Joel Kopple

Summary

Affiliation: Los Angeles Biomedical Research Institute
Country: USA

Publications

  1. ncbi The effect of obesity on chronic kidney disease
    Joel D Kopple
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    J Ren Nutr 21:66-71. 2011
  2. ncbi Frailty and protein-energy wasting in elderly patients with end stage kidney disease
    Jun Chul Kim
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Am Soc Nephrol 24:337-51. 2013
  3. ncbi Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, California, USA
    J Am Soc Nephrol 18:2975-86. 2007
  4. ncbi Growth hormone induces anabolism in malnourished maintenance haemodialysis patients
    Joel D Kopple
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90501, USA
    Nephrol Dial Transplant 20:952-8. 2005
  5. ncbi OPPORTUNITY: a randomized clinical trial of growth hormone on outcome in hemodialysis patients
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA 90509, USA
    Clin J Am Soc Nephrol 3:1741-51. 2008
  6. ncbi Obesity and chronic kidney disease
    Joel D Kopple
    Los Angeles Biomedical Research Institute and Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Ren Nutr 20:S29-30. 2010
  7. ncbi Effect of exercise on mRNA levels for growth factors in skeletal muscle of hemodialysis patients
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    J Ren Nutr 16:312-24. 2006
  8. ncbi OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients
    Joel D Kopple
    Department of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Nephrol Dial Transplant 26:4095-103. 2011
  9. ncbi How to reconcile conventional and altered risk factor patterns in dialysis patients
    Joel D Kopple
    Division of Nephrology and Hypertension and Department of Medicine and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, USA
    Semin Dial 20:602-5. 2007
  10. ncbi Phenylalanine and tyrosine metabolism in chronic kidney failure
    Joel D Kopple
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Nutr 137:1586S-1590S; discussion 1597S-1598S. 2007

Research Grants

  1. Dietary Protein Requirements in Hemodialysis Patients
    Joel Kopple; Fiscal Year: 2007

Detail Information

Publications83

  1. ncbi The effect of obesity on chronic kidney disease
    Joel D Kopple
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    J Ren Nutr 21:66-71. 2011
    ....
  2. ncbi Frailty and protein-energy wasting in elderly patients with end stage kidney disease
    Jun Chul Kim
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Am Soc Nephrol 24:337-51. 2013
    ..Here, we examine the causes and consequences of these conditions and examine the interplay between frailty and PEW in elderly CKD patients...
  3. ncbi Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, California, USA
    J Am Soc Nephrol 18:2975-86. 2007
  4. ncbi Growth hormone induces anabolism in malnourished maintenance haemodialysis patients
    Joel D Kopple
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90501, USA
    Nephrol Dial Transplant 20:952-8. 2005
    ..This study tested the hypothesis that recombinant human GH (rhGH) will induce an anabolic response, as assessed by long-term classic nitrogen-balance techniques, in malnourished MHD patients...
  5. ncbi OPPORTUNITY: a randomized clinical trial of growth hormone on outcome in hemodialysis patients
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA 90509, USA
    Clin J Am Soc Nephrol 3:1741-51. 2008
    ..The OPPORTUNITY Trial will examine whether GH reduces mortality and morbidity and improves overall health in hypoalbuminemic MHD patients...
  6. ncbi Obesity and chronic kidney disease
    Joel D Kopple
    Los Angeles Biomedical Research Institute and Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Ren Nutr 20:S29-30. 2010
    ..Therefore, there is a greater need for a better understanding of the causes of the excessive energy intake that leads to obesity and the mechanisms responsible for the refractoriness of obese individuals to treatment...
  7. ncbi Effect of exercise on mRNA levels for growth factors in skeletal muscle of hemodialysis patients
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    J Ren Nutr 16:312-24. 2006
    ..This study tested the hypothesis that in MHD patients endurance exercise training (EET) increases mRNA levels for insulin-like growth factors and reduces myostatin mRNA...
