Research Topics
Genomes and Genes | Fawzia Bardag-GorceSummaryAffiliation: Los Angeles Biomedical Research Institute Country: USA Publications
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Publications
Independent phenotype of binuclear hepatocytes and cellular localization of UbDJoan Oliva
Department of Pathology, LABiomed, Torrance, CA 90502, USA
Exp Mol Pathol 89:103-8. 2010..The identification of proteins that interact with UbD and the post translational modification of UbD would help to determine the regulation of this localization and function...
Nuclear effects of ethanol-induced proteasome inhibition in liver cellsFawzia Bardag-Gorce
The Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St Torrance, CA 90502, United States
World J Gastroenterol 15:1163-7. 2009..The present review highlights the consequences of ethanol-induced proteasome inhibition in the nucleus of liver cells that are chronically exposed to ethanol...- SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse modelFawzia Bardag-Gorce
Department of Pathology, LABioMed at Harbor UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 88:353-62. 2010..These results support the conclusion that MDBs form in FAT10 over-expressing hepatocytes where the up regulation of the immunoproteasome occurs at the expense of the 26S proteasome... - Effects of ethanol on the proteasome interacting proteinsFawzia Bardag-Gorce
Department of Pathology, LABioMed at Harbor UCLA Medical Center, 1124 W Carson St, Los Angeles, CA 90509, USA
World J Gastroenterol 16:1349-57. 2010.... - Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver diseaseFawzia Bardag-Gorce
Department of Pathology, LABioMed at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Exp Mol Pathol 90:123-30. 2011..In conclusion, proteasome inhibitor treatment used at a non toxic low dose has potential protective effects against oxidative stress due to chronic ethanol feeding... - Proteasome inhibitor treatment in alcoholic liver diseaseFawzia Bardag-Gorce
Department of Pathology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, United States
World J Gastroenterol 17:2558-62. 2011..The beneficial effects of proteasome inhibitor treatment in alcoholic liver disease are related to proteasome inhibitor reversibility and the rebound of proteasome activity 72 h post PS-341 administration... - Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed miceFawzia Bardag-Gorce
Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USA
Exp Mol Pathol 84:113-21. 2008..The results indicate that SAMe prevented the epigenetic cellular memory involved in the MDB formation... - Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesisJoan Oliva
Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson Street Torrance, CA 90509, USA
Exp Mol Pathol 84:102-12. 2008..The refeeding of DDC increased the percent of FAT10 hepatocytes... - The role of cytokines in UbD promoter regulation and Mallory-Denk body-like aggresomesJoan Oliva
Department of Pathology, LABiomed, Torrance, CA 90502, USA
Exp Mol Pathol 89:1-8. 2010..Previous studies indicate that S-adenosylmethionine or betaine prevented IFNg induced UbD and MDB formations... 
Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitorLi Nan
Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 80:228-40. 2006..The data supported the concept that MBs form as the result of hyperphosphorylation of cytokeratin 8 by p38...- CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formationFawzia Bardag-Gorce
Department of Pathology, LABioMed at Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USA
Exp Mol Pathol 81:191-201. 2006..This is the first report where ethanol caused Mallory body-like cytokeratin inclusions in transformed human liver cells in vitro... - CYP2E1 inhibition enhances mallory body formationFawzia Bardag-Gorce
Harbor UCLA Medical Center, L.A. Biomed, 1000 W. Carson Street, Torrance, CA 90502, USA
Exp Mol Pathol 78:207-11. 2005..It was concluded that CYP2E1 inhibits MB formation by increasing the rate of elimination of DDC and/or its toxic intermediates... - RNA interference of VCP/p97 increases Mallory body formationLi Nan
Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90505, USA
Exp Mol Pathol 78:1-9. 2005..These results indicate that VCP plays an important role in inducing MB formation, probably through its molecular chaperone function in the ubiquitin-proteasome system (UPS)... - The p105/50 NF-kappaB pathway is essential for Mallory body formationLi Nan
