DeCoster
    Neuroscience Center, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci Res 67:634-45. 2002
    ..These results indicate that sPLA2 affects neuronal responses to both nontoxic (0.1-10 microM) and toxic (=25 microM) concentrations of glutamate, implicating this enzyme in neuronal functions in pathology...
  46. pmc Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA
    M Soledad Cortina
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 51:804-10. 2010
    ....
  47. ncbi request reprint Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria
    M Soledad Cortina
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine in New Orleans, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Exp Eye Res 81:742-50. 2005
    ..Thus, DNA-repair enzymes such as polymerase gamma and 8-oxoguanine-DNA-glycosylase may provide novel pharmacologic targets to promote DNA repair and rescue photoreceptors in retinal degenerative diseases...
  48. ncbi request reprint Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin
    Elena B Rodriguez de Turco
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA
    J Neurochem 83:515-24. 2002
    ....
  49. ncbi request reprint Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors
    Peimin Zhu
    Neuroscience Center, School of Medicine, LSU Health Sciences Center, New Orleans, Louisiana
    J Neurosci Res 81:817-26. 2005
    ....
  50. ncbi request reprint Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression
    Victor L Marcheselli
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 278:43807-17. 2003
    ..These results challenge the view that docosahexaenoate only participates in brain damage and demonstrate that this fatty acid is also the endogenous precursor to a neuroprotective signaling response to ischemia-reperfusion...
  51. ncbi request reprint Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling
    Vittorio Colangelo
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 2272, USA
    J Neurosci Res 70:462-73. 2002
    ....
  52. ncbi request reprint Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis
    Guru Dutt Sharma
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 280:7917-24. 2005
    ....
  53. ncbi request reprint Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells
    Xiang Ma
    Department of Ophthalmology, Neuroscience Center of Excellence, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 45:2915-21. 2004
    ..The current study was conducted to investigate the direct effect of PAF on corneal neovascularization and on the expression of angiogenic growth factors in vascular endothelial cells...
  54. pmc Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1
    Jorgelina M Calandria
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 284:17877-82. 2009
    ..These results demonstrate that 15-lipoxygenase-1 is activated by oxidative stress in ARPE-19 cells and that NPD1 is part of an early survival signaling in RPE cells...
  55. ncbi request reprint Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity
    Paulo Ottino
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Mol Vis 10:341-50. 2004
    ....
  56. pmc Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
    Pranab K Mukherjee
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 101:8491-6. 2004
    ..Because both RPE and photoreceptor cells die in retinal degenerations, our findings contribute to the understanding of retinal cell survival signaling and potentially to the development of new therapeutic strategies...
  57. ncbi request reprint Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration
    T William Axelrad
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    FASEB J 18:568-70. 2004
    ..6:1, approximating the hypothesized ideal ratio of 2:1 necessary for the conversion of proMMP2 to MMP2. Our data support the involvement of PAF in vascular endothelial cell migration and invasion...
  58. pmc Mapping the entire human corneal nerve architecture
    Jiucheng He
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA
    Exp Eye Res 91:513-23. 2010
    ..Our study reveals that aging decreases the number of central epithelial nerve terminals, and increases the presence of irregular anomalies beneath the basal layer...
  59. ncbi request reprint Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors
    Miriam Kolko
    Lousiana State University Health Sciences Center, Neuroscience Center of Excellence and Department of Opthalmology, New Orleans, LA 70112, USA
    Neuroreport 13:1963-6. 2002
    ..Systemic administration of MK-801 to rats that had sPLA injected into the right striatum significantly decreased neuronal cell death. We conclude that glutamatergic synaptic activity modulates sPLA -induced neuronal cell death...
  60. ncbi request reprint Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons
    Shi Di
    Division of Neurobiology, Tulane University, New Orleans, Louisiana 70118 5698, USA
    Endocrinology 146:4292-301. 2005
    ....
  61. ncbi request reprint Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium
    Zahra Faghiri
    LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 47:397-404. 2006
    ....
  62. pmc Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation
    Lisa A Teather
    Neuroscience Center of Excellence, Louisiana State University Health Center, New Orleans, LA 70112, USA
    Learn Mem 9:41-7. 2002
    ..These findings indicate that COX-2 is a required biochemical component mediating the consolidation of hippocampal-dependent memory...
  63. ncbi request reprint Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 340:435-40. 2006
    ..The results suggest that the reduction of functional NMDAR in hippocampal neurons may underlie the SD-induced deficits in hippocampus-dependent contextual memory and long-term synaptic plasticity...
