GREGORY JOHN BAGBY

Summary

Affiliation: Louisiana State University Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112
    Am J Physiol Lung Cell Mol Physiol 286:L465-72. 2004
  2. ncbi request reprint The effect of chronic binge ethanol consumption on the primary stage of SIV infection in rhesus macaques
    Gregory J Bagby
    Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Alcohol Clin Exp Res 27:495-502. 2003
  3. ncbi request reprint Chronic binge ethanol consumption accelerates progression of simian immunodeficiency virus disease
    Gregory J Bagby
    Department of Physiology, LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Alcohol Clin Exp Res 30:1781-90. 2006
  4. ncbi request reprint Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 29:1198-205. 2005
  5. pmc Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication
    James E Walker
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 33:357-65. 2009
  6. ncbi request reprint Compartmentalization of macrophage inflammatory protein-2, but not cytokine-induced neutrophil chemoattractant, in rats challenged with intratracheal endotoxin
    Ping Zhang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Shock 17:104-8. 2002
  7. pmc Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Exp Med 202:761-9. 2005
  8. ncbi request reprint Neutrophil modulation of the pulmonary chemokine response to lipopolysaccharide
    Michael C Holmes
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Shock 18:555-60. 2002
  9. ncbi request reprint Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    J Infect Dis 187:62-9. 2003
  10. pmc Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Gene Therapy Program, and Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Immunol 170:4432-6. 2003

