Research Topics
Genomes and Genes | John S TordaySummaryAffiliation: Los Angeles Biomedical Research Institute Country: USA Publications
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Publications
Leptin stimulates Xenopus lung development: evolution in a dishJ S Torday
Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA 90502, USA
Evol Dev 11:219-24. 2009..This model provides a cipher for understanding the evolution of complex physiology...
Exploiting cellular-developmental evolution as the scientific basis for preventive medicineJ S Torday
Department of Pediatrics, David Geffen School of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, Los Angeles, California 90502, United States
Med Hypotheses 72:596-602. 2009..Since we have employed principles involved in all of development, this approach is amenable to all biologic structures, functions, adaptations, maladaptations, and diseases, providing an operational basis for preventive medicine...
The evolutionary continuum from lung development to homeostasis and repairJ S Torday
Department of Pedeatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502 2006, USA
Am J Physiol Lung Cell Mol Physiol 292:L608-11. 2007..This model demonstrates how epithelial-mesenchymal cross talk, when seen as a recapitulation of ontogeny and phylogeny (in both a forward and reverse direction), predicts novel, effective diagnostic and therapeutic targets...- Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory networkJohn S Torday
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California 90502, USA
Pediatr Res 60:382-8. 2006..This is the first evidence that alveolar fluid distension is an organizing principle for PTHrP signaling down-regulation of the Shh/Wnt/betacatenin pathway... - Neutral lipid trafficking regulates alveolar type II cell surfactant phospholipid and surfactant protein expressionJohn Torday
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502 2006, USA
Exp Lung Res 37:376-86. 2011..The authors propose, therefore, that ADRP is the physiologic determinant for the elusive coordinated, stoichiometric synthesis of surfactant phospholipid and protein by pulmonary ATII cells... - A cell-molecular approach predicts vertebrate evolutionJOHN STEVEN TORDAY
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Mol Biol Evol 28:2973-81. 2011..As a result, it predicts how cell-molecular changes in this process can cause disease and offers counterintuitive insights to diagnosis and treatment based on evolutionary principles... - Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasiaJohn S Torday
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Pediatr Res 62:2-7. 2007..It is critically important to judiciously select physiologically and developmentally relevant interventions when treating the preterm neonate... - Lung evolution as a cipher for physiologyJ S Torday
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Physiol Genomics 38:1-6. 2009..By reducing complex physiological traits to gene regulatory networks and arranging them hierarchically in a self-organizing map, like the periodic table of elements in physics, the first principles of physiology will emerge... - Leptin integrates vertebrate evolution: from oxygen to the blood-gas barrierJ S Torday
Department of Pediatrics, University of California Los Angeles, CA, USA
Respir Physiol Neurobiol 173:S37-42. 2010.... - Peroxisome proliferator-activated receptor gamma agonists enhance lung maturation in a neonatal rat modelYing Wang
Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Torrance, California 90502, USA
Pediatr Res 65:150-5. 2009.... - A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lungVirender K Rehan
Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
Am J Physiol Lung Cell Mol Physiol 293:L182-90. 2007.... - Reversal of nicotine-induced alveolar lipofibroblast-to-myofibroblast transdifferentiation by stimulants of parathyroid hormone-related protein signalingVirender K Rehan
Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson St, RB1, California, Torrance 90502, USA
Lung 185:151-9. 2007.... - Evidence for the presence of lipofibroblasts in human lungVirender K Rehan
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine, University of California, Los Angeles, California 90502, USA
Exp Lung Res 32:379-93. 2006.... - Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazoneChiranjib Dasgupta
Departments of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California, USA
Am J Physiol Lung Cell Mol Physiol 296:L1031-41. 2009..Administration of PPARgamma agonists may thus be a potential strategy to attenuate hyperoxia-induced lung injury and subsequent BPD... - Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, prevents hyperoxia-induced neonatal rat lung injury in vivoVirender K Rehan
Department of Pediatrics, Los Angeles Biomedical Research Center at Harbor UCLA, David Geffen UCLA School of Medicine, University of California at Los Angeles, Torrance, California 90502, USA
Pediatr Pulmonol 41:558-69. 2006.... - In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolismVirender K Rehan
