John M Kane

Summary

Affiliation: Long Island Jewish Medical Center
Country: USA

Publications

  1. ncbi request reprint A multidose study of haloperidol decanoate in the maintenance treatment of schizophrenia
    John M Kane
    Department of Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 159:554-60. 2002
  2. doi request reprint A multicenter, randomized, double-blind, placebo-controlled, 16-week study of adjunctive aripiprazole for schizophrenia or schizoaffective disorder inadequately treated with quetiapine or risperidone monotherapy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 70:1348-57. 2009
  3. ncbi request reprint Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
  4. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
  5. ncbi request reprint Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain
    Anil K Malhotra
    Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 69:904-12. 2012
  6. doi request reprint Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
    John M Kane
    The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Psychopharmacol 24:1019-29. 2010
  7. pmc Predictors of remission, schizophrenia, and bipolar disorder in adolescents with brief psychotic disorder or psychotic disorder not otherwise specified considered at very high risk for schizophrenia
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    J Child Adolesc Psychopharmacol 18:475-90. 2008
  8. ncbi request reprint Symptomatic remission in schizophrenia patients treated with aripiprazole or haloperidol for up to 52 weeks
    John M Kane
    The Zucker Hillside Hospital, 75 59 263 St, Glen Oaks, NY 11004, USA
    Schizophr Res 95:143-50. 2007
  9. pmc Does antipsychotic polypharmacy increase the risk for metabolic syndrome?
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
    Schizophr Res 89:91-100. 2007
  10. pmc Past and present progress in the pharmacologic treatment of schizophrenia
    John M Kane
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 71:1115-24. 2010

Detail Information

Publications133 found, 100 shown here

  1. ncbi request reprint A multidose study of haloperidol decanoate in the maintenance treatment of schizophrenia
    John M Kane
    Department of Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 159:554-60. 2002
    ..Maintenance medication is critical in the prevention of psychotic relapse and rehospitalization among patients with schizophrenia. Given potential adverse effects, identification of the minimum effective dose is clinically important...
  2. doi request reprint A multicenter, randomized, double-blind, placebo-controlled, 16-week study of adjunctive aripiprazole for schizophrenia or schizoaffective disorder inadequately treated with quetiapine or risperidone monotherapy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 70:1348-57. 2009
    ..Combining antipsychotics is common practice in the treatment of schizophrenia. This study investigated aripiprazole adjunctive to risperidone or quetiapine for treating schizophrenia and schizoaffective disorder...
  3. ncbi request reprint Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
    ..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects...
  4. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
    ....
  5. ncbi request reprint Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain
    Anil K Malhotra
    Psychiatry Research, Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 69:904-12. 2012
    ..Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk...
  6. doi request reprint Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
    John M Kane
    The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Psychopharmacol 24:1019-29. 2010
    ..In conclusion, akathisia with aripiprazole occurred early in treatment, was mild-to-moderate in severity, led to few study discontinuations, and did not compromise therapeutic efficacy...
  7. pmc Predictors of remission, schizophrenia, and bipolar disorder in adolescents with brief psychotic disorder or psychotic disorder not otherwise specified considered at very high risk for schizophrenia
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    J Child Adolesc Psychopharmacol 18:475-90. 2008
    ....
  8. ncbi request reprint Symptomatic remission in schizophrenia patients treated with aripiprazole or haloperidol for up to 52 weeks
    John M Kane
    The Zucker Hillside Hospital, 75 59 263 St, Glen Oaks, NY 11004, USA
    Schizophr Res 95:143-50. 2007
    ..This analysis examined symptomatic remission in acutely ill patients with schizophrenia receiving either aripiprazole or haloperidol for one year...
  9. pmc Does antipsychotic polypharmacy increase the risk for metabolic syndrome?
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
    Schizophr Res 89:91-100. 2007
    ..To determine whether the coprescribing of two or more antipsychotics, a relatively frequent practice with little data to support its safety and efficacy, is associated with an increased prevalence of metabolic syndrome...
  10. pmc Past and present progress in the pharmacologic treatment of schizophrenia
    John M Kane
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 71:1115-24. 2010
    ....
