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Species | Eric S DaarSummaryAffiliation: Los Angeles Biomedical Research Institute Country: USA Publications
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HIV-1 pol replication capacity predicts disease progressionEric S Daar
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center and the David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
AIDS 19:871-7. 2005..To determine the influence of pol replication capacity on the natural history of HIV-1 infection...
Confronting the emergence of drug-resistant HIV type 1: impact of antiretroviral therapy on individual and population resistanceEric S Daar
Division of HIV Medicine, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
AIDS Res Hum Retroviruses 21:343-57. 2005..The recent developments of new antiretroviral drugs, including the use of boosted protease inhibitors, suggest that treatment strategies can limit the development of resistance...
Stromal cell-derived factor-1 genotype, coreceptor tropism, and HIV type 1 disease progressionEric S Daar
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, and the David Geffen School of Medicine at UCLA, Los Angeles, USA
J Infect Dis 192:1597-605. 2005..Therefore, the increased frequency of X4-tropic viruses in subjects carrying the SDF1-3'A allele may explain the observed adverse effect that this allele has on the natural history of HIV-1 disease...
Human immunodeficiency virus and fertility care: embarking on a path of knowledge and accessEric S Daar
Los Angeles Biomedical Research Institute, Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
Fertil Steril 85:298-300; discussion 301. 2006....
Baseline HIV type 1 coreceptor tropism predicts disease progressionEric S Daar
Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles UCLA Medical Center and the David Geffen School of Medicine at UCLA, Torrance, USA
Clin Infect Dis 45:643-9. 2007..The impact of coreceptor tropism on the natural history of HIV-1 infection has not been fully explored...
Newer antiretroviral agents and how to use themHolly H Kim
Division of HIV Medicine and Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center and the David Geffen School of Medicine at UCLA, 1124 West Carson Street, N 24, Torrance, CA 90502, USA
Curr Infect Dis Rep 11:327-34. 2009....
Atazanavir plus ritonavir or efavirenz as part of a 3-drug regimen for initial treatment of HIV-1Eric S Daar
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, N 24, Torrance, CA 90502, USA
Ann Intern Med 154:445-56. 2011..Limited data compare once-daily options for initial therapy for HIV-1...
Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final resultsPaul E Sax
Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Infect Dis 204:1191-201. 2011..Due to higher virologic failure with ABC/3TC in the high HIV RNA stratum, blinded treatment was stopped in this group, but study follow-up continued for all patients...
Unprotected anal intercourse and substance use before and after HIV diagnosis among recently HIV-infected men who have sex with menLydia N Drumright
Antiviral Research Center, Department of Medicine, University of California, San Diego, California, USA
Sex Transm Dis 34:401-7. 2007..The objective of this study was to assess associations between unprotected anal intercourse (UAI) and substance use before and after HIV diagnosis among recently HIV-infected MSM...
Effect of hepatitis C virus (HCV) genotype on HCV and HIV-1 diseaseThomas W Yoo
Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles Medical Center, Divisions of HIV Medicine and Infectious Diseases, Department of Medicine, David Geffen School of Medicine, CA 90502, USA
J Infect Dis 191:4-10. 2005..44; P=.037). The present study suggests that HCV infection and genotype may influence the natural history of HCV and HIV-1 disease...
Unprotected anal intercourse and substance use among men who have sex with men with recent HIV infectionLydia N Drumright
Department of Medicine, Antiviral Research Center, University of California, San Diego, CA 92093, USA
J Acquir Immune Defic Syndr 43:344-50. 2006..To examine within-subjects and combined between- and within-subjects associations between substance use and unprotected anal intercourse (UAI) among men who have sex with men (MSM) with recent HIV infection...
Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacityJason D Barbour
Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
AIDS 20:2123-5. 2006..Viral polRC was measured before starting ART in all subjects. We examined 243 individuals for a median 260 days after initiating ART. Low baseline polRC was associated with greater CD4 T-cell gains independent of virological responses...
Platelet count is associated with plasma HIV type 1 RNA and disease progressionGunter Rieg
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California 90095, USA
AIDS Res Hum Retroviruses 23:1257-61. 2007..001 for both). While there may be multiple explanations for these novel observations, they do generate hypotheses related to the potential influence platelets may have on the natural history of HIV-1 disease...
