Research Topics
| Andre ObenausSummaryAffiliation: Loma Linda University Country: USA Publications
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Detail Information
Publications
Drill hole defects: induction, imaging, and analysis in the rodentAndre Obenaus
Non Invasive Imaging Laboratory, School of Medicine, Loma Linda University, Loma Linda, CA, USA
Methods Mol Biol 690:301-14. 2011..Mastering this technique will allow testing of stem cell therapies, novel scaffold designs, and biomolecules that can be used for clinical translation...
Hyperbaric oxygen therapy for traumatic brain injuryLei Huang
Department of Biophysics and Bioengineering, Loma Linda University, Griggs Hall, Room 227, 11065 Campus St, Loma Linda, California, 92354, USA
Med Gas Res 1:21. 2011..Thus HBOT may serve as a promising neuroprotective strategy that when combined with other therapeutic targets for TBI patients which could improve long-term outcomes...- Long-term magnetic resonance imaging of stem cells in neonatal ischemic injuryAndre Obenaus
Department Radiation Medicine, Loma Linda University, CA, USA
Ann Neurol 69:282-91. 2011.... - In vivo imaging demonstrates a time-line for new vessel formation in islet transplantationEba Hathout
Islet Transplant Laboratory, Department of Pediatrics, Radiation Medicine and Radiology, Loma Linda University, Loma Linda, CA 92354, USA
Pediatr Transplant 13:892-7. 2009..We anticipate that contrast extravasation captured by MRI may provide useful monitoring of graft angiogenesis if reproduced in a clinically relevant intraportal model... - Brain irradiation improves focal cerebral ischemia recovery in aged ratsElena Titova
Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
J Neurol Sci 306:143-53. 2011..We hypothesized that in aged rats a single brain-only exposure to a low radiation dose prior to focal brain ischemia would reduce glial proliferation and confer a long-term neuroprotective effect... - Monitoring neovascularization of intraportal islet grafts by dynamic contrast enhanced magnetic resonance imagingNathaniel Chan
Islet Transplant Laboratory, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA
Islets 1:249-55. 2009..To our knowledge, these results are the first to demonstrate using a FDA approved contrast agent that DCE MRI can effectively and non-invasively monitor the progression of angiogenesis in intraportal islet grafts... - Bone marrow cell cotransplantation with islets improves their vascularization and functionNaoaki Sakata
Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
Transplantation 89:686-93. 2010..CONCLUSIONS.: Cotransplantation of bone marrow cells with islets is associated with enhanced islet graft vascularization and function... - Hyperbaric oxygen therapy improves early posttransplant islet functionNaoaki Sakata
Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
Pediatr Diabetes 11:471-8. 2010..This study investigates the therapeutic potential of hyperbaric oxygen therapy (HBO) in reducing hypoxia and improving engraftment of intraportal islet transplants by promoting angiogenesis... - Correlation between angiogenesis and islet graft function in diabetic mice: magnetic resonance imaging assessmentNaoaki Sakata
Islet Transplant Laboratory, Department of Pediatrics, Pediatric Diabetes Center, Loma Linda University School of Medicine, 11175 Campus Street, Coleman Pavilion, A1120R, Loma Linda, CA 92354, USA
J Hepatobiliary Pancreat Sci 17:692-700. 2010..We examined the relationship between DCE-MRI and metabolic parameters such as blood glucose, serum insulin and glucose tolerance test (GTT) after intraportal islet transplantation... - (56)Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampusRoman Vlkolinsky
Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
Radiat Res 169:523-30. 2008..Our data show that (56)Fe-particle radiation affects the response of the hippocampus to an immunological stressor and that the alterations progress over time... - In vivo iron quantification in collagenase-induced microbleeds in rat brainGrant McAuley
Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
Magn Reson Med 67:711-7. 2012..Iron content estimation following BMB in an in vivo rodent model could shed light on the role and temporal evolution of iron-mediated tissue damage and efficacy of potential treatments in cerebrovascular diseases associated with BMB... - Neuroimaging assessment of memory-related brain structures in a rat model of acute space-like radiationLei Huang
Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, California, USA
J Magn Reson Imaging 29:785-92. 2009..To investigate the acute effects on the central nervous system (CNS) of (56)Fe radiation, a component of high-energy charged particles (HZE) in space radiation, using quantitative magnetic resonance imaging (MRI) noninvasively... - Diffusion-weighted imaging improves outcome prediction in pediatric traumatic brain injuryNicholas R Galloway
Department of Radiation Medicine, Loma Linda University, Loma Linda, California 92354, USA
J Neurotrauma 25:1153-62. 2008..Early identification of children at high risk for poor outcome may assist in aggressive clinical management of pediatric TBI patients... - Dynamic characteristics of 56Fe-particle radiation-induced alterations in the rat brain: magnetic resonance imaging and histological assessmentsLei Huang
Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