  8. ncbi OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients
    Joel D Kopple
    Department of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Nephrol Dial Transplant 26:4095-103. 2011
    ..Secondary end points were effects on number of hospitalizations, cardiovascular events, lean body mass (LBM), serum proteins, exercise capacity, QoL and adverse events...
  9. ncbi How to reconcile conventional and altered risk factor patterns in dialysis patients
    Joel D Kopple
    Division of Nephrology and Hypertension and Department of Medicine and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, USA
    Semin Dial 20:602-5. 2007
    ..Studies, including interventional clinical trials, are indicated to ascertain the causes of ARFPs and the therapeutic targets for these risk factors for individuals with chronic kidney disease and CKF...
  10. ncbi Phenylalanine and tyrosine metabolism in chronic kidney failure
    Joel D Kopple
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Nutr 137:1586S-1590S; discussion 1597S-1598S. 2007
    ..It is not known whether the elevated protein chlorotyrosine or nitrotyrosine or increased oxidative products of phenylalanine cause adverse metabolic or toxic effects in patients with CRF...
  11. ncbi The message for World Kidney Day 2009: hypertension and kidney disease: a marriage that should be prevented
    George L Bakris
    Hypertensive Diseases Unit, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    J Clin Hypertens (Greenwich) 11:144-7. 2009
    ..Therefore, treatment of hypertension has become the most important intervention in the management of all forms of CKD. For this reason, World Kidney Day on March 12, 2009 will emphasize the role of hypertension...
  12. ncbi Impaired exercise capacity and exercise training in maintenance hemodialysis patients
    Joel D Kopple
    Harbor-UCLA Medical Center, Torrance, CA 90509, USA
    J Ren Nutr 15:44-8. 2005
    ..These findings indicate that in sedentary MHD patients endurance exercise training for a few weeks can result in improved exercise capacity and a pattern of transcriptional factors that may promote an increase in skeletal muscle mass...
  13. ncbi Transcriptional levels of growth factors in skeletal muscle of maintenance hemodialysis patients
    Joel D Kopple
    Los Angeles Biomedical Research Institute, Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90501, USA
    J Ren Nutr 16:212-5. 2006
    ..These abnormalities may contribute to the sarcopenia and impaired endurance capacity, strength, and physical performance that occur in MHD patients...
  14. ncbi Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis population
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 46:489-500. 2005
    ..However, the association between changes in weight over time and prospective mortality is not known...
  15. ncbi Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients
    Huiyuan Wang
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509, USA
    Kidney Int 68:352-61. 2005
    ..We therefore investigated whether sedentary maintenance hemodialysis patients have decreased skeletal muscle mRNA levels and muscle and serum protein concentrations of certain growth factors...
  16. ncbi Association of serum prealbumin and its changes over time with clinical outcomes and survival in patients receiving hemodialysis
    Mehdi Rambod
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, General Clinical Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Clin Nutr 88:1485-94. 2008
    ..In patients receiving maintenance hemodialysis (MHD), a low serum prealbumin is an indicator of protein-energy wasting...
  17. ncbi The phenomenon of altered risk factor patterns or reverse epidemiology in persons with advanced chronic kidney failure
    Joel D Kopple
    Division of Nephrology and Hypertension, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Los Angeles, CA, USA
    Am J Clin Nutr 81:1257-66. 2005
    ....
  18. ncbi Association of Malnutrition-Inflammation Score with quality of life and mortality in hemodialysis patients: a 5-year prospective cohort study
    Mehdi Rambod
    Harold Simmons Center for Kidney Disease Research and Epidemiology, CA, USA
    Am J Kidney Dis 53:298-309. 2009
    ..We hypothesized that MIS risk stratification of hemodialysis (HD) patients in predicting outcomes is better than its components or laboratory markers of inflammation...
  19. ncbi The message for World Kidney Day 2009: hypertension and kidney disease--a marriage that should be prevented
    George L Bakris
    Department of Medicine, Hypertensive Diseases Unit, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA
    J Hypertens 27:666-9. 2009
    ..Therefore, treatment of hypertension has become the most important intervention in the management of all forms of CKD. For this reason, the forthcoming World Kidney Day on 12 March 2009 will emphasize the role of hypertension...
