Virender Rehan

Summary

Affiliation: Los Angeles Biomedical Research Institute
Country: USA

Publications

  1. ncbi request reprint Exploiting the PTHrP signaling pathway to treat chronic lung disease
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Drugs Today (Barc) 43:317-31. 2007
  2. doi request reprint Curcumin protects the developing lung against long-term hyperoxic injury
    R Sakurai
    Dept of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson St, Torrance, CA 90502
    Am J Physiol Lung Cell Mol Physiol 305:L301-11. 2013
  3. pmc Perinatal nicotine exposure induces asthma in second generation offspring
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center at David Geffen School of Medicine, 1124 West Carson Street, Torrance 90502, USA
    BMC Med 10:129. 2012
  4. pmc Sex-specific perinatal nicotine-induced asthma in rat offspring
    Jie Liu
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502 2006, USA
    Am J Respir Cell Mol Biol 48:53-62. 2013
  5. pmc A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung
    Zhang Li
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    BMC Cell Biol 12:54. 2011
  6. ncbi request reprint Reversal of nicotine-induced alveolar lipofibroblast-to-myofibroblast transdifferentiation by stimulants of parathyroid hormone-related protein signaling
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson St, RB1, California, Torrance 90502, USA
    Lung 185:151-9. 2007
  7. ncbi request reprint A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 293:L182-90. 2007
  8. pmc Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung
    Virender K Rehan
    Departments of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 301:L1-8. 2011
  9. pmc Antenatally administered PPAR-gamma agonist rosiglitazone prevents hyperoxia-induced neonatal rat lung injury
    Virender K Rehan
    Dept of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 299:L672-80. 2010
  10. ncbi request reprint In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine, University of California Los Angeles, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L323-33. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Exploiting the PTHrP signaling pathway to treat chronic lung disease
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Drugs Today (Barc) 43:317-31. 2007
    ..However, to avoid any subsequent unexpected adverse consequences, it is important to emphasize that before translating the suggested approach into human trials, further testing and refinement in animal models is needed...
  2. doi request reprint Curcumin protects the developing lung against long-term hyperoxic injury
    R Sakurai
    Dept of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson St, Torrance, CA 90502
    Am J Physiol Lung Cell Mol Physiol 305:L301-11. 2013
    ..Molecular effects of curcumin, both structural and cytoprotective, suggest that its actions against hyperoxia-induced lung injury are mediated via Erk1/2 activation and that it is a potential intervention against BPD. ..
  3. pmc Perinatal nicotine exposure induces asthma in second generation offspring
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center at David Geffen School of Medicine, 1124 West Carson Street, Torrance 90502, USA
    BMC Med 10:129. 2012
    ....
  4. pmc Sex-specific perinatal nicotine-induced asthma in rat offspring
    Jie Liu
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502 2006, USA
    Am J Respir Cell Mol Biol 48:53-62. 2013
    ....
  5. pmc A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung
    Zhang Li
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    BMC Cell Biol 12:54. 2011
    ..We hypothesized that the JNK pathway is an important regulator of hyperoxia-induced pulmonary responses in the developing murine lung...
  6. ncbi request reprint Reversal of nicotine-induced alveolar lipofibroblast-to-myofibroblast transdifferentiation by stimulants of parathyroid hormone-related protein signaling
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson St, RB1, California, Torrance 90502, USA
    Lung 185:151-9. 2007
    ....
  7. ncbi request reprint A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 293:L182-90. 2007
    ....
  8. pmc Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung
    Virender K Rehan
    Departments of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 301:L1-8. 2011
    ..These data are particularly relevant for designing specific therapeutic strategies, and for formulating public health policies to minimize THS exposure...
  9. pmc Antenatally administered PPAR-gamma agonist rosiglitazone prevents hyperoxia-induced neonatal rat lung injury
    Virender K Rehan