Radiat Res 173:729-37. 2010..The apparent diffusion coefficient appears to be a sensitive metric to reveal ongoing tissue modifications involving multiple cellular components in vivo... - Factors affecting islet graft embolization in the liver of diabetic miceNaoki Sakata
Islet Transplant Laboratory, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA
Islets 1:26-33. 2009..In this study, we examined the location of islets as well as the correlation between islet and portal vein size after intraportal islet transplantation, and evaluated liver and islet pathology... - Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interferenceJerome Badaut
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
J Cereb Blood Flow Metab 31:819-31. 2011..These findings have major clinical relevance as they suggest that imaging changes seen in acute neurologic disorders such as stroke and trauma are in part due to changes in tissue AQP4 levels... - MRI assessment of ischemic liver after intraportal islet transplantationNaoaki Sakata
Department of Pediatrics, Islet Transplant Laboratory, Loma Linda University School of Medicine, CA, USA
Transplantation 87:825-30. 2009..The resultant ischemia causes necrosis or apoptosis of cells within the liver. Thus, noninvasive assessment of the liver receiving the islet transplant is important to evaluate the status islet grafts... - Automated core-penumbra quantification in neonatal ischemic brain injuryNirmalya Ghosh
Department of Pediatrics, Loma Linda University, Loma Linda, California 92350, USA
J Cereb Blood Flow Metab 32:2161-70. 2012.... - Traumatic brain injury in young rats leads to progressive behavioral deficits coincident with altered tissue properties in adulthoodDavid O Ajao
Department of Physiology, Loma Linda University, Loma Linda, California, USA
J Neurotrauma 29:2060-74. 2012.... - Effects of hemodilution after traumatic brain injury in juvenile ratsGianluca Bertolizio
Department of Anesthesiology, Loma Linda University, Loma Linda, CA 92354, USA
Paediatr Anaesth 21:1198-208. 2011..Similar studies in juvenile rats have not been reported and outcomes are likely to be different. This study investigated the effects of normovolemic hemodilution (21% hematocrit) in a juvenile TBI (jTBI) model... 
Matrix metalloproteinase inhibition attenuates brain edema after surgical brain injuryVikram Jadhav
Department of Physiology and Pharmacology, Loma Linda University, RH 228, 11041 Campus Street, Loma Linda, CA, USA
Acta Neurochir Suppl 102:357-61. 2008..This surgical brain injury (SBI) can cause post-operative complications such as brain edema following blood-brain barrier (BBB) disruption leading to neurological deficits...- Rodent neonatal bilateral carotid artery occlusion with hypoxia mimics human hypoxic-ischemic injuryRebecca Recker
Department of Pediatrics, School of Medicine, Loma Linda University Medical Center, Loma Linda, California 92354, USA
J Cereb Blood Flow Metab 29:1305-16. 2009..This model can produce graded injury severity, similar to that seen in human neonates, but manipulation with hypoxia duration is unpredictable... - Automated ischemic lesion detection in a neonatal model of hypoxic ischemic injuryNirmalya Ghosh
Department of Pediatrics, Loma Linda University, Loma Linda, CA, USA
J Magn Reson Imaging 33:772-81. 2011.... - Iron quantification of microbleeds in postmortem brainGrant McAuley
Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
Magn Reson Med 65:1592-601. 2011..Our methods potentially allows the calculation of brain iron load indices based on BMB iron content and classification of BMB by size unobscured by the blooming effect... - The vascular neural network--a new paradigm in stroke pathophysiologyJohn H Zhang
Department of Neurosurgery, Loma Linda University School of Medicine, 11130 Anderson Street, Loma Linda, CA 92354, USA
Nat Rev Neurol 8:711-6. 2012..The authors also propose that the vascular neural network should be considered the main target for future therapeutic intervention after cerebrovascular insult... - Neuroimaging as a basis for rational stem cell therapyStephen Ashwal
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
Pediatr Neurol 40:227-36. 2009.... - Magnetic resonance imaging detects and predicts early brain injury after subarachnoid hemorrhage in a canine experimental modelVikram Jadhav
Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California 92354, USA
J Neurotrauma 25:1099-106. 2008..MR can also predict tissue histopathology and may be useful for assessing pharmacological treatments designed to ameliorate SAH... - Meta-analysis of apparent diffusion coefficients in the newborn brainJacqueline S Coats
Department of Pediatrics, Loma Linda University, Loma Linda, California
Pediatr Neurol 41:263-74. 2009..This meta-analysis provides the basis for normative apparent diffusion coefficient values in the newborn brain... - Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injuryWanqiu Chen
Department of Physiology, Loma Linda University, Loma Linda, CA 92354, USA
Exp Neurol 216:7-15. 2009..However, a better understanding of multifaceted HIF-1 function during brain development is required to explore potential targets for further therapeutic interventions in the neonate... - Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal strokeRong Wang
Department of Radiation Medicine, Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