  11. pmc Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability
    Katherine E Burdick
    Hillside Hospital, North Shore Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, NY 11004, USA
    Am J Psychiatry 167:436-43. 2010
    ..Thus, MET may be of particular interest as a candidate gene for neuropsychiatric diseases with a developmental etiology, including schizophrenia...
  12. ncbi request reprint Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
    ..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder...
  13. ncbi request reprint Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Biol Psychiatry 61:1208-10. 2007
    ....
  14. ncbi request reprint White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
    ..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset...
  15. pmc Differentiation in the preonset phases of schizophrenia and mood disorders: evidence in support of a bipolar mania prodrome
    Christoph U Correll
    Albert Einstein College of Medicine, Department of Psychiatry, Bronx, NY, USA
    Schizophr Bull 33:703-14. 2007
    ..The presence and specificity of a bipolar prodrome remains questioned. We aimed to characterize the prodrome prior to a first psychotic and nonpsychotic mania and to examine the phenotypic proximity to the schizophrenia prodrome...
  16. pmc Time to treatment response in first-episode schizophrenia: should acute treatment trials last several months?
    Juan A Gallego
    The Zucker Hillside Hospital, NY 11004, USA
    J Clin Psychiatry 72:1691-6. 2011
    ..This analysis explored trial duration with first-episode patients and asked whether early limited improvement predicts ultimate lack of treatment response with first-episode patients as it does with multiepisode patients...
  17. doi request reprint The efficacy of aripiprazole in the treatment of multiple symptom domains in patients with acute schizophrenia: a pooled analysis of data from the pivotal trials
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, New York, NY, USA
    Schizophr Res 105:208-15. 2008
    ..To examine the efficacy of aripiprazole across symptoms in patients with acute exacerbation of schizophrenia or schizoaffective disorder...
  18. pmc DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia
    Todd Lencz
    Division of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Pharmacogenet Genomics 20:569-72. 2010
    ..Given earlier evidence that deletion carriers show reduced symptom response to medication, additional study of appropriate treatment options for these patients seems warranted...
  19. pmc Obesity and coronary risk in patients treated with second-generation antipsychotics
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY, 11004, USA
    Eur Arch Psychiatry Clin Neurosci 261:417-23. 2011
    ..Obesity does not appear to be an independent predictor for the 10-year risk of coronary heart disease events in patients without metabolic syndrome treated with second-generation antipsychotics...
  20. ncbi request reprint DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients
    Todd Lencz
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:529-31. 2006
    ....
  21. doi request reprint Medical outcome of patients with dementia in a free-standing psychiatric hospital
    Peter Manu
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Geriatr Psychiatry Neurol 26:29-33. 2013
    ..The hospital outcome of patients with dementia is significantly worse than that of cognitively intact persons of the same age admitted to medical or surgical units but has not been investigated in psychiatric settings...
  22. pmc Quantifying clinical relevance in the treatment of schizophrenia
    Christoph U Correll
    Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Clin Ther 33:B16-39. 2011
    ..While in research studies, the use of quantitative assessments is ubiquitous, this is not the case in routine clinical practice, creating an important translational practice gap...
  23. pmc Antipsychotic drug administration does not correlate with prolonged rate-corrected QT interval in children and adolescents: results from a nested case-control study
    Christoph U Correll
    North Shore Long Island Jewish Health System, The Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
    J Child Adolesc Psychopharmacol 21:365-8. 2011
    ..The rate-corrected QT interval (QTc) prolongation is a risk factor for sudden cardiac death and may be induced by antipsychotic drugs...
  24. pmc Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
    Todd Lencz
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Proc Natl Acad Sci U S A 104:19942-7. 2007
    ..Other risk ROHs feature haplotypes that are also common in healthy individuals, possibly indicating a source of balancing selection...
  25. ncbi request reprint Dysbindin genotype and negative symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:532-4. 2006
    ....
  26. ncbi request reprint Ziprasidone-induced cognitive enhancement in schizophrenia: specificity or pseudospecificity?
    Anil K Malhotra
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, and Albert Einstein College of Medicine, United States
    Schizophr Res 87:181-4. 2006
    ..We tested the hypothesis that ziprasidone improves cognition in the absence of clinical improvement...
