Research Topics
Species | P R SzeszkoSummaryAffiliation: Long Island Jewish Medical Center Country: USA Publications
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Detail Information
Publications
Investigation of frontal lobe subregions in first-episode schizophreniaP R Szeszko
Department of Psychiatry Research, Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Psychiatry Res 90:1-15. 1999....- Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophreniaP R Szeszko
Department of Psychiatry Research, Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Schizophr Res 43:97-108. 2000..These findings suggest a link between executive deficits and dysfunction of the dorsal 'archicortical' system and implicate sex differences in their relationship in first-episode schizophrenia... - Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry studyPhilip R Szeszko
Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 165:1299-307. 2008.... - Magnetic resonance imaging predictors of treatment response in first-episode schizophreniaPhilip R Szeszko
Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA
Schizophr Bull 38:569-78. 2012.... - White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging studyPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 62:782-90. 2005.... - Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formationP R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
Mol Psychiatry 10:631-6. 2005..These findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers... - White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging studyPhilip R Szeszko
The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 162:602-5. 2005..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset... - DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophreniaPhilip R Szeszko
Feinstein Institute for Medical Research, Manhasset, NY, USA
Biol Psychol 79:103-10. 2008..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology... - Investigation of unirhinal olfactory identification in antipsychotic-free patients experiencing a first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, North Shore Long Island Jewish Health System, Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Schizophr Res 67:219-25. 2004.... - Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findingsPhilip R Szeszko
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 29:826-32. 2004..These preliminary findings suggest that abnormal asymmetry of the amygdala may play a role in the pathogenesis of OCD and that paroxetine treatment may be associated with a reduction in amygdala volume... - Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 160:2190-7. 2003..The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects... - Orbital frontal and amygdala volume reductions in obsessive-compulsive disorderP R Szeszko
Department of Psychiatry Research, Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 56:913-9. 1999..These brain regions have not been well investigated in patients with OCD, however, using magnetic resonance imaging... - Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophreniaPhilip R Szeszko
Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Br J Psychiatry 190:230-6. 2007..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia... - Neuropsychological correlates of hippocampal volumes in patients experiencing a first episode of schizophreniaPhilip R Szeszko
Department of Psychiatry Research, Hillside Hospital, a division of North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Am J Psychiatry 159:217-26. 2002..This study investigated the neuropsychological correlates of hippocampal volume in 43 men and 32 women experiencing a first episode of schizophrenia... - Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorderPhilip R Szeszko
Department of Psychiatry Research, Zucker Hilside Hospital, Glen Oaks, NY 11004, USA
Am J Psychiatry 161:1049-56. 2004..The authors investigated structural abnormalities in brain regions comprising cortical-striatal-thalamic-cortical loops in pediatric patients with obsessive-compulsive disorder (OCD)... - Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
Am J Psychiatry 160:1884-7. 2003..Few studies, however, have examined the relationship between cerebellar size and neuropsychological functioning in schizophrenia. The authors' goal was to examine this relationship in patients and healthy comparison subjects... - Increased stress and smaller anterior hippocampal volumePhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Neuroreport 17:1825-8. 2006..Our results may also have implications for neuropsychiatric disorders that have implicated stress and hippocampal abnormalities in their pathogenesis... - Patterns of stress in schizophreniaJulia D Betensky
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Psychiatry Res 160:38-46. 2008.... - Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 33:976-84. 2008..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder... - Volumetric and shape analysis of the thalamus in first-episode schizophreniaDenise M Coscia
The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
Hum Brain Mapp 30:1236-45. 2009..Our findings suggest that thalamic abnormalities are evident at the onset of a first episode of schizophrenia prior to extensive pharmacologic intervention and that these abnormalities have neuropsychological correlates... - A voxel-based diffusion tensor imaging study of white matter in bipolar disorderKatie Mahon
Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 34:1590-600. 2009..Our findings are consistent with models of bipolar disorder that implicate dysregulation of cortico-subcortical and cerebellar regions in the disorder and may have relevance for phenomenology... - Neurocognitive profile analysis in obsessive-compulsive disorderKatherine E Burdick
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
J Int Neuropsychol Soc 14:640-5. 2008..Findings of specific abnormalities on tasks of motor and processing speed are consistent with a hypothesized role of thalamocortical and basal ganglia regions in the pathogenesis of OCD... - A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypesTodd Lencz
Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 35:2284-91. 2010..05). The risk allele dosage also predicted impairments on a timed visuomotor performance task (trails A). Results support a role of ZNF804A in phenotypes reflecting altered neural connectivity... - DISC1 and neurocognitive function in schizophreniaKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
Neuroreport 16:1399-402. 2005..These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia... - Interferon-induced obsessive-compulsive disorderPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Gen Hosp Psychiatry 28:357-8. 2006 - Genetic variation in DTNBP1 influences general cognitive abilityKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
Hum Mol Genet 15:1563-8. 2006..These data suggest that DTNBP1 genetic variation influences human intelligence... - Sex differences in frontal lobe white matter microstructure: a DTI studyPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Neuroreport 14:2469-73. 2003..Our findings may be indicative of increased directional coherence and/or density of left hemisphere white matter fibers and a leftward asymmetry of this structural integrity among women compared to men... - White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging studySanjiv Kumra
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
