Saijun Fan

Summary

Affiliation: Long Island Jewish Medical Center
Country: USA

Publications

  1. ncbi Down-regulation of BRCA1 and BRCA2 in human ovarian cancer cells exposed to adriamycin and ultraviolet radiation
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA
    Int J Cancer 77:600-9. 1998
  2. ncbi Cellular effects of olomoucine in human lymphoma cells differing in p53 function
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
    Chemotherapy 45:437-45. 1999
  3. ncbi Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Cancer Res 60:5635-9. 2000
  4. ncbi Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270 05 76th Avenue, New Hyde Park, New York, NY 11040, USA
    Oncogene 20:4827-41. 2001
  5. pmc BRCA1 inhibition of telomerase activity in cultured cells
    Jingbo Xiong
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Mol Cell Biol 23:8668-90. 2003
  6. ncbi p300 Modulates the BRCA1 inhibition of estrogen receptor activity
    Saijun Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    Cancer Res 62:141-51. 2002
  7. ncbi Role of BRCA1 in heat shock response
    Yong Xian Ma
    Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Oncogene 22:10-27. 2003
  8. ncbi BRCA1 gene in breast cancer
    Eliot M Rosen
    Department of Radiation Oncology, Long Island Jewish Medical Center, New York, New York, USA
    J Cell Physiol 196:19-41. 2003
  9. ncbi Scatter factor mitigates HIV-1 gp120-induced human mesangial cell injury
    Aditi A Kapasi
    Department of Medicine, Long Island Jewish Medical Center LIJMC, New Hyde Park, NY, USA
    Nephron Exp Nephrol 103:e103-8. 2006
  10. ncbi p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells: associated with alteration of TGF-beta and Smad signaling
    Aditi A Kapasi
    Division of Nephrology, Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus, Albert Einstein College of Medicine, New Hyde Park, NY, USA
    Nephron Exp Nephrol 102:e30-8. 2006

Collaborators

  • Jingbo Xiong
  • R G Pestell
  • Suzanne A Fuqua
  • Paul Webb
  • B Gao
  • Eliot Rosen
  • Karen Auborn
  • Jian Wang
  • Yongxian Ma
  • Qinghui Meng
  • Aditi A Kapasi
  • Insoo Bae
  • Itzhak D Goldberg
  • Yong Xian Ma
  • Barbara Jaruga
  • Won Ho Kim
  • Yiyu Zhang
  • Jingwen Xu
  • Chenguang Wang
  • Maofu Fu
  • Feng Hong
  • Svetlana Radaeva
  • Changyan Hu
  • Pravin C Singhal
  • Pragati Katiyar
  • Zeguo Zhao
  • Ren Qi Yuan
  • Jeong Keun Rih
  • Hyo Jin Kang
  • Mahadev Rao
  • Chris Albanese
  • Timothy H Carter
  • Anna T Riegel
  • Laundette P Jones
  • John J Laterra
  • Priscilla A Furth
  • Benita S Katzenellenbogen
  • York Tomita
  • Zhiping Li
  • Alexander Kirilyuk
  • Hee Jeong Kim
  • Barbara Weber
  • Liang Nian Song
  • Richard Schlegel
  • Bassem Haddad
  • Peter J Kushner
  • Kongming Wu
  • Youzhi Tong
  • Michael P Lisanti
  • Maria L Avantaggiati
  • Lixin Zhou
  • Jiyou Li
  • Anil K Jaiswal
  • Gao Bin
  • Hee Jong Kim
  • Ming Yan
  • Christina Kitt
  • Rui Sun
  • Min Gao
  • Xueping Zhang
  • Chawnshang Chang
  • Toshiyuki Sakamaki
  • Selen Muratoglu
  • Steven Balk
  • Maria Laura Avantaggiati
  • Dolores Di Vizio
  • Jorma J Palvimo
  • Olli A Janne
  • DaZhi Chen
  • Osama El-Assal
  • Youhua Liu
  • Hongbo Cai
  • Stephen Strom
  • Kai Liu
  • Walter Ralph
  • Mei Qi
  • Fang Yuan

