Research Topics
Genomes and Genes
| Saijun FanSummaryAffiliation: Long Island Jewish Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Down-regulation of BRCA1 and BRCA2 in human ovarian cancer cells exposed to adriamycin and ultraviolet radiationS Fan
Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA
Int J Cancer 77:600-9. 1998..We speculate that the down-regulation of BRCA1 and BRCA2 may be part of a cellular survival response activated by certain forms of DNA damage...- Cellular effects of olomoucine in human lymphoma cells differing in p53 functionS Fan
Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
Chemotherapy 45:437-45. 1999..Therefore, our results give an impetus to continued research into olomoucine that might be a very useful chemotherapeutic strategy in the treatment of patients with mutant p53 tumors, at least in lymphoma patients... - Alcohol stimulates estrogen receptor signaling in human breast cancer cell linesS Fan
Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
Cancer Res 60:5635-9. 2000..Our findings suggest that inactivation of BRCA1 and increased estrogen-responsiveness might contribute to alcohol-induced breast cancer... - Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein bindingS Fan
Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270 05 76th Avenue, New Hyde Park, New York, NY 11040, USA
Oncogene 20:4827-41. 2001.... 
BRCA1 inhibition of telomerase activity in cultured cellsJingbo Xiong
Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
Mol Cell Biol 23:8668-90. 2003..Finally, endogenous BRCA1 and c-Myc were detected on transfected mouse and human TERT promoter segments in vivo. We postulate that inhibition of telomerase may contribute to the BRCA1 tumor suppressor activity...- p300 Modulates the BRCA1 inhibition of estrogen receptor activitySaijun Fan
Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
Cancer Res 62:141-51. 2002..They further suggest that the BRCA1 inhibition of ER-alpha activity may be attributable, at least in part, to the down-regulation of p300... - Role of BRCA1 in heat shock responseYong Xian Ma
Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
Oncogene 22:10-27. 2003..These findings suggest that in addition to its other functions, BRCA1 may participate in mammalian heat shock response pathways... - BRCA1 gene in breast cancerEliot M Rosen
Department of Radiation Oncology, Long Island Jewish Medical Center, New York, New York, USA
J Cell Physiol 196:19-41. 2003..Elucidation of the precise molecular functions of the BRCA1 gene product will greatly enhance our understanding of the pathogenesis of hereditary as well as sporadic mammary carcinogenesis... - Scatter factor mitigates HIV-1 gp120-induced human mesangial cell injuryAditi A Kapasi
Department of Medicine, Long Island Jewish Medical Center LIJMC, New Hyde Park, NY, USA
Nephron Exp Nephrol 103:e103-8. 2006..Nevertheless, SF attenuated the high-dose gp120-induced HMC apoptosis. Interestingly, gp120 at a low dose not only induced NF-kappaB activation but also increased p21(cip1/waf1) andp27(kip1) protein levels... - p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells: associated with alteration of TGF-beta and Smad signalingAditi A Kapasi
Division of Nephrology, Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus, Albert Einstein College of Medicine, New Hyde Park, NY, USA
Nephron Exp Nephrol 102:e30-8. 2006..In addition, HIV-1 gp120 results in phosphorylation of Smad2 and decreases c-Jun. These findings suggest that p300 acts as a potent transcriptional cofactor in HIV-1 gp120-induced apoptosis via TGF-beta and Smad signaling... - Structural determinants of the BRCA1 : estrogen receptor interactionYong Xian Ma
Department of Oncology, Lombardi Cancer Center, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20057, USA
Oncogene 24:1831-46. 2005..Based on these findings, a partial BRCA1 : ER-alpha three-dimensional structure is proposed. The implications of these findings for understanding the BRCA1 : ER-alpha interaction are discussed... - BRCA1 interaction with human papillomavirus oncoproteinsYiyu Zhang
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
J Biol Chem 280:33165-77. 2005..Finally, the ability of E6 and E7 to antagonize BRCA1 did not involve proteolytic degradation of BRCA1. These findings suggest functional interactions of BRCA1 with E7 and E6. The potential significance of these findings is discussed... - Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growthMaofu Fu
Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
Mol Cell Biol 23:8563-75. 2003..Thus, transcription factor acetylation regulates coactivator/corepressor complex binding, altering expression of specific growth control genes to promote aberrant cellular growth in vivo... - BRCA1 in hormone-responsive cancersEliot M Rosen
Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20057, USA