J Am Acad Child Adolesc Psychiatry 44:934-41. 2005..To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18)... - Reversed cerebellar asymmetry in men with first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Biol Psychiatry 53:450-9. 2003.... - Positive correlations between corpus callosum thickness and intelligenceEileen Luders
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, and Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
Neuroimage 37:1457-64. 2007..Our findings emphasize the importance of incorporating posterior (callosal) regions into the theories and models proposed to explain the anatomical substrates of intelligence... - Gray matter structural alterations in obsessive-compulsive disorder: relationship to neuropsychological functionsChristopher J Christian
Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, United States
Psychiatry Res 164:123-31. 2008..Moreover, our data suggest that gray matter structural alterations in OCD have neuropsychological correlates, which may be useful in further characterizing structure-function relations in this disorder... - Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractographyManzar Ashtari
Department of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York, USA
Arch Gen Psychiatry 64:1270-80. 2007..There is increasing evidence that schizophrenia is characterized by abnormalities in white matter... - A role for white matter abnormalities in the pathophysiology of bipolar disorderKatie Mahon
Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
Neurosci Biobehav Rev 34:533-54. 2010..Taken together, the evidence supports and clarifies a model of BD that involves disconnectivity in regions implicated in emotion generation and regulation... - White matter development during late adolescence in healthy males: a cross-sectional diffusion tensor imaging studyManzar Ashtari
The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Neuroimage 35:501-10. 2007..The authors investigated WM development in healthy adolescent males through age-associated changes in fractional anisotropy (FA), radial (lambda( perpendicular)) and axial (lambda(||)) diffusivity... - Amygdala and hippocampal volumes in familial early onset major depressive disorderFrank P MacMaster
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
Biol Psychiatry 63:385-90. 2008..To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD)... - Asymmetries of cortical shape: Effects of handedness, sex and schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Neuroimage 34:939-48. 2007.... - Greater regional cortical gray matter thickness in obsessive-compulsive disorderVeena M Narayan
Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California, USA
Neuroreport 19:1551-5. 2008.... - Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depressionShauna MacMillan
Department of Psychiatry, 9B, Wayne State University School of Medicine, 4201 St. Antoine Boulevard, Detroit, MI 48201, USA
J Child Adolesc Psychopharmacol 13:65-73. 2003..These results underscore the importance of assessment for comorbidity in the study of MDD... - Mapping cortical thickness and gray matter concentration in first episode schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1769, USA
Cereb Cortex 15:708-19. 2005..Cortical thickness and gray matter concentration mapping produce similar results, although the concentration metric may be influenced by diagnostic differences in extra-cortical cerebrospinal fluid and surface curvature/complexity... - Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophreniaClaudia I Rupp
Department of Psychiatry, Medical University Innsbruck, Austria
Schizophr Res 74:149-61. 2005..In this study, we examined the relationship between different olfactory functions and volumes of the hippocampus-amygdala complex (HAC) and the orbitofrontal brain region using magnetic resonance imaging (MRI)... - Mapping the relationship between cortical convolution and intelligence: effects of genderEileen Luders
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, USA
Cereb Cortex 18:2019-26. 2008..This might lead to the development of sexually dimorphic information processing strategies and affect the relationship between intelligence and cortical convolution... - Asymmetries of cortical thickness: effects of handedness, sex, and schizophreniaLiberty S Hamilton
Laboratory of Neuroimaging, Geffen School of Medicine at UCLA, Los Angeles, California 90095 7334, USA
Neuroreport 18:1427-31. 2007..Thus, dextrality relates to cortical thickness asymmetries, although schizophrenia may differentially affect asymmetry patterns across handedness... - Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorderMatthew J Hoptman
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Psychiatry Res 140:133-45. 2005..Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects... - Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophreniaBabak A Ardekani
Center for Advanced Brain Imaging, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA
Neuroreport 16:1455-9. 2005..Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia... - CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophreniaHandan Gunduz-Bruce
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Psychiatry Res 155:57-66. 2007..These results suggest that plasma osmolality is related to ventricle size in healthy volunteers and that this physiological link is impaired in patients with first episode schizophrenia... - Neuroimaging studies of children with serious emotional disturbances: a selective reviewJane Avery Serene
Harvard Medical School, Boston, Massachusetts, USA
Can J Psychiatry 52:135-45. 2007.... - Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophreniaHandan Gunduz-Bruce
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Schizophr Res 94:281-7. 2007..Larger scale studies are needed to conclude a link between the two measures, yet it is possible that the negative association that was previously shown in other disorders may not apply to schizophrenia... - Neurodevelopmental aspects of spatial navigation: a virtual reality fMRI studyDaniel S Pine
Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Building 10, Room 4N-222 [MSC1381, Bethesda, Maryland 20892-1381, USA
Neuroimage 15:396-406. 2002..Consistent with developmental models, these findings relate maturation in the coding of spatial information to functional changes in a distributed, left-lateralized neural network...
Research Grants
- Neuroimaging Studies of Frontal Lobe Pathology in OCDPhilip Szeszko; Fiscal Year: 2005....
- Diffusion Tensor Imaging in First-Episode SchizophreniaPhilip Szeszko; Fiscal Year: 2007..The identification of these abnormalities at the first episode of illness may be useful for identifying indicators of vulnerability, which may lead to improved early identification of individuals at risk for schizophrenia. ..
- Diffusion Tensor Imaging in First-Episode SchizophreniaPhilip Szeszko; Fiscal Year: 2009..The identification of these abnormalities at the first episode of illness may be useful for identifying indicators of vulnerability, which may lead to improved early identification of individuals at risk for schizophrenia. ..
- Diffusion Tensor Imaging in First-Episode SchizophreniaPhilip R Szeszko; Fiscal Year: 2010..The identification of these abnormalities at the first episode of illness may be useful for identifying indicators of vulnerability, which may lead to improved early identification of individuals at risk for schizophrenia. ..