Antiretroviral drug resistance and risk behavior among recently HIV-infected men who have sex with menPamina M Gorbach
Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 7353, USA
J Acquir Immune Defic Syndr 47:639-43. 2008..Examine associations among behaviors including substance use during sexual encounters, and transmitted HIV drug resistance in recently HIV-infected men who have sex with men (MSM)...
The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individualsChristine M Hogan
Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
J Infect Dis 205:87-96. 2012..The benefits of antiretroviral therapy during early human immunodeficiency virus type 1 (HIV-1) infection remain unproved...
Hepatitis C virus and death risk in hemodialysis patientsKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
J Am Soc Nephrol 18:1584-93. 2007..More diligent efforts to prevent and treat HCV infection may improve outcomes in MHD patients...
Antiretroviral regimens for treatment-experienced patients with HIV-1 infectionMeena Lagnese
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Division of HIV Medicine and Infectious Diseases, 1124 W Carson Street, N 24, Torrance, CA 90502, USA
Expert Opin Pharmacother 9:687-700. 2008..A significant number of treatment-experienced patients with HIV-1 infection develop drug-resistant virus...
Potency and durability of antiretroviral therapyEric S Daar
Harbor-UCLA Research and Education Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Acquir Immune Defic Syndr 34:S111-7. 2003
Behaviors of recently HIV-infected men who have sex with men in the year postdiagnosis: effects of drug use and partner typesPamina M Gorbach
Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
J Acquir Immune Defic Syndr 56:176-82. 2011..Assess behavior change of recently HIV-infected men who have sex with men (MSM)...
Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 Gag vaccinationArumugam Balamurugan
Division of Infectious Diseases, 37 121 CHS, UCLA Medical Center, 10833 LeConte Ave, Los Angeles, CA 90095, USA
J Virol 82:2784-91. 2008....
Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strainsOtto O Yang
37 121 Center for Health Sciences, Division of Infectious Diseases, 10833 LeConte Ave, UCLA Medical Center, Los Angeles, CA 90095, USA
J Virol 79:860-8. 2005..In conclusion, the rapid overgrowth of a superinfecting strain of HIV-1 of the same subtype raises major concerns for effective vaccine development...
Hepatitis C infection in dialysis patients: a link to poor clinical outcome?Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
Int Urol Nephrol 39:247-59. 2007..In this article, we review the link between the HCV infection and mortality in dialysis patients and compare HCV antibody to molecular methods to detect HCV infection in these individuals...
Newer antiretroviral agents and how to use themHolly H Kim
Division of HIV Medicine and Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center and the David Geffen School of Medicine at UCLA, 1124 W Carson Street, N 24, Torrance, CA 90502, USA
Curr HIV/AIDS Rep 6:55-62. 2009....
Increasing CTL targeting of conserved sequences during early HIV-1 infection is correlated to decreasing viremiaOtto O Yang
Division of Infectious Diseases, Department of Medicine, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
AIDS Res Hum Retroviruses 27:391-8. 2011..Circumventing this natural history by pre-targeting CTL against more conserved epitopes with a vaccine could minimize the initial period of viral escape and immune damage during acute infection, improving long-term containment of HIV-1...
Sex, race, and geographic region influence clinical outcomes following primary HIV-1 infectionAmie L Meditz
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
J Infect Dis 203:442-51. 2011..It is unknown whether sex and race influence clinical outcomes following primary human immunodeficiency virus type 1 (HIV-1) infection...
Antiretroviral-drug resistance among patients recently infected with HIVSusan J Little
Antiviral Research Center, Department of Medicine, University of California San Diego, San Diego 92103, USA
N Engl J Med 347:385-94. 2002..Among persons in North America who are newly infected with the human immunodeficiency virus (HIV), the prevalence of transmitted resistance to antiretroviral drugs has been estimated at 1 to 11 percent...