  20. ncbi The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis
    Kamyar Kalantar-Zadeh
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Mayo Clin Proc 85:991-1001. 2010
    ..To determine whether dry weight gain accompanied by an increase in muscle mass is associated with a survival benefit in patients receiving maintenance hemodialysis (HD)...
  21. ncbi Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Harbor Mailbox 406, 1000 West Carson St, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 42:761-73. 2003
    ..Elements of malnutrition-inflammation complex syndrome (MICS) may blunt the responsiveness of anemia of end-stage renal disease (ESRD) to recombinant human erythropoietin (EPO)...
  22. ncbi Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 42:864-81. 2003
    ..Clinical trials focusing on MICS and its possible causes and consequences are urgently required to improve poor clinical outcome in dialysis patients...
  23. ncbi Is controlling phosphorus by decreasing dietary protein intake beneficial or harmful in persons with chronic kidney disease?
    Christian S Shinaberger
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Clin Nutr 88:1511-8. 2008
    ..Dietary restrictions to control serum phosphorus, which are routinely recommended to persons with chronic kidney disease, are usually associated with a reduction in protein intake. This may lead to protein-energy wasting and poor survival...
  24. ncbi Revisiting mortality predictability of serum albumin in the dialysis population: time dependency, longitudinal changes and population-attributable fraction
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509 2910, USA
    Nephrol Dial Transplant 20:1880-8. 2005
    ..However, serum albumin may change over time. Hence, its time-varying associations with outcome may be different...
  25. ncbi Improvement of nutritional status after initiation of maintenance hemodialysis
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Harbor University of California at Los Angeles Medical Center, Torrance, CA 90509, USA
    Am J Kidney Dis 40:133-42. 2002
    ..We examined this question by reviewing records of all patients admitted to our outpatient dialysis unit within 30 days of initiation of MHD therapy...
  26. ncbi Outcome research, nutrition, and reverse epidemiology in maintenance dialysis patients
    Kamyar Kalantar-Zadeh
    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Ren Nutr 14:64-71. 2004
    ....
  27. ncbi Association of relatively low serum parathyroid hormone with malnutrition-inflammation complex and survival in maintenance hemodialysis patients
    Ramanath Dukkipati
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Ren Nutr 20:243-54. 2010
    ..We hypothesized that the malnutrition-inflammation complex is associated with low PTH levels in these patients and confounds the PTH-survival association...
  28. ncbi Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease
    Keith C Norris
    Associate Dean for Research, Charles R Drew University, 1731 E 120th Street, Los Angeles, CA 90059, USA
    J Am Soc Nephrol 17:2928-36. 2006
    ..These findings identify a subset of this high-risk population that might benefit from even more aggressive treatment...
  29. ncbi Age-related decline in serum parathyroid hormone in maintenance hemodialysis patients is independent of inflammation and dietary nutrient intake
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Ren Nutr 14:134-42. 2004
    ..The pathophysiologic basis of this age-related decline in serum iPTH levels remains unclear, although others have proposed that it is related to low dietary phosphorus intakes...
  30. ncbi Dietary protein intake in patients with advanced chronic kidney disease and on dialysis
    Ramanath Dukkipati
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California 90502, USA
    Semin Dial 23:365-72. 2010
    ..In general, there are no large differences in the protein intake recommended by different expert groups for a given stage of CKD...
  31. ncbi Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Semin Dial 17:455-65. 2004
    ..Until then, all attempts should be made to adhere to the National Kidney Foundation Kidney Disease and Dialysis Outcome Quality Initiative guidelines to maintain a serum bicarbonate level in ESRD patients of at least 22 mEq/L...
