Sewite Negash

Summary

Affiliation: Los Angeles Biomedical Research Institute
Country: USA

Publications

  1. pmc Role of cGMP-dependent protein kinase in regulation of pulmonary vascular smooth muscle cell adhesion and migration: effect of hypoxia
    S Negash
    Division of Neonatology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA
    Am J Physiol Heart Circ Physiol 297:H304-12. 2009
  2. ncbi request reprint Regulation of cGMP-dependent protein kinase-mediated vasodilation by hypoxia-induced reactive species in ovine fetal pulmonary veins
    Sewite Negash
    Division of Neonatology, Harbor UCLA Medical Center, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1012-20. 2007
  3. pmc Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase
    Yuansheng Gao
    Division of Neonatology, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 295:L889-96. 2008
  4. pmc Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase and myocardin
    Weilin Zhou
    Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 296:L780-9. 2009
  5. pmc Long-term effects of prenatal hypoxia on endothelium-dependent relaxation responses in pulmonary arteries of adult sheep
    Jie Liu
    Division of Neonatology, Harbor University of California, Los Angeles Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 296:L547-54. 2009
  6. ncbi request reprint Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase
    Weilin Zhou
    Division of Neonatology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1459-66. 2007
  7. ncbi request reprint Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia
    Yuansheng Gao
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California and Los Angeles Biomedical Research Institute, Los Angeles, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L678-84. 2007
  8. ncbi request reprint Fluorophore-assisted light inactivation of calmodulin involves singlet-oxygen mediated cross-linking and methionine oxidation
    Ping Yan
    Cell Biology and Biochemistry Group, Division of Biological Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Biochemistry 45:4736-48. 2006
  9. ncbi request reprint CDK5 regulates cell adhesion and migration in corneal epithelial cells
    Chun Gao
    National Eye Institute, NIH, Bethesda, MD Yang Ming University, Taipei, Taiwan
    Mol Cancer Res 1:12-24. 2002
  10. ncbi request reprint Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells
    Sewite Negash
    National Eye Institute, NIH, Bethesda, MD 20892, USA
    J Cell Sci 115:2109-17. 2002

Collaborators

Detail Information

Publications11

  1. pmc Role of cGMP-dependent protein kinase in regulation of pulmonary vascular smooth muscle cell adhesion and migration: effect of hypoxia
    S Negash
    Division of Neonatology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA
    Am J Physiol Heart Circ Physiol 297:H304-12. 2009
    ..Together, these findings identify cGMP/PKG1 signaling as central to the functional differences between PVSMC exposed to normoxia versus hypoxia...
  2. ncbi request reprint Regulation of cGMP-dependent protein kinase-mediated vasodilation by hypoxia-induced reactive species in ovine fetal pulmonary veins
    Sewite Negash
    Division of Neonatology, Harbor UCLA Medical Center, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1012-20. 2007
    ..However, after 4 h of hypoxia, PKG nitration and decreased PKG expression are involved...
  3. pmc Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase
    Yuansheng Gao
    Division of Neonatology, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 295:L889-96. 2008
    ..These results suggest that CH in utero upregulates PKG activity but attenuates PKG action in fetal pulmonary veins. These effects are offset by the diminished ROCK action on MYPT1 and MLC and thus lead to an unaltered response to cGMP...
  4. pmc Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase and myocardin
    Weilin Zhou
    Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 296:L780-9. 2009
    ..The inhibitory effects of hypoxia on PKG may explain hypoxia-induced SMC phenotype modulation by decreasing the effects of PKG on myocardin...
  5. pmc Long-term effects of prenatal hypoxia on endothelium-dependent relaxation responses in pulmonary arteries of adult sheep
    Jie Liu
    Division of Neonatology, Harbor University of California, Los Angeles Medical Center, Geffen School of Medicine at University of California, and Los Angeles Biomedical Research Institute, Los Angeles, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 296:L547-54. 2009
    ....
  6. ncbi request reprint Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase
    Weilin Zhou
    Division of Neonatology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1459-66. 2007
    ..These results suggest that PKG could be one of the determinants for the expression of SMC phenotype marker proteins and may be involved in the maintenance of the differentiated phenotype in pulmonary vascular SMCs in hypoxia...
  7. ncbi request reprint Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia
    Yuansheng Gao
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California and Los Angeles Biomedical Research Institute, Los Angeles, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L678-84. 2007
    ..Increased ROCK activity may inhibit PKG action through increased phosphorylation of MYPT1 at Thr696 and Thr850...
  8. ncbi request reprint Fluorophore-assisted light inactivation of calmodulin involves singlet-oxygen mediated cross-linking and methionine oxidation
    Ping Yan
    Cell Biology and Biochemistry Group, Division of Biological Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Biochemistry 45:4736-48. 2006
    ..Our results provide a rationale for proteomic screens using FALI to inhibit the function of many signaling proteins, which, like CaM, commonly present methionines at binding interfaces...
  9. ncbi request reprint CDK5 regulates cell adhesion and migration in corneal epithelial cells
    Chun Gao
    National Eye Institute, NIH, Bethesda, MD Yang Ming University, Taipei, Taiwan
    Mol Cancer Res 1:12-24. 2002
    ..These findings indicate that CDK5 may be an important regulator of adhesion and migration of corneal epithelial cells...
  10. ncbi request reprint Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells
    Sewite Negash
    National Eye Institute, NIH, Bethesda, MD 20892, USA
    J Cell Sci 115:2109-17. 2002
    ..In addition, Cdk5 overexpression decreased cell-cell adhesion as measured by a cell aggregation assay. These findings suggest that Cdk5 plays a role in regulating both cell-matrix and cell-cell interactions in the lens...
  11. ncbi request reprint The inhibitory action of phospholamban involves stabilization of alpha-helices within the Ca-ATPase
    Suren A Tatulian
    Biochemistry and Biophysics Section, Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045 2106, USA
    Biochemistry 41:741-51. 2002
    ....