Research Grants

  1. BIOMEDICAL ALCOHOL RESEARCH TRAINING PROGRAM
    GREGORY BAGBY; Fiscal Year: 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112
    Am J Physiol Lung Cell Mol Physiol 286:L465-72. 2004
    ..Our results show that CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus...
  2. ncbi request reprint The effect of chronic binge ethanol consumption on the primary stage of SIV infection in rhesus macaques
    Gregory J Bagby
    Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
    Alcohol Clin Exp Res 27:495-502. 2003
    ..This study was initiated to study the combined effects of chronic binge alcohol consumption on the primary stage of SIV infection...
  3. ncbi request reprint Chronic binge ethanol consumption accelerates progression of simian immunodeficiency virus disease
    Gregory J Bagby
    Department of Physiology, LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Alcohol Clin Exp Res 30:1781-90. 2006
    ..Therefore, we examined the effect of ethanol on simian immunodeficiency virus (SIV) disease progression in a well-defined model utilizing rhesus macaques...
  4. ncbi request reprint Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 29:1198-205. 2005
    ..Here we hypothesized that exogenous chemokine administration would mitigate the suppressive effect of alcohol on neutrophil recruitment into the lung...
  5. pmc Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication
    James E Walker
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 33:357-65. 2009
    ..The effect of acute alcohol intoxication on AE2 cell expression of LIX is unknown...
  6. ncbi request reprint Compartmentalization of macrophage inflammatory protein-2, but not cytokine-induced neutrophil chemoattractant, in rats challenged with intratracheal endotoxin
    Ping Zhang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Shock 17:104-8. 2002
    ....
  7. pmc Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Exp Med 202:761-9. 2005
    ..pneumoniae, the former of which is required for IFN-gamma expression and the latter of which is required for IL-17 production...
  8. ncbi request reprint Neutrophil modulation of the pulmonary chemokine response to lipopolysaccharide
    Michael C Holmes
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Shock 18:555-60. 2002
    ..t. LPS. These data show that as neutrophils are recruited into the lung, they alter chemokine levels, which most likely serves to down-regulate the inflammatory response...
  9. ncbi request reprint Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    J Infect Dis 187:62-9. 2003
    ..IFN-gamma increases the pulmonary CXC chemokine response, which may serve as one mechanism underlying enhanced PMNL delivery into the lung...
  10. pmc Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection
    Kyle I Happel
    Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Gene Therapy Program, and Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Immunol 170:4432-6. 2003
    ..These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8(+) T cell IL-17 production...
  11. ncbi request reprint Alcohol intoxication inhibits pulmonary S100A8 and S100A9 expression in rats challenged with intratracheal lipopolysaccharide
    Ping Zhang
    Department of Medicine, Section of Pulmonary CCM, Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol Clin Exp Res 31:113-21. 2007
    ..During infection and inflammation, recruited neutrophils (PMNs) release S100 proteins that function to promote the recruitment of additional phagocytes...
  12. pmc Alcohol exposure impairs myeloid dendritic cell function in rhesus macaques
    Robert W Siggins
    Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
    Alcohol Clin Exp Res 33:1524-31. 2009
    ..This study investigated the impact of chronic alcohol exposure on the alteration of hematopoietic precursor cell and DC populations in the bone marrow and peripheral blood of rhesus macaques...
  13. pmc Characterization of SIV in the oral cavity and in vitro inhibition of SIV by rhesus macaque saliva
    Jessica S Thomas
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    AIDS Res Hum Retroviruses 26:901-11. 2010
    ..This work also demonstrates that SIV-infected rhesus macaques provide a relevant model to examine the innate and adaptive immune responses that inhibit HIV/SIV in the oral cavity...
  14. ncbi request reprint Effects of in vitro ethanol on tumor necrosis factor-alpha production by blood obtained from simian immunodeficiency virus-infected rhesus macaques
    David A Stoltz
    Department of Medicine, Section of Pulmonary Critical Care, Louisiana State University Health Sciences Center, New Orleans, USA
    Alcohol Clin Exp Res 26:527-34. 2002
    ..Tumor necrosis factor-alpha (TNF-alpha), a product of monocytes and macrophages, functions as an important proinflammatory cytokine in the host's response to invading pathogens...
  15. pmc Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide
    Kyle I Happel
    Louisiana State University Health Sciences Center, Alcohol Research Center, Section of Pulmonary Critical Care, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
    Alcohol 41:325-33. 2007
    ..These results implicate acute ethanol intoxication as a significant inhibitor of lymphocyte chemoattractant expression during pulmonary inflammation...
  16. pmc The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Stem Cells 26:1778-86. 2008
    ..Functional modifications of these primitive hematopoietic precursors are critical for enhancing granulocyte production following bacterial infection...
  17. doi request reprint The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide
    Lisa Gamble
    Departments of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Shock 31:212-7. 2009
    ..If impaired, this may be one mechanism underlying the increased mortality observed in patients with liver disease who develop pneumonia...
  18. ncbi request reprint Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infection
    Patricia E Molina
    Department of Physiology, LSUHSC, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 30:2065-78. 2006
    ..HIV infection has become a more chronic disease during which alcohol-induced metabolic alterations may become more prevalent and pronounced...
  19. ncbi request reprint The granulocyte colony-stimulating factor response after intrapulmonary and systemic bacterial challenges
    Lee J Quinton
    Department of Physiology, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Infect Dis 185:1476-82. 2002
