Norman A Doggett
Affiliation: Los Alamos National Laboratory
- Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblastsStephanie M Cohen
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
BMC Genomics 7:301. 2006..This was accomplished by first creating a cosmid library containing DNA enriched in sequences that replicate early in the S phase of normal human fibroblasts. Clone ends were then sequenced and aligned to the human genome...
- A 360-kb interchromosomal duplication of the human HYDIN locusNorman A Doggett
DOE Joint Genome Institute and Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Genomics 88:762-71. 2006..1. Both copies of the HYDIN gene are expressed in alternatively spliced transcripts. Elucidation of the role of HYDIN in human disease susceptibility will require careful discrimination among the paralogous copies...
- The complete genome sequence of Bacillus thuringiensis Al HakamJean F Challacombe
Department of Energy Joint Genome Institute, Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
J Bacteriol 189:3680-1. 2007..thuringiensis Al Hakam, which was collected in Iraq by the United Nations Special Commission (L. Radnedge, P. Agron, K. Hill, P. Jackson, L. Ticknor, P. Keim, and G. Andersen, Appl. Environ. Microbiol. 69:2755-2764, 2003)...
- Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracisCliff S Han
Department of Energy Joint Genome Institute, Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
J Bacteriol 188:3382-90. 2006..cereus G9241 and nonpathogenic strains B. cereus ATCC 10987 and B. cereus ATCC 14579. Comparison of these genomes revealed differences in terms of virulence, metabolic competence, structural components, and regulatory mechanisms...
- The sequence and analysis of duplication-rich human chromosome 16Joel Martin
DOE Joint Genome Institute, 2800 Mitchell Avenue, Walnut Creek, California 94598, USA
Nature 432:988-94. 2004....
- Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genesJason A Powell
Centre for Medical Genetics, Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, South Australia, 5006, Australia
Genomics 80:303-10. 2002..3 LOH. Three of the genes, CYBA, Hs.7970, and CBFA2T3, exhibited variability ten times higher than the baseline. The possible role of these genes as tumor suppressors is discussed...
- Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinomaChi Kwong So
Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, New Jersey, USA
Clin Cancer Res 10:19-27. 2004..Additional ESCC samples were analyzed using different sets of microsatellite markers (CS1-CS5) within the introns or in close proximity to the 3' end of the CBP gene...