Research Topics
Genomes and Genes | GREGORY JOHN BAGBYSummaryAffiliation: Louisiana State University Health Sciences Center Country: USA Publications
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Publications
Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitmentLee J Quinton
Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112
Am J Physiol Lung Cell Mol Physiol 286:L465-72. 2004..Our results show that CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus...- The effect of chronic binge ethanol consumption on the primary stage of SIV infection in rhesus macaquesGregory J Bagby
Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112 1393, USA
Alcohol Clin Exp Res 27:495-502. 2003..This study was initiated to study the combined effects of chronic binge alcohol consumption on the primary stage of SIV infection... - Chronic binge ethanol consumption accelerates progression of simian immunodeficiency virus diseaseGregory J Bagby
Department of Physiology, LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
Alcohol Clin Exp Res 30:1781-90. 2006..Therefore, we examined the effect of ethanol on simian immunodeficiency virus (SIV) disease progression in a well-defined model utilizing rhesus macaques... - Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitmentLee J Quinton
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Alcohol Clin Exp Res 29:1198-205. 2005.... 
Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxicationJames E Walker
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Alcohol Clin Exp Res 33:357-65. 2009..The effect of acute alcohol intoxication on AE2 cell expression of LIX is unknown...- Compartmentalization of macrophage inflammatory protein-2, but not cytokine-induced neutrophil chemoattractant, in rats challenged with intratracheal endotoxinPing Zhang
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA
Shock 17:104-8. 2002.... - Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniaeKyle I Happel
Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Exp Med 202:761-9. 2005..pneumoniae, the former of which is required for IFN-gamma expression and the latter of which is required for IL-17 production... - Neutrophil modulation of the pulmonary chemokine response to lipopolysaccharideMichael C Holmes
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Shock 18:555-60. 2002..t. LPS. These data show that as neutrophils are recruited into the lung, they alter chemokine levels, which most likely serves to down-regulate the inflammatory response... - Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challengePing Zhang
Department of Medicine, Section of Pulmonary/Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans 70112, USA
J Infect Dis 187:62-9. 2003..IFN-gamma increases the pulmonary CXC chemokine response, which may serve as one mechanism underlying enhanced PMNL delivery into the lung... - Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infectionKyle I Happel
Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Gene Therapy Program, and Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
J Immunol 170:4432-6. 2003..These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8(+) T cell IL-17 production... - Alcohol intoxication inhibits pulmonary S100A8 and S100A9 expression in rats challenged with intratracheal lipopolysaccharidePing Zhang
Department of Medicine, Section of Pulmonary CCM, Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Alcohol Clin Exp Res 31:113-21. 2007..During infection and inflammation, recruited neutrophils (PMNs) release S100 proteins that function to promote the recruitment of additional phagocytes... - Alcohol exposure impairs myeloid dendritic cell function in rhesus macaquesRobert W Siggins
Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 1393, USA
Alcohol Clin Exp Res 33:1524-31. 2009..This study investigated the impact of chronic alcohol exposure on the alteration of hematopoietic precursor cell and DC populations in the bone marrow and peripheral blood of rhesus macaques... - Characterization of SIV in the oral cavity and in vitro inhibition of SIV by rhesus macaque salivaJessica S Thomas
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
AIDS Res Hum Retroviruses 26:901-11. 2010..This work also demonstrates that SIV-infected rhesus macaques provide a relevant model to examine the innate and adaptive immune responses that inhibit HIV/SIV in the oral cavity... - Effects of in vitro ethanol on tumor necrosis factor-alpha production by blood obtained from simian immunodeficiency virus-infected rhesus macaquesDavid A Stoltz
Department of Medicine, Section of Pulmonary/Critical Care, Louisiana State University Health Sciences Center, New Orleans, USA
Alcohol Clin Exp Res 26:527-34. 2002..However, intoxicating doses of alcohol suppress this response, and this may contribute to the immunocompromised state of the host... - Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharideKyle I Happel
Louisiana State University Health Sciences Center, Alcohol Research Center, Section of Pulmonary Critical Care, 1901 Perdido Street, Suite 3205, New Orleans, LA 70112, USA
Alcohol 41:325-33. 2007..These results implicate acute ethanol intoxication as a significant inhibitor of lymphocyte chemoattractant expression during pulmonary inflammation... - The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c micePing Zhang
Department of Medicine, Section of Pulmonary Critical Care Medicine, LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
Stem Cells 26:1778-86. 2008..Functional modifications of these primitive hematopoietic precursors are critical for enhancing granulocyte production following bacterial infection... 