  32. ncbi Association of serum total iron-binding capacity and its changes over time with nutritional and clinical outcomes in hemodialysis patients
    Rachelle Bross
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Nephrol 29:571-81. 2009
    ..03) compared to the stable TIBC group. Hence, low baseline serum TIBC is associated with iron deficiency, PEW, inflammation, poor QoL and mortality, and its decline over time is independently associated with increased death risk...
  33. ncbi An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility study
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    J Ren Nutr 15:318-31. 2005
    ..8 g/dL, a marker of malnutrition-inflammation complex syndrome, is observed in approximately half of all maintenance hemodialysis (MHD) patients in the United States and is strongly associated with increased mortality...
  34. ncbi Comparing body composition assessment tests in long-term hemodialysis patients
    Rachelle Bross
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Kidney Dis 55:885-96. 2010
    ..The accuracy and reliability of field methods to measure body composition is unknown in this population...
  35. ncbi Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Harbor Mailbox 406, 1000 West Carson Street, Torrance, CA 90509 2910, USA
    Nephrol Dial Transplant 19:1507-19. 2004
    ..However, it is not clear which one is a more sensitive and stronger predictor of outcome...
  36. ncbi Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patients
    Thomas W Storer
    Division of Health Sciences, El Camino College, 16007 Crenshaw Blvd, Torrance, CA 90506, USA
    Nephrol Dial Transplant 20:1429-37. 2005
    ..Because many MHD patients are profoundly deconditioned and exhibit significant muscle weakness, endurance training may also improve muscle strength and physical performance in these patients. This study assessed this possibility...
  37. ncbi Association of dietary phosphorus intake and phosphorus to protein ratio with mortality in hemodialysis patients
    Nazanin Noori
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90502, USA
    Clin J Am Soc Nephrol 5:683-92. 2010
    ..The hypothesis that higher dietary phosphorus intake and higher phosphorus content per gram of dietary protein intake are each associated with increased mortality in MHD patients was examined...
  38. ncbi Causes and prevention of protein-energy wasting in chronic kidney failure
    Ramnath Dukkipati
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Semin Nephrol 29:39-49. 2009
    ..Early initiation and adequate doses of renal replacement therapy, rapid treatment of reversible inflammatory processes, ensuring an adequate nutrient intake, and prevention of acidemia may be used to prevent and treat PEW...
  39. ncbi Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients
    Deborah L Regidor
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    J Am Soc Nephrol 19:2193-203. 2008
    ..Prospective controlled trials will be necessary to test whether serum AlkPhos measurements could be used to improve the management of renal osteodystrophy...
  40. ncbi Dietary assessment of individuals with chronic kidney disease
    Rachelle Bross
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    Semin Dial 23:359-64. 2010
    ..Ongoing and future studies will ascertain additional strengths and limitations of dietary assessment methods in CKD populations including the assessment of food intake during an actual hemodialysis treatment...
  41. ncbi Effect of diabetes mellitus on protein-energy wasting and protein wasting in end-stage renal disease
    Nazanin Noori
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Semin Dial 23:178-84. 2010
    ..Mechanisms by which these metabolic disorders in diabetic ESRD patients may cause PW or PEW are discussed...
  42. ncbi Effect of high-normal compared with low-normal arterial pH on protein balances in automated peritoneal dialysis patients
    Rajnish Mehrotra
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Clin Nutr 90:1532-40. 2009
    ..Although the protein catabolic effects of metabolic acidosis are well established, it is unclear whether the entire reference range of arterial pH (7.37-7.44) is equivalent for protein balance...
  43. ncbi A1C and survival in maintenance hemodialysis patients
    Kamyar Kalantar-Zadeh
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
    Diabetes Care 30:1049-55. 2007
    ..The optimal target for glycemic control has not been established in diabetic dialysis patients...
  44. ncbi Longitudinal associations between dietary protein intake and survival in hemodialysis patients
    Christian S Shinaberger
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA
    Am J Kidney Dis 48:37-49. 2006
    ..Whether the association between time-varying protein intake and survival is causal or a consequence of anorexia secondary to MICS or other factors needs to be explored further in interventional trials...
