LAWRENCE LONGO

Summary

Affiliation: Loma Linda University
Country: USA

Publications

  1. pmc Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity
    Lawrence D Longo
    Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Curr Vasc Pharmacol 11:655-711. 2013
  2. pmc Ovine middle cerebral artery characterization and quantification of ultrastructure and other features: changes with development
    Ravi Goyal
    Center for Perinatal Biology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Regul Integr Comp Physiol 302:R433-45. 2012
  3. doi request reprint A challenge for the 21st century: whither physician-scientists in obstetrics, gynecology, and the reproductive sciences?
    Lawrence D Longo
    Department of Obstetrics Gynecology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Am J Obstet Gynecol 198:489-95. 2008
  4. ncbi request reprint William Osler's historical scholarship: a contradiction in terms?
    Lawrence D Longo
    Center for Perinatal Biology, Loma Linda University, Loma Linda, CA 92350, USA
    J Med Biogr 15:6-10. 2007
  5. doi request reprint Some historical aspects of understanding placental development, structure and function
    Lawrence D Longo
    Center for Perinatal Biology, Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, California, USA
    Int J Dev Biol 54:237-55. 2010
  6. pmc Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway
    Katherine Chang
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 296:H1840-9. 2009
  7. doi request reprint Effect of long-term high-altitude hypoxia on fetal pulmonary vascular contractility
    Qin Xue
    Dept of Physiology and Pharmacology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    J Appl Physiol (1985) 104:1786-92. 2008
  8. ncbi request reprint Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC
    Daliao Xiao
    Center for Perinatal Biology, Dept of Pharmacology and Physiology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 288:H2828-35. 2005
  9. pmc Extracellular signal-regulated kinases and contractile responses in ovine adult and fetal cerebral arteries
    Yu Zhao
    Center for Perinatal Biology, Departments of Physiology and Pharmacology, and Obstetrics and Gynecology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    J Physiol 551:691-703. 2003
  10. ncbi request reprint L-type Ca2+ channels in fetal and adult ovine cerebral arteries
    Arlin B Blood
    Center for Perinatal Biology, Department of Physiology Pharmacology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 282:R131-8. 2002

Research Grants

  1. CEREBROVASCULAR ADAPTATIONS TO LONG-TERM HYPOXIA
    LAWRENCE LONGO; Fiscal Year: 1993
  2. FETAL OXYGENATION AND PLACENTAL GAS EXCHANGE
    LAWRENCE LONGO; Fiscal Year: 1991
  3. ADRENERGIC CEREBROVASCULAR MECHANISMS AND DEVELOPMENT
    LAWRENCE LONGO; Fiscal Year: 2003
  4. CEREBROVASCULAR ADRENERGIC-MEDIATED MECHANISMS
    LAWRENCE LONGO; Fiscal Year: 2007
  5. FETAL OXYGENATION AND PLACENTAL GAS EXCHANGE
    LAWRENCE LONGO; Fiscal Year: 1980