Pediatr Res 62:261-6. 2007..The reasons why albumin was not neuroprotective in neonatal stroke compared with adults remain uncertain. Effective strategies in adult models need to be reassessed in the neonate... - Tissue vulnerability is increased following repetitive mild traumatic brain injury in the ratLei Huang
Department of Anesthesiology, Loma Linda University, 11234 Anderson Street, Loma Linda, CA 92354, USA
Brain Res 1499:109-20. 2013..Collectively, our findings suggest that the mildly-impacted brain is more vulnerable to repetitive injury when delivered within 3 days following initial mTBI... - The role of morphine in a rat model of hypoxic-ischemic injuryAra Festekjian
Department of Emergency Medicine, Division of Pediatric Emergency Medicine, Loma Linda University Children s Hospital, Loma Linda, California, USA
Pediatr Neurol 45:77-82. 2011..Morphine was ineffective as a neuroprotectant in rat pups with severe hypoxic-ischemic injury and may have contributed to their decreased survival... - Effects of lipopolysaccharide on 56Fe-particle radiation-induced impairment of synaptic plasticity in the mouse hippocampusRoman Vlkolinsky
Department of Radiation Medicine, Loma Linda University, Loma Linda, California 92354, USA
Radiat Res 168:462-70. 2007..Our results indicate that HZE-particle radiation alters normal electrophysiological properties of the CNS and the hippocampal response to LPS... - Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injuryMitsuo Yamaguchi
Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, California 92354, USA
Neurosurgery 61:1067-75; discussion 1075-6. 2007..The present study seeks to test a matrix metalloproteinase (MMP) inhibitor for preventing postoperative brain edema and BBB disruption in an in vivo model of surgically-induced brain injury... - Magnetic resonance imaging in cerebral ischemia: focus on neonatesAndre Obenaus
Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
Neuropharmacology 55:271-80. 2008..We review the clinical basis of imaging for stroke and ischemia diagnosis and the methods for post-processing of MR data that could provide novel insights into the evolution and pathophysiology of stroke in the newborn... - Magnetic resonance imaging of functional anatomy: use for small animal epilepsy modelsAndre Obenaus
Non Invasive Imaging Laboratory, Radiation Medicine Department, Loma Linda University, Loma Linda, California 92354, USA
Epilepsia 48:11-7. 2007..These two diverse MRI methods can be applied to animal models to provide important information about the functional status of anatomical regions that may be altered by epilepsy... - Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental strokeNicolas G Bazan
Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Exp Neurol 236:122-30. 2012..In addition, administration of synthetic AT-NPD1, in either its sodium salt or as the methyl ester, was able to attenuate cerebral ischemic injury which leads to a novel approach for pharmaceutical intervention and clinical translation... - Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiationDaila S Gridley
Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
Int J Radiat Biol 84:549-59. 2008..To assess the long-term consequences of high-linear energy transfer (LET) iron ion radiation on immune and other critical body systems in the context of assessing potential effects astronauts may experience during exploratory missions... - Comparison of two neonatal ischemic injury models using magnetic resonance imagingStephen Ashwal
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92320, USA
Pediatr Res 61:9-14. 2007.... - Quantification of punctate iron sources using magnetic resonance phaseGrant McAuley
Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California 92354, USA
Magn Reson Med 63:106-15. 2010..This research is a potential first step toward quantification of punctate brain iron sources such as brain microbleeds... - In vivo magnetic resonance imaging of vascularization in islet transplantationEba Hathout
Islet Transplant Laboratory, Department of Pediatrics, Loma Linda University School of Medicine, CA, USA
Transpl Int 20:1059-65. 2007..This technique may be useful in developing pro-angiogenic strategies to improve the transplantation outcome in experimental and clinical settings... - Multi-modal magnetic resonance imaging alterations in two rat models of mild neurotraumaAndre Obenaus
Department of Radiation Medicine, Loma Linda University, Loma Linda, California 92354, USA
J Neurotrauma 24:1147-60. 2007..In summary, traumatic brain injury is less severe in mild CCI than FPI, based on the temporal events assessed with MRI... - Neuroprotection against surgically induced brain injuryVikram Jadhav
Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
Surg Neurol 67:15-20; discussion 20. 2007..Brain tissue at the periphery of the operative site is at risk of injury by various means, including incisions and direct trauma, electrocautery, hemorrhage, and retractor stretch... - Cell-permeant calcium buffer induced neuroprotection after cortical devascularizationBrenda L Bartnik
Department of Radiation Medicine, Loma Linda University, Radiobiology Program CSP A1010, Loma Linda, CA 92354, USA
Exp Neurol 192:357-64. 2005..Tissue analysis showed that APTRA-AM significantly reduced the infarct size by 85% and extent of inflammatory cell infiltration by 94%. The results clearly demonstrate significant neuroprotection by APTRA-AM when given after injury...