Pravin Singhal

Summary

Affiliation: Long Island Jewish Medical Center
Country: USA

Publications

  1. ncbi Vasoactive agents modulate migration of monocytes across glomerular endothelial cells
    P C Singhal
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    J Investig Med 48:110-7. 2000
  2. ncbi Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis
    Pravin C Singhal
    Immunology and Inflammation Center, North Shore Long Island Jewish Research Institute and Division of Kidney Diseases and Hypertension, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    J Immunol 168:4025-33. 2002
  3. ncbi Vancomycin-induced acute granulomatous interstitial nephritis: therapeutic options
    Susana Hong
    Departments of Medicine and Pathology, Long Island Jewish Medical Center, 410 Lakeville Road, New Hyde Park, NY 11042, USA
    Am J Med Sci 334:296-300. 2007
  4. ncbi Monocyte apoptosis in dialysis patients is Fas ligand-mediated
    R Ranjan
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    Clin Nephrol 58:423-30. 2002
  5. ncbi Morphine modulates HIV-1 gp160-induced murine macrophage and human monocyte apoptosis by disparate ways
    Aditi A Kapasi
    Immunology and Inflammation Center, North Shore LIJ Research Institute, The Division of Kidney Disease and Hypertension, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    J Neuroimmunol 148:86-96. 2004
  6. ncbi Nitric oxide and superoxide in rat mesangial cells: modulation by C-reactive protein
    Howard Trachtman
    Department of Pediatrics Division of Nephrology, Schneider Children s Hospital, Albert Einstein College of Medicine, New Hyde Park, NY 11040 1432, USA
    Pediatr Nephrol 21:619-26. 2006
  7. ncbi Angiotensin II induces apoptosis in rat glomerular epithelial cells
    Guohua Ding
    Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Am J Physiol Renal Physiol 283:F173-80. 2002
  8. ncbi Nitric oxide and tubulointerstitial nephritides
    Joseph Mattana
    Research Institute, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Semin Nephrol 24:345-53. 2004
  9. ncbi Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation
    Rajani S Bhat
    Long Island Jewish Medical Center, 410 Lakeville Road, Suite 207, New Hyde Park, NY 11040, USA
    J Leukoc Biol 75:1131-8. 2004
  10. ncbi HIV-1 gp120-induced tubular epithelial cell apoptosis is mediated through p38-MAPK phosphorylation
    Aditi A Kapasi
    Immunology and Inflammation Center for Excellence, North Shore-Long Island Jewish Research Institute, Manhasset, New York 11040, USA
    Mol Med 8:676-85. 2002

Research Grants

  1. p66ShcA in HIV associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2010
  2. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
  3. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2002
  4. Renin Angioensin Aldosterone System in Drub Abuse and HIV-associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2010