Department of Pathology, Harbor-UCLA Medical Center, 1000 W. Carson Street, Torrance, CA 90502, USA
Exp Mol Pathol 78:198-206. 2005..The results indicate that the p105 NF-kappaB pathway which putatively regulates ERK at both the transcriptional and post-translational levels regulates MB formation by way of changes in gene expression... - Proteasome inhibition induces cytokeratin accumulation in vivoFawzia Bardag-Gorce
Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
Exp Mol Pathol 76:83-9. 2004..Accumulation of cytokeratin in this way may ultimately lead to Mallory body formation as seen in alcoholic hepatitis... - SAMe prevents the up regulation of toll-like receptor signaling in Mallory-Denk body forming hepatocytesFawzia Bardag-Gorce
LABioMed at Harbor UCLA Medical Center, Torrance CA 90502, USA
Exp Mol Pathol 88:376-9. 2010..INFgamma stimulates the up regulation of TLR2. The ability of SAMe feeding to prevent TLR signaling up regulation has not been previously described... - S-adenosylmethionine decreases the peak blood alcohol levels 3 h after an acute bolus of ethanol by inducing alcohol metabolizing enzymes in the liverFawzia Bardag-Gorce
Department of Pathology, LABioMed Harbor UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 89:217-21. 2010.... - Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanismsJoan Oliva
Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 86:77-86. 2009..The results further support the concept that MDB formation is the result of an epigenetic phenomenon, where a change in methionine metabolism causes global gene expression changes in hepatocytes... - The role of the ubiquitin-proteasome pathway in the formation of mallory bodiesFawzia Bardag-Gorce
Department of Pathology and Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
Exp Mol Pathol 73:75-83. 2002..In conclusion, the results support the concept that Mallory bodies are aggresomes which form as the result of the failure of the ubiquitin-proteasome complex to adequately eliminate cytokeratins destined for proteolysis... - S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memoryJun Li
Harbor UCLA Medical Center, Torrance, CA 90509, USA
Hepatology 47:613-24. 2008..No evidence for the involvement of oxidative stress in induction of the memory was found. The molecular memory included the up-regulation of the expression of genes associated with the development of liver cell preneoplasia... - Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levelsFawzia Bardag-Gorce
Department of Pathology, LA Biomed Research Institute, Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USA
Exp Mol Pathol 82:197-202. 2007..beta-Catenin was increased in the nuclear extract at the UAL troughs, where increased gene expression was absent. The increase in gene expression at the peaks was due, in part, to increased acetylation of histone 3 at lysine 9... - Microarray analysis of gene expression in the liver during the urinary ethanol cycle in rats fed ethanol intragastrically at a constant rateBarbara A French
Department of Pathology, Harbor-UCLA Medical Center and LABioMed Research Institute, 1000 W. Carson St, Torrance, CA 90509, USA
Exp Mol Pathol 79:87-94. 2005..For instance, the importance of blood alcohol levels at the time that the assays were performed, profoundly changed the gene expression, protein level, and protein phosphorylation level profiles... - The regulation of non-coding RNA expression in the liver of mice fed DDCJoan Oliva
Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 87:12-9. 2009..The dysregulation of ncRNA in MDB forming liver cells has been observed for the first time in drug-primed mice associated with liver preneoplastic foci and tumors... - Epigenetics of proteasome inhibition in the liver of rats fed ethanol chronicallyJoan Oliva
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St Torrance, CA 90502, USA
World J Gastroenterol 15:705-12. 2009..To examine the effects of ethanol-induced proteasome inhibition, and the effects of proteasome inhibition in the regulation of epigenetic mechanisms... - Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models comparedFawzia Bardag-Gorce
Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 80:241-51. 2006..These two enzymes have antioxidant effects. In summary, remarkably similar responses to high alcohol levels in the form of changes in gene expression pathways were found in the in vivo and in vitro models tested... - Mallory body forming cells express the preneoplastic hepatocyte phenotypeLi Nan