  27. ncbi request reprint The effects of clozapine and risperidone on spatial working memory in schizophrenia
    Susan R McGurk
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    Am J Psychiatry 162:1013-6. 2005
    ..The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia...
  28. pmc Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents
    Christoph U Correll
    Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, 75 59 263rd St, Glen Oaks, NY 11004, USA
    JAMA 302:1765-73. 2009
    ..Cardiometabolic effects of second-generation antipsychotic medications are concerning but have not been sufficiently studied in pediatric and adolescent patients naive to antipsychotic medication...
  29. doi request reprint Adjunctive armodafinil for negative symptoms in adults with schizophrenia: a double-blind, placebo-controlled study
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, 75 59 263rd Street, Kaufmann Bldg, Suite 103, Glen Oaks, NY 11004 1150, USA
    Schizophr Res 135:116-22. 2012
    ..This study investigated the efficacy and tolerability of adjunctive armodafinil for treatment of negative symptoms in adults with schizophrenia receiving antipsychotic medications...
  30. ncbi request reprint Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes
    Delbert G Robinson
    Department of Psychiatry, The Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:2096-102. 2006
    ..The authors compared 4-month treatment outcomes for olanzapine versus risperidone in patients with first-episode schizophrenia spectrum disorders...
  31. ncbi request reprint COMT genotype and manic symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, and Harvard Partners Center for Genetics and Genomics, Boston, MA, United States
    Schizophr Res 87:28-31. 2006
    ..These data suggest that the effect of COMT variation may be associated with comorbid manic symptoms in SZ...
  32. ncbi request reprint White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study
    Sanjiv Kumra
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 44:934-41. 2005
    ..To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18)...
  33. pmc Safety and tolerability of antipsychotic polypharmacy
    Juan A Gallego
    The Zucker Hillside Hospital, Psychiatry Research, North Shore LIJ Health System, Glen Oaks, NY 11004, USA
    Expert Opin Drug Saf 11:527-42. 2012
    ..Prior reviews have focused on the efficacy of APP, but no systematic review exists regarding the safety and tolerability of this practice...
  34. ncbi request reprint Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis
    Taro Kishi
    Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Hum Psychopharmacol 27:63-9. 2012
    ..We sought to assess the relationship between genotype alterations in 5-HT6 receptors and schizophrenia both in a case-control study and a meta-analysis...
  35. doi request reprint Aripiprazole intramuscular depot as maintenance treatment in patients with schizophrenia: a 52-week, multicenter, randomized, double-blind, placebo-controlled study
    John M Kane
    The Zucker Hillside Hospital and The Hofstra North Shore LIJ School of Medicine, Glen Oaks, NY 11004 1100, USA
    J Clin Psychiatry 73:617-24. 2012
    ..To evaluate the efficacy and tolerability of a once-monthly intramuscular (IM) depot formulation of the dopamine partial agonist aripiprazole as maintenance treatment in adults meeting DSM-IV-TR schizophrenia criteria...
  36. ncbi request reprint Aripiprazole for treatment-resistant schizophrenia: results of a multicenter, randomized, double-blind, comparison study versus perphenazine
    John M Kane
    Zucker Hillside Hospital and The Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 68:213-23. 2007
    ..Treatment-resistant schizophrenia poses a major therapeutic challenge. This multicenter, double-blind, randomized study compared the efficacy and safety of aripiprazole and perphenazine in treatment-resistant patients with schizophrenia...
  37. ncbi request reprint Clinical insights into pharmacogenetics and schizophrenia, part 2
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 69:1006-13. 2008
  38. ncbi request reprint Early identification and high-risk strategies for bipolar disorder
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Bipolar Disord 9:324-38. 2007
    ..To describe and compare the relative merits of different identification strategies for individuals at risk for bipolar disorder (BPD)...
  39. pmc Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes
    Todd Lencz
    The Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, New York 11004, USA
    Br J Psychiatry 194:313-8. 2009
    ..Brain-derived neurotrophic factor variants may help clarify the status of schizoaffective disorder...