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine, University of California Los Angeles, 1124 West Carson St, Torrance, CA 90502, USA
Am J Physiol Lung Cell Mol Physiol 292:L323-33. 2007..More importantly, concomitant administration of PPAR-gamma agonists can effectively attenuate many of the effects of in utero exposure to nicotine on ATII cells... - Evidence for in vivo nicotine-induced alveolar interstitial fibroblast-to-myofibroblast transdifferentiationMelissa Krebs
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Exp Lung Res 36:390-8. 2010..More importantly, these data are likely to provide specific interventions to augment the pulmonary mesenchymal lipogenic pathway to ameliorate nicotine-induced in utero lung injury... - Effect of maternal food restriction on fetal rat lung lipid differentiation programAhmet Karadag
Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
Pediatr Pulmonol 44:635-44. 2009..We conclude that MFR alters fetal lung lipid differentiation programming and lung morphometry by affecting specific epithelial-mesenchymal signaling pathways, offering the possibility for specific interventions to overcome these effects... - Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat modelVirender K Rehan
Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California, USA
Pediatr Pulmonol 47:162-71. 2012.... - The effects of smoking on the developing lung: insights from a biologic model for lung development, homeostasis, and repairVirender K Rehan
Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA 90502, USA
Lung 187:281-9. 2009.... - Curcumin augments lung maturation, preventing neonatal lung injury by inhibiting TGF-β signalingReiko Sakurai
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Am J Physiol Lung Cell Mol Physiol 301:L721-30. 2011.... - Antenatally administered PPAR-gamma agonist rosiglitazone prevents hyperoxia-induced neonatal rat lung injuryVirender K Rehan
Dept of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson St, Torrance, CA 90502, USA
Am J Physiol Lung Cell Mol Physiol 299:L672-80. 2010..In conclusion, PPAR-γ agonists can enhance fetal lung maturation and can effectively prevent hyperoxia-induced neonatal lung injury... - Sex-specific perinatal nicotine-induced asthma in rat offspringJie Liu
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502 2006, USA
Am J Respir Cell Mol Biol 48:53-62. 2013.... - Postnatal rosiglitazone administration to neonatal rat pups does not alter the young adult metabolic phenotypeNghia C Truong
Department of Pediatrics, David Geffen School of Medicine, University of California at Los Angeles, Torrance, Calif, USA
Neonatology 101:217-24. 2012..However, whether this exposure to RGZ in neonatal life alters the adult metabolic phenotype is not known... - Deconvoluting lung evolution using functional/comparative genomicsJohn S Torday
Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance, CA, 90502
Am J Respir Cell Mol Biol 31:8-12. 2004..This mechanism is discussed as a function of increased evolutionary respiratory demand to keep up with the increased metabolic demand for oxygen, and the role of the PTHrP signaling mechanism in leveraging this process... - Perinatal nicotine exposure induces asthma in second generation offspringVirender K Rehan
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center at David Geffen School of Medicine, 1124 West Carson Street, Torrance 90502, USA
BMC Med 10:129. 2012.... - Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lungVirender K Rehan
Departments of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Am J Physiol Lung Cell Mol Physiol 301:L1-8. 2011..These data are particularly relevant for designing specific therapeutic strategies, and for formulating public health policies to minimize THS exposure... - Mechanism of nicotine-induced pulmonary fibroblast transdifferentiationVirender K Rehan
Dept of Pediatrics, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
Am J Physiol Lung Cell Mol Physiol 289:L667-76. 2005..Potential therapeutic implications of these observations against in utero nicotine-induced lung injury remain to be tested... - Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblastsReiko Sakurai
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, California, USA
Exp Lung Res 37:144-54. 2011.... - Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblastsLaszlo G Boros
Division of Pediatric Endocrinology, Department of Pediatrics, Stable Isotope Research Laboratory, UCLA School of Medicine, Harbor UCLA Research and Education Institute, 1124 West Carson St, RB1, Torrance, CA 90502, USA
Mol Genet Metab 77:230-6. 2002..Hyperoxia-induced metabolic changes thus play a key role in the transdifferentiation of lung fibroblasts to myofibroblasts and the pathogenesis of BPD... - Exploiting the PTHrP signaling pathway to treat chronic lung diseaseVirender K Rehan
Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
Drugs Today (Barc) 43:317-31. 2007..However, to avoid any subsequent unexpected adverse consequences, it is important to emphasize that before translating the suggested approach into human trials, further testing and refinement in animal models is needed... - Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlookLaura Cerny
