Research Topics
Species | R MehrotraSummaryAffiliation: Los Angeles Biomedical Research Institute Country: USA Publications
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Detail Information
Publications
Relationship of body size and initial dialysis modality on subsequent transplantation, mortality and weight gain of ESRD patientsHanna Lievense
Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA, USA
Nephrol Dial Transplant 27:3631-8. 2012..We undertook this study to determine the interrelationship between body size and initial dialysis modality on transplantation, mortality and weight gain...- Neighborhood location, rurality, geography, and outcomes of peritoneal dialysis patients in the United StatesRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Perit Dial Int 32:322-31. 2012..No data are available on the effect of neighborhood characteristics or regional differences on the outcomes of PD patients in the United States... 
Comparing outcomes of hemodialysis and peritoneal dialysis patients: consider the pitfallsRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, Calif 90502, USA
Contrib Nephrol 178:30-4. 2012....- Dialysis modality and outcomes in kidney transplant recipientsMiklos Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Harbor University of California at Los Angeles Medical Center, Torrance, CA 90509 2910, USA
Clin J Am Soc Nephrol 7:332-41. 2012..This study examined associations of pretransplant dialysis modality with post-transplant outcomes in a large national cohort of kidney transplant recipients... - Choice of dialysis modalityRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 W Carson Street, Torrance, California 90502, USA
Kidney Int 80:909-11. 2011..Such studies, thus, are insufficient to deny patients a choice in selecting their dialysis modality... - Similar outcomes with hemodialysis and peritoneal dialysis in patients with end-stage renal diseaseRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Arch Intern Med 171:110-8. 2011..Since 1996, there has been no change in the first-year mortality of HD patients, but both short- and long-term outcomes of PD patients have improved... 
Changing patterns of peritoneal dialysis utilization in the United StatesRajnish Mehrotra
Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, and David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90502, USA
Perit Dial Int 27:S51-2. 2007..Understanding the reasons for historically low CPD take-on and recent steep declines in utilization may allow for plans to reverse these trends to be developed...- Patient education and access of ESRD patients to renal replacement therapies beyond in-center hemodialysisRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 68:378-90. 2005..In the United States, kidney transplant rates remain low and <10% of patients utilize home dialysis therapies. This study examined the effect of pre-ESRD processes on the selection of RRT among incident ESRD patients... - Chronic kidney disease, hypovitaminosis D, and mortality in the United StatesRajnish Mehrotra
Division of Nephrology and Hypertension, Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
Kidney Int 76:977-83. 2009..Randomized, controlled trials are needed to conclusively determine whether vitamin D supplementation reduces mortality... - Progression of coronary artery calcification in diabetics with and without chronic kidney diseaseRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 68:1258-66. 2005..There is limited information on the progression of CAC during earlier stages of diabetic chronic kidney disease (CKD)... - Disordered mineral metabolism and vascular calcification in nondialyzed chronic kidney disease patientsRajnish Mehrotra
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute, Harbor UCLA, Torrance, CA, USA
J Ren Nutr 16:100-18. 2006..Finally, there is a need to identify alternative pathogenetic mechanisms that may be important causes of the high calcification burden observed early in CKD... - Chronic peritoneal dialysis in the United States: declining utilization despite improving outcomesRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
J Am Soc Nephrol 18:2781-8. 2007..The decline in utilization has occurred at a time when the early outcomes of CPD patients have improved... - The John F. Maher Award Recipient Lecture 2006. The continuum of chronic kidney disease and end-stage renal disease: challenges and opportunities for chronic peritoneal dialysis in the United StatesRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Perit Dial Int 27:125-30. 2007..Understanding the reasons for historically low CPD take-on and recent steep declines in utilization may allow the development of plans to reverse these trends... - Serum fetuin-A in nondialyzed patients with diabetic nephropathy: relationship with coronary artery calcificationRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 67:1070-7. 2005..Fetuin-A is the most potent circulating inhibitor of calcium phosphorus precipitation and, possibly, an important mediator of insulin resistance... - Hypovitaminosis D, neighborhood poverty, and progression of chronic kidney disease in disadvantaged populationsR Mehrotra
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Center at Harbor UCLA, Torrance, CA, USA
Clin Nephrol 74:S95-8. 2010..A greater Understanding of these factors is important in order to reduce the racial disparities in the United States... - Long-term outcomes in automated peritoneal dialysis: similar or better than in continuous ambulatory peritoneal dialysis?Rajnish Mehrotra