  40. pmc Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry
    John M Kane
    The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, 75 59 263 St, Glen Oaks, NY 11004, USA
    J Clin Epidemiol 66:S37-41. 2013
    ..To date, many studies comparing LAIs and oral antipsychotics have been conducted; however, the results are mixed, and careful interpretation of the data is required...
  41. pmc Effectiveness of a cognitive behavioral weight management intervention in obese patients with psychotic disorders compared to patients with nonpsychotic disorders or no psychiatric disorders: results from a 12-month, real-world study
    Jian Ping Zhang
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychopharmacol 32:458-64. 2012
    ..Therefore, we compared the effect of a cognitive-behavioral weight loss intervention in obese subjects with psychotic disorders, other psychiatric diagnoses, and without psychiatric disorders...
  42. ncbi request reprint Review of treatments that can ameliorate nonadherence in patients with schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 67:9-14. 2006
    ....
  43. ncbi request reprint A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 70:572-81. 2009
    ..To evaluate the effectiveness of olanzapine versus aripiprazole in patients with schizophrenia...
  44. pmc CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia
    Handan Gunduz-Bruce
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychiatry Res 155:57-66. 2007
    ..These results suggest that plasma osmolality is related to ventricle size in healthy volunteers and that this physiological link is impaired in patients with first episode schizophrenia...
  45. pmc QT interval duration and dispersion in children and adolescents treated with ziprasidone
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 72:854-60. 2011
    ..To assess the incidence of symptoms (palpitations, syncope) and electrocardiographic signs (increased QT duration and dispersion) of an increased risk of torsades de pointes in youth treated with ziprasidone...
  46. ncbi request reprint Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia
    Handan Gunduz-Bruce
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Res 94:281-7. 2007
    ..Larger scale studies are needed to conclude a link between the two measures, yet it is possible that the negative association that was previously shown in other disorders may not apply to schizophrenia...
  47. doi request reprint A randomized placebo-controlled trial of asenapine for the prevention of relapse of schizophrenia after long-term treatment
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, 75 59 263rd St, Kaufmann Bldg, Ste 103, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 72:349-55. 2011
    ..Long-term efficacy of asenapine in preventing schizophrenia relapse was assessed in a 26-week double-blind, placebo-controlled trial that followed 26 weeks of open-label treatment...
  48. doi request reprint Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004 1150, USA
    J Clin Psychiatry 71:1475-81. 2010
    ..To evaluate the efficacy and tolerability of armodafinil, the longer-lasting isomer of modafinil, as adjunctive therapy in patients with schizophrenia...
  49. ncbi request reprint Atypical antipsychotics: sedation versus efficacy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 69:18-31. 2008
    ....
  50. doi request reprint The QTc interval and its dispersion in patients receiving two atypical antipsychotics
    Christoph U Correll
    Medical Services, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Eur Arch Psychiatry Clin Neurosci 259:23-7. 2009
    ..Polytherapy with atypical antipsychotics is becoming common, but the effect of this practice on the QTc has not been explored in detail...
  51. ncbi request reprint Proceedings and data from The Schizophrenia Summit: a critical appraisal to improve the management of Schizophrenia
    Henry A Nasrallah
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson St, Suite 3224, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 70:4-46. 2009
    ..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...
  52. doi request reprint Equally increased risk for metabolic syndrome in patients with bipolar disorder and schizophrenia treated with second-generation antipsychotics
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Bipolar Disord 10:788-97. 2008
    ..We compared bipolar disorder and schizophrenia patients receiving SGAs to determine whether MetS prevalence is influenced by the primary psychiatric diagnosis or concomitant mood stabilizer treatment...
  53. ncbi request reprint Metabolic syndrome and the risk of coronary heart disease in 367 patients treated with second-generation antipsychotic drugs
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 67:575-83. 2006
    ....
  54. ncbi request reprint Genetic variation in DTNBP1 influences general cognitive ability
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
    Hum Mol Genet 15:1563-8. 2006
    ..These data suggest that DTNBP1 genetic variation influences human intelligence...
  55. ncbi request reprint Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:2190-7. 2003
    ..The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects...
