Andre Obenaus

Summary

Affiliation: Loma Linda University
Country: USA

Publications

  1. doi request reprint Drill hole defects: induction, imaging, and analysis in the rodent
    Andre Obenaus
    Non Invasive Imaging Laboratory, School of Medicine, Loma Linda University, Loma Linda, CA, USA
    Methods Mol Biol 690:301-14. 2011
  2. pmc Hyperbaric oxygen therapy for traumatic brain injury
    Lei Huang
    Department of Biophysics and Bioengineering, Loma Linda University, Griggs Hall, Room 227, 11065 Campus St, Loma Linda, California, 92354, USA
    Med Gas Res 1:21. 2011
  3. pmc Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury
    Andre Obenaus
    Department Radiation Medicine, Loma Linda University, CA, USA
    Ann Neurol 69:282-91. 2011
  4. pmc In vivo imaging demonstrates a time-line for new vessel formation in islet transplantation
    Eba Hathout
    Islet Transplant Laboratory, Department of Pediatrics, Radiation Medicine and Radiology, Loma Linda University, Loma Linda, CA 92354, USA
    Pediatr Transplant 13:892-7. 2009
  5. doi request reprint Brain irradiation improves focal cerebral ischemia recovery in aged rats
    Elena Titova
    Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Neurol Sci 306:143-53. 2011
  6. doi request reprint Monitoring neovascularization of intraportal islet grafts by dynamic contrast enhanced magnetic resonance imaging
    Nathaniel Chan
    Islet Transplant Laboratory, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA
    Islets 1:249-55. 2009
  7. pmc Bone marrow cell cotransplantation with islets improves their vascularization and function
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
    Transplantation 89:686-93. 2010
  8. pmc Hyperbaric oxygen therapy improves early posttransplant islet function
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Pediatr Diabetes 11:471-8. 2010
  9. doi request reprint Correlation between angiogenesis and islet graft function in diabetic mice: magnetic resonance imaging assessment
    Naoaki Sakata
    Islet Transplant Laboratory, Department of Pediatrics, Pediatric Diabetes Center, Loma Linda University School of Medicine, 11175 Campus Street, Coleman Pavilion, A1120R, Loma Linda, CA 92354, USA
    J Hepatobiliary Pancreat Sci 17:692-700. 2010
  10. doi request reprint (56)Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampus
    Roman Vlkolinsky
    Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    Radiat Res 169:523-30. 2008