Collaborators

  • BALAKUNTALAM KASINATH
  • Assaad El-Hakim
  • J D Wagner
  • Joseph Mattana
  • Mohammad Husain
  • Moin A Saleem
  • A Malhotra
  • Saijun Fan
  • P W Mathieson
  • Stephen Futterweit
  • Wei Liang
  • Davorka Messmer
  • Ikusuke Hatsukari
  • Madhu Bhaskaran
  • Aditi A Kapasi
  • Krishna Reddy
  • Nicholas Franki
  • Guohua Ding
  • Neetu Radhakrishnan
  • Anju Yadav
  • Aftab A Malik
  • Amit Dinda
  • Rajani S Bhat
  • Anil Mongia
  • Joanna Mikulak
  • Jaimita Patel
  • Dileep Kumar
  • Arthur D Smith
  • Himanshu Vashistha
  • Junya Jia
  • Susana Hong
  • Akhtar Ashfaq
  • Lia Frenklakh
  • Howard Trachtman
  • Michael Gitman
  • Michael D Gitman
  • Nagarathna Manjappa
  • Kalpesh Patel
  • Joel Patrick A Aldana
  • Geeta Patel
  • R Ranjan
  • Sridevi Vallabu
  • Douglas N Charney
  • Praveen N Chander
  • Cheng Chen
  • Shitij Arora
  • Jili Zhu
  • Ahmad N Chaudhary
  • Elsa Valderrama
  • Priyanka Singh
  • Hitesh Patni
  • Hitesh H Shah
  • Michael Esposito
  • Jessica Bod
  • Christopher Arzberger
  • Meera Sharma
  • Shilpa Sharma
  • Haddassah Gorman
  • Judah Goldschmiedt
  • Salvatore A Coscia
  • Naoko Hitosugi
  • Noosha Baqi
  • Manish P Pandya
  • Benjamin R Lee
  • Rajani Bhat
  • Robert Marcovich
  • Neetu Radhakrishanan
  • Anuj Goenka
  • Neeraj Modi
  • Nilay Nahar
  • Dhimant Dani
  • Nora Morgenstern
  • Pavni Mehrotra
  • K Reddy
  • Nora Gibbons
  • H Shah
  • A A Kapasi
  • E Varghese
  • M Bhaskaran
  • J Siu