  64. pmc Deafness and retinal degeneration in a novel USH1C knock-in mouse model
    Jennifer J Lentz
    Department of Genetics, LSU Health Sciences Center, New Orleans, Louisiana, USA
    Dev Neurobiol 70:253-67. 2010
    ..This knock-in mouse reproduces the dual sensory loss of human Usher I, providing a novel resource to study the disease mechanism and the development of therapies...
  65. ncbi request reprint A2E selectively induces cox-2 in ARPE-19 and human neural cells
    Walter J Lukiw
    LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, New Orleans, 70112, USA
    Curr Eye Res 31:259-63. 2006
    ....
  66. pmc Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia
    Ludmila Belayev
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Stroke 40:3121-6. 2009
    ..This study was conducted to assess whether DHA would show neuroprotective efficacy when systemically administered in different doses after middle cerebral artery occlusion (MCAo) in rats...
  67. ncbi request reprint Expression and location of mRNAs encoding multiple forms of secretory phospholipase A2 in the rat retina
    Miriam Kolko
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci Res 77:517-24. 2004
    ..We suggest that these enzymes are themselves intercellular signaling modulators of retinal cell function and perhaps also of retinal degeneration...
  68. pmc Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus
    Carmel M McDermott
    Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70115, USA
    J Physiol 570:553-65. 2006
    ..This synaptic alteration may underlie the cognitive deficits seen following sleep deprivation and could represent a target for future intervention studies...
  69. ncbi request reprint Agrin downregulation induced by nerve injury contributes to neuropathic pain
    Jian Guo Cui
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Neurosci 30:15286-97. 2010
    ..In conclusion, 50 kDa agrin modulates neuropathic pain through NR1 phosphorylation in GABA neurons. This mechanism may open new approaches for treating not only neuropathic pain, but also epilepsy, tremors, and spasticity...
  70. ncbi request reprint Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism
    Dayanand D Deo
    Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:21237-45. 2002
    ..Taken together, these findings suggest the production of PAF is important for bFGF-mediated signaling and that a dual kinase mechanism is involved in the PAF-mediated signal transduction cascade...
  71. ncbi request reprint Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons
    Chu Chen
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Neurophysiol 93:929-41. 2005
    ....
  72. pmc Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus
    Shi Di
    Department of Cell and Molecular Biology, 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118 5698, USA
    J Physiol 569:751-60. 2005
    ..This activity-dependent regulation of excitatory synaptic input by endocannabinoids may play a role in determining spiking patterns characteristic of magnocellular neurones under stimulated conditions...
  73. ncbi request reprint Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy
    Salomon Esquenazi
    Department of Ophthalmology and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Cataract Refract Surg 31:1632-9. 2005
    ..To evaluate in a rabbit model the differences in cellular and matrix stromal response in low and high attempted corrections between photorefractive keratectomy (PRK) and laser-assisted subepithelial keratectomy (LASEK)...
  74. pmc LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia
    Ludmila Belayev
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Neurol 214:253-8. 2008
    ..Thus, this PAF receptor antagonist exhibits potent and sustained neuroprotection that may be of value for the design of stroke therapies...
  75. ncbi request reprint Wound-healing response and refractive regression after conductive keratoplasty
    Salomon Esquenazi
    LSU Eye Center, LSU Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Cataract Refract Surg 32:480-6. 2006
    ..To characterize the histological changes that occur after conductive keratoplasty (CK) using a rabbit model...
  76. ncbi request reprint Use of autologous serum in corneal epithelial defects post-lamellar surgery
    Salomon Esquenazi
    Department of Ophthalmology and Neuroscience Center of Excellence, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Cornea 24:992-7. 2005
    ..To evaluate the efficacy of an autologous serum treatment of post-LASIK (laser in situ keratomileusis) corneal epithelial defects in a rabbit model...
  77. ncbi request reprint Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity
    Chu Chen
    Neuroscience Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurophysiol 87:2851-7. 2002
    ..Our results indicate that COX-2-generated PGE2 regulates membrane excitability and long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses...
  78. ncbi request reprint Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia
    Walter J Lukiw
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 44:4163-70. 2003
    ..Effects of the carboxamide CGP43182 were tested on COX-2 and VEGF activation and prostaglandin (PG)E(2) release...