Harbor UCLA CHOC Neonatal Perinatal Fellowship Program, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Lung 186:75-89. 2008.... - Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related proteinLewis P Rubin
Department of Pediatrics, Brown Medical School and Women and Infants Hospital, Providence, Rhode Island 02905 2499, USA
Dev Dyn 230:278-89. 2004.... - PPARγ agonist rosiglitazone prevents perinatal nicotine exposure-induced asthma in rat offspringJie Liu
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Physiol Lung Cell Mol Physiol 300:L710-7. 2011..These data suggest that perinatal smoke exposure-induced asthma can be effectively blocked by PPARγ agonists... - Mechanism of reduced lung injury by high-frequency nasal ventilation in a preterm lamb model of neonatal chronic lung diseaseVirender K Rehan
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Pediatr Res 70:462-6. 2011.... - Prenatal rosiglitazone administration to neonatal rat pups does not alter the adult metabolic phenotypeHernan Sierra
Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, Torrance, CA 90502, USA
PPAR Res 2012:604216. 2012..Conclusions. When administered prenatally, RGZ does not affect long-term fetal programming and may be safe for enhancing fetal lung maturation... - Lower parathyroid hormone-related protein content of tracheal aspirates in very low birth weight infants who develop bronchopulmonary dysplasiaVirender K Rehan
Departmet of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Reserach Institute at Harbor UCLA, CA 90502, USA
Pediatr Res 60:216-20. 2006..In contrast, MMP-8 levels did not correlate with BPD. We conclude that lower TA PTHrP content during the first week of life in ventilated VLBWI inversely correlates with prolonged ventilation and the later development of BPD... - 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cellsVirender K Rehan
Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance, CA, USA
Mol Genet Metab 76:46-56. 2002.... - Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expressionAhmed K Abdel-Hakeem
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Am J Obstet Gynecol 199:252.e1-7. 2008..We investigated whether reduced nephrogenesis may be programmed by dysregulation of factors controlling ureteric bud branching and mesenchyme to epithelial transformation... - The physiologic significance of 11beta-hydroxysteroid dehydrogenase type 1 in fetal lung development reduxJ S Torday
Departments of Pediatrics and Obstetrics and Gynecology, The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Horm Metab Res 37:56-7; discussion 58. 2005 - Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptinJ S Torday
Department of Obstetrics and Gynecology, Harbor University of California Los Angeles Research and Education Institute, Torrance, California 90502, USA
Am J Physiol Lung Cell Mol Physiol 283:L130-5. 2002..We conclude that the effect of stretch on alveolar LF and TII differentiation is coordinated by PTHrP, leptin, and their receptors... - PPARγ Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the LungVirender K Rehan
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine, University of California at Los Angeles, Torrance, CA 90502, USA
PPAR Res 2012:289867. 2012..By understanding mechanisms of health and disease as an evolutionary continuum rather than as dissociated processes, we can evolve predictive medicine... - Cell-cell signaling drives the evolution of complex traits: introduction-lung evo-devoJohn S Torday
Laboratory for Evolutionary Preventive Medicine, Department of Pediatrics, David Geffen School of Medicine at UCLA, Laboratory for Evolutionary Preventive Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
Integr Comp Biol 49:142-54. 2009..This symposium surveyed the phylogenetic origins of such vertically integrated mechanisms for the evolution of cell-cell communication as the basis for complex physiologic traits, from sponges to man... - Paracrine mediators of mechanotransduction in lung developmentJ S Torday
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA
Am J Med Sci 316:205-8. 1998..Experimental interruption of this mechanism at any of these steps blocks the spontaneous maturation of the lung in vitro, as evidenced by the inhibition of surfactant production... - Mechanical stretch promotes alveolar epithelial type II cell differentiationJ Sanchez-Esteban
Department of Pediatrics, Brown Medical School and Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02905, USA
J Appl Physiol 91:589-95. 2001..Expression of the SP-C gene appears to be highly responsive to mechanical stimulation... - Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturationJ S Torday
Department of Pediatrics and Obstetrics and Gynecology, Harbor University of California Los Angeles Research and Education Institute, Torrance, California 90502, USA
Am J Physiol Lung Cell Mol Physiol 282:L405-10. 2002..This is the first demonstration of a paracrine loop that functionally cooperates to induce alveolar acinar lung development... - Testing for fetal lung maturation: a biochemical "window" to the developing fetusJ S Torday
