Research Topics
Genomes and GenesSpecies | Anil MalhotraSummaryAffiliation: Long Island Jewish Medical Center Country: USA Publications
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Publications
Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gainAnil K Malhotra
Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 69:904-12. 2012..Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk...
Pharmacogenetics in psychiatry: translating research into clinical practiceA K Malhotra
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Mol Psychiatry 17:760-9. 2012..Taken together, these data provide insights into the design and methodological considerations that may enhance the potential for clinical utility of PGx studies...
Implications for health and disease in the genetic signature of the Ashkenazi Jewish populationSaurav Guha
Department of Psychiatry, Division of Research, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, 75 59, 263rd St Glen Oaks, NY 11004, USA
Genome Biol 13:R2. 2012..Comparison of the genotyping data with that of neighboring European and Asian populations enabled the Ashkenazi Jewish-specific component of the variance to be characterized with respect to disease-relevant alleles and pathways...- Candidate gene studies of antipsychotic drug efficacy and drug-induced weight gainAnil K Malhotra
Department of Psychiatry Research, Albert Einstein College of Medicine, Zucker Hillside Hospital, 57 59 263rd Street, Glen Oaks, NY 11004, USA
Neurotox Res 6:51-6. 2004.... - Individualizing antipsychotic drug therapy in schizophrenia: the promise of pharmacogeneticsCharles U Nnadi
Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Curr Psychiatry Rep 9:313-8. 2007.... - Genomics and the future of pharmacotherapy in psychiatryAnil K Malhotra
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Int Rev Psychiatry 19:523-30. 2007..These increasingly comprehensive approaches should provide informative data on the genes associated with psychotropic drug response, a critical step towards the ultimate goal of 'personalized' medicine... - No evidence for phenotypic variation between probands in case-control versus family-based association studies of schizophreniaAnil K Malhotra
Hillside Hospital, Psychiatry Research, Glen Oaks, New York 11004, USA
Am J Med Genet 114:509-11. 2002.... - A functional polymorphism in the COMT gene and performance on a test of prefrontal cognitionAnil K Malhotra
Unit of Molecular Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
Am J Psychiatry 159:652-4. 2002..The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. The current study investigated whether prefrontal cognition varies with COMT genotype... - Ziprasidone-induced cognitive enhancement in schizophrenia: specificity or pseudospecificity?Anil K Malhotra
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, and Albert Einstein College of Medicine, United States
Schizophr Res 87:181-4. 2006..We tested the hypothesis that ziprasidone improves cognition in the absence of clinical improvement... - Pharmacogenetics of psychotropic drug responseAnil K Malhotra
Department of Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 161:780-96. 2004..These pharmacogenetic strategies offer the prospect of identifying biological predictors of psychotropic drug response and could provide the means of determining the molecular substrates of drug efficacy and drug-induced adverse events... - Emotion-based decision-making in healthy subjects: short-term effects of reducing dopamine levelsSerge Sevy
Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Yeshiva University, Bronx, and Psychiatry Research Department, The Zucker Hillside Hospital, Glen Oaks, NY, USA
Psychopharmacology (Berl) 188:228-35. 2006..So far, it is unclear what aspects of addictive behaviors are related to a dopaminergic dysfunction... - Impaired attention as an endophenotype for molecular genetic studies of schizophreniaB A Cornblatt
Hillside Hospital, Psychiatry Research, Glen Oaks, New York 11004, USA
Am J Med Genet 105:11-5. 2001.... - Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formationP R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
Mol Psychiatry 10:631-6. 2005..These findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers... - Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophreniaT Lencz
Department of Psychiatry Research, The Zucker Hillside Hospital, Division of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Mol Psychiatry 12:572-80. 2007..The presence of cytokine receptor abnormalities in schizophrenia may help explain prior epidemiologic data relating the risk for this illness to altered rates of autoimmune disorders, prenatal infection and familial leukemia... - Early identification and high-risk strategies for bipolar disorderChristoph U Correll
The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Bipolar Disord 9:324-38. 2007..To describe and compare the relative merits of different identification strategies for individuals at risk for bipolar disorder (BPD)... - Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophreniaPhilip R Szeszko
Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Br J Psychiatry 190:230-6. 2007..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia... - Increased stress and smaller anterior hippocampal volumePhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Neuroreport 17:1825-8. 2006..Our results may also have implications for neuropsychiatric disorders that have implicated stress and hippocampal abnormalities in their pathogenesis... - DTNBP1 genotype influences cognitive decline in schizophreniaKatherine E Burdick
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