  56. ncbi request reprint Reduced frontal white matter integrity in early-onset schizophrenia: a preliminary study
    Sanjiv Kumra
    Department of Research, Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
    Biol Psychiatry 55:1138-45. 2004
    ..Diffusion tensor imaging provides a relatively new approach for quantifying possible connectivity of WM in vivo...
  57. doi request reprint Medical outcome of psychiatric inpatients with admission hyponatremia
    Peter Manu
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
    Psychiatry Res 198:24-7. 2012
    ..Admission hyponatremia is associated with an increased rate of significant medical deteriorations of psychiatric inpatients and should trigger enhanced clinical monitoring to identify and treat somatic disorders...
  58. pmc Incidence of tardive dyskinesia with risperidone or olanzapine in the elderly: results from a 2-year, prospective study in antipsychotic-naïve patients
    Margaret G Woerner
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Neuropsychopharmacology 36:1738-46. 2011
    ..This information is relevant for all patients receiving antipsychotics, not just the especially sensitive elderly...
  59. doi request reprint Comparative utility of aripiprazole and haloperidol in schizophrenia: post hoc analysis of two 52-week, randomized, controlled trials
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
    Appl Health Econ Health Policy 7:109-19. 2009
    ..Since their introduction, second-generation antipsychotics (SGAs) have become the drugs of choice for the treatment of schizophrenia. However, recent findings have questioned the benefits of SGAs over first-generation antipsychotics (FGAs)...
  60. ncbi request reprint DISC1 and neurocognitive function in schizophrenia
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Neuroreport 16:1399-402. 2005
    ..These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia...
  61. ncbi request reprint Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry 190:230-6. 2007
    ..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia...
  62. pmc Antipsychotic combinations vs monotherapy in schizophrenia: a meta-analysis of randomized controlled trials
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, New York, NY 11004, USA
    Schizophr Bull 35:443-57. 2009
    ..Despite lacking evidence for its safety and efficacy, antipsychotic cotreatment is common in schizophrenia. Objective: To evaluate therapeutic and adverse effects of antipsychotic cotreatment vs monotherapy in schizophrenia...
  63. doi request reprint Olanzapine long-acting injection: a 24-week, randomized, double-blind trial of maintenance treatment in patients with schizophrenia
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 167:181-9. 2010
    ..The purpose of the present study was to evaluate the efficacy and tolerability of olanzapine long-acting injection for maintenance treatment of schizophrenia...
  64. ncbi request reprint Oral ziprasidone in the treatment of schizophrenia: a review of short-term trials
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 64:19-25. 2003
    ..Available clinical data support rapid titration to > or = 120 mg/day for optimal efficacy in patients with acute exacerbation of schizophrenia...
  65. ncbi request reprint Clozapine as a first treatment for schizophrenia
    Margaret G Woerner
    Department of Psychiatry, Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:1514-6. 2003
    ..The authors' goal was to explore whether clozapine given as the first antipsychotic treatment favorably affects the course of schizophrenia...
  66. ncbi request reprint Identification of high-risk coronary heart disease patients receiving atypical antipsychotics: single low-density lipoprotein cholesterol threshold or complex national standard?
    Christoph U Correll
    Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 69:578-83. 2008
    ..The study was performed in patients receiving second-generation antipsychotics (SGAs), a medication class associated with CHD risk...
  67. ncbi request reprint Efficacy and tolerability of ziprasidone in patients with treatment-resistant schizophrenia
    John M Kane
    The Zucker Hillside Hospital and The Albert Einstein College of Medicine, Glen Oaks, New York, USA
    Int Clin Psychopharmacol 21:21-8. 2006
    ..Ziprasidone was associated with a greater decrease in median prolactin levels and a lower incidence of clinically significant weight change. Neither agent caused any clinically important changes in QTc interval...
  68. doi request reprint A double-blind, randomized study comparing the efficacy and safety of sertindole and risperidone in patients with treatment-resistant schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 72:194-204. 2011
    ..The objective of this study was to examine the efficacy and safety of sertindole, compared to risperidone, in this patient population...
