Matthew Schrag

Summary

Affiliation: Loma Linda University
Country: USA

Publications

  1. pmc Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    Prog Neurobiol 94:296-306. 2011
  2. pmc The effect of formalin fixation on the levels of brain transition metals in archived samples
    Matthew Schrag
    Neurosurgery Center for Research, Loma Linda University, 11175 Campus Street, Coleman Pavilion Suite 11113, Loma Linda, CA 92350, USA
    Biometals 23:1123-7. 2010
  3. pmc Assessing candidate serum biomarkers for Alzheimer's disease: a longitudinal study
    Matthew Zabel
    Neurosurgery Center for Research, Loma Linda University, Loma Linda, CA 92354, USA
    J Alzheimers Dis 30:311-21. 2012
  4. pmc Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Coleman Pavilion, Suite 11113, 11175 Campus St, Loma Linda, CA 92350, USA
    Acta Neuropathol 119:291-302. 2010
  5. pmc Altered serum iron and copper homeostasis predicts cognitive decline in mild cognitive impairment
    Claudius Mueller
    Neurosurgery Center for Research, Loma Linda University, Loma Linda, CA, USA
    J Alzheimers Dis 29:341-50. 2012
  6. ncbi request reprint Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer's disease
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    J Alzheimers Dis 24:137-49. 2011
  7. doi request reprint In vivo iron quantification in collagenase-induced microbleeds in rat brain
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 67:711-7. 2012
  8. pmc A shift in microglial β-amyloid binding in Alzheimer's disease is associated with cerebral amyloid angiopathy
    Matthew Zabel
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA 92354, USA
    Brain Pathol 23:390-401. 2013
  9. doi request reprint Targeted proteomics for quantification of histone acetylation in Alzheimer's disease
    Kangling Zhang
    Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Proteomics 12:1261-8. 2012
  10. doi request reprint Iron quantification of microbleeds in postmortem brain
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 65:1592-601. 2011

Collaborators

Detail Information

Publications15

  1. pmc Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    Prog Neurobiol 94:296-306. 2011
    ..29), copper was significantly depleted in AD (p=0.0003). In light of these findings, it will be important to re-evaluate the hypothesis that transition metal overload accounts for oxidative injury noted in AD...
  2. pmc The effect of formalin fixation on the levels of brain transition metals in archived samples
    Matthew Schrag
    Neurosurgery Center for Research, Loma Linda University, 11175 Campus Street, Coleman Pavilion Suite 11113, Loma Linda, CA 92350, USA
    Biometals 23:1123-7. 2010
    ..These results indicate that transition metal data obtained from fixed tissue may be heavily distorted and care should be taken in interpreting this data...
  3. pmc Assessing candidate serum biomarkers for Alzheimer's disease: a longitudinal study
    Matthew Zabel
    Neurosurgery Center for Research, Loma Linda University, Loma Linda, CA 92354, USA
    J Alzheimers Dis 30:311-21. 2012
    ..However, a more thorough assessment in longitudinal studies with higher statistical power is warranted...
  4. pmc Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Coleman Pavilion, Suite 11113, 11175 Campus St, Loma Linda, CA 92350, USA
    Acta Neuropathol 119:291-302. 2010
    ..Correlation of imaging findings to tissue pathology in our cases indicates that a variety of CAA-related pathologies produce MR-identified signal voids and further supports the use of SWI as a biomarker for this disease...
  5. pmc Altered serum iron and copper homeostasis predicts cognitive decline in mild cognitive impairment
    Claudius Mueller
    Neurosurgery Center for Research, Loma Linda University, Loma Linda, CA, USA
    J Alzheimers Dis 29:341-50. 2012
    ....
  6. ncbi request reprint Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer's disease
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    J Alzheimers Dis 24:137-49. 2011
    ..Together, these findings demonstrate that CAA is a significant variable affecting transition metals in AD...
  7. doi request reprint In vivo iron quantification in collagenase-induced microbleeds in rat brain
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 67:711-7. 2012
    ..Iron content estimation following BMB in an in vivo rodent model could shed light on the role and temporal evolution of iron-mediated tissue damage and efficacy of potential treatments in cerebrovascular diseases associated with BMB...
  8. pmc A shift in microglial β-amyloid binding in Alzheimer's disease is associated with cerebral amyloid angiopathy
    Matthew Zabel
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA 92354, USA
    Brain Pathol 23:390-401. 2013
    ....
  9. doi request reprint Targeted proteomics for quantification of histone acetylation in Alzheimer's disease
    Kangling Zhang
    Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Proteomics 12:1261-8. 2012
    ..With this methodology, we find that histone acetylation is significantly lower in AD temporal lobe than found in aged controls. Targeted proteomics warrants increased application for studying epigenetics of neurodegenerative diseases...
  10. doi request reprint Iron quantification of microbleeds in postmortem brain
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 65:1592-601. 2011
    ..Our methods potentially allows the calculation of brain iron load indices based on BMB iron content and classification of BMB by size unobscured by the blooming effect...
  11. doi request reprint Iron regulatory protein 2 is involved in brain copper homeostasis
    Claudius Mueller
    Neurosurgery Center for Research, Training and Education, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    J Alzheimers Dis 18:201-10. 2009
    ..05) and showed a trend toward upregulation in the thalamus (p < 0.1). This is the first study to demonstrate that iron regulatory proteins affect brain copper levels, which has significant implications for neurodegenerative diseases...
  12. pmc Serial susceptibility weighted MRI measures brain iron and microbleeds in dementia
    Wolff Kirsch
    Neurosurgery Center for Research, Training, and Education, Loma Linda University, 11175 Campus Street, Suite 11113, Loma Linda, CA 92350, USA
    J Alzheimers Dis 17:599-609. 2009
    ..06 (95% confidence interval 1.37-3.12)]. SWI is useful to measure regional iron changes and presence of BMB, both of which may be important MR-based biomarkers for neurodegenerative diseases...
  13. pmc The heme degradation pathway is a promising serum biomarker source for the early detection of Alzheimer's disease
    Claudius Mueller
    Loma Linda University School of Medicine, Loma Linda, CA, USA
    J Alzheimers Dis 19:1081-91. 2010
    ..These findings strongly implicate the heme degradation pathway as a promising source of protein biomarkers for the early detection of AD...
  14. pmc A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation
    Agus Darwanto
    Department of Basic Sciences, Biochemistry Division, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    J Biol Chem 285:21868-76. 2010
    ..Therefore, we propose that a catalytic and inhibitory loop mechanism may better describe the cross-talk relationship between H2B ubiquitination and H3 Lys-79 methylation...
  15. doi request reprint Quantification of punctate iron sources using magnetic resonance phase
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 63:106-15. 2010
    ..This research is a potential first step toward quantification of punctate brain iron sources such as brain microbleeds...