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, and David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Perit Dial Int 29:S111-4. 2009..In summary, the long-term outcomes of CAPD and APD appear to be similar, and patient and physician preference are likely to increase the utilization of APD in many parts of the world... - Peritoneal dialysis penetration in the United States: march toward the fringes?Rajnish Mehrotra
Division of Nephrology and Hypertension and Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA
Perit Dial Int 26:419-22. 2006 - The outcomes of continuous ambulatory and automated peritoneal dialysis are similarRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California 90502, USA
Kidney Int 76:97-107. 2009..Thus, the improved chronic peritoneal dialysis outcomes cannot be attributed to a greater use of automated peritoneal dialysis... - Serum albumin as a predictor of mortality in peritoneal dialysis: comparisons with hemodialysisRajnish Mehrotra
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA, USA
Am J Kidney Dis 58:418-28. 2011..Whether the threshold level of serum albumin at which mortality risk increases in peritoneal dialysis (PD) patients is the same as for hemodialysis (HD) patients has not been studied... - Higher strength lanthanum carbonate provides serum phosphorus control with a low tablet burden and is preferred by patients and physicians: a multicenter studyRajnish Mehrotra
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Clin J Am Soc Nephrol 3:1437-45. 2008..This phase IIIb trial assessed the efficacy of increased dosages (3000 to 4500 mg/d) of reformulated lanthanum carbonate (500-, 750-, and 1000-mg tablets) in nonresponders to dosages of up to 3000 mg/d... - Racial differences in mortality among those with CKDRajnish Mehrotra
Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
J Am Soc Nephrol 19:1403-10. 2008..This higher risk for death in early stages of CKD may explain the apparent survival advantage observed among black individuals who live long enough to reach stage 5 CKD... - Ownership patterns of dialysis units and peritoneal dialysis in the United States: utilization and outcomesRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Am J Kidney Dis 54:289-98. 2009..We undertook this study to determine the relationship between dialysis unit ownership with PD use and outcomes... - Hypovitaminosis D in chronic kidney diseaseRajnish Mehrotra
Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Clin J Am Soc Nephrol 3:1144-51. 2008.... - Determinants of coronary artery calcification in diabetics with and without nephropathyRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 66:2022-31. 2004..On the other hand, accumulating evidence suggests that disordered mineral metabolism significantly contributes to the vascular calcification in individuals with end-stage renal disease (ESRD)... - Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney diseaseR Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 72:137-40. 2007..These findings underscore the need to further clarify the multiple, systemic effects of fetuin-A and its role in health and various stages of CKD... - Pill burden, adherence, hyperphosphatemia, and quality of life in maintenance dialysis patientsYi Wen Chiu
Los Angeles Biomedical Research Institute, Torrance, California, USA
Clin J Am Soc Nephrol 4:1089-96. 2009..Dialysis patients have a high burden of co-existing diseases, poor health-related quality of life (HR-QOL), and are prescribed many medications. There are no data on daily pill burden and its relationship to HR-QOL and adherence to therapy... - Associations of pretransplant serum albumin with post-transplant outcomes in kidney transplant recipientsM Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Am J Transplant 11:1006-15. 2011..Clinical trials to examine interventions to improve nutritional status in transplant-waitlisted hemodialysis patients and their impacts on post-transplant outcomes are indicated... - Age-related decline in serum parathyroid hormone in maintenance hemodialysis patients is independent of inflammation and dietary nutrient intakeRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, CA 90502, USA
J Ren Nutr 14:134-42. 2004..The pathophysiologic basis of this age-related decline in serum iPTH levels remains unclear, although others have proposed that it is related to low dietary phosphorus intakes... - Coronary artery, aortic wall, and valvular calcification in nondialyzed individuals with type 2 diabetes and renal diseaseRaffi Merjanian
Division of Nephrology and Hypertension, Department of Pediatrics, Harbor-UCLA Medical Center and Research and Education Institute, Torrance, California 90502, USA
Kidney Int 64:263-71. 2003..The data also suggest that the coronary artery and aortic wall calcification may represent atherosclerosis... - Vitamin D and the cardiovascular systemJorge N Artaza
Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Clin J Am Soc Nephrol 4:1515-22. 2009.... - Vascular calcification and disordered mineral metabolism in dialysis patientsMary Alice Kalpakian
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Semin Dial 20:139-43. 2007..However, the preponderance of evidence argues strongly in favor of aggressive management of these abnormalities from starting early in the course of chronic kidney disease in the hope of improving patient outcomes... - Nodular glomerulosclerosis in a patient with metabolic syndrome without diabetesPierre Souraty
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute, Torrance, CA, USA