  45. ncbi Reverse epidemiology of hypertension and cardiovascular death in the hemodialysis population: the 58th annual fall conference and scientific sessions
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, Calif 90509 2910, USA
    Hypertension 45:811-7. 2005
    ..Although these associations may not be causal, they call into question whether treatment goals for the general population can be applied to dialysis patients or other similar populations...
  46. ncbi Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire
    Kamyar Kalantar-Zadeh
    University of California Los Angeles School of Medicine, Los Angeles, CA, USA
    J Ren Nutr 12:17-31. 2002
    ..We hypothesize that FFQ is a useful tool to assess the food intake differences between patients receiving dialysis and patients not receiving dialysis...
  47. ncbi Obesity paradox in patients on maintenance dialysis
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Contrib Nephrol 151:57-69. 2006
    ....
  48. ncbi Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor University of California, Los Angeles Medical Center, Harbor Mailbox 406, 1000 West Carson Street, Torrance, CA 90509 2910, USA
    Am J Clin Nutr 80:299-307. 2004
    ..Malnutrition-inflammation complex syndrome, an outcome predictor in maintenance hemodialysis (MHD) patients, may be related to anorexia...
  49. ncbi Inflammation and nutrition in renal insufficiency
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and David Geffen School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
    Adv Ren Replace Ther 10:155-69. 2003
    ....
  50. ncbi Normalized protein nitrogen appearance is correlated with hospitalization and mortality in hemodialysis patients with Kt/V greater than 1.20
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, David Geffen UCLA School of Medicine, Los Angeles, CA, USA
    J Ren Nutr 13:15-25. 2003
    ..We therefore investigated whether nPNA is associated with outcome in patients who have adequate or high Kt/V...
  51. ncbi Observations with regard to the National Kidney Foundation K/DOQI clinical practice guidelines concerning serum transthyretin in chronic renal failure
    Joel D Kopple
    Division of Nephrology and Hypertension and the Research and Education Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Chem Lab Med 40:1308-12. 2002
    ..6) MHD patients with serum TTR levels less than 25-30 mg/dl should be evaluated for protein-energy malnutrition and inflammation...
  52. ncbi Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Clin Nutr 83:202-10. 2006
    ..In maintenance hemodialysis (MHD) patients, a larger body size is associated with better survival but a worse self-reported quality of life (QoL). It is not clear whether muscle mass or body fat confers the survival advantage...
  53. ncbi Associations between changes in hemoglobin and administered erythropoiesis-stimulating agent and survival in hemodialysis patients
    Deborah L Regidor
    Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509-2910, USA
    J Am Soc Nephrol 17:1181-91. 2006
    ..Falling hemoglobin and requiring higher ESA doses were associated with decreased survival. Randomized clinical trials are required to examine these associations...
  54. ncbi Trace elements and vitamins in maintenance dialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and David Geffen School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
    Adv Ren Replace Ther 10:170-82. 2003
    ..Dietary requirements for vitamins and trace elements in maintenance dialysis patients are reviewed and the recommended daily intakes are discussed...
  55. ncbi Is there a role for intradialytic parenteral nutrition? A review of the evidence
    Ramanath Dukkipati
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center and David Geffen School of Medicine at UCLA, Torrance and Los Angeles, CA, USA
    Am J Kidney Dis 55:352-64. 2010
    ....
  56. ncbi Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney disease
    Kamyar Kalantar-Zadeh
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
    Clin J Am Soc Nephrol 5:519-30. 2010
    ..Provision of in-center and monitored meals during hemodialysis treatment sessions in the dialysis clinic may facilitate the achievement of these goals...
  57. ncbi A low serum iron level is a predictor of poor outcome in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor University of California at Los Angeles Medical Center, Torrance 90509 2910, USA
    Am J Kidney Dis 43:671-84. 2004
    ..Iron administration has been implicated as a cause of poor clinical outcome in maintenance hemodialysis (MHD) patients. However, the role of low iron levels in the clinical outcome of MHD patients is not clear...