  69. ncbi request reprint Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies
    Christoph U Correll
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Schneider Children s Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:414-25. 2004
    ..This hypothesis was examined in a systematic review of studies involving open or controlled treatment with any second-generation antipsychotic...
  70. ncbi request reprint Long-acting injectable risperidone: efficacy and safety of the first long-acting atypical antipsychotic
    John M Kane
    The Zucker Hillside Hospital, New York, NY 11004, USA
    Am J Psychiatry 160:1125-32. 2003
    ..The authors assessed the efficacy and safety of the first long-acting atypical antipsychotic (long-acting injectable risperidone) in patients with schizophrenia...
  71. ncbi request reprint Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder
    John M Kane
    Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 63:763-71. 2002
    ..Aripiprazole is an investigational agent for treating schizophrenia that has a novel pharmacologic profile. The present study investigated the efficacy, safety, and tolerability of aripiprazole and haloperidol compared with placebo...
  72. pmc Antipsychotic polypharmacy: a survey study of prescriber attitudes, knowledge and behavior
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Schizophr Res 131:58-62. 2011
    ..Although common in psychiatric practice, reasons for antipsychotic polypharmacy (APP) have remained unclear...
  73. ncbi request reprint Genomics and the future of pharmacotherapy in psychiatry
    Anil K Malhotra
    Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Int Rev Psychiatry 19:523-30. 2007
    ..These increasingly comprehensive approaches should provide informative data on the genes associated with psychotropic drug response, a critical step towards the ultimate goal of 'personalized' medicine...
  74. ncbi request reprint Low-density lipoprotein cholesterol in patients treated with atypical antipsychotics: missed targets and lost opportunities
    Christoph U Correll
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Schizophr Res 92:103-7. 2007
    ..Lowering low-density lipoprotein-cholesterol (LDL-C) to individualized targets of 100, 130 or 160 mg/dl reduces the risk of CHD. We determined the prevalence of above-target LDL-C and its management during psychiatric hospitalization...
  75. ncbi request reprint Cost-effective screening for the metabolic syndrome in patients treated with second-generation antipsychotic medications
    David Straker
    Department of Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Am J Psychiatry 162:1217-21. 2005
    ..The authors' goal was to explore the relationship between second-generation antipsychotics and the metabolic syndrome...
  76. ncbi request reprint Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 159:1155-9. 2002
    ..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder...
  77. ncbi request reprint Metabolic effects of treatment with atypical antipsychotics
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 65:1447-55. 2004
  78. ncbi request reprint Utilization of long-acting antipsychotic medication in patient care
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, New York, NY, USA
    CNS Spectr 11:1-7; quiz 7-8. 2006
    ..Injectables and long-acting formulations of antipsychotics offer additional benefits in terms of ensuring treatment adherence...
  79. ncbi request reprint Commentary on the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE)
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, USA
    J Clin Psychiatry 67:831-2. 2006
  80. ncbi request reprint Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005
    ..These criteria should facilitate research and support a positive, longer-term approach to studying outcome in patients with schizophrenia...
  81. ncbi request reprint Treatment models and designs for intervention research during the psychotic prodrome
    John M Kane
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Schizophr Bull 29:747-56. 2003
    ..Finally, the methodology of completed and ongoing intervention trials in putative prodromal populations is discussed...
  82. ncbi request reprint PORT recommendations
    John M Kane
    Psychiatric Research, Long Island Jewish Hillside Medical Center, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Schizophr Bull 30:605-7. 2004
  83. ncbi request reprint Lithium treatment of acute mania in adolescents: a large open trial
    Vivian Kafantaris
    Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Am Acad Child Adolesc Psychiatry 42:1038-45. 2003
    ....
  84. doi request reprint Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Clin Psychopharmacol 30:106-15. 2010
    ..Post hoc analyses indicated that efficacy was similar with asenapine and haloperidol; greater contrasts were seen in AEs, especially extrapyramidal symptoms...
  85. ncbi request reprint Introduction. Ziprasidone in schizophrenia: from acute treatment to long-term management
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 64:3-5. 2003
  86. doi request reprint Strategies for making an accurate differential diagnosis of schizoaffective disorder
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, New York, USA
    J Clin Psychiatry 71:4-7. 2010
    ..Careful documentation of symptoms and recording of the basis for diagnosis are crucial so that the diagnosis can be reevaluated over time...
