C U Correll

..The presence and specificity of a bipolar prodrome remains questioned. We aimed to characterize the prodrome prior to a first psychotic and nonpsychotic mania and to examine the phenotypic proximity to the schizophrenia prodrome...

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..To provide an update on tardive dyskinesia rates in patients treated with first-generation or second-generation antipsychotics in studies published since the last systematic review in 2004...

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..This study compared the costs of antipsychotic polypharmacy for patients who initiated on 1 of the 3 most commonly prescribed atypical antipsychotics - olanzapine, quetiapine, or risperidone...

..This study assessed the annual rate and duration of antipsychotic monotherapy and its inverse, antipsychotic polypharmacy, among schizophrenia patients initiated on commonly used atypical antipsychotic medications...

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..The study was performed in patients receiving second-generation antipsychotics (SGAs), a medication class associated with CHD risk...

..7%). The presence of these subgroups, which require confirmation and extension regarding potentially identifiable biological markers, may help individualizing treatment in patients with schizophrenia...

..To describe and compare the relative merits of different identification strategies for individuals at risk for bipolar disorder (BPD)...

..Although common in psychiatric practice, reasons for antipsychotic polypharmacy (APP) have remained unclear...

..To review weight and metabolic effects of mood-stabilizing treatments in pediatric bipolar disorder...

..The aim of this study was to assess the 1-year risk of second-generation antipsychotics (SGAs) for tardive dyskinesia (TD) in children and adolescents with assumed minimal past exposure to first-generation antipsychotics...

..To compare antipsychotic and mood stabilizer (MS) efficacy and tolerability in youth and adults with bipolar mania...

..Cardiometabolic effects of second-generation antipsychotic medications are concerning but have not been sufficiently studied in pediatric and adolescent patients naive to antipsychotic medication...

..We compared bipolar disorder and schizophrenia patients receiving SGAs to determine whether MetS prevalence is influenced by the primary psychiatric diagnosis or concomitant mood stabilizer treatment...

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..To optimize outcomes, antipsychotic treatment should be pharmacologically informed and measurement based, combining both acute and long-term management goals and balancing efficacy and adverse effect considerations...

..A national cardiometabolic screening program for patients in a variety of public mental health facilities, group practices, and community behavioral health clinics was funded by Pfizer Inc. between 2005 and 2008...

..Despite lacking evidence for its safety and efficacy, antipsychotic cotreatment is common in schizophrenia. Objective: To evaluate therapeutic and adverse effects of antipsychotic cotreatment vs monotherapy in schizophrenia...

..Research is required to elucidate risk factors, mechanisms and best interventions for antipsychotic related adverse endocrine and metabolic effects in pediatric patients...

..These data, although inconclusive, contribute to clinicians' understanding of the etiology of the disorder. Further research may lead to an increased understanding of the disorder, improved treatment, and, ultimately, better outcomes...

..The aim of this study was to examine the characteristics and outcome of adolescents with psychotic disorder not otherwise specified (PsyNOS) and brief psychotic disorder (BrPsy), two neglected subsyndromal diagnostic entities...

..This hypothesis was examined in a systematic review of studies involving open or controlled treatment with any second-generation antipsychotic...

..While the research conducted to date has already yielded crucial information, the translation of the concept of a clinically identifiable PRS into clinical practice does not seem justified at this point...

..This article presents an overview of SGA-related side effects in children and adolescents and strategies to monitor health outcomes effectively in youngsters receiving SGAs...

..It is hoped that research on drug-specific biomarkers that can predict response in specific patient groups will advance personalized psychiatric care and improve patient outcomes...

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..Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications...

..To determine whether the coprescribing of two or more antipsychotics, a relatively frequent practice with little data to support its safety and efficacy, is associated with an increased prevalence of metabolic syndrome...

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..The authors' goal was to examine the predictive value of early symptom changes indicating response to antipsychotic medication in schizophrenia...

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..The authors' goal was to explore the relationship between second-generation antipsychotics and the metabolic syndrome...

..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...

..Despite increasing pediatric psychiatric emergency room service (PPERS) visits, data are lacking regarding visit characteristics and appropriateness...

..Combining antipsychotics is common practice in the treatment of schizophrenia. This study investigated aripiprazole adjunctive to risperidone or quetiapine for treating schizophrenia and schizoaffective disorder...

..Moreover, new treatment options are needed that affect nondopaminergic targets with relevance for symptom reduction, relapse prevention, enhanced efficacy for nonresponders, and reduced key adverse effects...

..We conclude that a neurodevelopmental model of schizophrenia is supported by our data and that a range of novel treatment strategies may be neuroprotective by directly affecting the disorder's vulnerability core...

..In conclusion, akathisia with aripiprazole occurred early in treatment, was mild-to-moderate in severity, led to few study discontinuations, and did not compromise therapeutic efficacy...

..The dimensional quantification of prodromal symptom severity may be an important direction for future studies of the assessment of at-risk states...

..Finally, the methodology of completed and ongoing intervention trials in putative prodromal populations is discussed...

..In the obese, the metabolic syndrome (MetS) is assumed to reflect insulin resistance...

..These increasingly comprehensive approaches should provide informative data on the genes associated with psychotropic drug response, a critical step towards the ultimate goal of 'personalized' medicine...

..We hypothesized: (1) risperidone would be associated with hyperprolactinemia most frequently, and (2) postpubertal females may be at higher risk of prolactin elevation and associated adverse effects...

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..This study reports the results of a prospective, naturalistic treatment study of adolescents considered to be in the prodromal (i.e., prepsychotic) phase of schizophrenia...

..Treatment regimens that include both pharmacotherapy and psychosocial interventions are needed to comprehensively treat children and adolescents with schizophrenia...

..To enhance power, future studies should pay close attention to population selection and avoidance/control of confounds, particularly past treatment exposure...

..Although stimulants have opposing dopamine receptor and adverse effects, it is unclear whether stimulant co-treatment counteracts the therapeutic or side effects of antipsychotics...

..Lowering low-density lipoprotein-cholesterol (LDL-C) to individualized targets of 100, 130 or 160 mg/dl reduces the risk of CHD. We determined the prevalence of above-target LDL-C and its management during psychiatric hospitalization...

..Clinicians may need to employ pharmacotherapeutic interventions such as reducing dosage, switching antipsychotics, or prescribing adjunctive agents to minimize or prevent these negative side effects and improve patients' outcomes...

..Polytherapy with atypical antipsychotics is becoming common, but the effect of this practice on the QTc has not been explored in detail...

..Antipsychotics with no or minimal cardiometabolic liability, as well as interventions that prevent or normalize adverse antipsychotic cardiometabolic effects are needed...

..The utility of the method is exemplified with the presentation of clinical data from patients receiving ziprasidone...

..Future research should focus on combining treatment modalities or agents and on exploring novel mechanism-based interventions...

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..The present study evaluated the effectiveness and safety of clozapine versus "high-dose" olanzapine in treatment-refractory adolescents with schizophrenia...

..The use of first- or second-generation antipsychotics for psychosis treatment, dosing guidelines, and the antipsychotic side-effect profile will also be addressed...

..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..