Trends Endocrinol Metab 14:378-85. 2003..Its expression is regulated by carcinogens and anticarcinogens that modulate ER alpha signaling, suggesting a molecular linkage between BRCA1 and hormone-responsive cancers... - BRCA1 regulates gene expression for orderly mitotic progressionInsoo Bae
Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
Cell Cycle 4:1641-66. 2005..Finally, BRCA1 knockdown caused the accumulation of multinucleated cells, suggesting a defect in cytokinesis. We conclude that BRCA1 regulates gene expression for orderly mitotic progression... - Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytesSvetlana Radaeva
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
Gastroenterology 122:1020-34. 2002..CONCLUSIONS: IFN-alpha directly targets human hepatocytes, followed by activation of multiple STATs and regulation of a wide variety of genes, which may contribute to the antiviral and antitumor activities of IFN-alpha in human liver... - BRCA1 regulation of transcriptionEliot M Rosen
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road, NW, Box 571469, Washington, DC 20057 1469, USA
Cancer Lett 236:175-85. 2006..This review will focus on how BRCA1 selectively regulates transcription and how this regulatory function may relate to tumor suppression... - The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cellsYongxian Ma
Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
Mol Endocrinol 20:14-34. 2006..These findings suggest that BRCA1 regulates the activity of progesterone, a major hormone of pregnancy that may also participate in mammary carcinogenesis... - Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activityChenguang Wang
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007, USA
Cancer Res 65:6557-67. 2005..As cyclin D1 abundance is regulated by oncogenic and mitogenic signals, the antagonism of the BRCA1-mediated ERalpha repression by cyclin D1 may contribute to the selective induction of BRCA1-regulated target genes... - Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinumYongxian Ma
Department of Oncology, Lombardi Comprehensive Cancer Center/Georgetown University, Washington, District of Columbia 20057-1469, USA
Anticancer Drugs 17:733-51. 2006.... - Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1Jingwen Xu
Department of Oncology, Lombardi Cancer Center, Georgetown University, 3970 Reservoir Road Northwest, Box 571469, Washington, D.C. 20057-1469, USA
Endocrinology 146:2031-47. 2005..Our findings suggest that BRCA1 globally inhibits the response to estrogen in a dose- and time-dependent fashion. The implications of these findings for understanding how BRCA1 may act to restrain E2 action in vivo are considered... - BRCA1 induces antioxidant gene expression and resistance to oxidative stressInsoo Bae
Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
Cancer Res 64:7893-909. 2004..These findings suggest a novel function for BRCA1, i.e., to protect cells against oxidative stress. This function would be consistent with the postulated role of BRCA1 as a caretaker gene in preserving genomic integrity... - ERR-10: a new repressor in transcriptional signaling activation of estrogen receptor-alphaQinghui Meng
Department of Oncology, Lombardi Compreshensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
FEBS Lett 576:190-200. 2004..Estrogen modulation of estrogen-responsive gene expression was markedly blocked by ERR-10. These results suggest that ERR-10 is a novel mediator in ER transcriptional activation... - Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathwaysBarbara Jaruga
Section on Liver Biology, NIAAA/NIH, Park Bldg. Rm. 120, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892, USA
Am J Physiol Gastrointest Liver Physiol 287:G471-9. 2004..Downregulation of the antiapoptotic STAT3 signal may also contribute to alcohol potentiation of T cell hepatitis... - Indole-3-carbinol is a negative regulator of estrogenKaren J Auborn
North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
J Nutr 133:2470S-2475S. 2003..Because of the synergistic effect of I3C and genistein, the potential exists for prophylactic or therapeutic efficacy of lower concentrations of each phytochemical when used in combination... - STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injuryWon Ho Kim
Section on Liver Biology, National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD 20892, USA
Am J Physiol Gastrointest Liver Physiol 285:G761-8. 2003..Taken together, these findings suggest that STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury... - Diindolylmethane alters gene expression in human keratinocytes in vitroTimothy H Carter
North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
J Nutr 132:3314-24. 2002.... - Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activityYongxian Ma
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C 20057 1469, USA
Mol Endocrinol 21:1905-23. 2007..These findings suggest that BRCA1 regulates Akt signaling and the PI3K/Akt pathway modulates the ability of BRCA1 to repress ER-alpha, in part through serine phosphorylation events in the activation function-1 domain of ER-alpha...