Detail Information

Publications33

  1. ncbi Vasoactive agents modulate migration of monocytes across glomerular endothelial cells
    P C Singhal
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    J Investig Med 48:110-7. 2000
    ..In both human and experimental animal models of focal glomerulosclerosis (FSGS), infiltration of macrophages in the mesangium has been considered key in the development of FSGS...
  2. ncbi Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis
    Pravin C Singhal
    Immunology and Inflammation Center, North Shore Long Island Jewish Research Institute and Division of Kidney Diseases and Hypertension, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    J Immunol 168:4025-33. 2002
    ..Both TGF-beta and inducible NO synthase play an important role in morphine-induced downstream signaling, which seems to activate proteins involved in both extrinsic (Fas and FasL) and intrinsic (p53 and Bax) cell death pathways...
  3. ncbi Vancomycin-induced acute granulomatous interstitial nephritis: therapeutic options
    Susana Hong
    Departments of Medicine and Pathology, Long Island Jewish Medical Center, 410 Lakeville Road, New Hyde Park, NY 11042, USA
    Am J Med Sci 334:296-300. 2007
    ..In the index case, we have evaluated the effect of treatment on the basis of the type of cellular infiltrates and provided a follow-up by carrying out the repeat biopsy...
  4. ncbi Monocyte apoptosis in dialysis patients is Fas ligand-mediated
    R Ranjan
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    Clin Nephrol 58:423-30. 2002
    ..The mononuclear phagocyte system plays an important role in host defense. Since dialysis patients have been reported to show enhanced leukocytes apoptosis, we evaluated the mechanism of increased apoptosis of monocytes in dialysis patients...
  5. ncbi Morphine modulates HIV-1 gp160-induced murine macrophage and human monocyte apoptosis by disparate ways
    Aditi A Kapasi
    Immunology and Inflammation Center, North Shore LIJ Research Institute, The Division of Kidney Disease and Hypertension, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    J Neuroimmunol 148:86-96. 2004
    ..On the other hand, free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuated morphine and gp160-induced human monocyte apoptosis...
  6. ncbi Nitric oxide and superoxide in rat mesangial cells: modulation by C-reactive protein
    Howard Trachtman
    Department of Pediatrics Division of Nephrology, Schneider Children s Hospital, Albert Einstein College of Medicine, New Hyde Park, NY 11040 1432, USA
    Pediatr Nephrol 21:619-26. 2006
    ..C-reactive protein (CRP) has been linked to cardiovascular and renal disease. We evaluated the effects of CRP on the production of nitric oxide (NO) and superoxide by rat mesangial cells (RMC) and the impact on cell function...
  7. ncbi Angiotensin II induces apoptosis in rat glomerular epithelial cells
    Guohua Ding
    Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Am J Physiol Renal Physiol 283:F173-80. 2002
    ..These studies suggest that ANG II induces GEC apoptosis by a mechanism involving TGF-beta1 expression that may, importantly, contribute to the pathogenesis of glomerulosclerosis...
  8. ncbi Nitric oxide and tubulointerstitial nephritides
    Joseph Mattana
    Research Institute, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Semin Nephrol 24:345-53. 2004
    ..In this review we discuss some of the recent contributions to this important field...
  9. ncbi Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation
    Rajani S Bhat
    Long Island Jewish Medical Center, 410 Lakeville Road, Suite 207, New Hyde Park, NY 11040, USA
    J Leukoc Biol 75:1131-8. 2004
    ....
  10. ncbi HIV-1 gp120-induced tubular epithelial cell apoptosis is mediated through p38-MAPK phosphorylation
    Aditi A Kapasi
    Immunology and Inflammation Center for Excellence, North Shore-Long Island Jewish Research Institute, Manhasset, New York 11040, USA
    Mol Med 8:676-85. 2002
    ..CONCLUSION: Gp120 through interaction with CD4 triggers tubular cell apoptosis. This effect of gp120 on tubular cells is mediated through phosphorylation of p38 MAPK...
  11. ncbi Angiotensin II induces apoptosis in renal proximal tubular cells
    Madhu Bhaskaran
    Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Am J Physiol Renal Physiol 284:F955-65. 2003
    ..Modulation of tubular cell expression of HO-1 has an inverse relationship with the ANG II-induced tubular cell apoptosis...
  12. ncbi Morphine-induced degradation of the host defense barrier role of intestinal mucosal injury
    Lia Frenklakh
    Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA
    Dig Dis Sci 51:318-25. 2006
    ..These findings suggest that morphine-induced intestinal injury is mediated through NO generation. However, the degradation of the host defense barrier correlates with macrophage injury, but not intestinal injury...
  13. ncbi Morphine modulates monocyte-macrophage conversion phase
    Ikuske Hatsukari
    Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Cell Immunol 239:41-8. 2006
    ..These findings suggest that the PMA-induced macrophage phenotype conversion may be accelerating their migration; whereas, morphine may be preventing the migration of monocytes by inhibiting MMCP...
  14. ncbi Cocaine-induced renal disease
    Michael D Gitman
    Long Island Jewish Medical Center, Division of Kidney Diseases and Hypertension, 410 Lakeville Road, 207 New Hyde Park, New York, NY11042, USA
    Expert Opin Drug Saf 3:441-8. 2004
    ..This article will review the spectrum of cocaine-induced kidney disease and attempt to give insight into the pathophysiological mechanisms involved...
  15. ncbi Ethanol promotes T cell apoptosis through the mitochondrial pathway
    Aditi A Kapasi
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Immunology 108:313-20. 2003
    ..In addition, binge drinking induced the cleavage of caspase-3, suggesting activation of caspase-3 in T cells. These results suggest that ethanol promotes T cell apoptosis through the activation of intrinsic or mitochondrial pathway...
  16. ncbi Morphine-induced macrophage apoptosis modulates migration of macrophages: use of in vitro model of urinary tract infection
    Aftab A Malik
    Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    J Endourol 16:605-10. 2002
    ..CONCLUSION: Morphine inhibits macrophage migration both in vivo and in vitro. This attenuated transmigration of macrophages seems to be secondary to the apoptotic effect of morphine...
  17. ncbi Immune response to laparoscopic bowel injury
    Joel Patrick A Aldana
    Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York, USA
    J Endourol 17:317-22. 2003
    ..The difference in the degree of cellular death may be secondary to a smaller degree of stimulation of the immune response in laparoscopic surgery...
  18. ncbi HIV-1 and kidney cells: better understanding of viral interaction
    Joanna Mikulak
    Feinstein Institute for Medical Research and Long Island Jewish Medical Center, New Hyde Park, NY, USA
    Nephron Exp Nephrol 115:e15-21. 2010
    ..It appears that the presence of specific genetic and host factors in in vivo conditions may be facilitating the development of the productive HIV-1 infection in kidney cells...
  19. ncbi Morphine priming rescues high-dose morphine-induced biological perturbations
    Madhu Bhaskaran
    North Shore University Hospital, Immunology and Inflammation Center, Feinstein Institute for Medical Research, Manhasset, NY, USA
    J Infect Dis 195:1860-9. 2007
    ..These results suggest that MP provides protection against HDM-induced degradation of the host defense barrier through preservation of macrophage function...
  20. ncbi p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells: associated with alteration of TGF-beta and Smad signaling
    Aditi A Kapasi
    Division of Nephrology, Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus, Albert Einstein College of Medicine, New Hyde Park, NY, USA
    Nephron Exp Nephrol 102:e30-8. 2006
    ..In addition, HIV-1 gp120 results in phosphorylation of Smad2 and decreases c-Jun. These findings suggest that p300 acts as a potent transcriptional cofactor in HIV-1 gp120-induced apoptosis via TGF-beta and Smad signaling...
  21. ncbi Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis
    Mohammad Husain
    Department of Medicine, Division of Kidney Diseases and Hypertension, North Shore Long Island Jewish Health System, New Hyde Park, New York 11040, USA
    J Biol Chem 284:16648-58. 2009
    ..We conclude that inhibition of p66ShcA redox activity prevents generation of HIV-1 stress signals and activation of the CIDHP apoptosis program...
  22. ncbi Dialysis membrane-induced oxidative stress: role of heme oxygenase-1
    Madhu Bhaskaran
    Division of Kidney Diseases and Hypertension, North Shore University Hospital, Manhasset and Long Island Jewish Medical Center, New Hyde Park, NY, USA
    Nephron Exp Nephrol 105:e24-32. 2007
    ..We suggest that oxidative injury associated with dialysis membrane and monocyte interaction plays a role in monocyte injury. Pre-induction of HO-1 may attenuate dialysis membrane-induced monocyte apoptosis...
  23. ncbi Role of heme oxygenase-1 in morphine-modulated apoptosis and migration of macrophages
    Kalpesh Patel
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    J Infect Dis 187:47-54. 2003
    ..In in vitro studies, pretreatment of macrophages with hemin exacerbated morphine-induced apoptosis, whereas pretreatment with zinc protoporphyrin attenuated morphine-induced macrophage apoptosis...
  24. ncbi Hepatocyte growth factor modulates H2O2-induced mesangial cell apoptosis through induction of heme oxygenase-1
    Neetu Radhakrishnan
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
    Nephron Physiol 101:p92-8. 2005
    ..These findings suggest that H2O2-induced apoptosis occurs through the mitochondrial pathway. HGF provides protection against H2O2-induced MMC apoptosis through induction of HO-1...
  25. ncbi Immunomodulatory effect of morphine: therapeutic implications
