Research Topics
| Jerald C NelsonSummaryAffiliation: Loma Linda University Country: USA Publications
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Detail Information
Publications
The nature of analogue-based free thyroxine estimatesJerald C Nelson
Department of Medicine, Loma Linda University School of Medicine, Loma Linda, California, USA
Thyroid 14:1030-6. 2004..T(4) quantifications included large analytical losses that are unaccounted for. These assays passed tests of correlation with FT(4) concentrations, but they failed tests of specificity for FT(4) and accuracy in T(4) quantification...
Underestimates and overestimates of total thyroxine concentrations caused by unwanted thyroxine-binding protein effectsJerald C Nelson
Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
Thyroid 15:12-5. 2005..We attribute the unexpected total T4 values to a combination of incomplete protein-bound T4 release from T4-binding proteins during quantification, and variably inaccurate quantifications of the protein-bound T4 that remained...
Direct equilibrium dialysis compared with two non-dialysis free T4 methods in premature infantsDouglas D Deming
Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
J Pediatr 151:404-8. 2007..To compare the incidence of low free T4 values reported by a direct equilibrium dialysis method to their incidence reported by 2 non-dialysis methods...
Quantifying spurious free T4 results attributable to thyroxine-binding proteins in serum dialysates and ultrafiltratesKristofer S Fritz
Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA
Clin Chem 53:985-8. 2007..The presence of these proteins in dialysates or ultrafiltrates will yield spuriously high free T(4) values when free T(4) is quantified by RIA...
Analog-based free testosterone test results linked to total testosterone concentrations, not free testosterone concentrationsKristofer S Fritz
Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
Clin Chem 54:512-6. 2008..Analog-based free testosterone test results, sex hormone binding globulin (SHBG) concentrations, and total testosterone concentrations are somehow related. This study used new experiments to clarify these relationships...
A direct free thyroxine (T4) immunoassay with the characteristics of a total T4 immunoassayKristofer S Fritz
Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA
Clin Chem 53:911-5. 2007..Whether this is evidence of a relationship to total T(4) concentrations has not been reported...
Accuracy issues in free thyroxine testing methodsJerald C Nelson
Loma Linda University School of Medicine, Loma Linda, CA, USA
Semin Perinatol 32:403-6. 2008..The protein that binds T(4) can have a major influence on some of the total T(4) assay results that may be used in free T(4) index methods...
Incidence of low free T4 values in premature infants as determined by direct equilibrium dialysisChristopher W Rabin
Department of Pediatrics, Coleman Pavilion Room 11121C, Loma Linda University School of Medicine, 11175 Campus Street, Coleman Pavilion, Suite 11121, Loma Linda, CA 92354, USA
J Perinatol 24:640-4. 2004....
Assessing thyroid hormone status in a patient with thyroid disease and renal failure: from theory to practiceElaine M Kaptein
Department of Medicine, University of Southern California, Los Angeles, California 90033, USA
Thyroid 14:397-400. 2004....
Measurement of free thyroxine in laboratory medicine--proposal of measurand definitionLinda M Thienpont
Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
Clin Chem Lab Med 45:563-4. 2007
Unequal concentrations of free T3 and free T4 after ultrafiltrationKristofer S Fritz
Clin Chem 53:1384-5. 2007
Proposal of a candidate international conventional reference measurement procedure for free thyroxine in serumLinda M Thienpont
Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
Clin Chem Lab Med 45:934-6. 2007..The WG-STFT stresses that according to this recommendation it is a prerequisite to strictly adhere to the defined equilibrium dialysis procedure, whereas it is permissible to introduce variants in the ID-LC/tandem MS procedure...
Follow-up of newborns with elevated screening T4 concentrationsStephen H LaFranchi
Department of Pediatrics, Oregon Health and Science University, Pediatric Endocrinology, Legacy Emanuel Children s Hospital, and Oregon State Public Health Laboratory, Portland, Oregon, USA
J Pediatr 143:296-301. 2003..To determine the type and incidence of hyperthyroxinemic disorders detected by follow-up of infants with elevated screening total T4 (TT4) values...
Initial treatment dose of L-thyroxine in congenital hypothyroidismKarin A Selva
Department of Pediatrics, Oregon Health and Sciences University, Oregon State Public Health Laboratories, and Northwest Kaiser Permanente, Portland, Oregon, USA
J Pediatr 141:786-92. 2002..0 ng/dL for free T(4) during the first 2 weeks of L-thyroxine treatment. After 2 weeks of treatment, the target range drops to 10 to 16 microg/dL for T(4) and 1.6 to 2.2 for free T(4)...