  79. ncbi request reprint Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT2 receptor
    Chu Chen
    Neuroscience Center of Excellence, School of Medicine, LSU Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA
    Neuroreport 14:743-7. 2003
    ..The results suggest that APAP-induced modification of synaptic plasticity at hippocampal lateral perforant path-dentate granule cell synapses may be mediated by a presynaptic 5-HT(2) receptor...
  80. doi request reprint Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosis
    Walter J Lukiw
    LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA 70112 2272, USA
    Mol Neurobiol 42:10-6. 2010
    ....
  81. pmc LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat
    Ludmila Belayev
    Neuroscience Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    Brain Res 1253:184-90. 2009
    ..3 +/- 4.6% vs. 46.0 +/- 10.3%, respectively). These results establish that LAU-0901 confers enduring ischemic neuroprotection...
  82. pmc Docosahexaenoic acid and the aging brain
    Walter J Lukiw
    Department of Ophthalmology, LSU Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Nutr 138:2510-4. 2008
    ....
  83. ncbi request reprint Comparative in vivo high-resolution confocal microscopy of corneal epithelium, sub-basal nerves and stromal cells in mice with and without dry eye after photorefractive keratectomy
    Salomon Esquenazi
    LSU Eye Center and Neuroscience Center, LSU Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
    Clin Experiment Ophthalmol 35:545-9. 2007
    ....
  84. ncbi request reprint DNA repair in photoreceptor survival
    M Soledad Cortina
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Mol Neurobiol 28:111-22. 2003
    ....
  85. ncbi request reprint Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells
    Merete Boedker
    Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Neurosci Lett 380:176-80. 2005
    ....
  86. ncbi request reprint Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments
    Miriam Kolko
    Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark
    Invest Ophthalmol Vis Sci 48:1401-9. 2007
    ..To identify intracellular phospholipases A(2) (PLA(2)) in the human retina and to explore the role of these enzymes in human retinal pigment epithelium (RPE) phagocytosis of photoreceptor outer segments (POS)...
  87. ncbi request reprint Secretory phospholipase A(2) induces delayed neuronal COX-2 expression compared with glutamate
    Miriam Kolko
    Laboratory of Neuropathology, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 69:169-77. 2002
    ..We conclude that sPLA(2) may modulate neuronal COX-2 expression through mechanisms that differ from those of glutamate-induced COX-2 expression...
  88. ncbi request reprint Glutamate signalling and secretory phospholipase A2 modulate the release of arachidonic acid from neuronal membranes
    Elena B Rodriguez de Turco
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    J Neurosci Res 68:558-67. 2002
    ....
  89. ncbi request reprint Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release
    Renato Malcher-Lopes
    Neuroscience Program, Tulane University, New Orleans, Louisiana 70118, USA
    J Neurosci 26:6643-50. 2006
    ....
  90. pmc Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways
    David S Gelinas
    Department of Pharmacology, University of Montreal, Montreal QC, Canada
    Br J Pharmacol 137:1021-30. 2002
    ..5. In conclusion, VEGF induces an immediate cGMP synthesis through the PLC-Ca2+/CaM pathway, and that the induction of delayed cGMP synthesis implies Akt and PKC activity...
  91. ncbi request reprint DNA damage and repair in light-induced photoreceptor degeneration
    William C Gordon
    Louisiana State University Health Sciences Center, Department of Ophthalmology and Neuroscience Center, New Orleans 70112, USA
    Invest Ophthalmol Vis Sci 43:3511-21. 2002
    ..However, cells lost 10 days after light treatment are fewer than the TUNEL-labeled cells observed earlier. Therefore, this study was undertaken to monitor DNA fragmentation and cell death to explain the discrepancy...
  92. ncbi request reprint Survival signalling in Alzheimer's disease
    W J Lukiw
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112 2272, USA or
    Biochem Soc Trans 34:1277-82. 2006
    ....

Research Grants64

  1. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2010
    ..These findings have the potential to open a new translational avenue for clinical therapies of cerebrovascular diseases. ..
  2. RPE Messengers, Transcription & Photoreceptor Renewal
    Nicolas Bazan; Fiscal Year: 2005
    ..This will include defining the mechanism of prosaposin gene induction in RPE cytoprotection, making use of LAU-0901. We aim for a better understanding of AMD and to contribute to the development of effective therapies. ..
  3. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    Nicolas Bazan; Fiscal Year: 2005
    ....
  4. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2005
    ..This work is expected to provide new insights into neuronal signaling in epileptogenesis, to uncover novel molecular pathways in seizure-induced neuronal injury and define events for neuroprotective pharmacological interventions. ..