    Amit Dinda
    Department of Medicine, Long Island Jewish Medical Center, 410 Lakeville Road, New Hyde Park, NY 11040, USA
    Expert Opin Drug Saf 4:669-75. 2005
    ..It may encourage further clinical studies to elucidate the influence of morphine treatment on immune regulation in different specialties of medicine...
  26. ncbi Role of oxidative stress and heme oxygenase activity in morphine-induced glomerular epithelial cell growth
    Jaimita Patel
    Immunology and Inflammation Center for Excellence, North Shore Long Island Jewish Research Institute, New Hyde Park, NY 11040, USA
    Am J Physiol Renal Physiol 285:F861-9. 2003
    ..Morphine, de novo, had bimodal effects on HO activity: lower concentrations increased and higher concentrations decreased HO activity. It appears that HO activity may be modifying morphine-induced GEC growth...
  27. ncbi Tubular cell-Escherichia coli interaction products modulate migration of monocytes through generation of transforming growth factor-beta and macrophage-monocyte chemoattractant protein-1
    Aftab A Malik
    Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    J Endourol 16:599-603. 2002
    ..We hypothesized that bacteria activate tubular cells to secrete cytokines, which may promote migration of mononuclear cells at the site of interaction...
  28. ncbi HIVAN phenotype: consequence of epithelial mesenchymal transdifferentiation
    Anju Yadav
    Immunonlogy Center, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    Am J Physiol Renal Physiol 298:F734-44. 2010
    ..Similarly, TRM showed diminished expression of alpha-SMA and FSP1 by both PECs-PGCs and TCs-PTCs compared with SRM. We conclude that EMT contributes to the manifestation of the proliferative phenotype in HIVAN mice...
  29. ncbi Morphine reciprocally regulates IL-10 and IL-12 production by monocyte-derived human dendritic cells and enhances T cell activation
    Davorka Messmer
    Laboratory of Experimental Immunology, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, USA
    Mol Med 12:284-90. 2006
    ..The change in surface phenotype was paralleled by a p38 MAPK-dependent decrease in IL-10 and increase in IL-12 secretion. Our data indicate that morphine exerts an immunostimulatory effect by modulating LPS-induced DC maturation...
  30. ncbi Protease inhibitors modulate apoptosis in mesangial cells derived from a mouse model of HIVAN
    Anil Mongia
    Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Kidney Int 65:860-70. 2004
    ..CONCLUSION: Oxidative stress seems to play a role in the accelerated rate of HTrMC apoptosis both under basal and MSS. Saquinavir may be inhibiting HTrMC apoptosis by mitigating oxidative stress...
  31. ncbi Angiotensin II infusion induces nephrin expression changes and podocyte apoptosis
    Junya Jia
    Division of Nephrology, Renmin Hospital, Wuhan University, Wuhan, China
    Am J Nephrol 28:500-7. 2008
    ..The present study evaluates the effects of Ang II infusion in rats on podocyte nephrin expression and apoptosis and the molecular mechanisms involved in Ang II-induced proteinuria and mesangial expansion...
  32. ncbi HIV-1 expression induces tubular cell G2/M arrest and apoptosis
    Himanshu Vashistha
    Immunology and Inflammation Center, Feinstein Institute for Medical Research, Manhasset, New York, USA
    Ren Fail 30:655-64. 2008
    ..These findings suggest that in addition to the activation of apoptotic pathway, HIV-1-induced G2/M arrest may also contribute to tubular cell injury...
  33. ncbi Emerging strategies for lowering serum phosphorous in patients with end-stage renal disease
    Akhtar Ashfaq
    Division of Kidney Division and Hypertension, North Shore University Hospital, 100 Community Drive, Great Neck, New York 11021, USA
    Expert Opin Pharmacother 7:1897-905. 2006
    ..These have prompted the development of new classes of medications with potentially better efficacy and few short-term and long-term side effects. This article reviews the causes, mechanism and management of hyperphosphataemia...

Research Grants12

  1. p66ShcA in HIV associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2010
    ..At present, there is no specific treatment to cure this disease. Our long term research goal is to develop strategies to slow down the progression and/or cure of this devastating kidney disease. ..
  2. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
    ..2. Oxidative stress modulated by drugs accelerates the progression of renal injury in a mouse model of HIVAN. 3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. ..
  3. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2002
    ..We believe that tubulointerstitial lesions determine the accelerated course of renal failure in drug addicts with HIV infection. ..
  4. Renin Angioensin Aldosterone System in Drub Abuse and HIV-associated Nephropathy
    Pravin C Singhal; Fiscal Year: 2010
    ..Our long term research goal is to develop strategies to slow down the progression as well as find a cure of this devastating kidney disease. ..