Thomas R Magee

Summary

Affiliation: Los Angeles Biomedical Research Institute
Country: USA

Publications

  1. ncbi Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass
    Thomas R Magee
    Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA
    J Gene Med 8:1171-81. 2006
  2. ncbi Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat
    Thomas R Magee
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    J Sex Med 4:633-43. 2007
  3. ncbi Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    Thomas R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90509, USA
    Biol Reprod 67:1033-41. 2002
  4. ncbi Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    Thomas R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, CA 90509, USA
    Biol Reprod 67:20-8. 2002
  5. ncbi Profibrotic role of myostatin in Peyronie's disease
    Liliana P Cantini
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Los Angeles, CA, USA
    J Sex Med 5:1607-22. 2008
  6. ncbi Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease
    Hugo H Davila
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 71:1568-77. 2004
  7. ncbi Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease
    Dolores Vernet
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 73:1199-210. 2005
  8. ncbi Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring
    Diana Wolfe
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Obstet Gynecol 207:308.e1-6. 2012
  9. ncbi Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection
    Monica G Ferrini
    Research and Education Institute, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Comp Neurol 458:46-61. 2003
  10. ncbi Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model
    Dolores Vernet
    Division of Urology, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
    Nitric Oxide 7:262-76. 2002

Collaborators

Detail Information

Publications18

  1. ncbi Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass
    Thomas R Magee
    Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA
    J Gene Med 8:1171-81. 2006
    ..We investigated whether a plasmid expressing a short hairpin interfering RNA (shRNA) against myostatin and transduced using electroporation would increase local skeletal muscle mass...
  2. ncbi Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat
    Thomas R Magee
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    J Sex Med 4:633-43. 2007
    ..Over-expression of penile neuronal nitric oxide synthase (PnNOS) from a plasmid ameliorates aging-related erectile dysfunction (ED), whereas over-expression of the protein inhibitor of NOS (PIN), that binds to nNOS, increases ED...
  3. ncbi Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    Thomas R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90509, USA
    Biol Reprod 67:1033-41. 2002
    ..In conclusion, intracavernosal gene therapy with PnNOS cDNA corrected the aging-related erectile dysfunction for at least 18 days when given by electroporation in a helper-dependent AdV at low viral loads...
  4. ncbi Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    Thomas R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, CA 90509, USA
    Biol Reprod 67:20-8. 2002
    ..In conclusion, intracavernosal gene therapy with PnNOS cDNA corrected the aging-related erectile dysfunction for at least 18 days when given by electroporation in a helper-dependent AdV at low viral loads...
  5. ncbi Profibrotic role of myostatin in Peyronie's disease
    Liliana P Cantini
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Los Angeles, CA, USA
    J Sex Med 5:1607-22. 2008
    ..The primary histologic finding in many urologic disorders, including Peyronie's disease (PD), is fibrosis, mainly mediated by the transforming growth factor beta1 (TGFbeta1)...
  6. ncbi Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease
    Hugo H Davila
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 71:1568-77. 2004
    ..The piNOS gene transfer regressed the PD plaque and expression of profibrotic factors, supporting the view that endogenous iNOS induction in PD is defense mechanism by the tissue against fibrosis...
  7. ncbi Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease
    Dolores Vernet
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 73:1199-210. 2005
    ..This may explain progression of fibrosis in the PD plaque and its eventual calcification...
  8. ncbi Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring
    Diana Wolfe
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Obstet Gynecol 207:308.e1-6. 2012
    ....
  9. ncbi Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection
    Monica G Ferrini
    Research and Education Institute, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Comp Neurol 458:46-61. 2003
    ..These results indicate that both nNOS variants, and their respective regulatory proteins are present and colocalize in the hypothalamic and spinal cord regions involved in penile erection...
  10. ncbi Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model
    Dolores Vernet
    Division of Urology, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
    Nitric Oxide 7:262-76. 2002
    ....
  11. ncbi Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 146:3547-57. 2005
    ..In conclusion, myostatin promotes the differentiation of multipotent mesenchymal cells into the adipogenic lineage and inhibits myogenesis...
  12. ncbi Peyronie's disease associated with increase in plasminogen activator inhibitor in fibrotic plaque
    Hugo H Davila
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    Urology 65:645-8. 2005
    ..CONCLUSIONS: The observed increase in PAI-1 in the human PD plaque agrees with what has been observed in the rat and suggests that PAI-1 may be a key pro-fibrotic factor in the development of human PD...
  13. ncbi Maternal undernourished fetal kidneys exhibit differential regulation of nephrogenic genes including downregulation of the Notch signaling pathway
    Thomas R Magee
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Reprod Sci 18:563-76. 2011
    ..These data together show that maternal undernutrition results in developmental disruption in fetal nephrogenesis gene expression signaling...
  14. ncbi Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring
    Thomas R Magee
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Obstet Gynecol 199:271.e1-5. 2008
    ..We hypothesized that IUGR-induced inhibition of hepatic peroxisome proliferator-activated receptors (PPARs) is associated with an increased inflammatory response...
  15. ncbi Maternal undernutrition programs offspring adrenal expression of steroidogenic enzymes
    Naseem M Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center and David Geffen School of Medicine at University of California, Los Angeles, CA 90502, USA
    Reprod Sci 18:931-40. 2011
    ..The common finding of increased ACTH receptor expression in MUN adults of both genders suggests an increased sensitivity of these offspring to stress...
  16. ncbi AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells
    Louiza Belkacemi
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90502, USA
    Life Sci 82:1272-80. 2008
    ..Thus, modulation of AQP1 expression by maternal hormones may regulate invasion and fetal-placental-amnion water homeostasis during gestation...
  17. ncbi Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression
    Ahmed K Abdel-Hakeem
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Am J Obstet Gynecol 199:252.e1-7. 2008
    ..We investigated whether reduced nephrogenesis may be programmed by dysregulation of factors controlling ureteric bud branching and mesenchyme to epithelial transformation...
  18. ncbi Gene expression profiles in the Peyronie's disease plaque
    Thomas R Magee
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90509, USA
    Urology 59:451-7. 2002
    ....