Department of Pediatrics, David Geffen School of Medicine, Harbor UCLA Research and Education Institute, University of California Los Angeles, 1124 West Carson Street, Torrance, CA 90502 2006, USA
Clin Lab Med 23:361-83. 2003..These technical and clinical issues are framed by the scientific and empiric evidence that is used as the rationale for such testing and its implementation in the effective management of preterm delivery... - Parathyroid hormone-related protein is a gravisensor in lung and bone cell biologyJ S Torday
Harbor UCLA Research and Education Institute, Departments of Pediatrics and Obstetrics and Gynecology, Torrance, California, 90502 2066, USA
Adv Space Res 32:1569-76. 2003..The loss of the PTHrP signaling mechanism may be corrected using chemical agents that up-regulate this pathway. In conclusion, PTHrP represents a stretch-sensitive paracrine signaling mechanism that may sense gravity... - The role of fibroblast transdifferentiation in lung epithelial cell proliferation, differentiation, and repair in vitroJ S Torday
Department of Pediatrics, Harbor UCLA Research and Education Institute, Center for Developmental Biology, Torrance, California 90502, USA
Pediatr Pathol Mol Med 22:189-207. 2003..We conclude that alveolar overdistension can cause fibroblast transdifferentiation, resulting in failed alveolarization... - Mechanotransduction determines the structure and function of lung and bone: a theoretical model for the pathophysiology of chronic diseaseJ S Torday
Department of Pediatrics, Harbor UCLA Medical Center Research and Education Institute, Torrance, CA 90502 2006, USA
Cell Biochem Biophys 37:235-46. 2003.... - 1alpha,25(OH)2D3 and its 3-epimer promote rat lung alveolar epithelial-mesenchymal interactions and inhibit lipofibroblast apoptosisR Sakurai
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Physiol Lung Cell Mol Physiol 297:L496-505. 2009.... - Fetal androgen exposure inhibits fetal rat lung fibroblast lipid uptake and releaseA Rodriguez
Division of Neonatology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
Exp Lung Res 27:13-24. 2001..These data suggest that in utero exposure to androgens (1) delay the developmental increase in triglyceride content and (2) oppose the effects of glucocorticoid on cultured FRLF triglyceride uptake and PGE2-mediated release... - Biologic role of fetal lung fibroblast triglycerides as antioxidantsJ S Torday
Division of Neonatology, Department of Pediatrics, Harbor UCLA Medical Center, Research and Education Institute, RB 1, Torrance, California, USA
Pediatr Res 49:843-9. 2001..These data are consistent with the hypothesized role of FRLF triglycerides as antioxidants... - Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanismK A King
Department of Pediatrics, Children s Hospital, Boston, MA, USA
Proc Natl Acad Sci U S A 92:4357-61. 1995..Furthermore, components of branchpoints may induce pulmonary neuroendocrine cell differentiation as part of a positive feedback loop, which could account in part for the high prevalence of these cells at branchpoints... - Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lungLin Shan
Department of Pathology, Children s and Brigham and Women s Hospitals and Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Lung Cell Mol Physiol 286:L165-73. 2004..Cumulative data suggest the involvement of multiple BLP receptors, including novel molecules, and argue against simple functional redundancy within this gene family during lung development... - Role of adipose differentiation-related protein in lung surfactant production: a reassessmentAmy L Magra
Membrane Regulation Section, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8028, USA
J Lipid Res 47:2367-73. 2006..We found no role for ADFP in the lipid transfer and conclude that a lipase associated with the lipid droplets hydrolyzes their core triacylglycerols, releasing fatty acids that are taken up by the epithelial cells... - "Failure to communicate" due to forgetting "marriage vow"?John S Torday
Am J Respir Crit Care Med 169:1164; author reply 1164-5. 2004
Research Grants
- HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGYJohn Torday; Fiscal Year: 2007..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..
- Hormonal Control of Lung Development: PTHrP BiologyJohn Torday; Fiscal Year: 2004..Understanding these mechanisms will enhance knowledge of normal alveolization and response to injury, and may lead to novel treatments for chronic lung disease in infants. ..
- Hormonal Control of Lung Development: PTHrP BiologyJohn Torday; Fiscal Year: 2003..Understanding these mechanisms will enhance knowledge as to how stem cell function in lung injury/repair, and how they may be used effectively to treat lung injury and chronic lung disease in infants. ..
- HORMONAL CONTROL OF LUNG DEVELOPMENT--PTHRP BIOLOGYJohn Torday; Fiscal Year: 1999....
- HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGYJohn Torday; Fiscal Year: 2009..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..