Collaborators

Detail Information

Publications59

  1. pmc Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity
    Lawrence D Longo
    Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Curr Vasc Pharmacol 11:655-711. 2013
    ..Of vital importance, a more complete understanding of these mechanisms promises hope for improved strategies for therapeutic intervention and clinical management of intensive care of the premature newborn. ..
  2. pmc Ovine middle cerebral artery characterization and quantification of ultrastructure and other features: changes with development
    Ravi Goyal
    Center for Perinatal Biology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Regul Integr Comp Physiol 302:R433-45. 2012
    ..Ovine CAs at 95 GD appeared morphologically immature and poorly equipped to respond to major hemodynamic adjustments with maturation...
  3. doi request reprint A challenge for the 21st century: whither physician-scientists in obstetrics, gynecology, and the reproductive sciences?
    Lawrence D Longo
    Department of Obstetrics Gynecology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Am J Obstet Gynecol 198:489-95. 2008
    ....
  4. ncbi request reprint William Osler's historical scholarship: a contradiction in terms?
    Lawrence D Longo
    Center for Perinatal Biology, Loma Linda University, Loma Linda, CA 92350, USA
    J Med Biogr 15:6-10. 2007
    ..This essay considers Osler's scholarship as evidenced in his historical and biographical writings, and some lessons that we might learn from his endeavours...
  5. doi request reprint Some historical aspects of understanding placental development, structure and function
    Lawrence D Longo
    Center for Perinatal Biology, Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, California, USA
    Int J Dev Biol 54:237-55. 2010
    ....
  6. pmc Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway
    Katherine Chang
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 296:H1840-9. 2009
    ....
  7. doi request reprint Effect of long-term high-altitude hypoxia on fetal pulmonary vascular contractility
    Qin Xue
    Dept of Physiology and Pharmacology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    J Appl Physiol (1985) 104:1786-92. 2008
    ....
  8. ncbi request reprint Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC
    Daliao Xiao
    Center for Perinatal Biology, Dept of Pharmacology and Physiology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 288:H2828-35. 2005
    ..In addition, phosphorylated CPI-17 may regulate Ca(2+) sensitivity by interacting with caldesmon and reversing its inhibitory effect on myosin ATPase...
  9. pmc Extracellular signal-regulated kinases and contractile responses in ovine adult and fetal cerebral arteries
    Yu Zhao
    Center for Perinatal Biology, Departments of Physiology and Pharmacology, and Obstetrics and Gynecology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    J Physiol 551:691-703. 2003
    ....
  10. ncbi request reprint L-type Ca2+ channels in fetal and adult ovine cerebral arteries
    Arlin B Blood
    Center for Perinatal Biology, Department of Physiology Pharmacology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 282:R131-8. 2002
    ..This may have important implications in the regulation of cerebral blood flow in the developing organism...
  11. pmc alpha(1)-Adrenergic receptor subtype function in fetal and adult cerebral arteries
    Ravi Goyal
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda Univ, School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 298:H1797-806. 2010
    ..We speculate that in fetal CA alpha(1B)-AR and alpha(1D)-AR subtypes may be a critical factor associated with cerebrovascular growth and function...
  12. ncbi request reprint Cortisol-mediated regulation of uterine artery contractility: effect of chronic hypoxia
    Daliao Xiao
    Center for Perinatal Biology, Dept of Physiology and Pharmacology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 286:H716-22. 2004
    ..Chronic hypoxia suppresses uterine artery sensitivity to cortisol, which may play an important role in the adaptation of uterine vascular tone and blood flow in response to chronic stress of hypoxia during pregnancy...
  13. ncbi request reprint Maternal oxygen administration and fetal cerebral oxygenation: studies on near-term fetal lambs at both low and high altitude
    Takuji Tomimatsu
    Center for Perinatal Biology, Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Am J Obstet Gynecol 195:535-41. 2006
    ....
  14. ncbi request reprint Pre- and postjunctional alpha(2)-adrenergic receptors in fetal and adult ovine cerebral arteries
    John M Bishai
    Center for Perinatal Biology, Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1654-62. 2002