Detail Information

Publications28

  1. ncbi Down-regulation of BRCA1 and BRCA2 in human ovarian cancer cells exposed to adriamycin and ultraviolet radiation
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA
    Int J Cancer 77:600-9. 1998
    ..We speculate that the down-regulation of BRCA1 and BRCA2 may be part of a cellular survival response activated by certain forms of DNA damage...
  2. ncbi Cellular effects of olomoucine in human lymphoma cells differing in p53 function
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
    Chemotherapy 45:437-45. 1999
    ..Therefore, our results give an impetus to continued research into olomoucine that might be a very useful chemotherapeutic strategy in the treatment of patients with mutant p53 tumors, at least in lymphoma patients...
  3. ncbi Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Cancer Res 60:5635-9. 2000
    ..Our findings suggest that inactivation of BRCA1 and increased estrogen-responsiveness might contribute to alcohol-induced breast cancer...
  4. ncbi Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding
    S Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, 270 05 76th Avenue, New Hyde Park, New York, NY 11040, USA
    Oncogene 20:4827-41. 2001
    ....
  5. pmc BRCA1 inhibition of telomerase activity in cultured cells
    Jingbo Xiong
    Department of Radiation Oncology, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Mol Cell Biol 23:8668-90. 2003
    ..Finally, endogenous BRCA1 and c-Myc were detected on transfected mouse and human TERT promoter segments in vivo. We postulate that inhibition of telomerase may contribute to the BRCA1 tumor suppressor activity...
  6. ncbi p300 Modulates the BRCA1 inhibition of estrogen receptor activity
    Saijun Fan
    Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    Cancer Res 62:141-51. 2002
    ..They further suggest that the BRCA1 inhibition of ER-alpha activity may be attributable, at least in part, to the down-regulation of p300...
  7. ncbi Role of BRCA1 in heat shock response
    Yong Xian Ma
    Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Oncogene 22:10-27. 2003
    ..These findings suggest that in addition to its other functions, BRCA1 may participate in mammalian heat shock response pathways...
  8. ncbi BRCA1 gene in breast cancer
    Eliot M Rosen
    Department of Radiation Oncology, Long Island Jewish Medical Center, New York, New York, USA
    J Cell Physiol 196:19-41. 2003
    ..Elucidation of the precise molecular functions of the BRCA1 gene product will greatly enhance our understanding of the pathogenesis of hereditary as well as sporadic mammary carcinogenesis...
  9. ncbi Scatter factor mitigates HIV-1 gp120-induced human mesangial cell injury
    Aditi A Kapasi
    Department of Medicine, Long Island Jewish Medical Center LIJMC, New Hyde Park, NY, USA
    Nephron Exp Nephrol 103:e103-8. 2006
    ..Nevertheless, SF attenuated the high-dose gp120-induced HMC apoptosis. Interestingly, gp120 at a low dose not only induced NF-kappaB activation but also increased p21(cip1/waf1) andp27(kip1) protein levels...
  10. ncbi p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells: associated with alteration of TGF-beta and Smad signaling
    Aditi A Kapasi
    Division of Nephrology, Department of Medicine, Long Island Jewish Medical Center, The Long Island Campus, Albert Einstein College of Medicine, New Hyde Park, NY, USA
    Nephron Exp Nephrol 102:e30-8. 2006
    ..In addition, HIV-1 gp120 results in phosphorylation of Smad2 and decreases c-Jun. These findings suggest that p300 acts as a potent transcriptional cofactor in HIV-1 gp120-induced apoptosis via TGF-beta and Smad signaling...
  11. ncbi Structural determinants of the BRCA1 : estrogen receptor interaction
    Yong Xian Ma
    Department of Oncology, Lombardi Cancer Center, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20057, USA
    Oncogene 24:1831-46. 2005
    ..Based on these findings, a partial BRCA1 : ER-alpha three-dimensional structure is proposed. The implications of these findings for understanding the BRCA1 : ER-alpha interaction are discussed...
  12. ncbi BRCA1 interaction with human papillomavirus oncoproteins
    Yiyu Zhang
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
    J Biol Chem 280:33165-77. 2005
    ..Finally, the ability of E6 and E7 to antagonize BRCA1 did not involve proteolytic degradation of BRCA1. These findings suggest functional interactions of BRCA1 with E7 and E6. The potential significance of these findings is discussed...
  13. pmc Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth
    Maofu Fu
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    Mol Cell Biol 23:8563-75. 2003
    ..Thus, transcription factor acetylation regulates coactivator/corepressor complex binding, altering expression of specific growth control genes to promote aberrant cellular growth in vivo...
  14. ncbi BRCA1 in hormone-responsive cancers
    Eliot M Rosen
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20057, USA
    Trends Endocrinol Metab 14:378-85. 2003
    ..Its expression is regulated by carcinogens and anticarcinogens that modulate ER alpha signaling, suggesting a molecular linkage between BRCA1 and hormone-responsive cancers...
