Guochuan E Tsai

Summary

Affiliation: Los Angeles Biomedical Research Institute
Country: USA

Publications

  1. ncbi request reprint Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis
    Guochuan E Tsai
    Department of Psychiatry, Harbor UCLA Medical Center, HH2121, 1000 W Carson Street, Torrance, CA 90509, USA
    Curr Pharm Des 16:522-37. 2010
  2. pmc NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease
    Yu Jhen Huang
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan
    Curr Neuropharmacol 10:272-85. 2012
  3. doi request reprint Disposition of D-serine in healthy adults
    Guochuan E Tsai
    Department of Psychiatry, Harbor UCLA Medical Center, F9, 1000 W Carson Street, Torrance, CA 90509, USA
    J Clin Pharmacol 48:524-7. 2008
  4. ncbi request reprint D-alanine added to antipsychotics for the treatment of schizophrenia
    Guochuan E Tsai
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Biol Psychiatry 59:230-4. 2006
  5. doi request reprint Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Schizophr Res 146:231-7. 2013
  6. doi request reprint A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Int J Neuropsychopharmacol 13:451-60. 2010
  7. doi request reprint Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan2Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    JAMA Psychiatry 70:1267-75. 2013
  8. doi request reprint RGS4 polymorphisms predict clinical manifestations and responses to risperidone treatment in patients with schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    J Clin Psychopharmacol 28:64-8. 2008
  9. ncbi request reprint Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Arch Gen Psychiatry 62:1196-204. 2005
  10. doi request reprint Synergistic effects of COMT and TPH2 on social cognition
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Psychiatry 76:273-94. 2013