Collaborators

Detail Information

Publications44

  1. doi request reprint Drill hole defects: induction, imaging, and analysis in the rodent
    Andre Obenaus
    Non Invasive Imaging Laboratory, School of Medicine, Loma Linda University, Loma Linda, CA, USA
    Methods Mol Biol 690:301-14. 2011
    ..Mastering this technique will allow testing of stem cell therapies, novel scaffold designs, and biomolecules that can be used for clinical translation...
  2. pmc Hyperbaric oxygen therapy for traumatic brain injury
    Lei Huang
    Department of Biophysics and Bioengineering, Loma Linda University, Griggs Hall, Room 227, 11065 Campus St, Loma Linda, California, 92354, USA
    Med Gas Res 1:21. 2011
    ..Thus HBOT may serve as a promising neuroprotective strategy that when combined with other therapeutic targets for TBI patients which could improve long-term outcomes...
  3. pmc Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury
    Andre Obenaus
    Department Radiation Medicine, Loma Linda University, CA, USA
    Ann Neurol 69:282-91. 2011
    ....
  4. pmc In vivo imaging demonstrates a time-line for new vessel formation in islet transplantation
    Eba Hathout
    Islet Transplant Laboratory, Department of Pediatrics, Radiation Medicine and Radiology, Loma Linda University, Loma Linda, CA 92354, USA
    Pediatr Transplant 13:892-7. 2009
    ..We anticipate that contrast extravasation captured by MRI may provide useful monitoring of graft angiogenesis if reproduced in a clinically relevant intraportal model...
  5. doi request reprint Brain irradiation improves focal cerebral ischemia recovery in aged rats
    Elena Titova
    Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Neurol Sci 306:143-53. 2011
    ..We hypothesized that in aged rats a single brain-only exposure to a low radiation dose prior to focal brain ischemia would reduce glial proliferation and confer a long-term neuroprotective effect...
  6. doi request reprint Monitoring neovascularization of intraportal islet grafts by dynamic contrast enhanced magnetic resonance imaging
    Nathaniel Chan
    Islet Transplant Laboratory, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA
    Islets 1:249-55. 2009
    ..To our knowledge, these results are the first to demonstrate using a FDA approved contrast agent that DCE MRI can effectively and non-invasively monitor the progression of angiogenesis in intraportal islet grafts...
  7. pmc Bone marrow cell cotransplantation with islets improves their vascularization and function
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
    Transplantation 89:686-93. 2010
    ..CONCLUSIONS.: Cotransplantation of bone marrow cells with islets is associated with enhanced islet graft vascularization and function...
  8. pmc Hyperbaric oxygen therapy improves early posttransplant islet function
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Pediatr Diabetes 11:471-8. 2010
    ..This study investigates the therapeutic potential of hyperbaric oxygen therapy (HBO) in reducing hypoxia and improving engraftment of intraportal islet transplants by promoting angiogenesis...
  9. doi request reprint Correlation between angiogenesis and islet graft function in diabetic mice: magnetic resonance imaging assessment
    Naoaki Sakata
    Islet Transplant Laboratory, Department of Pediatrics, Pediatric Diabetes Center, Loma Linda University School of Medicine, 11175 Campus Street, Coleman Pavilion, A1120R, Loma Linda, CA 92354, USA
    J Hepatobiliary Pancreat Sci 17:692-700. 2010
    ..We examined the relationship between DCE-MRI and metabolic parameters such as blood glucose, serum insulin and glucose tolerance test (GTT) after intraportal islet transplantation...
  10. doi request reprint (56)Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampus
    Roman Vlkolinsky
    Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    Radiat Res 169:523-30. 2008
    ..Our data show that (56)Fe-particle radiation affects the response of the hippocampus to an immunological stressor and that the alterations progress over time...
  11. doi request reprint In vivo iron quantification in collagenase-induced microbleeds in rat brain
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 67:711-7. 2012
    ..Iron content estimation following BMB in an in vivo rodent model could shed light on the role and temporal evolution of iron-mediated tissue damage and efficacy of potential treatments in cerebrovascular diseases associated with BMB...
  12. doi request reprint Neuroimaging assessment of memory-related brain structures in a rat model of acute space-like radiation
    Lei Huang
    Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, California, USA
    J Magn Reson Imaging 29:785-92. 2009
    ..To investigate the acute effects on the central nervous system (CNS) of (56)Fe radiation, a component of high-energy charged particles (HZE) in space radiation, using quantitative magnetic resonance imaging (MRI) noninvasively...
  13. doi request reprint Diffusion-weighted imaging improves outcome prediction in pediatric traumatic brain injury
    Nicholas R Galloway
    Department of Radiation Medicine, Loma Linda University, Loma Linda, California 92354, USA
    J Neurotrauma 25:1153-62. 2008
    ..Early identification of children at high risk for poor outcome may assist in aggressive clinical management of pediatric TBI patients...
  14. doi request reprint Dynamic characteristics of 56Fe-particle radiation-induced alterations in the rat brain: magnetic resonance imaging and histological assessments
    Lei Huang
    Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Radiat Res 173:729-37. 2010
    ..The apparent diffusion coefficient appears to be a sensitive metric to reveal ongoing tissue modifications involving multiple cellular components in vivo...