  58. ncbi History of dietary protein therapy for the treatment of chronic renal disease from the mid 1800s until the 1950s
    Joel D Kopple
    Department of Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90501, USA
    Am J Nephrol 22:278-83. 2002
  59. ncbi Protein and energy nutrition among adult patients treated with chronic peritoneal dialysis
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Adv Ren Replace Ther 10:194-212. 2003
    ..There is a need to carry out clinical trials that examine whether an improvement in the nutritional status of CPD patients is associated with an improvement in their mortality, morbidity and/or quality of life...
  60. ncbi Hepatitis C virus and death risk in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    J Am Soc Nephrol 18:1584-93. 2007
    ..More diligent efforts to prevent and treat HCV infection may improve outcomes in MHD patients...
  61. ncbi Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
    Kidney Int 63:793-808. 2003
    ..It is possible that new standards or goals for such traditional risk factors as body mass, serum cholesterol, and blood pressure should be considered for these individuals...
  62. ncbi A matched comparison of serum lipids between hemodialysis patients and nondialysis morbid controls
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomiedical Research Institute, Los Angeles, California 90509 2910, USA
    Hemodial Int 9:314-24. 2005
    ....
  63. ncbi The End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ): testing the psychometric properties in patients receiving in-center hemodialysis
    Youngmee Kim
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, CA, USA
    Nephrol Nurs J 37:377-93. 2010
    ..The findings support that the instrument is reliable and valid and is easy to administer. Future studies are needed in a larger sample to determine whether additional modifications are needed...
  64. ncbi Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysis
    Elani Streja
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 52:727-36. 2008
    ..High doses of human recombinant erythropoietin (rHuEPO) to achieve hemoglobin levels greater than 13 g/dL in patients with chronic kidney disease appear to be associated with increased mortality...
  65. ncbi Ratio of paricalcitol dosage to serum parathyroid hormone level and survival in maintenance hemodialysis patients
    Christian S Shinaberger
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Clin J Am Soc Nephrol 3:1769-76. 2008
    ..It was hypothesized that the ratio of the administered paricalcitol dosage to serum PTH level discloses better the underlying dosage-survival association...
  66. ncbi Mental health, depression, and anxiety in patients on maintenance dialysis
    Usama Feroze
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension, and Department of Psychiatry, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    Iran J Kidney Dis 4:173-80. 2010
    ..The interaction between racial/ethnic characteristics of patients on maintenance dialysis with depression and anxiety needs to be studied more extensively, in order to assess better approaches to healthcare for these individuals...
  67. ncbi Association between serum bicarbonate and death in hemodialysis patients: is it better to be acidotic or alkalotic?
    Dennis Y Wu
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502 2064, USA
    Clin J Am Soc Nephrol 1:70-8. 2006
    ..Although previous epidemiologic studies indicated an association between high serum HCO3(-) and increased mortality in MHD patients, this effect seems to be due substantially to the effect of MICS on survival...
  68. ncbi Dietary potassium intake and mortality in long-term hemodialysis patients
    Nazanin Noori
    Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Kidney Dis 56:338-47. 2010
    ..Hyperkalemia has been associated with higher mortality in long-term hemodialysis (HD) patients. There are few data concerning the relationship between dietary potassium intake and outcome...
  69. ncbi Role of adipose tissue in determining muscle mass in patients with chronic kidney disease
    Carmen Castaneda-Sceppa
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Ren Nutr 17:314-22. 2007
    ..Arm muscle area was used as an indicator of muscle mass...
  70. ncbi L-carnitine infusions may suppress serum C-reactive protein and improve nutritional status in maintenance hemodialysis patients
    Vincenzo Savica
    University of Messina, Messina, Italy
    J Ren Nutr 15:225-30. 2005
    ..These preliminary findings suggest that in MHD patients, L-carnitine therapy may suppress inflammation, particularly among those patients with C-reactive protein > or =3 mg/dL, and may improve protein-energy nutritional status...