    Dept of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 299:L672-80. 2010
    ..In conclusion, PPAR-γ agonists can enhance fetal lung maturation and can effectively prevent hyperoxia-induced neonatal lung injury...
  10. ncbi request reprint In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine, University of California Los Angeles, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L323-33. 2007
    ..More importantly, concomitant administration of PPAR-gamma agonists can effectively attenuate many of the effects of in utero exposure to nicotine on ATII cells...
  11. pmc Mechanism of reduced lung injury by high-frequency nasal ventilation in a preterm lamb model of neonatal chronic lung disease
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Pediatr Res 70:462-6. 2011
    ....
  12. ncbi request reprint Evidence for the presence of lipofibroblasts in human lung
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine, University of California, Los Angeles, California 90502, USA
    Exp Lung Res 32:379-93. 2006
    ....
  13. pmc Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California, USA
    Pediatr Pulmonol 47:162-71. 2012
    ....
  14. ncbi request reprint Lower parathyroid hormone-related protein content of tracheal aspirates in very low birth weight infants who develop bronchopulmonary dysplasia
    Virender K Rehan
    Departmet of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Reserach Institute at Harbor UCLA, CA 90502, USA
    Pediatr Res 60:216-20. 2006
    ..In contrast, MMP-8 levels did not correlate with BPD. We conclude that lower TA PTHrP content during the first week of life in ventilated VLBWI inversely correlates with prolonged ventilation and the later development of BPD...
  15. ncbi request reprint Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, prevents hyperoxia-induced neonatal rat lung injury in vivo
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Center at Harbor UCLA, David Geffen UCLA School of Medicine, University of California at Los Angeles, Torrance, California 90502, USA
    Pediatr Pulmonol 41:558-69. 2006
    ....
  16. ncbi request reprint Mechanism of nicotine-induced pulmonary fibroblast transdifferentiation
    Virender K Rehan
    Dept of Pediatrics, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 289:L667-76. 2005
    ..Potential therapeutic implications of these observations against in utero nicotine-induced lung injury remain to be tested...
  17. pmc The effects of smoking on the developing lung: insights from a biologic model for lung development, homeostasis, and repair
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA 90502, USA
    Lung 187:281-9. 2009
    ....
  18. pmc Peroxisome proliferator-activated receptor gamma agonists enhance lung maturation in a neonatal rat model
    Ying Wang
    Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Torrance, California 90502, USA
    Pediatr Res 65:150-5. 2009
    ....
  19. pmc Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone
    Chiranjib Dasgupta
    Departments of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1031-41. 2009
    ..Administration of PPARgamma agonists may thus be a potential strategy to attenuate hyperoxia-induced lung injury and subsequent BPD...
  20. pmc Evidence for in vivo nicotine-induced alveolar interstitial fibroblast-to-myofibroblast transdifferentiation
    Melissa Krebs
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Exp Lung Res 36:390-8. 2010
    ..More importantly, these data are likely to provide specific interventions to augment the pulmonary mesenchymal lipogenic pathway to ameliorate nicotine-induced in utero lung injury...
  21. ncbi request reprint Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts
    Laszlo G Boros
    Division of Pediatric Endocrinology, Department of Pediatrics, Stable Isotope Research Laboratory, UCLA School of Medicine, Harbor UCLA Research and Education Institute, 1124 West Carson St, RB1, Torrance, CA 90502, USA
    Mol Genet Metab 77:230-6. 2002
    ..Hyperoxia-induced metabolic changes thus play a key role in the transdifferentiation of lung fibroblasts to myofibroblasts and the pathogenesis of BPD...
  22. doi request reprint Neutral lipid trafficking regulates alveolar type II cell surfactant phospholipid and surfactant protein expression
    John Torday
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502 2006, USA
    Exp Lung Res 37:376-86. 2011
    ..The authors propose, therefore, that ADRP is the physiologic determinant for the elusive coordinated, stoichiometric synthesis of surfactant phospholipid and protein by pulmonary ATII cells...
  23. pmc Hypoxia-induced inhibition of lung development is attenuated by the peroxisome proliferator-activated receptor-γ agonist rosiglitazone