  15. doi request reprint Factors affecting islet graft embolization in the liver of diabetic mice
    Naoki Sakata
    Islet Transplant Laboratory, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA
    Islets 1:26-33. 2009
    ..In this study, we examined the location of islets as well as the correlation between islet and portal vein size after intraportal islet transplantation, and evaluated liver and islet pathology...
  16. pmc Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference
    Jerome Badaut
    Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    J Cereb Blood Flow Metab 31:819-31. 2011
    ..These findings have major clinical relevance as they suggest that imaging changes seen in acute neurologic disorders such as stroke and trauma are in part due to changes in tissue AQP4 levels...
  17. pmc MRI assessment of ischemic liver after intraportal islet transplantation
    Naoaki Sakata
    Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
    Transplantation 87:825-30. 2009
    ..The resultant ischemia causes necrosis or apoptosis of cells within the liver. Thus, noninvasive assessment of the liver receiving the islet transplant is important to evaluate the status islet grafts...
  18. pmc Automated core-penumbra quantification in neonatal ischemic brain injury
    Nirmalya Ghosh
    Department of Pediatrics, Loma Linda University, Loma Linda, California 92350, USA
    J Cereb Blood Flow Metab 32:2161-70. 2012
    ....
  19. pmc Traumatic brain injury in young rats leads to progressive behavioral deficits coincident with altered tissue properties in adulthood
    David O Ajao
    Department of Physiology, Loma Linda University, Loma Linda, California, USA
    J Neurotrauma 29:2060-74. 2012
    ....
  20. doi request reprint Effects of hemodilution after traumatic brain injury in juvenile rats
    Gianluca Bertolizio
    Department of Anesthesiology, Loma Linda University, Loma Linda, CA 92354, USA
    Paediatr Anaesth 21:1198-208. 2011
    ..Similar studies in juvenile rats have not been reported and outcomes are likely to be different. This study investigated the effects of normovolemic hemodilution (21% hematocrit) in a juvenile TBI (jTBI) model...
  21. ncbi request reprint Matrix metalloproteinase inhibition attenuates brain edema after surgical brain injury
    Vikram Jadhav
    Department of Physiology and Pharmacology, Loma Linda University, RH 228, 11041 Campus Street, Loma Linda, CA, USA
    Acta Neurochir Suppl 102:357-61. 2008
    ..This surgical brain injury (SBI) can cause post-operative complications such as brain edema following blood-brain barrier (BBB) disruption leading to neurological deficits...
  22. doi request reprint Rodent neonatal bilateral carotid artery occlusion with hypoxia mimics human hypoxic-ischemic injury
    Rebecca Recker
    Department of Pediatrics, School of Medicine, Loma Linda University Medical Center, Loma Linda, California 92354, USA
    J Cereb Blood Flow Metab 29:1305-16. 2009
    ..This model can produce graded injury severity, similar to that seen in human neonates, but manipulation with hypoxia duration is unpredictable...
  23. doi request reprint Tissue vulnerability is increased following repetitive mild traumatic brain injury in the rat
    Lei Huang
    Department of Anesthesiology, Loma Linda University, 11234 Anderson Street, Loma Linda, CA 92354, USA
    Brain Res 1499:109-20. 2013
    ..Collectively, our findings suggest that the mildly-impacted brain is more vulnerable to repetitive injury when delivered within 3 days following initial mTBI...
  24. pmc The vascular neural network--a new paradigm in stroke pathophysiology
    John H Zhang
    Department of Neurosurgery, Loma Linda University School of Medicine, 11130 Anderson Street, Loma Linda, CA 92354, USA
    Nat Rev Neurol 8:711-6. 2012
    ..The authors also propose that the vascular neural network should be considered the main target for future therapeutic intervention after cerebrovascular insult...
  25. doi request reprint Iron quantification of microbleeds in postmortem brain
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 65:1592-601. 2011
    ..Our methods potentially allows the calculation of brain iron load indices based on BMB iron content and classification of BMB by size unobscured by the blooming effect...
  26. doi request reprint Automated ischemic lesion detection in a neonatal model of hypoxic ischemic injury
    Nirmalya Ghosh
    Department of Pediatrics, Loma Linda University, Loma Linda, CA, USA
    J Magn Reson Imaging 33:772-81. 2011
    ....
  27. doi request reprint Neuroimaging as a basis for rational stem cell therapy
    Stephen Ashwal
    Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
    Pediatr Neurol 40:227-36. 2009
    ....
  28. ncbi request reprint Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke
    Rong Wang
    Department of Radiation Medicine, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Pediatr Res 62:261-6. 2007
    ..The reasons why albumin was not neuroprotective in neonatal stroke compared with adults remain uncertain. Effective strategies in adult models need to be reassessed in the neonate...
  29. pmc Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury
    Wanqiu Chen
    Department of Physiology, Loma Linda University, Loma Linda, CA 92354, USA
    Exp Neurol 216:7-15. 2009
    ..However, a better understanding of multifaceted HIF-1 function during brain development is required to explore potential targets for further therapeutic interventions in the neonate...
  30. doi request reprint Meta-analysis of apparent diffusion coefficients in the newborn brain
    Jacqueline S Coats
    Department of Pediatrics, Loma Linda University, Loma Linda, California