Schizophr Res 89:169-72. 2007..The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1)... - Disrupted in schizophrenia 1 genotype and positive symptoms in schizophreniaPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Biol Psychiatry 61:1208-10. 2007.... - The FEZ1 gene shows no association to schizophrenia in Caucasian or African American populationsColin A Hodgkinson
Section of Human Neurogenetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
Neuropsychopharmacology 32:190-6. 2007..Neuropsychopharmacology (2007) 32, 190-196. doi:10.1038/sj.npp.1301177; published online 16 August 2006... - Analysis of TBX1 variation in patients with psychotic and affective disordersBirgit H Funke
Harvard Partners Center for Genetics and Genomics, Boston, MA 02139, USA
Mol Med 13:407-14. 2007..Based on these results we conclude that TBX1 variation does not make a strong contribution to the genetic etiology of nonsyndromic forms of psychiatric disorders commonly seen in patients with 22q11DS... - COMT genotype increases risk for bipolar I disorder and influences neurocognitive performanceKatherine E Burdick
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Bipolar Disord 9:370-6. 2007..A large body of evidence suggests that COMT is associated with cognitive performance in patients with schizophrenia and in healthy volunteers but there have been no reports of its relationship to cognition in BPD... - Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 33:976-84. 2008..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder... - DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophreniaPhilip R Szeszko
Feinstein Institute for Medical Research, Manhasset, NY, USA
Biol Psychol 79:103-10. 2008..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology... - Runs of homozygosity reveal highly penetrant recessive loci in schizophreniaTodd Lencz
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Proc Natl Acad Sci U S A 104:19942-7. 2007..Other risk ROHs feature haplotypes that are also common in healthy individuals, possibly indicating a source of balancing selection... - Cognitive dysfunction in bipolar disorder: future place of pharmacotherapyKatherine E Burdick
Department of Psychiatry, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
CNS Drugs 21:971-81. 2007..Finally, psychosocial intervention and/or cognitive remediation should be considered as alternatives to medications, although these techniques will also require additional systematic study... - Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?Terry E Goldberg
Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 64:1115-22. 2007..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects... - Patterns of stress in schizophreniaJulia D Betensky
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Psychiatry Res 160:38-46. 2008.... - Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performanceCarolin Opgen-Rhein
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, United States
Schizophr Res 103:169-77. 2008..Our aim in this study was to investigate the relationship between DAOA variation and schizophrenia, and the influence of DAOA on cognitive performance... - Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trialRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 33:1217-28. 2008..A significant and surprisingly large placebo/practice effect was observed among placebo-treated patients, and is a serious consideration in future clinical trial study designs for potential cognitive enhancing compounds in schizophrenia... - Clinical insights into pharmacogenetics and schizophrenia, part 2John M Kane
Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA
J Clin Psychiatry 69:1006-13. 2008 - Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive bindingKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Hum Mol Genet 17:2462-73. 2008..These data suggest that NDEL1 significantly influences risk for SZ via an interaction with DISC1. We propose a model where NDEL1 and NDE1 compete for binding with DISC1... - Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophreniaHugh M D Gurling
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, United Kingdom
Arch Gen Psychiatry 63:844-54. 2006..There is evidence of linkage to a schizophrenia susceptibility locus on chromosome 8p21-22 found by several family linkage studies... - COMT genotype and manic symptoms in schizophreniaPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, and Harvard Partners Center for Genetics and Genomics, Boston, MA, United States
Schizophr Res 87:28-31. 2006..These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ... - Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorderColin A Hodgkinson
Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Am J Hum Genet 75:862-72. 2004..These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders... - Association of the DTNBP1 locus with schizophrenia in a U.S. populationBirgit Funke
Harvard Medical School Partners Center for Genetics and Genomics, Boston, MA 02115, USA
Am J Hum Genet 75:891-8. 2004..005). Our study provides further evidence for a role of the DTNBP1 gene in the genetic etiology of schizophrenia... - Effects of serotonin transporter promoter polymorphisms on serotonin functionGwenn S Smith
Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 29:2226-34. 2004.... - Pharmacogenetics of antipsychotic-induced weight gainChristoph U Correll
