CHRISTINA C WANG

Summary

Affiliation: Los Angeles Biomedical Research Institute
Country: USA

Publications

  1. pmc A new combination of testosterone and nestorone transdermal gels for male hormonal contraception
    Niloufar Ilani
    Department of Medicine, Harbor University of California, Los Angeles, Medical Center and Los Angeles Biomedical Research Institute, 1000 West Carson Street, Torrance, California 90509, USA
    J Clin Endocrinol Metab 97:3476-86. 2012
  2. doi request reprint Dietary fat modulates the testosterone pharmacokinetics of a new self-emulsifying formulation of oral testosterone undecanoate in hypogonadal men
    Anthony Yin
    Division of Endocrinology, Department of Medicine and the UCLA Clinical and Translational Science Institute, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    J Androl 33:1282-90. 2012
  3. doi request reprint Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen-deficient men
    Christina Wang
    Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA
    Clin Endocrinol (Oxf) 75:836-43. 2011
  4. doi request reprint Reexamination of pharmacokinetics of oral testosterone undecanoate in hypogonadal men with a new self-emulsifying formulation
    Anthony Y Yin
    Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center, Torrance, California, USA
    J Androl 33:190-201. 2012
  5. ncbi request reprint Pratical aspects of testosterone substitution
    C Wang
    Division of Endocrinology, Department of Medicine Harbor UCLA Medical Center and Los Angeles Biomedical Research Center, Torrance, USA
    J Endocrinol Invest 28:109-11. 2005
  6. ncbi request reprint Levonorgestrel implants enhanced the suppression of spermatogenesis by testosterone implants: comparison between Chinese and non-Chinese men
    Christina Wang
    General Clinical Research Center, Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90509, USA
    J Clin Endocrinol Metab 91:460-70. 2006
  7. ncbi request reprint transient scrotal hyperthermia and levonorgestrel enhance testosterone-induced spermatogenesis suppression in men through increased germ cell apoptosis
    Christina Wang
    Department of Medicine, Harbor University of California, Los Angeles, Torrance, California 90509, USA
    J Clin Endocrinol Metab 92:3292-304. 2007
  8. pmc Validation of a testosterone and dihydrotestosterone liquid chromatography tandem mass spectrometry assay: Interference and comparison with established methods
    Christina Wang
    General Clinical Research Center, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, 1000 Carson Street, Torrance, CA 90509, USA
    Steroids 73:1345-52. 2008
  9. doi request reprint Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations
    Christina Wang
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    Eur Urol 55:121-30. 2009
  10. doi request reprint ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males
    C Wang
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Int J Impot Res 21:1-8. 2009

Research Grants

  1. Prostate Cancer Development & Growth
    Christina Wang; Fiscal Year: 2004
  2. Harbor-UCLA Initiative for Minority Student Development
    Christina Wang; Fiscal Year: 2005
  3. AMERICAN SOCIETY OF ANDROLOGY ANNUAL MEETING
    Christina Wang; Fiscal Year: 2007