    Teodora Nicola
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Am J Physiol Lung Cell Mol Physiol 301:L125-34. 2011
    ..PPAR-γ agonists may be of potential therapeutic significance in attenuating TGF-β signaling and improving alveolar development...
  24. pmc Effect of maternal food restriction on fetal rat lung lipid differentiation program
    Ahmet Karadag
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Pediatr Pulmonol 44:635-44. 2009
    ..We conclude that MFR alters fetal lung lipid differentiation programming and lung morphometry by affecting specific epithelial-mesenchymal signaling pathways, offering the possibility for specific interventions to overcome these effects...
  25. ncbi request reprint Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasia
    John S Torday
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Pediatr Res 62:2-7. 2007
    ..It is critically important to judiciously select physiologically and developmentally relevant interventions when treating the preterm neonate...
  26. doi request reprint Leptin stimulates Xenopus lung development: evolution in a dish
    J S Torday
    Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Evol Dev 11:219-24. 2009
    ..This model provides a cipher for understanding the evolution of complex physiology...
  27. ncbi request reprint Deconvoluting lung evolution using functional/comparative genomics
    John S Torday
    Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance, CA, 90502
    Am J Respir Cell Mol Biol 31:8-12. 2004
    ..This mechanism is discussed as a function of increased evolutionary respiratory demand to keep up with the increased metabolic demand for oxygen, and the role of the PTHrP signaling mechanism in leveraging this process...
  28. ncbi request reprint Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory network
    John S Torday
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California 90502, USA
    Pediatr Res 60:382-8. 2006
    ..This is the first evidence that alveolar fluid distension is an organizing principle for PTHrP signaling down-regulation of the Shh/Wnt/betacatenin pathway...
  29. doi request reprint Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook
    Laura Cerny
    Harbor UCLA CHOC Neonatal Perinatal Fellowship Program, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Lung 186:75-89. 2008
    ....
  30. ncbi request reprint Prevention of bronchopulmonary dysplasia: finally, something that works
    Virender K Rehan
    David Geffen School of Medicine at UCLA, Torrance, USA
    Indian J Pediatr 73:1027-32. 2006
    ..However, to avoid any later surprises, it is important to emphasize that before translating it into human trials, this approach needs further testing and refinement in animal models...
  31. ncbi request reprint 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance, CA, USA
    Mol Genet Metab 76:46-56. 2002
    ....
  32. doi request reprint Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner
    Caterina Tiozzo
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    Endocr Relat Cancer 19:111-22. 2012
    ..Our results indicate that Pten has a pivotal role in thyroid development and its deletion results in thyroid tumor formation, with the timing and severity of the tumor depending on the particular genetic background...
  33. pmc Curcumin augments lung maturation, preventing neonatal lung injury by inhibiting TGF-β signaling
    Reiko Sakurai
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 301:L721-30. 2011
    ....
  34. pmc PPARγ agonist rosiglitazone prevents perinatal nicotine exposure-induced asthma in rat offspring
    Jie Liu
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 300:L710-7. 2011
    ..These data suggest that perinatal smoke exposure-induced asthma can be effectively blocked by PPARγ agonists...
  35. ncbi request reprint Outcome of very-low-birth-weight (< 1,500 grams) infants born to mothers with diabetes
    Virender K Rehan
    Harbor UCLA Medical Center, Research and Education Institute, RB1, 1124 West Carson Street, Torrance, CA 90502, USA
    Clin Pediatr (Phila) 41:481-91. 2002
    ..It seems that with reasonable diabetic control, prematurity rather than the diabetic state determines the neonatal outcome, and this knowledge can be useful in parental counselling...

Research Grants9

  1. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2009
    ..abstract_text> ..
  2. Fibroblast Cell Signaling in Utero Nicotine-Induced Lung Injury
    Virender K Rehan; Fiscal Year: 2010
    ....
  3. Fibroblast Cell Signaling in Utero Nicotine-Induced Lung Injury
    Virender K Rehan; Fiscal Year: 2010
    ....