Nat Clin Pract Nephrol 4:639-42. 2008..Diabetes mellitus was ruled out by a 2 h oral glucose tolerance test and two glycated hemoglobin (HbA 1c) measurements. A renal biopsy showed evidence of nodular glomerulosclerosis... - Poor correlation between coronary artery calcification and obstructive coronary artery disease in an end-stage renal disease patientLi Li Tong
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Torrance, California, U S A
Hemodial Int 12:16-22. 2008..Thus, this case demonstrates that even an extremely high coronary calcium score may not be a satisfactory surrogate marker for obstructive atherosclerosis in elderly diabetic dialysis patients... - Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patientsDeborah L Regidor
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
J Am Soc Nephrol 19:2193-203. 2008..Prospective controlled trials will be necessary to test whether serum AlkPhos measurements could be used to improve the management of renal osteodystrophy... - Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination SurveyDavid Martins
Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
Arch Intern Med 167:1159-65. 2007..Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D... - The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysisKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Mayo Clin Proc 85:991-1001. 2010..To determine whether dry weight gain accompanied by an increase in muscle mass is associated with a survival benefit in patients receiving maintenance hemodialysis (HD)... - Emphasizing patient choice: the modality selection project in ESRD Network 18Rajnish Mehrotra
Division of Nephrology, Research and Education Institute, Harbor-UCLA Medical Center, School of Medicine, USA
Nephrol News Issues 17:30-6. 2003..This in turn, would lead to better preparation of patients for RRT and hopefully, have a positive impact on the morbidity and mortality of maintenance dialysis patients... - Diabetes and progression of coronary calcium under the influence of statin therapyMatthew J Budoff
Division of Cardiology, Harbor UCLA Medical Center Research and Education Institute, Torrance, Calif 90502, USA
Am Heart J 149:695-700. 2005..We sought to evaluate the progression of atherosclerosis in asymptomatic persons with type 2 diabetes and measure the influence of statin therapy on CAC progression... - Differential management of cardiovascular disease in ESRD by nephrologists and cardiologistsHamik A Martirosyan
Division of Nephrology and Hypertension, Harbor-University of California, Los Angeles Research and Education Institute, Torrance, CA, USA
Am J Kidney Dis 44:309-21. 2004..The discipline-driven differential management approaches observed emphasize the need for better evidence-based management strategies for this population... - Is controlling phosphorus by decreasing dietary protein intake beneficial or harmful in persons with chronic kidney disease?Christian S Shinaberger
Harold Simmons Center for Kidney Disease Research and Epidemiology, Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Clin Nutr 88:1511-8. 2008..Dietary restrictions to control serum phosphorus, which are routinely recommended to persons with chronic kidney disease, are usually associated with a reduction in protein intake. This may lead to protein-energy wasting and poor survival... - Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney diseaseKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
Clin J Am Soc Nephrol 5:519-30. 2010..Provision of in-center and monitored meals during hemodialysis treatment sessions in the dialysis clinic may facilitate the achievement of these goals... - Cardiovascular implications of chronic kidney disease in older adultsRamnath Dukkipati
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Drugs Aging 25:241-53. 2008..To conclude, the available evidence indicates that early identification of CKD may allow physicians to aggressively modify cardiovascular risk, which, in turn, has the potential to improve patient outcomes... - Coronary artery calcification and mortality in diabetic patients with proteinuriaYi Wen Chiu
Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, California, USA
Kidney Int 77:1107-14. 2010..Additional studies need to determine whether altering the natural history of coronary artery calcification in early chronic kidney disease prolongs survival... - Nutritional management of maintenance dialysis patients: why aren't we doing better?R Mehrotra
Division of Nephrology and Hypertension, UCLA School of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
Annu Rev Nutr 21:343-79. 2001..We offer suggestions for predialysis and dialysis care of these patients that can result in improvement in their nutritional status. Whether this improvement will result in a decrease in patient morbidity and mortality is unknown... - Treatment of advanced renal failure: low-protein diets or timely initiation of dialysis?R Mehrotra
Division of Nephrology and Hypertension, University of California, Los Angeles, and Harbor UCLA Medical Center, Torrance, California 90509, USA
Kidney Int 58:1381-8. 2000..Concerns still exist regarding their nutritional safety in the remainder. Initiation of dialysis results in improved nutritional status and should be considered in a timely fashion... - Is the declining use of long-term peritoneal dialysis justified by outcome data?Osman Khawar
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
Clin J Am Soc Nephrol 2:1317-28. 2007..There is a need for large observational and interventional studies among peritoneal dialysis patients to sustain and enforce the improvements in both dialysis therapies... - Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failureKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