  87. ncbi request reprint Early prediction of antipsychotic response in schizophrenia
    Christoph U Correll
    Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:2063-5. 2003
    ..The authors' goal was to examine the predictive value of early symptom changes indicating response to antipsychotic medication in schizophrenia...
  88. pmc Unanswered questions in schizophrenia clinical trials
    John M Kane
    The Zucker Hillside Hospital, Glen Oaks, New York, NY, USA
    Schizophr Bull 34:302-9. 2008
  89. doi request reprint Clinical guideline recommendations for antipsychotic long-acting injections
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, 75 59 263 Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry Suppl 52:S63-7. 2009
    ..Long-acting injections (LAIs) of antipsychotic drugs were developed over 40 years ago in an attempt to improve the long-term treatment of schizophrenia...
  90. ncbi request reprint Sex differences in frontal lobe white matter microstructure: a DTI study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neuroreport 14:2469-73. 2003
    ..Our findings may be indicative of increased directional coherence and/or density of left hemisphere white matter fibers and a leftward asymmetry of this structural integrity among women compared to men...
  91. ncbi request reprint Relapse prevention in patients with schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 69:e11. 2008
    ..To help the patient achieve treatment goals, intervention strategies such as switching medications and implementing psychosocial therapies are considered...
  92. doi request reprint Creating a health care team to manage chronic medical illnesses in patients with severe mental illness: the public policy perspective
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 70:37-42. 2009
    ..Mental health providers should help improve the integration of primary care and mental health care and implement treatment strategies for changing modifiable health risk factors in their patients with severe mental illness...
  93. pmc Issues in psychopharmacology
    John M Kane
    The Zucker Hillside Hospital Glen Oaks, New York, NY, USA
    Schizophr Bull 34:258. 2008
  94. ncbi request reprint Impairments in perceptual competency and maintenance on a visual delayed match-to-sample test in first-episode schizophrenia
    Todd Lencz
    Department of Psychiatry, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Arch Gen Psychiatry 60:238-43. 2003
    ..It was hypothesized that patients in the first episode of schizophrenia would exhibit dissociable deficits in both WM domains...
  95. doi request reprint Long-term efficacy and safety of iloperidone: results from 3 clinical trials for the treatment of schizophrenia
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Clin Psychopharmacol 28:S29-35. 2008
    ..4 msec (haloperidol) at end point. Iloperidone demonstrated long-term efficacy equivalent to haloperidol and a favorable long-term safety profile, potentially making this agent a suitable option as maintenance therapy for schizophrenia...
  96. ncbi request reprint Pharmacological treatments for first-episode schizophrenia
    Delbert G Robinson
    Research Department, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Schizophr Bull 31:705-22. 2005
    ....
  97. ncbi request reprint Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital, Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 45:105-12. 2002
    ..Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression...
  98. pmc DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia
    Philip R Szeszko
    Feinstein Institute for Medical Research, Manhasset, NY, USA
    Biol Psychol 79:103-10. 2008
    ..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology...
  99. ncbi request reprint Linking the PANSS, BPRS, and CGI: clinical implications
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Munich, Munchen, Germany
    Neuropsychopharmacology 31:2318-25. 2006
    ..Clinicians seem to base CGI ratings on relative change rather than on absolute change of symptoms...
  100. ncbi request reprint The Mount Sinai conference on the pharmacotherapy of schizophrenia
    Stephen R Marder
    VA Desert Pacific Mental Illness Research Education and Clinical Center, West Los Angeles VA Health Care Center, CA 90073, USA
    Schizophr Bull 28:5-16. 2002
    ....
  101. ncbi request reprint Clinical predictors of response to clozapine treatment in ambulatory patients with schizophrenia
    Daniel S Umbricht
    Department of Psychiatric Research, Psychiatric University Hospital, Zurich, Switzerland
    J Clin Psychiatry 63:420-4. 2002
    ..Clinicians would be well served if clinical characteristics could be identified that predict a favorable response to clozapine. A few studies addressing this issue have reported inconsistent results...