    ..We conclude that in fetal and adult ovine cerebral arteries, alpha(2)-AR appear to be chiefly prejunctional. Nonetheless, the fetal cerebral arteries appear to have a significant component of postjunctional alpha(2)-AR...
  15. pmc Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility
    Ravi Goyal
    Center for Perinatal Biology and Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1377-86. 2010
    ..The latter may play a key role in the pathophysiologic disorders associated with acclimatization to high altitude...
  16. pmc Cerebral blood flow and oxygenation in ovine fetus: responses to superimposed hypoxia at both low and high altitude
    Jorge Pereyra Pena
    Center for Perinatal Biology, Department of Physiology, Obstetrics and Gynecology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    J Physiol 578:359-70. 2007
    ..In addition, despite differences in several variables, the fetus at high altitude showed evidence of successful acclimatization, supporting the hypothesis that such fetuses demonstrate no compromise in cerebral oxygenation...
  17. ncbi request reprint Postnatal maturation attenuates pressure-evoked myogenic tone and stretch-induced increases in Ca2+ in rat cerebral arteries
    Shelton M Charles
    Department of Physiology and Pharmacology, Center for Perinaltal Biology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Regul Integr Comp Physiol 293:R737-44. 2007
    ..The greater cerebral myogenic response in P14 compared with adult MCA appears to be due to greater pressure-induced increases in [Ca(2+)](i), rather than enhanced augmentation of myofilament calcium sensitivity...
  18. ncbi request reprint Ten-minute umbilical cord occlusion markedly reduces cerebral blood flow and heat production in fetal sheep
    Fred K Lotgering
    Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, California, USA
    Am J Obstet Gynecol 189:233-8. 2003
    ..The study was undertaken to determine to what extent a 10-minute total umbilical cord occlusion affects autoregulation of cerebral blood flow and cerebral heat production in the fetus...
  19. ncbi request reprint ERK-mediated uterine artery contraction: role of thick and thin filament regulatory pathways
    Daliao Xiao
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Heart Circ Physiol 286:H1615-22. 2004
    ..In contrast, ERK attenuates the thin filament regulatory pathway and suppresses contractions independent of changes in LC20 phosphorylation in the uterine artery...
  20. ncbi request reprint Effect of cortisol on norepinephrine-mediated contractions in ovine uterine arteries
    Daliao Xiao
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Heart Circ Physiol 284:H1142-51. 2003
    ..In addition, the results suggest that pregnancy increases type 2 11 beta-hydroxysteroid dehydrogenase activity in the UA...
  21. ncbi request reprint Regulation of baseline Ca2+ sensitivity in permeabilized uterine arteries: effect of pregnancy
    Daliao Xiao
    Department of Physiology and Pharmacology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 291:H413-20. 2006
    ..In addition, PKC plays an important role in the regulation of basal Ca2+ sensitivity, which is downregulated during pregnancy...
  22. pmc PKC regulates alpha(1)-adrenoceptor-mediated contractions and baseline Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia
    Daliao Xiao
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, California, USA
    High Alt Med Biol 11:153-61. 2010
    ..However, the PKC-mediated thin-filament regulatory pathway is upregulated, resulting in increased baseline Ca(2+) sensitivity in the uterine artery during pregnancy at high altitude...
  23. pmc Increased nitrite reductase activity of fetal versus adult ovine hemoglobin
    Arlin B Blood
    Department of Pediatrics, Division of Neonatology, School of Medicine, Loma Linda University, Loma Linda, CA, USA
    Am J Physiol Heart Circ Physiol 296:H237-46. 2009
    ..The findings suggest an augmented nitrite reductase activity of fetal hemoglobin and that the production of nitrite may participate in the regulation of vascular NO homeostasis in the fetus...
  24. pmc Maturation and the role of PKC-mediated contractility in ovine cerebral arteries
    Ravi Goyal
    Department of Physiology, Center for Perinatal Biology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 297:H2242-52. 2009
    ..Overall, the present study demonstrates an important maturational shift from RhoA/ROCK-mediated to CPI-17/caldesmon-mediated PKC-induced contractile response in ovine cerebral arteries...
  25. ncbi request reprint Fetal hypercapnia in high-altitude acclimatized sheep: cerebral blood flow and cerebral oxygenation
    Takuji Tomimatsu