Collaborators

Detail Information

Publications33

  1. pmc A new combination of testosterone and nestorone transdermal gels for male hormonal contraception
    Niloufar Ilani
    Department of Medicine, Harbor University of California, Los Angeles, Medical Center and Los Angeles Biomedical Research Institute, 1000 West Carson Street, Torrance, California 90509, USA
    J Clin Endocrinol Metab 97:3476-86. 2012
    ..Combinations of testosterone (T) and nestorone (NES; a nonandrogenic progestin) transdermal gels may suppress spermatogenesis and prove appealing to men for contraception...
  2. doi request reprint Dietary fat modulates the testosterone pharmacokinetics of a new self-emulsifying formulation of oral testosterone undecanoate in hypogonadal men
    Anthony Yin
    Division of Endocrinology, Department of Medicine and the UCLA Clinical and Translational Science Institute, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    J Androl 33:1282-90. 2012
    ....
  3. doi request reprint Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen-deficient men
    Christina Wang
    Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA
    Clin Endocrinol (Oxf) 75:836-43. 2011
    ..In this study, we assessed the safety, pharmacokinetics, and efficacy of the 2% formulation of testosterone topical solution applied daily to the axillae...
  4. doi request reprint Reexamination of pharmacokinetics of oral testosterone undecanoate in hypogonadal men with a new self-emulsifying formulation
    Anthony Y Yin
    Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center, Torrance, California, USA
    J Androl 33:190-201. 2012
    ..Dihydrotestosterone-testosterone ratios increased 3-fold after oral TU administration. Oral T 200 mg twice daily as TU in a new SEDDS formulation may be a viable therapy for hypogonadal men...
  5. ncbi request reprint Pratical aspects of testosterone substitution
    C Wang
    Division of Endocrinology, Department of Medicine Harbor UCLA Medical Center and Los Angeles Biomedical Research Center, Torrance, USA
    J Endocrinol Invest 28:109-11. 2005
    ..Monitoring for manifestations of prostate disease, erythrocytosis and other adverse events of androgen treatment is critical in the management of older men with androgen replacement therapy...
  6. ncbi request reprint Levonorgestrel implants enhanced the suppression of spermatogenesis by testosterone implants: comparison between Chinese and non-Chinese men
    Christina Wang
    General Clinical Research Center, Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90509, USA
    J Clin Endocrinol Metab 91:460-70. 2006
    ..Previous male contraceptive studies showed that progestins enhance spermatogenesis suppression by androgens in men...
  7. ncbi request reprint transient scrotal hyperthermia and levonorgestrel enhance testosterone-induced spermatogenesis suppression in men through increased germ cell apoptosis
    Christina Wang
    Department of Medicine, Harbor University of California, Los Angeles, Torrance, California 90509, USA
    J Clin Endocrinol Metab 92:3292-304. 2007
    ..In rodents and monkeys, a combination of hormonal and physical agents accelerates germ cell death...
  8. pmc Validation of a testosterone and dihydrotestosterone liquid chromatography tandem mass spectrometry assay: Interference and comparison with established methods
    Christina Wang
    General Clinical Research Center, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, 1000 Carson Street, Torrance, CA 90509, USA
    Steroids 73:1345-52. 2008
    ....
  9. doi request reprint Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations
    Christina Wang
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    Eur Urol 55:121-30. 2009
    ....
  10. doi request reprint ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in males
    C Wang
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Int J Impot Res 21:1-8. 2009
    ....
  11. doi request reprint Pharmacokinetics and safety of long-acting testosterone undecanoate injections in hypogonadal men: an 84-week phase III clinical trial
    Christina Wang
    Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA 90509, USA
    J Androl 31:457-65. 2010
    ..TU injections would be an acceptable alternative to the currently available 2-3 weekly injectables...
  12. pmc Hormonal approaches to male contraception
    Christina Wang
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    Curr Opin Urol 20:520-4. 2010
    ..Hormonal male contraceptive methods have undergone extensive clinical trials in healthy men and shown to be efficacious, reversible and appear to be well tolerated...
  13. ncbi request reprint Low-fat high-fiber diet decreased serum and urine androgens in men
    Christina Wang
    Department of Medicine and Pediatrics and the General Clinical Research Center, Harbor University of California at Los Angeles Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    J Clin Endocrinol Metab 90:3550-9. 2005
    ..We conclude that reduction in dietary fat intake (and increase in fiber) results in 12% consistent lowering of circulating androgen levels without changing the clearance...
  14. ncbi request reprint Three-year follow-up of androgen treatment in hypogonadal men: preliminary report with testosterone gel
    R S Swerdloff
    Swerdloff, Harbor UCLA Medical Center, Division of Endocrinology, Box 446, 1000 W Carson Street, Torrance, CA 90509 2910, USA
    Aging Male 6:207-11. 2003
    ..Monitoring for prostate disease through PSA measurements and digital rectal examination is recommended for hypogonadal men in the older age groups when treated with testosterone...
  15. ncbi request reprint Transdermal androgens: pharmacology and applicability to hypogonadal elderly men
    R S Swerdloff
    Division of Endocrinology, Department of Medicine Harbor UCLA Medical Center and Los Angeles Biomedical Research Center, Torrance 90509, USA
    J Endocrinol Invest 28:112-6. 2005
    ....
  16. ncbi request reprint Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a General Clinical Research Center Study
    C Wang
    Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
    J Clin Endocrinol Metab 85:964-9. 2000
    ..Dose-ranging studies are required to determine dosage regimens for T gel application as a replacement therapy in hypogonadal men...
  17. ncbi request reprint Comparative pharmacokinetics of three doses of percutaneous dihydrotestosterone gel in healthy elderly men--a clinical research center study
    C Wang
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    J Clin Endocrinol Metab 83:2749-57. 1998