Semin Dial 17:455-65. 2004..Until then, all attempts should be made to adhere to the National Kidney Foundation Kidney Disease and Dialysis Outcome Quality Initiative guidelines to maintain a serum bicarbonate level in ESRD patients of at least 22 mEq/L... - Protein and energy nutrition among adult patients treated with chronic peritoneal dialysisRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, CA 90502, USA
Adv Ren Replace Ther 10:194-212. 2003..There is a need to carry out clinical trials that examine whether an improvement in the nutritional status of CPD patients is associated with an improvement in their mortality, morbidity and/or quality of life... - Reducing peritonitis rates in a peritoneal dialysis program of indigent ethnic minoritiesRajnish Mehrotra
Division of Nephrology and Hypertension, Research and Education Institute at Harbor-UCLA Medical Center, Torrance, California, USA
Perit Dial Int 23:83-5. 2003 - Observations with regard to the National Kidney Foundation K/DOQI clinical practice guidelines concerning serum transthyretin in chronic renal failureJoel D Kopple
Division of Nephrology and Hypertension and the Research and Education Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Clin Chem Lab Med 40:1308-12. 2002..6) MHD patients with serum TTR levels less than 25-30 mg/dl should be evaluated for protein-energy malnutrition and inflammation... - An analysis of dialysis training in the United States and CanadaRajnish Mehrotra
Harbor University of California at Los Angeles Medical Center and Research and Education Institute, Torrance, CA 90502, USA
Am J Kidney Dis 40:152-60. 2002..Because the prevalence of end-stage renal disease (ESRD) has progressively increased in both the United States and Canada, patients with ESRD are likely to constitute progressively larger proportions of nephrology practices... - Improvement of nutritional status after initiation of maintenance hemodialysisRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor University of California at Los Angeles Medical Center, Torrance, CA 90509, USA
Am J Kidney Dis 40:133-42. 2002..We examined this question by reviewing records of all patients admitted to our outpatient dialysis unit within 30 days of initiation of MHD therapy... - Dietary protein requirements and dialysate protein losses in chronic peritoneal dialysis patientsWytske M Westra
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Perit Dial Int 27:192-5. 2007..The relative contribution of dialysate protein and amino acid losses to these high protein requirements or total nitrogen losses is uncertain... - What should define optimal correction of metabolic acidosis in chronic kidney disease?Yi Wen Chiu
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA
Semin Dial 23:411-4. 2010.... - Association of hemodialysis treatment time and dose with mortality and the role of race and sexJessica E Miller
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 55:100-12. 2010..The association of survival with characteristics of thrice-weekly hemodialysis (HD) treatment, including dose or duration of treatment, has not been completely elucidated, especially in different race and sex categories... - Effect of high-normal compared with low-normal arterial pH on protein balances in automated peritoneal dialysis patientsRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Am J Clin Nutr 90:1532-40. 2009..Although the protein catabolic effects of metabolic acidosis are well established, it is unclear whether the entire reference range of arterial pH (7.37-7.44) is equivalent for protein balance... - Quality indicators for the care of hypertension in vulnerable eldersLillian C Min
Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
J Am Geriatr Soc 55:S359-65. 2007 - Association of hemoglobin and survival in peritoneal dialysis patientsMiklos Z Molnar
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Center at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, California 90502, USA
Clin J Am Soc Nephrol 6:1973-81. 2011.... - Racial differences in mortality and ESRDKeith Norris
Am J Kidney Dis 52:205-8. 2008 - Battleground: chronic kidney disorders mineral and bone disease--calcium obsession, vitamin d, and binder confusionCsaba P Kovesdy
Division of Nephrology, Salem Veterans Affairs Medical Center, Salem, Virginia 24153, USA
Clin J Am Soc Nephrol 3:168-73. 2008..Also assessed is what the key unanswered questions are in this field, and practical solutions to the discussed issues are provided... - Coronary artery calcification in nondialyzed patients with chronic kidney diseasesRajnish Mehrotra
Am J Kidney Dis 45:963. 2005 - Serum and dialysate potassium concentrations and survival in hemodialysis patientsCsaba P Kovesdy
Division of Nephrology, Salem Veterans Affairs Medical Center, Salem, Virginia, USA
Clin J Am Soc Nephrol 2:999-1007. 2007..Controlling serum potassium is an important goal in maintenance hemodialysis patients. We examined the achievement of potassium balance through hemodialysis treatments and the associated fluctuations in serum potassium... - Quality of care in profit vs not-for-profit dialysis centersKamyar Kalantar-Zadeh
JAMA 289:3089; author reply 3089-90. 2003 - Does in vitro fluoroquinolone resistance predict clinical failure in urinary tract infections?Loren G Miller
Int J Antimicrob Agents 29:605-7. 2007 - Education, research, peritoneal dialysis, and the North American chapter of the International Society for Peritoneal DialysisRajnish Mehrotra
Perit Dial Int 25:14-5. 2005