    Center for Perinatal Biology, Department of Physiology and Obstetrics, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Reprod Sci 14:51-8. 2007
    ..In response to hypercapnia in high-altitude, acclimatized, long-term hypoxic fetal sheep, the response of CBF and cerebral oxygenation did not differ significantly from that of low-altitude controls...
  26. pmc Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin II in adult offspring
    Daliao Xiao
    Center for Perinatal Biology, Department of Pharmacology and Physiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Hypertension 51:1239-47. 2008
    ....
  27. ncbi request reprint Fetal hypercapnia and cerebral tissue oxygenation: studies in near-term sheep
    Takuji Tomimatsu
    Department of Physiology, Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Pediatr Res 60:711-6. 2006
    ..Hypercapnia favored cerebral tissue oxygenation of the fetal brain; and cortical tPo2 and sagittal sinus [HbO2] complement or support one another as indices of cerebral oxygenation under hypercapnic conditions...
  28. pmc Expression of several cytoskeletal proteins in ovine cerebral arteries: developmental and functional considerations
    Yu Zhao
    Center for Perinatal Biology, Department of Physiology and Pharmacology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    J Physiol 558:623-32. 2004
    ..In addition, the relatively constant expression levels of alpha-actin and cyclophilin A with development, suggest that these are useful internal standards for studies of cytosolic protein expression...
  29. ncbi request reprint PKC-induced ERK1/2 interactions and downstream effectors in ovine cerebral arteries
    Yu Zhao
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 289:R164-71. 2005
    ..In addition, ERK1/2-dependent phosphorylation of caldesmon(Ser789) was not necessary for PDBu-induced contraction and appears not to be involved in the reversal of caldesmon's inhibitory effect on actin-myosin ATPase...
  30. ncbi request reprint Fetal cerebrovascular acclimatization responses to high-altitude, long-term hypoxia: a model for prenatal programming of adult disease?
    Lawrence D Longo
    Center for Perinatal Biology, Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Regul Integr Comp Physiol 288:R16-24. 2005
    ..In addition to highlighting independent regulation of various elements of the signal transduction cascade, the studies demonstrate the potential for LTH to program the fetus for cerebrovascular and other disease as an adult...
  31. ncbi request reprint Fetal cardiac and cerebrovascular acclimatization responses to high altitude, long-term hypoxia
    Raymond D Gilbert
    Departments of Physiology and Pharmacology, Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA, USA
    High Alt Med Biol 4:203-13. 2003
    ..They specifically highlight the significant differences in acclimatization responses between the fetus and adult...
  32. pmc Fetal lamb cerebral blood flow (CBF) and oxygen tensions during hypoxia: a comparison of laser Doppler and microsphere measurements of CBF
    John M Bishai
    Center for Perinatal Biology, Departments of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    J Physiol 546:869-78. 2003
    ..Flow compensations in acute hypoxia are not adequate to sustain O(2) delivery, and other compensations, including reduced metabolic rate, are possible...
  33. ncbi request reprint Regulation of alpha1-adrenoceptor-mediated contractions of uterine arteries by PKC: effect of pregnancy
    Hongying Zhang
    Center for Perinatal Biology, Dept of Physiology and Pharmacology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 291:H2282-9. 2006
    ....
  34. ncbi request reprint Fetal and adult cerebral artery K(ATP) and K(Ca) channel responses to long-term hypoxia
    Wen Long
    Center for Perinatal Biology, Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, California 92350, USA
    J Appl Physiol (1985) 92:1692-701. 2002
    ..These results also support the hypothesis of significant developmental differences with maturation from fetus to adult...
  35. pmc Chronic hypoxia inhibits sex steroid hormone-mediated attenuation of ovine uterine arterial myogenic tone in pregnancy
    Katherine Chang
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Hypertension 56:750-7. 2010
    ....
  36. ncbi request reprint Modulation of BK channel calcium affinity by differential phosphorylation in developing ovine basilar artery myocytes
    Mike T Lin
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 291:H732-40. 2006
    ..Lower Ca0 and Kd values in BK channels of fetal myocytes can be explained by a greater extent of channel phosphorylation of fetal than adult myocytes...