Antiretroviral resistance in clinical practiceEric S Daar
Division of HIV Medicine, Harbor-UCLA Medical Center, David Geffen School of Medicine, University of California, Los Angeles, USA
J Int Assoc Physicians AIDS Care (Chic Ill) 2:S4-18. 2003
Improving adherence to antiretroviral therapyEric S Daar
University of California, Los Angeles, School of Medicine, USA
AIDS Read 13:81-2, 85-6, 88-90. 2003..Care providers need to be aware of the challenges and obstacles faced by their patients on antiretroviral regimens, and efforts to maximize adherence must begin even before the patient has the first prescriptions filled...
Asymptomatic sexually transmitted infections in HIV-infected men who have sex with men: prevalence, incidence, predictors, and screening strategiesGunter Rieg
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, California 90502, USA
AIDS Patient Care STDS 22:947-54. 2008..Our data support current Center for Disease Control and Prevention STI guidelines that recommend routine screening at increased frequency for HIV-infected MSM...
Primary human immunodeficiency virus type 1 infectionMalini Soogoor
Division of HIV Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502, USA
Curr HIV/AIDS Rep 2:55-60. 2005....
Emerging resistance profiles of newly approved antiretroviral drugsEric S Daar
David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
Top HIV Med 16:110-6. 2008..Daar, MD, at an International AIDS Society-USA Continuing Medical Education course in Los Angeles in March 2008. The original presentation is available as a Webcast at www.iasusa.org...
Diagnostic discordance for hepatitis C virus infection in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Kidney Dis 46:290-300. 2005....
Barriers and unmet need for supportive services for HIV patients in care in Los Angeles County, CaliforniaAmy Rock Wohl
HIV Epidemiology Program, Los Angeles County Department of Public Health, Los Angeles, California 90005 4001, USA
AIDS Patient Care STDS 25:525-32. 2011..The reported reasons that services were not obtained suggest needed improvements in information dissemination on availability and location of HIV support services and more streamlined delivery of services...
Treatment of primary HIV infectionEric S Daar
Division of HIV Medicine, Harbor-UCLA Medical Center and Research and Education Institute, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
MedGenMed 4:15. 2002
Transmission behaviors of recently HIV-infected men who have sex with menPamina M Gorbach
Department of Epidemiology, School of Public Health and Division of Infections Diseases, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095 1772, USA
J Acquir Immune Defic Syndr 42:80-5. 2006..Analyze postdiagnosis behaviors of recently HIV-infected men who have sex with men (MSM)...
New approaches and resolve may define the future of the global HIV pandemicEric S Daar
Division of HIV Medicine, Harbor-UCLA Medical Center, Los Angeles, California, USA
Res Initiat Treat Action 12:8-10. 2007
Antiretroviral rounds. The when, why and how of switchingKeith Henry
AIDS Clin Care 15:58-9. 2003
Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infectionAndrew J Leigh Brown
University of Edinburgh, Edinburgh, Scotland
J Virol 78:2242-6. 2004..This supports the view that variation in PR function is directly responsible for variation in fitness among strains in primary infection...
Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistanceLin Liu
University of California San Diego, La Jolla, California 92093 0679, USA
AIDS 22:835-9. 2008..We compared eight genotypic interpretation methods to determine whether the method used would affect the rates of reported transmitted drug resistance...
A randomized controlled trial of therapeutic drug monitoring in treatment-naive and -experienced HIV-1-infected patientsBrookie M Best
University of California, San Diego, San Diego, CA 92013, USA
J Acquir Immune Defic Syndr 46:433-42. 2007..To improve the utility of therapeutic drug monitoring (TDM) by defining the proportion of patients with and predictors of above or below target protease inhibitor (PI) or nonnucleoside reverse transcriptase inhibitor (NNRTI) concentrations...
Incorporating novel virologic tests into clinical practiceEric S Daar
Harbor University of California Los Angeles Medical Center, CA, USA
Top HIV Med 15:126-9. 2007..Daar, MD, at an International AIDS Society-USA Continuing Medical Education course in Chicago in May 2007. The original presentation is available as a Webcast at www.iasusa.org...
Longitudinal analysis of CD8 T-cell responses to HIV and hepatitis C virus in a cohort of co-infected haemophiliacsGillian C Harcourt
Nuffield Department of Medicine, University of Oxford, UK
AIDS 19:1135-43. 2005..005). CONCLUSION: HCV infection has an impact on the phenotype of HIV-specific CD8 T cells. In this well-defined cohort, failure to maintain effective CD8 T-cell responses against HIV may contribute to disease progression...