The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharideLisa Gamble
Departments of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Shock 31:212-7. 2009..If impaired, this may be one mechanism underlying the increased mortality observed in patients with liver disease who develop pneumonia...- Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infectionPatricia E Molina
Department of Physiology, LSUHSC, New Orleans, Louisiana 70112, USA
Alcohol Clin Exp Res 30:2065-78. 2006..HIV infection has become a more chronic disease during which alcohol-induced metabolic alterations may become more prevalent and pronounced... - The granulocyte colony-stimulating factor response after intrapulmonary and systemic bacterial challengesLee J Quinton
Department of Physiology, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Infect Dis 185:1476-82. 2002..coli increased plasma G-CSF and TNF-alpha, but neither cytokine was detected in BALF. These data show that, after an intrapulmonary infection, both lung and circulating G-CSF increase and that the lung is the likely source... - Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infectionKyle I Happel
Section of Pulmonary Critical Care Medicine, Lousiana State University Health Sciences Center, New Orleans, Louisiana, USA
Alcohol Clin Exp Res 30:1200-7. 2006..We investigated the effect of acute alcohol intoxication on the IL-23 response to this infection... - TNF-alpha contributes to endothelial dysfunction in ischemia/reperfusion injuryCuihua Zhang
Department of Anesthesiology, LSU Health Sciences Center, New Orleans, LA 70112, USA
Arterioscler Thromb Vasc Biol 26:475-80. 2006.... - Sex differences in the modulation by ethanol of lung chemotaxisJudy A Spitzer
Department of Physiology and Alcohol Research Center, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Alcohol 28:95-102. 2002..Because excessive PMN recruitment with subsequent release of granular contents is associated with tissue damage, these results indicate a potential protective mechanism against pulmonary damage in female rats... - The granulopoietic cytokine response and enhancement of granulopoiesis in mice during endotoxemiaPing Zhang
Department of Medicine, Section of Pulmonary/Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-1393, USA
Shock 23:344-52. 2005..Because the tissue mass in extramedullary organs far exceeds that in the bone marrow, extramedullary production of these cytokines likely play a critical role in the regulation of the host's granulopoietic response to endotoxemia... - Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulationLotfollah M Shahbazian
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Crit Care Med 32:1740-6. 2004..coli or G-CSF in addition to activation by in vitro G-CSF stimulation. CONCLUSIONS: During pulmonary infection, locally produced cytokines enter the circulation and may play an important role in initiating a granulopoietic response... - Acute alcohol intoxication inhibits the lineage- c-kit+ Sca-1+ cell response to Escherichia coli bacteremiaPing Zhang
Department of Medicine, Section of Pulmonary Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Immunol 182:1568-76. 2009..These data show that alcohol inhibits the hematopoietic precursor cell response to bacteremia, which may serve as one mechanism underlying the impaired host defense in alcohol abusers with severe bacterial infections... - Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wastingPatricia E Molina
LSUHSC Department of Physiology and Alcohol Research Center, New Orleans, Louisiana 70112, USA
Alcohol Clin Exp Res 32:138-47. 2008..We hypothesized that alcohol-induced loss in lean body mass is likely to exacerbate the AIDS wasting syndrome, particularly at the terminal stage of AIDS (SAIDS)... - Acute alcohol intoxication suppresses the CXC chemokine response during endotoxemiaPing Zhang
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Alcohol Clin Exp Res 26:65-73. 2002..This disruption of host-defense function may serve as one mechanism underlying the increased risk of infectious diseases in hosts who abuse alcohol... - Alcohol unmasks simian immunodeficiency virus-induced cognitive impairments in rhesus monkeysPeter J Winsauer
Department of Parmacology and Experiemntal Therapeutics, Louisiana State University Health Sciences Center, New Orleans 70112-1393, USA
Alcohol Clin Exp Res 26:1846-57. 2002.... - Impact of alcohol intoxication on hemodynamic, metabolic, and cytokine responses to hemorrhagic shockHerbert Phelan
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-1393, USA
J Trauma 52:675-82. 2002..Taken together, these alterations in metabolic and inflammatory responses to hemorrhage are likely to impair immediate outcome and predispose to tissue injury... - Ethanol upregulates glucocorticoid-induced leucine zipper expression and modulates cellular inflammatory responses in lung epithelial cellsMarla Gomez
Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Immunol 184:5715-22. 2010.... - Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniaeDarren M Boé
Department of Physiology, Alcohol Research Center, Louisianna State University Health Sciences Center, New Orleans 70112, USA
Alcohol Clin Exp Res 27:1838-45. 2003..The purpose of this study was to determine whether alcohol-induced chemokine suppression is responsible for impaired neutrophil recruitment into the lung during infection of the alcohol-intoxicated host... - Pulmonary host defenses and alcoholPing Zhang
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Front Biosci 7:d1314-30. 2002..Immunotherapy to improve or enhance pulmonary host defense function in conjunction with aggressive antimicrobial regimens may provide a new approach in the management of infections in these patients... - Alcohol abuse, immunosuppression, and pulmonary infectionPing Zhang
Department of Medicine, Section of Pulmonary CCM, Louisiana State University Health Sciences Center, New Orleans, Louisiana, LA 70112, USA
Curr Drug Abuse Rev 1:56-67. 2008..Potential immunomodulatory strategies for enhancing host defense function in alcohol-consuming patients are also discussed... - Adipose tumor necrosis factor-alpha is reduced during onset of insulin resistance in Sprague-Dawley ratsStephen E Borst
Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112 1394, USA
Cytokine 26:217-22. 2004..Our findings do not support the adipose-endocrine model of TNF-alpha in insulin resistance. Our findings do support a paracrine role for TNF-alpha or for a reduction in endogenous TNF-alpha inhibitors in insulin resistance... - Neonatal sepsis and neutrophil insufficienciesJohn Nicholas Melvan
Department of Physiology and Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
Int Rev Immunol 29:315-48. 2010..This article reviews current strategies for the clinical management of neonatal sepsis and analyzes mechanisms underlying insufficiencies of neutrophil defense in neonates with emphasis on new directions for adjuvant therapy development...
Research Grants
- BIOMEDICAL ALCOHOL RESEARCH TRAINING PROGRAMGREGORY BAGBY; Fiscal Year: 2007..abstract_text> ..