  37. pmc Maturation of intracellular calcium homeostasis in sheep pulmonary arterial smooth muscle cells
    Ravi Goyal
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Lung Cell Mol Physiol 295:L905-14. 2008
    ..Overall, the results of this study demonstrate selective adaptations in receptor-mediated Ca(2+) signaling, but not in cellular Ca(2+) homeostasis...
  38. ncbi request reprint Absence of robust ischemic preconditioning by five 1-minute total umbilical cord occlusions in fetal sheep
    Fred K Lotgering
    Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, California, USA
    J Soc Gynecol Investig 11:449-56. 2004
    ....
  39. pmc Fetal cerebral blood flow, electrocorticographic activity, and oxygenation: responses to acute hypoxia
    Stephen J Lee
    Center for Perinatal Biology, Department of Physiology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    J Physiol 587:2033-47. 2009
    ..For the normoxic fetus, CBF was closely related to ECoG state, but this association was less evident during acute hypoxia. We speculate that, in the otherwise stressed fetus, acute hypoxia may further compromise cerebral oxygenation...
  40. ncbi request reprint Maternal caffeine administration and cerebral oxygenation in near-term fetal sheep
    Takuji Tomimatsu
    Center for Perinatal Biology, Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Reprod Sci 14:588-94. 2007
    ..The authors speculate that for a fetus that may be otherwise compromised, this increase in CMRO(2) with decreased cortical tPO(2) could present a problem...
  41. ncbi request reprint Fetal cerebral oxygenation: the role of maternal hyperoxia with supplemental CO2 in sheep
    Takuji Tomimatsu
    Center for Perinatal Biology and the Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Obstet Gynecol 196:359.e1-5. 2007
    ..We tested the hypothesis that supplemental CO2 can enhance the effect of maternal oxygen administration on fetal cerebral oxygenation...
  42. ncbi request reprint Developmental differences in Ca2+-activated K+ channel activity in ovine basilar artery
    Mike T Lin
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 285:H701-9. 2003
    ..e., the calcium set points) at 0 mV were 8.8 and 4.7 microM for adult and fetal myocytes, respectively. Thus the increased BKCa current density in fetal myocytes appears to result from a lower calcium set point...
  43. ncbi request reprint Ca2+-activated K+ channel-associated phosphatase and kinase activities during development
    Mike T Lin
    Center for Perinatal Biology, School of Medicine, Loma Linda Univ, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 289:H414-25. 2005
    ..In addition, these findings suggest that the functional stoichiometry of CAPAKs varies significantly during development and that such variation may be a hitherto unrecognized mechanism of ion channel regulation...
  44. pmc Development affects in vitro vascular tone and calcium sensitivity in ovine cerebral arteries
    Greg G Geary
    Department of Physiology and Pharmacology, Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92407, USA
    J Physiol 558:883-96. 2004
    ..We speculate that these changes have important implications in the regulation of cerebral blood flow in the developing organism...
  45. pmc Pregnancy downregulates actin polymerization and pressure-dependent myogenic tone in ovine uterine arteries
    Daliao Xiao
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, CA 92350, USA
    Hypertension 56:1009-15. 2010
    ....
  46. ncbi request reprint Furthering the profession: the early years of the American Gynecological Club and its first European tours
    Michael W Eby
    Department of Obstetrics and Gynecology, Loma Linda, California 92350, USA
    Obstet Gynecol 99:308-15. 2002
    ..The early years of the American Gynecological Club represent a somewhat idyllic and bygone era in medicine and obstetrics and gynecology...
  47. pmc Gene expression in the placenta: maternal stress and epigenetic responses
    Ciprian P Gheorghe
    Center for Perinatal Biology, Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA
    Int J Dev Biol 54:507-23. 2010
    ....
  48. pmc Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling following exposure to high altitude long-term hypoxia
    Lavonne Sheng
    Division of Neonatology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Los Angeles, California, USA
    High Alt Med Biol 10:365-72. 2009
    ..Our data indicate that EGFR plays a role in fetal ovine pulmonary vascular remodeling following long-term fetal hypoxia and that inhibition of EGFR signaling may ameliorate hypoxia-induced pulmonary vascular remodeling...
  49. doi request reprint Brain renin-angiotensin system: fetal epigenetic programming by maternal protein restriction during pregnancy