    Pediatr Neurol 41:263-74. 2009
    ..This meta-analysis provides the basis for normative apparent diffusion coefficient values in the newborn brain...
  31. pmc Magnetic resonance imaging detects and predicts early brain injury after subarachnoid hemorrhage in a canine experimental model
    Vikram Jadhav
    Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
    J Neurotrauma 25:1099-106. 2008
    ..MR can also predict tissue histopathology and may be useful for assessing pharmacological treatments designed to ameliorate SAH...
  32. doi request reprint The role of morphine in a rat model of hypoxic-ischemic injury
    Ara Festekjian
    Department of Emergency Medicine, Division of Pediatric Emergency Medicine, Loma Linda University Children s Hospital, Loma Linda, California, USA
    Pediatr Neurol 45:77-82. 2011
    ..Morphine was ineffective as a neuroprotectant in rat pups with severe hypoxic-ischemic injury and may have contributed to their decreased survival...
  33. ncbi request reprint Effects of lipopolysaccharide on 56Fe-particle radiation-induced impairment of synaptic plasticity in the mouse hippocampus
    Roman Vlkolinsky
    Department of Radiation Medicine, Loma Linda University, Loma Linda, California 92354, USA
    Radiat Res 168:462-70. 2007
    ..Our results indicate that HZE-particle radiation alters normal electrophysiological properties of the CNS and the hippocampal response to LPS...
  34. ncbi request reprint Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury
    Mitsuo Yamaguchi
    Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, California 92354, USA
    Neurosurgery 61:1067-75; discussion 1075-6. 2007
    ..The present study seeks to test a matrix metalloproteinase (MMP) inhibitor for preventing postoperative brain edema and BBB disruption in an in vivo model of surgically-induced brain injury...
  35. doi request reprint Magnetic resonance imaging in cerebral ischemia: focus on neonates
    Andre Obenaus
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    Neuropharmacology 55:271-80. 2008
    ..We review the clinical basis of imaging for stroke and ischemia diagnosis and the methods for post-processing of MR data that could provide novel insights into the evolution and pathophysiology of stroke in the newborn...
  36. ncbi request reprint Magnetic resonance imaging of functional anatomy: use for small animal epilepsy models
    Andre Obenaus
    Non Invasive Imaging Laboratory, Radiation Medicine Department, Loma Linda University, Loma Linda, California 92354, USA
    Epilepsia 48:11-7. 2007
    ..These two diverse MRI methods can be applied to animal models to provide important information about the functional status of anatomical regions that may be altered by epilepsy...
  37. pmc Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke
    Nicolas G Bazan
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Neurol 236:122-30. 2012
    ..In addition, administration of synthetic AT-NPD1, in either its sodium salt or as the methyl ester, was able to attenuate cerebral ischemic injury which leads to a novel approach for pharmaceutical intervention and clinical translation...
  38. doi request reprint Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Int J Radiat Biol 84:549-59. 2008
    ..To assess the long-term consequences of high-linear energy transfer (LET) iron ion radiation on immune and other critical body systems in the context of assessing potential effects astronauts may experience during exploratory missions...
  39. pmc In vivo magnetic resonance imaging of vascularization in islet transplantation
    Eba Hathout
    Islet Transplant Laboratory, Department of Pediatrics, Loma Linda University School of Medicine, CA, USA
    Transpl Int 20:1059-65. 2007
    ..This technique may be useful in developing pro-angiogenic strategies to improve the transplantation outcome in experimental and clinical settings...
  40. ncbi request reprint Comparison of two neonatal ischemic injury models using magnetic resonance imaging
    Stephen Ashwal
    Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92320, USA
    Pediatr Res 61:9-14. 2007
    ....
  41. doi request reprint Quantification of punctate iron sources using magnetic resonance phase
    Grant McAuley
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
    Magn Reson Med 63:106-15. 2010
    ..This research is a potential first step toward quantification of punctate brain iron sources such as brain microbleeds...
  42. ncbi request reprint Multi-modal magnetic resonance imaging alterations in two rat models of mild neurotrauma
    Andre Obenaus
    Department of Radiation Medicine, Loma Linda University, Loma Linda, California 92354, USA
    J Neurotrauma 24:1147-60. 2007
    ..In summary, traumatic brain injury is less severe in mild CCI than FPI, based on the temporal events assessed with MRI...
  43. ncbi request reprint Cell-permeant calcium buffer induced neuroprotection after cortical devascularization
    Brenda L Bartnik
    Department of Radiation Medicine, Loma Linda University, Radiobiology Program CSP A1010, Loma Linda, CA 92354, USA
    Exp Neurol 192:357-64. 2005
    ..Tissue analysis showed that APTRA-AM significantly reduced the infarct size by 85% and extent of inflammatory cell infiltration by 94%. The results clearly demonstrate significant neuroprotection by APTRA-AM when given after injury...
  44. pmc Neuroprotection against surgically induced brain injury
    Vikram Jadhav
    Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Surg Neurol 67:15-20; discussion 20. 2007
    ..Brain tissue at the periphery of the operative site is at risk of injury by various means, including incisions and direct trauma, electrocautery, hemorrhage, and retractor stretch...