    ..coli increased plasma G-CSF and TNF-alpha, but neither cytokine was detected in BALF. These data show that, after an intrapulmonary infection, both lung and circulating G-CSF increase and that the lung is the likely source...
  20. ncbi request reprint Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection
    Kyle I Happel
    Section of Pulmonary Critical Care Medicine, Lousiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Alcohol Clin Exp Res 30:1200-7. 2006
    ..We investigated the effect of acute alcohol intoxication on the IL-23 response to this infection...
  21. ncbi request reprint TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injury
    Cuihua Zhang
    Department of Anesthesiology, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Arterioscler Thromb Vasc Biol 26:475-80. 2006
    ....
  22. ncbi request reprint Sex differences in the modulation by ethanol of lung chemotaxis
    Judy A Spitzer
    Department of Physiology and Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Alcohol 28:95-102. 2002
    ..Because excessive PMN recruitment with subsequent release of granular contents is associated with tissue damage, these results indicate a potential protective mechanism against pulmonary damage in female rats...
  23. ncbi request reprint The granulopoietic cytokine response and enhancement of granulopoiesis in mice during endotoxemia
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Shock 23:344-52. 2005
    ..Because the tissue mass in extramedullary organs far exceeds that in the bone marrow, extramedullary production of these cytokines likely play a critical role in the regulation of the host's granulopoietic response to endotoxemia...
  24. ncbi request reprint Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation
    Lotfollah M Shahbazian
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Crit Care Med 32:1740-6. 2004
    ..The process by which hematopoietic tissues respond to a pulmonary infection remains poorly understood. This study investigated the potential role of lung-derived granulopoietic cytokines in facilitating this response...
  25. pmc Acute alcohol intoxication inhibits the lineage- c-kit+ Sca-1+ cell response to Escherichia coli bacteremia
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 182:1568-76. 2009
    ..These data show that alcohol inhibits the hematopoietic precursor cell response to bacteremia, which may serve as one mechanism underlying the impaired host defense in alcohol abusers with severe bacterial infections...
  26. pmc Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting
    Patricia E Molina
    LSUHSC Department of Physiology and Alcohol Research Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 32:138-47. 2008
    ..We hypothesized that alcohol-induced loss in lean body mass is likely to exacerbate the AIDS wasting syndrome, particularly at the terminal stage of AIDS (SAIDS)...
  27. ncbi request reprint Acute alcohol intoxication suppresses the CXC chemokine response during endotoxemia
    Ping Zhang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 26:65-73. 2002
    ..This study investigated the effects of alcohol on CXC chemokine macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (CINC) responses in rats challenged with intravenous lipopolysaccharide (LPS)...
  28. ncbi request reprint Alcohol unmasks simian immunodeficiency virus-induced cognitive impairments in rhesus monkeys
    Peter J Winsauer
    Department of Parmacology and Experiemntal Therapeutics, Louisiana State University Health Sciences Center, New Orleans 70112 1393, USA
    Alcohol Clin Exp Res 26:1846-57. 2002
    ..Few studies, preclinical or clinical, have examined whether alcohol administration exacerbates the neuropsychological deficits in subjects with lentiviruses such as HIV...
  29. ncbi request reprint Impact of alcohol intoxication on hemodynamic, metabolic, and cytokine responses to hemorrhagic shock
    Herbert Phelan
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    J Trauma 52:675-82. 2002
    ..We hypothesized that acute alcohol intoxication would aggravate the immediate outcome from hemorrhagic shock by impairing homeostatic counterregulation to blood loss...
  30. pmc Ethanol upregulates glucocorticoid-induced leucine zipper expression and modulates cellular inflammatory responses in lung epithelial cells
    Marla Gomez
    Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 184:5715-22. 2010
    ....
  31. ncbi request reprint Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae
    Darren M Boé
    Department of Physiology, Alcohol Research Center, Louisianna State University Health Sciences Center, New Orleans 70112, USA
    Alcohol Clin Exp Res 27:1838-45. 2003
    ..The purpose of this study was to determine whether alcohol-induced chemokine suppression is responsible for impaired neutrophil recruitment into the lung during infection of the alcohol-intoxicated host...
  32. ncbi request reprint Pulmonary host defenses and alcohol
    Ping Zhang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Front Biosci 7:d1314-30. 2002
    ..Immunotherapy to improve or enhance pulmonary host defense function in conjunction with aggressive antimicrobial regimens may provide a new approach in the management of infections in these patients...
  33. ncbi request reprint Alcohol abuse, immunosuppression, and pulmonary infection
    Ping Zhang
    Department of Medicine, Section of Pulmonary CCM, Louisiana State University Health Sciences Center, New Orleans, Louisiana, LA 70112, USA
    Curr Drug Abuse Rev 1:56-67. 2008
    ..Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed...
  34. ncbi request reprint Adipose tumor necrosis factor-alpha is reduced during onset of insulin resistance in Sprague-Dawley rats
    Stephen E Borst
    Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112 1394, USA
    Cytokine 26:217-22. 2004
    ..Our findings do not support the adipose-endocrine model of TNF-alpha in insulin resistance. Our findings do support a paracrine role for TNF-alpha or for a reduction in endogenous TNF-alpha inhibitors in insulin resistance...
  35. pmc Neonatal sepsis and neutrophil insufficiencies
    John Nicholas Melvan
    Department of Physiology and Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Int Rev Immunol 29:315-48. 2010
    ..This article reviews current strategies for the clinical management of neonatal sepsis and analyzes mechanisms underlying insufficiencies of neutrophil defense in neonates with emphasis on new directions for adjuvant therapy development...

Research Grants2

  1. BIOMEDICAL ALCOHOL RESEARCH TRAINING PROGRAM
    GREGORY BAGBY; Fiscal Year: 2007
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