    Ravi Goyal
    Center for Perinatal Biology, Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Reprod Sci 17:227-38. 2010
    ..In the current study, we tested the hypothesis that antenatal maternal low protein diet (MLPD) leads to epigenetic changes and alterations in gene expression of brain RAS of the mouse fetus...
  50. ncbi request reprint Gene expression patterns in the developing murine placenta
    Ciprian Gheorghe
    Center for Perinatal Biology, Department of Physiology, Loma Linda University, Loma Linda, California 92350, USA
    J Soc Gynecol Investig 13:256-62. 2006
    ..To examine genetic aspects of placental development, we investigated gene expression patterns in the murine placenta at embryonic day 10.5 (E10.5), E12.5, E15.5, and E17.5...
  51. ncbi request reprint Gene expression patterns in the hypoxic murine placenta: a role in epigenesis?
    Ciprian P Gheorghe
    Center for Perinatal Biology, Department of Physiology and Obstetrics, Loma Linda University, School of Medicine, Loma Linda, California 92350, USA
    Reprod Sci 14:223-33. 2007
    ..The observation that hypoxia upregulates reactive oxygen species metabolism, in conjunction with DNA methylation enzymes, suggests that hypoxia may contribute to long-term epigenetic changes in stressed fetal tissues and organs...
  52. pmc CO and NO pulmonary diffusing capacity during pregnancy: Safety and diagnostic potential
    Gerald S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, 6420 Clayton Road, Suite 290, Saint Louis, MO 63117, USA
    Respir Physiol Neurobiol 170:215-25. 2010
    ..The risk of late fetal or neonatal death from increased Hb(CO) from diffusion testing is considerably less than the risk of death from all causes reported by the Centers for Disease Control, and is therefore considered "minimal risk"...
  53. ncbi request reprint Heme oxygenase activity in fetal and adult sheep is not altered by acclimatization to high altitude hypoxia
    Robert T Kinobe
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Can J Physiol Pharmacol 84:893-901. 2006
    ..Also, except for the spleen where there is a high expression of HO-1 under normal conditions, tissue HO activity is correlated with the expression of HO-2, the constitutive isozyme...
  54. ncbi request reprint Howard A. Kelly's development as an academician: some insights from his letters to Robert P. Harris
    Lawrence D Longo
    Trans Stud Coll Physicians Phila 24:93-136. 2002
    ....
  55. ncbi request reprint Of books and men
    Lawrence D Longo
    J Med Biogr 11:126-7. 2003
  56. ncbi request reprint Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia
    Yuansheng Gao
    Division of Neonatology, Harbor UCLA Medical Center, Geffen School of Medicine at University of California and Los Angeles Biomedical Research Institute, Los Angeles, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L678-84. 2007
    ..Increased ROCK activity may inhibit PKG action through increased phosphorylation of MYPT1 at Thr696 and Thr850...
  57. ncbi request reprint Steroids LIV. Synthesis of 19-nor-17alpha-ethynyltestosterone and 19-nor-17alpha-methyltestosterone. 1954
    Carl Djerassi
    Am J Obstet Gynecol 194:289; discussion 290. 2006
  58. ncbi request reprint Beyond the physician charter: reflections on medical professionalism
    Herbert M Swick
    Institute of Medicine and Humanities, University of Montana and St Patrick Hospital and Health Sciences Center, Missoula, 59802, USA
    Perspect Biol Med 49:263-75. 2006
    ....
  59. ncbi request reprint Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs
    Christine E Bixby
    Division of Neonatology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1475-82. 2007
    ..These findings suggest that increased PAF-R protein expression and increased PAF binding contribute to pulmonary vascular remodeling in these animals and may predispose them to persistent pulmonary hypertension after birth...

Research Grants36

  1. CEREBROVASCULAR ADAPTATIONS TO LONG-TERM HYPOXIA
    LAWRENCE LONGO; Fiscal Year: 1993
    ....
  2. FETAL OXYGENATION AND PLACENTAL GAS EXCHANGE
    LAWRENCE LONGO; Fiscal Year: 1991
    ....
  3. ADRENERGIC CEREBROVASCULAR MECHANISMS AND DEVELOPMENT
    LAWRENCE LONGO; Fiscal Year: 2003
    ....
  4. CEREBROVASCULAR ADRENERGIC-MEDIATED MECHANISMS
    LAWRENCE LONGO; Fiscal Year: 2007
    ..Overall, these studies will form a basis for gene or other therapy for the prevention and/or amelioration of these disorders. ..
  5. FETAL OXYGENATION AND PLACENTAL GAS EXCHANGE
    LAWRENCE LONGO; Fiscal Year: 1980
    ..We will quantify the relation of fetal oxygen levels to placental diffusing capacity, and the relation of fetal oxygenation to severity of maternal exercise. ..