A Vambutas

Summary

Affiliation: Long Island Jewish Medical Center
Country: USA

Publications

  1. ncbi Altered expression of TAP-1 and major histocompatibility complex class I in laryngeal papillomatosis: correlation of TAP-1 with disease
    A Vambutas
    Department of Otolaryngology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Clin Diagn Lab Immunol 7:79-85. 2000
  2. ncbi Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11
    Andrea Vambutas
    North Shore Long Island Jewish Research Institute, and Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    J Infect Dis 189:871-9. 2004
  3. ncbi Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus model
    A Vambutas
    North Shore Long Island Jewish Research Institute, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Vaccine 23:5271-80. 2005
  4. ncbi Alternate splicing of interleukin-1 receptor type II (IL1R2) in vitro correlates with clinical glucocorticoid responsiveness in patients with AIED
    Andrea Vambutas
    The Apelian Cochlear Implant Center, Department of Otolaryngology, North Shore LIJ Health System, Clinical Teaching Campus for the Albert Einstein College of Medicine, New Hyde Park, New York, United States of America
    PLoS ONE 4:e5293. 2009
  5. ncbi Interaction of human papillomavirus type 11 E7 protein with TAP-1 results in the reduction of ATP-dependent peptide transport
    A Vambutas
    Department of Otolaryngology, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Clin Immunol 101:94-9. 2001
  6. ncbi Failure of gamma interferon but not interleukin-10 expression in response to human papillomavirus type 11 E6 protein in respiratory papillomatosis
    James A DeVoti
    Division of Allergy and Immunology, Department of Pediatrics, Long Island Jewish Medical Center and North Shore Long-Island Jewish Research Institute, New Hyde Park, New York 11040, USA
    Clin Diagn Lab Immunol 11:538-47. 2004
  7. ncbi HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis
    Vincent R Bonagura
    Division of Allergy and Immunology, North Shore Long Island Jewish Research Institute, Department of Pediatrics, Long Island Jewish Medical Center, New Hyde Park, New York, USA
    Hum Immunol 65:773-82. 2004

Research Grants

  1. TAP-1/E7 INTERACTION: ROLE IN RESPIRATORY PAPILLOMAS
    Andrea Vambutas; Fiscal Year: 2004

Collaborators

Detail Information

Publications7

  1. ncbi Altered expression of TAP-1 and major histocompatibility complex class I in laryngeal papillomatosis: correlation of TAP-1 with disease
    A Vambutas
    Department of Otolaryngology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Clin Diagn Lab Immunol 7:79-85. 2000
    ..This up-regulation of class I MHC antigen at the cell surface potentially allows the infected cell to become a target for the immune system again. This finding provides some promise for nonsurgical treatment of laryngeal papillomas...
  2. ncbi Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11
    Andrea Vambutas
    North Shore Long Island Jewish Research Institute, and Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    J Infect Dis 189:871-9. 2004
    ..However, this association appeared to mitigate the severity of disease (P=.04). Therefore, severity of disease in a patient with RRP might be determined by sequencing TAP1, in conjunction with HLA class II genes...
  3. ncbi Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus model
    A Vambutas
    North Shore Long Island Jewish Research Institute, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Vaccine 23:5271-80. 2005
    ..Thus, this study shows promise for treatment of RRP by vaccination with long peptides...
  4. ncbi Alternate splicing of interleukin-1 receptor type II (IL1R2) in vitro correlates with clinical glucocorticoid responsiveness in patients with AIED
    Andrea Vambutas
    The Apelian Cochlear Implant Center, Department of Otolaryngology, North Shore LIJ Health System, Clinical Teaching Campus for the Albert Einstein College of Medicine, New Hyde Park, New York, United States of America
    PLoS ONE 4:e5293. 2009
    ..Thus, induced expression of mIL1R2 appears to be a protective mechanism in hearing homeostasis and warrants further investigation in a large prospective clinical trial to determine if IL1R2 can be used as a specific biomarker for AIED...
  5. ncbi Interaction of human papillomavirus type 11 E7 protein with TAP-1 results in the reduction of ATP-dependent peptide transport
    A Vambutas
    Department of Otolaryngology, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Clin Immunol 101:94-9. 2001
    ....
  6. ncbi Failure of gamma interferon but not interleukin-10 expression in response to human papillomavirus type 11 E6 protein in respiratory papillomatosis
    James A DeVoti
    Division of Allergy and Immunology, Department of Pediatrics, Long Island Jewish Medical Center and North Shore Long-Island Jewish Research Institute, New Hyde Park, New York 11040, USA
    Clin Diagn Lab Immunol 11:538-47. 2004
    ..In summary, E6 is the dominant inducer of cytokine expression in RRP, and it induces a skewed expression of IL-10 compared to the expression of IFN-gamma...
  7. ncbi HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis
    Vincent R Bonagura
    Division of Allergy and Immunology, North Shore Long Island Jewish Research Institute, Department of Pediatrics, Long Island Jewish Medical Center, New Hyde Park, New York, USA
    Hum Immunol 65:773-82. 2004
    ....

Research Grants1

  1. TAP-1/E7 INTERACTION: ROLE IN RESPIRATORY PAPILLOMAS
    Andrea Vambutas; Fiscal Year: 2004
    ..To determine whether the interaction between TAP-1 and E7 in naturally occurring infections sufficient to result in a loss of peptide transport and whether this loss correlates with viral protein load and the patients clinical course. ..