  71. ncbi Body mass index and risk for end-stage renal disease
    Kamyar Kalantar-Zadeh
    Ann Intern Med 144:701; author reply 701-2. 2006
  72. ncbi Quality of care in profit vs not-for-profit dialysis centers
    Kamyar Kalantar-Zadeh
    JAMA 289:3089; author reply 3089-90. 2003
  73. ncbi Rights of chronic renal failure patients undergoing chronic dialysis therapy
    Vittorio E Andreucci
    Department of Nephrology, School of Medicine, University Federico II of Naples, Via Giacomo Puccini 18, I 80127 Naples, Italy
    Nephrol Dial Transplant 19:30-8. 2004
    ....
  74. ncbi A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90509, USA
    J Am Soc Nephrol 15:442-53. 2004
    ..The lowest tHcy quartile confers a twofold increase in risk of death independent of hypoalbuminemia. The nutritional feature of tHcy in MHD patients may explain its reverse association with outcome...
  75. ncbi Dietary protein requirements and dialysate protein losses in chronic peritoneal dialysis patients
    Wytske M Westra
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Perit Dial Int 27:192-5. 2007
    ..The relative contribution of dialysate protein and amino acid losses to these high protein requirements or total nitrogen losses is uncertain...
  76. ncbi Effect of dietary protein restriction on the progression of kidney disease: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study
    Andrew S Levey
    Division of Nephrology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Kidney Dis 48:879-88. 2006
    ..CONCLUSION: The efficacy of a 2- to 3-year intervention of dietary protein restriction on progression of nondiabetic kidney disease remains inconclusive. Future studies should include a longer duration of intervention and follow-up...
  77. ncbi Serum and dialysate potassium concentrations and survival in hemodialysis patients
    Csaba P Kovesdy
    Division of Nephrology, Salem Veterans Affairs Medical Center, Salem, Virginia, USA
    Clin J Am Soc Nephrol 2:999-1007. 2007
    ..Controlling serum potassium is an important goal in maintenance hemodialysis patients. We examined the achievement of potassium balance through hemodialysis treatments and the associated fluctuations in serum potassium...
  78. ncbi Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions
    Biruh T Workeneh
    Medicine and Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Am Soc Nephrol 17:3233-9. 2006
    ....
  79. ncbi Long-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Institutions, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    Arch Intern Med 168:832-9. 2008
    ..A low blood pressure (BP) goal (BP, <130/80 mm Hg) is also recommended. The objective of this study was to determine the long-term effects of currently recommended BP therapy in 1094 African Americans with hypertensive CKD...
  80. ncbi Do low-protein diets retard the loss of kidney function in patients with diabetic nephropathy?
    Joel D Kopple
    Am J Clin Nutr 88:593-4. 2008
  81. ncbi Relationship between serum carnitine, acylcarnitines, and renal function in patients with chronic renal disease
    Denis Fouque
    Department of Nephrology, Hopital E Herriot, and JE 2411, University Claude Bernard Lyon 1, Lyon, France
    J Ren Nutr 16:125-31. 2006
    ..If serum compounds increase as GFR decreases, this suggests that impaired excretion may predispose to these values...
  82. ncbi Reverse epidemiology of blood pressure in dialysis patients
    Kamyar Kalantar-Zadeh
    Kidney Int 67:2067; author reply 2067-8. 2005
  83. ncbi Association between serum lipids and survival in hemodialysis patients and impact of race
    Ryan D Kilpatrick
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, CA 90509 2910, USA
    J Am Soc Nephrol 18:293-303. 2007
    ..Although these associations may not be causal, they call into question whether specific subgroups of dialysis patients are better targets for cholesterol-lowering therapy...

Research Grants9

  1. Dietary Protein Requirements in Hemodialysis Patients
    Joel Kopple; Fiscal Year: 2007
    ..Before and after these 5 months, total body protein will be assessed by TBNuf, body cell mass (TBK), and other components of body composition using anthropometry, DXA, and near infra-red interactance. ..