  15. ncbi BRCA1 regulates gene expression for orderly mitotic progression
    Insoo Bae
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
    Cell Cycle 4:1641-66. 2005
    ..Finally, BRCA1 knockdown caused the accumulation of multinucleated cells, suggesting a defect in cytokinesis. We conclude that BRCA1 regulates gene expression for orderly mitotic progression...
  16. ncbi Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes
    Svetlana Radaeva
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 122:1020-34. 2002
    ..Primary mouse and rat hepatocytes respond poorly to IFN-alpha stimulation. Thus, it is very important to examine the IFN-alpha signal pathway in primary human hepatocytes...
  17. ncbi BRCA1 regulation of transcription
    Eliot M Rosen
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road, NW, Box 571469, Washington, DC 20057 1469, USA
    Cancer Lett 236:175-85. 2006
    ..This review will focus on how BRCA1 selectively regulates transcription and how this regulatory function may relate to tumor suppression...
  18. ncbi The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells
    Yongxian Ma
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
    Mol Endocrinol 20:14-34. 2006
    ..These findings suggest that BRCA1 regulates the activity of progesterone, a major hormone of pregnancy that may also participate in mammary carcinogenesis...
  19. ncbi Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity
    Chenguang Wang
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007, USA
    Cancer Res 65:6557-67. 2005
    ..As cyclin D1 abundance is regulated by oncogenic and mitogenic signals, the antagonism of the BRCA1-mediated ERalpha repression by cyclin D1 may contribute to the selective induction of BRCA1-regulated target genes...
  20. ncbi Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum
    Yongxian Ma
    Department of Oncology, Lombardi Comprehensive Cancer Center Georgetown University, Washington, District of Columbia 20057 1469, USA
    Anticancer Drugs 17:733-51. 2006
    ....
  21. ncbi Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1
    Jingwen Xu
    Department of Oncology, Lombardi Cancer Center, Georgetown University, 3970 Reservoir Road Northwest, Box 571469, Washington, D C 20057 1469, USA
    Endocrinology 146:2031-47. 2005
    ..Our findings suggest that BRCA1 globally inhibits the response to estrogen in a dose- and time-dependent fashion. The implications of these findings for understanding how BRCA1 may act to restrain E2 action in vivo are considered...
  22. ncbi BRCA1 induces antioxidant gene expression and resistance to oxidative stress
    Insoo Bae
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
    Cancer Res 64:7893-909. 2004
    ..These findings suggest a novel function for BRCA1, i.e., to protect cells against oxidative stress. This function would be consistent with the postulated role of BRCA1 as a caretaker gene in preserving genomic integrity...
  23. ncbi ERR-10: a new repressor in transcriptional signaling activation of estrogen receptor-alpha
    Qinghui Meng
    Department of Oncology, Lombardi Compreshensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    FEBS Lett 576:190-200. 2004
    ..Estrogen modulation of estrogen-responsive gene expression was markedly blocked by ERR-10. These results suggest that ERR-10 is a novel mediator in ER transcriptional activation...
  24. ncbi Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways
    Barbara Jaruga
    Section on Liver Biology, NIAAA NIH, Park Bldg Rm 120, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 287:G471-9. 2004
    ..Downregulation of the antiapoptotic STAT3 signal may also contribute to alcohol potentiation of T cell hepatitis...
  25. ncbi Indole-3-carbinol is a negative regulator of estrogen
    Karen J Auborn
    North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Nutr 133:2470S-2475S. 2003
    ..Because of the synergistic effect of I3C and genistein, the potential exists for prophylactic or therapeutic efficacy of lower concentrations of each phytochemical when used in combination...
  26. ncbi STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury
    Won Ho Kim
    Section on Liver Biology, National Institute on Alcohol Abuse and Alcoholism National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 285:G761-8. 2003
    ..Taken together, these findings suggest that STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury...
  27. ncbi Diindolylmethane alters gene expression in human keratinocytes in vitro
    Timothy H Carter
    North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Nutr 132:3314-24. 2002
    ....
  28. ncbi Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity
    Yongxian Ma
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C 20057 1469, USA
    Mol Endocrinol 21:1905-23. 2007
    ..These findings suggest that BRCA1 regulates Akt signaling and the PI3K/Akt pathway modulates the ability of BRCA1 to repress ER-alpha, in part through serine phosphorylation events in the activation function-1 domain of ER-alpha...