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Psychopharmacology (Berl) 174:477-89. 2004..To enhance power, future studies should pay close attention to population selection and avoidance/control of confounds, particularly past treatment exposure... - Sex differences in frontal lobe white matter microstructure: a DTI studyPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Neuroreport 14:2469-73. 2003..Our findings may be indicative of increased directional coherence and/or density of left hemisphere white matter fibers and a leftward asymmetry of this structural integrity among women compared to men... - Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 160:2190-7. 2003..The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects... - Early prediction of antipsychotic response in schizophreniaChristoph U Correll
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Am J Psychiatry 160:2063-5. 2003..The authors' goal was to examine the predictive value of early symptom changes indicating response to antipsychotic medication in schizophrenia... - Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophreniaRobert M Bilder
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Biol Psychiatry 52:701-7. 2002.... - Discovery and utilization of haplotypes for pharmacogenetic studies of psychotropic drug responseMaria C Athanasiou
Genaissance Pharmaceuticals, Inc, New Haven, Connecticut 06511, USA
Psychiatr Genet 12:89-96. 2002..This approach has clear implications for the discovery of psychiatric disease-associated genes as well as for the development of safer, more efficacious psychiatric drugs... - A prospective study of hyperprolactinemia in children and adolescents treated with atypical antipsychotic agentsEma Saito
Department of Psychiatry Research, The Zucker Hillside Hospital, Long Island Jewish Medical Center, New Hyde Park, NY, USA
J Child Adolesc Psychopharmacol 14:350-8. 2004..We hypothesized: (1) risperidone would be associated with hyperprolactinemia most frequently, and (2) postpubertal females may be at higher risk of prolactin elevation and associated adverse effects... - White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging studyPhilip R Szeszko
The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 162:602-5. 2005..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset... - White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging studyPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 62:782-90. 2005.... - Interferon-induced obsessive-compulsive disorderPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Gen Hosp Psychiatry 28:357-8. 2006 - Neurocognition as a stable endophenotype in bipolar disorder and schizophreniaKatherine E Burdick
Bipolar Disorders Research Program, Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA
J Nerv Ment Dis 194:255-60. 2006..These preliminary findings suggest that neurocognitive domains appear longitudinally stable across broad domains in schizophrenia. In contrast, stable functioning may be more limited to attentional domains in bipolar disorder... - Dysbindin genotype and negative symptoms in schizophreniaPamela DeRosse
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Am J Psychiatry 163:532-4. 2006.... - DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patientsTodd Lencz
Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Am J Psychiatry 163:529-31. 2006.... - Genetic variation in DTNBP1 influences general cognitive abilityKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
Hum Mol Genet 15:1563-8. 2006..These data suggest that DTNBP1 genetic variation influences human intelligence... - Recognizing and monitoring adverse events of second-generation antipsychotics in children and adolescentsChristoph U Correll
The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Child Adolesc Psychiatr Clin N Am 15:177-206. 2006..This article presents an overview of SGA-related side effects in children and adolescents and strategies to monitor health outcomes effectively in youngsters receiving SGAs... - The Third Annual Pharmacogenetics in Psychiatry Meeting, 2004Youssef Hassoun
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Psychiatr Genet 15:155-6. 2005 - DISC1 and neurocognitive function in schizophreniaKatherine E Burdick
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
Neuroreport 16:1399-402. 2005..These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia... - Genetics and psychopharmacology: prospects for individualized treatmentCharles U Nnadi
Department of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, New York, USA
Essent Psychopharmacol 6:193-208. 2005..This research promises to strengthen the accuracy, effectiveness, safety, and cost of our psychopharmacological practices... - Metabolism and biochemical effects of nicotine for primary care providersChristine N Metz
Laboratory of Medicinal Biochemistry, Center for Patient Oriented Research, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
Med Clin North Am 88:1399-413, ix. 2004..This article covers the absorption and metabolism of nicotine, nicotine toxicity, pharmacologic effects of nicotine, nicotine-drug interactions, and the use of nicotine for the treatment of disease... - Amphetamine-induced dopamine release and post-synaptic specific binding in patients with mild tardive dyskinesiaCaleb M Adler
Experimental Therapeutics Branch, National Institute of Mental Health/NIH, Bethesda, MD, USA
Neuropsychopharmacology 26:295-300. 2002..More research is needed to unravel the neurobiology of this debilitating disorder... - Pharmacogenetics in psychiatry satellite meeting at the American College of Neuropsychopharmacology, 2000Anil K Malhotra
Hillside Hospital, Unit of Molecular Psychiatry, Glen Oaks, NY, USA
Neuropsychopharmacology 26:123-7. 2002
Research Grants
- CLINICAL TRIALS IN SCHIZOPHRENIA--MOLECULAR APPROACHESAnil Malhotra; Fiscal Year: 2003..abstract_text> ..
- Genetic Variation and Functional Disability in SchizophreniaAnil Malhotra; Fiscal Year: 2007....
- Genetic Variation and Functional Disability in SchizophreniaAnil K Malhotra; Fiscal Year: 2010....