Measuring below the bar: what is it telling us?Eric S Daar
AIDS 20:2385-7. 2006
Molecular analysis of HIV strains from a cluster of worker infections in the adult film industry, Los Angeles 2004John T Brooks
Epidemiology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
AIDS 20:923-8. 2006..As part of the investigation of this infection cluster, we evaluated whether viral strains collected from infected individuals were significantly related...
Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated populationAndrew J Leigh Brown
Department of Pathology, University of California, San Diego, California, USA
J Infect Dis 187:683-6. 2003..It revealed that resistant virus was transmitted only approximately 20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains...
Incidence of HIV superinfection following primary infectionDavey M Smith
JAMA 292:1177-8. 2004
What's next? Treatment options when the first antiretroviral regimen fails virologically or is not tolerated, Part 1Peter J Ruane
AIDS Read 14:421-6, 431-2, 434. 2004..This article suggests treatment algorithms for those experiencing adverse events or the emergence of drug resistance with commonly used antiretroviral regimens...
Antiretroviral rounds. Putting resistance to workEric S Daar
AIDS Clin Care 16:56, 60. 2004
Cognitive-behavioral intervention to enhance adherence to antiretroviral therapy: a randomized controlled trial (CCTG 578)Glenn J Wagner
RAND Corporation, 1776 Main Street, Santa Monica, CA 90407, USA
AIDS 20:1295-302. 2006..We conducted a randomized, multi-site, controlled trial of a cognitive-behavioral adherence intervention for patients initiating or changing an antiretroviral (ART) regimen...
Isolation and characterization of an infectious HIV type 1 molecular clone from a patient with primary infectionHiroaki Takeuchi
Department of Virology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai 980-8575, Japan
AIDS Res Hum Retroviruses 18:1127-33. 2002..This HIV-1 DNA done will be a useful prototype for investigating the mechanism of HIV-1 transmission...
Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypesManish Sagar
Division of Human Biology, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, USA
J Virol 78:7279-83. 2004..S. women, one U.S. man, and one Kenyan man near the time of seroconversion. These findings suggest that early HIV-1 genetic diversity is not exclusive to women from Africa or to infection with any particular HIV-1 subtype...
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus loadNicole Frahm
Partners AIDS Research Center, Massachusetts General Hospital, No. 5214, 149 13th Street, Charlestown, MA 02129, USA
J Virol 79:10218-25. 2005..The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection...
Characteristics of recently HIV-infected men who use the Internet to find male sex partners and sexual practices with those partnersDavey M Smith
University of California San Diego, 9500 Gilman Drive 0679, La Jolla, CA 92093, USA
J Acquir Immune Defic Syndr 43:582-7. 2006....
What's next? Treatment options when the first antiretroviral regimen fails virologically or is not tolerated, Part 2Peter J Ruane
AIDS Read 14:487-98. 2004..This article builds on Part 1 by suggesting treatment algorithms for those experiencing adverse events or the emergence of drug resistance when using recommended or common alternative and emerging anti-HIV regimens...
Lack of neutralizing antibody response to HIV-1 predisposes to superinfectionDavey M Smith
University of California San Diego, La Jolla, CA 92093 0679, USA
Virology 355:1-5. 2006..These data have considerable implications for vaccine development...
Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1Matthew C Strain
Department of Physics, University of California at San Diego, La Jolla, California, USA
J Infect Dis 191:1410-8. 2005..1 IUPM; P<.0005). These results suggest that treatment <6 months after seroconversion may facilitate long-term control of cellular reservoirs that maintain HIV-1 infection during treatment...
Strategies for initiating combination antiretroviral therapyMichael L Tapper
NYU School of Medicine and Lenox Hill Hospital, New York, New York, USA
AIDS Patient Care STDS 19:224-38. 2005..This paper reviews the results of recent clinical trials focusing on initial therapy and addresses important considerations when beginning antiretroviral therapy (ART) in treatment-naive individuals...