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis
    Guochuan E Tsai
    Department of Psychiatry, Harbor UCLA Medical Center, HH2121, 1000 W Carson Street, Torrance, CA 90509, USA
    Curr Pharm Des 16:522-37. 2010
    ..Other drug targets that may enhance NMDA neurotransmission more than the molecules tested so far need to be explored...
  2. pmc NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease
    Yu Jhen Huang
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan
    Curr Neuropharmacol 10:272-85. 2012
    ..Prospective study using NMDA enhancers in patients with Alzheimer's disease and associated behavioral disturbance is needed to verify this hypothesis...
  3. doi request reprint Disposition of D-serine in healthy adults
    Guochuan E Tsai
    Department of Psychiatry, Harbor UCLA Medical Center, F9, 1000 W Carson Street, Torrance, CA 90509, USA
    J Clin Pharmacol 48:524-7. 2008
  4. ncbi request reprint D-alanine added to antipsychotics for the treatment of schizophrenia
    Guochuan E Tsai
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Biol Psychiatry 59:230-4. 2006
    ..D-alanine is another endogenous agonist of the NMDA-glycine site that might have beneficial effects on schizophrenia...
  5. doi request reprint Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Schizophr Res 146:231-7. 2013
    ..The current study employed structural equation modeling (SEM) to examine whether clinical symptoms mediate the relationship between cognitive function and functional outcome in a large cohort of patients with schizophrenia...
  6. doi request reprint A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Int J Neuropsychopharmacol 13:451-60. 2010
    ..These findings suggest that the GlyT-1 inhibitor is more efficacious than the NMDA/glycine site agonist in treatment for schizophrenia, including life quality and global function, at the dosages tested...
  7. doi request reprint Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan2Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    JAMA Psychiatry 70:1267-75. 2013
    ..Another method to enhance NMDA function is to raise the levels of d-amino acids by blocking their metabolism. Sodium benzoate is a d-amino acid oxidase inhibitor...
  8. doi request reprint RGS4 polymorphisms predict clinical manifestations and responses to risperidone treatment in patients with schizophrenia
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    J Clin Psychopharmacol 28:64-8. 2008
    ....
  9. ncbi request reprint Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Arch Gen Psychiatry 62:1196-204. 2005
    ....
  10. doi request reprint Synergistic effects of COMT and TPH2 on social cognition
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Psychiatry 76:273-94. 2013
    ..The findings suggest that genetic variations of COMT and TPH2 have synergistic effects on social cognition in the general population. ..
  11. ncbi request reprint Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University and Hospital, Taichung, Taiwan
    Biol Psychiatry 63:9-12. 2008
    ..However, the efficacy of these agents as a primary antipsychotic agent has not yet been demonstrated...
  12. doi request reprint Clozapine protects bone mineral density in female patients with schizophrenia
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    Int J Neuropsychopharmacol 15:897-906. 2012
    ..007) were associated with LBMD. This study suggests that clozapine treatment is beneficial for BMD compared to PR antipsychotic treatment in women with chronic schizophrenia, and clozapine's bone-density protecting effect is dose-related...
  13. pmc MET and AKT genetic influence on facial emotion perception
    Ming Teng Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    PLoS ONE 7:e36143. 2012
    ..The MET/AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism. This study explores the possible role of MET/AKT cascade in facial emotion perception...
  14. doi request reprint Sarcosine therapy for obsessive compulsive disorder: a prospective, open-label study
    Po Lun Wu
    Department of Psychiatry, China Medical University Hospital, Taichung, Taipei, Taiwan
    J Clin Psychopharmacol 31:369-74. 2011
    ..In this 10-week open-label trial, we examined the potential benefit of sarcosine treatment in OCD patients...
  15. ncbi request reprint Benzoate, a d-amino Acid oxidase inhibitor, for the treatment of early-phase Alzheimer disease: a randomized, double-blind, placebo-controlled trial
    Chieh Hsin Lin
    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Biol Psychiatry 75:678-85. 2014
    ..This study examined the efficacy and safety of sodium benzoate, a D-amino acid oxidase inhibitor, for the treatment of amnestic mild cognitive impairment and mild AD...
  16. doi request reprint Glutamate signaling in the pathophysiology and therapy of schizophrenia
    Chieh Hsin Lin
    Department of Psychiatry, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Pharmacol Biochem Behav 100:665-77. 2012
    ....
  17. pmc NMDA neurotransmission as a critical mediator of borderline personality disorder
    Bernadette Grosjean
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, California 90509, USA
    J Psychiatry Neurosci 32:103-15. 2007
    ..This impairment may be the result of a combination of biological vulnerability and environmental influences mediated by the NMDA neurotransmission...
  18. ncbi request reprint Novel therapies for schizophrenia: understanding the glutamatergic synapse and potential targets for altering N-methyl-D-aspartate neurotransmission
    Christina Hui
    Department of Psychiatry, Harbor UCLA Medical Center, HH212, 1000 West Carson Street, Torrance, CA 90509, USA
    Recent Pat CNS Drug Discov 4:220-38. 2009
    ..The 21(st) century holds promise as the era in which an entirely new type of medication for schizophrenia may be created, one with more success at treating the debilitating negative and cognitive symptoms of this disease...
  19. doi request reprint Assessing gene-gene interactions in pharmacogenomics
    Hsien Yuan Lane
    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan
    Mol Diagn Ther 16:15-27. 2012
    ....
  20. pmc The C-terminal region of G72 increases D-amino acid oxidase activity
    Sunny Li Yun Chang
    Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, No 91, Hsueh Shih Road, Taichung 40402, Taiwan
    Int J Mol Sci 15:29-43. 2014
    ....
  21. pmc Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice
    Amy Lawson-Yuen
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Brain Res 1180:1-6. 2007
    ..The male mice experience early death. Analysis of Ube3a mRNA and protein levels in the Mecp2(R168X) male mice showed no significant difference in expression compared to their wild type littermates...
  22. ncbi request reprint Low cerebrospinal fluid glutamate and glycine in refractory affective disorder
    Mark A Frye
    Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
    Biol Psychiatry 61:162-6. 2007
    ..Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness...
  23. ncbi request reprint Searching for rational anti N-methyl-D-aspartate treatment for depression
    Guochuan E Tsai
    Arch Gen Psychiatry 64:1099-100; author reply 1100-1. 2007
  24. ncbi request reprint A case series of D-cycloserine added to donepezil in the treatment of Alzheimer's disease
    William E Falk
    J Neuropsychiatry Clin Neurosci 14:466-7. 2002