  5. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2005
    ..The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana. ..
  6. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    Nicolas Bazan; Fiscal Year: 2004
    ....
  7. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2004
    ..This work is expected to provide new insights into neuronal signaling in epileptogenesis, to uncover novel molecular pathways in seizure-induced neuronal injury and define events for neuroprotective pharmacological interventions. ..
  8. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2004
    ..The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana. ..
  9. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2003
    ..This work is expected to provide new insights into neuronal signaling in epileptogenesis, to uncover novel molecular pathways in seizure-induced neuronal injury and define events for neuroprotective pharmacological interventions. ..
  10. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2003
    ..The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana. ..
  11. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2006
    ..The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana. ..
  12. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    Nicolas Bazan; Fiscal Year: 2006
    ....
  13. RPE Messengers, Transcription & Photoreceptor Renewal
    Nicolas Bazan; Fiscal Year: 2009
    ..This will include defining the mechanism of prosaposin gene induction in RPE cytoprotection, making use of LAU-0901. We aim for a better understanding of AMD and to contribute to the development of effective therapies. ..
  14. Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience
    Nicolas Bazan; Fiscal Year: 2009
    ..abstract_text> ..
  15. Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2010
    ..We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana. ..
  16. RPE Messengers, Transcription & Photoreceptor Renewal
    Nicolas Bazan; Fiscal Year: 2009
    ..This will include defining the mechanism of prosaposin gene induction in RPE cytoprotection, making use of LAU-0901. We aim for a better understanding of AMD and to contribute to the development of effective therapies. ..
  17. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    Nicolas Bazan; Fiscal Year: 2009
    ....
  18. Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience
    Nicolas Bazan; Fiscal Year: 2009
    ..We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana. ..
  19. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2007
    ..abstract_text> ..
  20. Neuroprotection Lipid Signaling in Ischemia Reperfusion
    Nicolas Bazan; Fiscal Year: 2007
    ....
  21. RPE Messengers, Transcription & Photoreceptor Renewal
    Nicolas Bazan; Fiscal Year: 2007
    ..This will include defining the mechanism of prosaposin gene induction in RPE cytoprotection, making use of LAU-0901. We aim for a better understanding of AMD and to contribute to the development of effective therapies. ..
  22. Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience
    Nicolas Bazan; Fiscal Year: 2007
    ..We view the four target faculty, the four to-be-recruited faculty, and additional PJIs as the critical building blocks to reinforce and energize a strong neuroscience research environment throughout the State of Louisiana. ..
  23. RPE Messengers, Transcription & Photoreceptor Renewal
    Nicolas Bazan; Fiscal Year: 2006
    ..This will include defining the mechanism of prosaposin gene induction in RPE cytoprotection, making use of LAU-0901. We aim for a better understanding of AMD and to contribute to the development of effective therapies. ..
  24. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2002
    ..This work is expected to provide new insights into neuronal signaling in epileptogenesis, to uncover novel molecular pathways in seizure-induced neuronal injury and define events for neuroprotective pharmacological interventions. ..
  25. LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1992
    ..The results will define the involvement of second messengers in the interactions between visual cells and retinal pigment epithelium during photoreceptor renewal...
  26. PHOSPHOLIPIDS AND ARACHIDONIC ACID AND EP
    Nicolas Bazan; Fiscal Year: 1999
    ....
  27. RPE MESSENGERS, TRANSCRIPTION AND PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1999
    ....
  28. PHOSPHOLIPIDS AND ARACHIDONIC ACID AND EP
    Nicolas Bazan; Fiscal Year: 2000
    ....
  29. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1993
    ....
  30. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1992
    ....
  31. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1991
    ....
  32. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1990
    ....
  33. LEUKOTRIENES AND PROSTAGLANDINS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1991
    ..The results obtained will define the involvement of the arachidonic acid cascade and the inositol lipid cycle in the modulation of the interactions between visual cells and retinal pigment epithelium...
  34. LEUKOTRIENES AND PROSTAGLANDINS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1990
    ..The results obtained will define the involvement of the arachidonic acid cascade and the inositol lipid cycle in the modulation of the interactions between visual cells and retinal pigment epithelium...
  35. MENTORING NEUROSCIENCE IN LOUISIANA
    Nicolas Bazan; Fiscal Year: 2002
    ..The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana. ..