Harbor-UCLA Medical Center, Department of Pathology, Los Angeles Biomedical Research Institute, 1000 W. Carson St, Torrance, CA 90502, USA
Exp Mol Pathol 80:109-18. 2006..Thus, the tumor markers used to identify hepatocellular carcinoma were upregulated in cells forming MBs in vivo and in vitro, suggesting that MB forming cells express preneoplastic phenotypic features... - Modifications in P62 occur due to proteasome inhibition in alcoholic liver diseaseFawzia Bardag-Gorce
Harbor-UCLA Medical Center, Torrance, CA 90502, USA
Life Sci 77:2594-602. 2005..P62 protein levels were also increased in the purified proteasome fraction of rats given PS-341. This data indicates that modifications in P62 occur due to proteasome inhibition in experimental alcoholic liver disease... - The proteasome inhibitor, PS-341, causes cytokeratin aggresome formationFawzia Bardag-Gorce
Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 76:9-16. 2004..At the same time, the cells became dissociated from each other, however. The results simulated MB formation. MBs differ from cytokeratin aggresomes both morphologically and in ultrastructure... - Hyperphosphorylation of rat liver proteasome subunits: the effects of ethanol and okadaic acid are comparedFawzia Bardag-Gorce
Department of Pathology, Harbor UCLA Medical Center, 1000 W. Carson Street, Torrance, CA 90502, USA
Life Sci 75:585-97. 2004..In conclusion hyperphosphorylation of the proteasome subunits occurs in the ethanol treated proteasomal subunits which could be one mechanism of the inhibition of the 26S proteasome caused by ethanol feeding... - Mallory body formation is associated with epigenetic phenotypic change in hepatocytes in vivoFawzia Bardag Gorce
Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USA
Exp Mol Pathol 83:160-8. 2007.... - p62 is involved in the mechanism of Mallory body formationLi Nan
Department of Pathology, Harbor-UCLA Medical Center, Torrance, CA 90502, USA
Exp Mol Pathol 77:168-75. 2004..Overexpression of p62 in normal mouse hepatocytes induced MB-like aggresomes that were stained by Ub but not by CK8. The results indicate that p62 is involved in the mechanism of MB formation... - Alcohol, nutrition and liver cancer: role of Toll-like receptor signalingSamuel W French
Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USA
World J Gastroenterol 16:1344-8. 2010..It provides a nutritional approach, which could prevent HCC from developing in many chronic liver diseases... - Liver hypoxia and lack of recovery after reperfusion at high blood alcohol levels in the intragastric feeding model of alcohol liver diseaseJun Li
Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 77:184-92. 2004..These results support the hypothesis that hypoxia occurs at the peaks of the BAL cycle and recovery from ischemia is impaired at the peaks... - The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro studyYong Wu
Department of Pathology, Harbor-UCLA Medical Center, 1000 W. Carson Street, Torrance, CA 90502, USA
Exp Mol Pathol 79:1-8. 2005..The data indicate that laminin-integrin signaling which activates ERK, triggered MB formation in vitro, and an inhibitor of the signaling cascade reduced MB formation... - Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitroJoan Oliva
Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Exp Mol Pathol 90:295-9. 2011..In conclusion, the in vitro model of oxidative stress induced by ethanol provided evidence that all 4 agents tested prevented some aspect of liver cell injury caused by ethanol... - The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenalFawzia Bardag-Gorce
Department of Pathology, Harbor UCLA Medical Center, 1000 W. Carson Street, Torrance, CA 90509, USA
Exp Mol Pathol 78:109-15. 2005..An adduct of 4-HNE formed with the Rpt4 subunit of 26 S could impede the association of 19 S and 20 S and thus account for the observed decrease of proteasomal activity... - Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liverYong Wu
Department of Pathology, Harbor University of California Los Angeles Research and Education Institute, Torrance, USA
Mol Pharmacol 65:550-7. 2004..Regulation of hepatic GSH levels by RXRalpha is essential to protect hepatocytes from oxidative stress, whereas up-regulation of phase I drug metabolism genes by RXRalpha may render the liver more sensitive to APAP-induced toxicity... - Mechanism of the alcohol cyclic pattern: role of catecholaminesJun Li