    ..0001) on both days 1 and 14. We conclude that the three doses of DHT gel tested might provide adequate androgen replacement in hypogonadal men at the low, middle, and high physiological androgen (T + DHT) range...
  18. ncbi request reprint Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men
    C Wang
    Divisions of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, CA, USA
    Clin Endocrinol (Oxf) 54:739-50. 2001
    ..Androgen replacement has been reported to increase bone mineral density (BMD) in hypogonadal men. We studied the effects of 6 months of treatment with a new transdermal testosterone (T) gel preparation on bone turnover markers and BMD...
  19. ncbi request reprint Androgen replacement therapy
    C Wang
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    Ann Med 29:365-70. 1997
    ..In the future, designer androgens with specific beneficial effect on sexual function, mood, bone and muscle mass but with attenuated effects on serum lipid profiles and the prostate gland may be developed...
  20. ncbi request reprint Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study
    C Wang
    Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance 90509 2910, USA
    J Clin Endocrinol Metab 81:3654-62. 1996
    ....
  21. doi request reprint Obesity, low testosterone levels and erectile dysfunction
    M Diaz-Arjonilla
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90803, USA
    Int J Impot Res 21:89-98. 2009
    ..This review describes the relationships between low serum testosterone concentrations and ED in obese patients and those with metabolic syndrome and type 2 diabetes mellitus...
  22. ncbi request reprint Levonorgestrel implants (Norplant II) for male contraception clinical trials: combination with transdermal and injectable testosterone
    I T Gaw Gonzalo
    Division of Endocrinology, Department of Medicine, Harbor University of California at Los Angeles Medical Center and Research and Education Institute, Torrance, California 90509, USA
    J Clin Endocrinol Metab 87:3562-72. 2002
    ..This study demonstrates that the dose or route of administration of androgens is critical for sperm suppression in combined androgen-progestagen regimens for hormonal male contraception...
  23. ncbi request reprint Aging-related increased expression of inducible nitric oxide synthase and cytotoxicity markers in rat hypothalamic regions associated with male reproductive function
    M Ferrini
    Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA
    Neuroendocrinology 74:1-11. 2001
    ....
  24. ncbi request reprint Oligozoospermia induced by exogenous testosterone is associated with normal functioning residual spermatozoa
    C Wang
    Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance 90509, USA
    Fertil Steril 68:149-53. 1997
    ..To determine the functional capacity of residual spermatozoa in semen samples from normal men with T enanthate-induced oligozoospermia...
  25. ncbi request reprint Effect of increased scrotal temperature on sperm production in normal men
    C Wang
    Department of Medicine, Harbor University of California, Los Angeles Medical Center, Torrance 90509 2910, USA
    Fertil Steril 68:334-9. 1997
    ..To determine whether application of polyester-lined athletic supports to bring the testes closer to the abdomen increases scrotal temperature and decreases sperm production...
  26. ncbi request reprint Liquid chromatography-tandem mass spectrometry assay for human serum testosterone and trideuterated testosterone
    B Starcevic
    Department of Molecular Pharmacology, UCLA Olympic Analytical Laboratory, University of California, 2122 Granville Avenue, Los Angeles, CA 90025, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 792:197-204. 2003
    ..8 and 5.6%. The inter-day precision at these levels was 10.0 and 7.6% and inter-day accuracy was 5.7 and 3.4%. The concentrations of T in the 38 healthy subjects ranged from 2.5 to 14.0 ng/ml (mean 6.2 ng/ml)...
  27. ncbi request reprint Graded testosterone infusions distinguish gonadotropin negative-feedback responsiveness in Asian and white men--a Clinical Research Center study
    C Wang
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    J Clin Endocrinol Metab 83:870-6. 1998
    ..Whether these differences contribute to the observed differences in suppression of spermatogenesis in Asians vs. non-Asians in male contraceptive studies is not yet known...
  28. ncbi request reprint Suppression of spermatogenesis in man induced by Nal-Glu gonadotropin releasing hormone antagonist and testosterone enanthate (TE) is maintained by TE alone
    R S Swerdloff
    Department of Medicine, Harbor University of California, Los Angeles Medical Center, Torrance 90509, USA
    J Clin Endocrinol Metab 83:3527-33. 1998
    ..This concept should be explored further in the development of effective, safe, and affordable hormonal male contraceptives...
  29. ncbi request reprint Impairment of spermatogenesis in transgenic mice with selective overexpression of Bcl-2 in the somatic cells of the testis
    C M Yamamoto
    Department of Medicine, Harbor-UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
    J Androl 22:981-91. 2001
    ..Collectively, these results support the critical role of Bcl-2 in male germ cell development and are consistent with the gender-specific role of the Bcl-2 family members in reproduction...
  30. ncbi request reprint Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement
    C Wang
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    J Androl 20:509-18. 1999
    ..Replacement therapy with LH for 6 months does not decrease or delay the testicular dysfunction associated with aging. It is unlikely that hypothalamic-pituitary dysregulation is the major cause of testicular aging...
  31. doi request reprint Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis
    Yanhe Lue
    Division of Endocrinology, Department of Medicine, Los Angeles Biomedical Research Institute and Harbor UCLA Medical Center, Torrance, California 90502, USA
    Endocrinology 151:350-7. 2010
    ..Perturbation of this interaction is important in enhancing or preventing germ cell death, providing new targets for future therapies...

Research Grants8

  1. Prostate Cancer Development & Growth
    Christina Wang; Fiscal Year: 2004
    ..The results will provide the important missing link between diet fat and CaP growth and development. ..
  2. Harbor-UCLA Initiative for Minority Student Development
    Christina Wang; Fiscal Year: 2005
    ....
  3. AMERICAN SOCIETY OF ANDROLOGY ANNUAL MEETING
    Christina Wang; Fiscal Year: 2007
    ....