Dept. of Pathology, Harbor-University of California Los Angeles Medical Center, 1000 W. Carson St, Torrance, CA 90509, USA
Am J Physiol Gastrointest Liver Physiol 285:G442-8. 2003..In conclusion, catecholamine supplements prevented the UAL cycle by increasing the metabolic rate to the point at which fluctuations in the metabolic rate caused by alcohol were prevented... - S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in ratsJoan Oliva
Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509, USA
Exp Mol Pathol 90:239-43. 2011..In this way the proinflammatory response, fibrogenesis, cirrhosis and hepatocellular carcinoma formation due to alcohol liver disease could be prevented by SAMe... - The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in ratsFawzia Bardag-Gorce
Department of Pathology, Harbor UCLA Medical Center, Torrance, California 90509, USA
Gastroenterology 123:325-35. 2002..There was a marked shift in NADH/NAD redox state at the peaks caused by hypoxia. This shift could account for the reduced rate of ethanol elimination by alcohol dehydrogenase at the peaks... - Catecholamines are involved in the mechanism of the urinary alcohol level cycle in rats fed ethanol intragastrically at a constant rateJun Li
Department of Pathology, Harbor-UCLA Medical Center, 1000 W. Carson St, Torrance, CA 90509, USA
Life Sci 75:3043-51. 2004..Phenoxybenzamine, an alpha blocker disrupted the cycle and elevated ethanol to fatal levels. The results indicate that both alpha and beta adrenergic mechanisms are required for the cycle to occur... - Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrolJoan Oliva
Department of Pathology, Harbor UCLA Medical Center, 1000 W Carson St Torrance, CA 90509, USA
Exp Mol Pathol 85:155-9. 2008..However, resveratrol did not reduce the liver pathology caused by chronic ethanol feeding... - Preneoplastic liver cell foci expansion induced by thioacetamide toxicity in drug-primed miceM Waheed Roomi
Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
Exp Mol Pathol 81:8-14. 2006..These preneoplastic cells selectively proliferate in response to the promoter effects of necrosis-induced liver cell regeneration ("chemical partial hepatectomy")... - Proteasome inhibitor treatment reduced fatty acid, triacylglycerol and cholesterol synthesisJoan Oliva
Dept of Pathology, LA BioMed at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Exp Mol Pathol 93:26-34. 2012.... - Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changesJun Li
LABioMed Research Institute at Harbor UCLA Medical Center, 1000 W Carson St, Los Angeles, CA, 90509, USA
Genes Nutr 5:169-79. 2010..In conclusion, profound changes in gene expression evolved between 3 h and 12 post ethanol bolus. SAMe down regulated these changes in gene expression at 3 h, and less so at 12 h... - S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytesMaria Lauda Tomasi
Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, The Southern California Research Center for Alcoholic and Pancreatic Diseases and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hepatology 51:2152-61. 2010..SAM treatment increases DUSP1 expression through multiple mechanisms, and this may suppress ERK activity and malignant degeneration... - Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341Fawzia Bardag-Gorce
Department of Pathology, Harbor UCLA Medical Center, 1000 W. Carson Street, Torrance, CA 90509, USA
Free Radic Biol Med 32:17-21. 2002..In ethanol-withdrawn rats injected with PS-341, CYP2E1 remained at the induced level. These results show, for the first time, that the proteasome is responsible for ethanol-induced CYP2E1 degradation in vivo... - Mallory-Denk body pathogenesis revisitedSamuel W French
Samuel W French, Joan Oliva, Barbara A French, Jun Li, Fawzia Bardag Gorce, Department of Pathology, Harbor UCLA Medical Center, CA 90509, United States
World J Hepatol 2:295-301. 2010..All of these mechanisms are induced by drug toxicity, and are prevented by feeding the methyl donors SAMe and betaine, supporting the epigenetic response of MDB formation... - Delta-aminolevulinic dehydratase is a proteasome interacting proteinFawzia Bardag-Gorce
Harbor UCLA Medical Center, Torrance, CA 90502, USA
Exp Mol Pathol 91:485-9. 2011..This indicates that ALAD may play a significant role in regulating proteasome activity. The data supports the hypothesis that ALAD, an important enzyme for heme synthesis, is also important as a proteasome interacting protein...