D S Gridley

Summary

Affiliation: Loma Linda University
Country: USA

Publications

  1. ncbi request reprint Radiation and secondary immune response to lipopolysaccharide
    Michael J Pecaut
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 22:423-34. 2008
  2. pmc Comparison of acute proton, photon, and low-dose priming effects on genes associated with extracellular matrix and adhesion molecules in the lungs
    Jian Tian
    Department of Radiation Medicine, Radiation Research Laboratories and Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA
    Fibrogenesis Tissue Repair 6:4. 2013
  3. doi request reprint Space-relevant radiation modifies cytokine profiles, signaling proteins and Foxp3+ T cells
    Daila S Gridley
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA, USA
    Int J Radiat Biol 89:26-35. 2013
  4. ncbi request reprint Effects of minocycline on hematopoietic recovery after whole-body irradiation
    Shalini Mehrotra
    Department of Basic Sciences, Divisions of Biochemistry and Microbiology, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 27:11-28. 2013
  5. ncbi request reprint Analysis of minocycline as a countermeasure against acute radiation syndrome
    Shalini Mehrotra
    Department of Basic Sciences, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 26:743-58. 2012
  6. doi request reprint Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Int J Radiat Biol 84:549-59. 2008
  7. doi request reprint Proton-beam therapy for tumors of the CNS
    Daila S Gridley
    Department of Radiation Medicine, Chan Shun Pavilion, 11175 Campus Street, Loma Linda University, Loma Linda, CA 92354, USA
    Expert Rev Neurother 10:319-30. 2010
  8. doi request reprint A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model
    Adeola Y Makinde
    Department of Basic Sciences and, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    Radiat Res 173:441-52. 2010
  9. ncbi request reprint Hypergravity-induced immunomodulation in a rodent model: lymphocytes and lymphoid organs
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine, Loma Linda, CA 92354 USA
    J Gravit Physiol 9:15-27. 2002
  10. ncbi request reprint Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    In Vivo 22:159-69. 2008

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Radiation and secondary immune response to lipopolysaccharide
    Michael J Pecaut
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 22:423-34. 2008
    ..The purpose of this study was to determine whether secondary immune responses to lipopolysaccharide (LPS) were altered by exposure to radiation...
  2. pmc Comparison of acute proton, photon, and low-dose priming effects on genes associated with extracellular matrix and adhesion molecules in the lungs
    Jian Tian
    Department of Radiation Medicine, Radiation Research Laboratories and Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA
    Fibrogenesis Tissue Repair 6:4. 2013
    ..abstract:..
  3. doi request reprint Space-relevant radiation modifies cytokine profiles, signaling proteins and Foxp3+ T cells
    Daila S Gridley
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA, USA
    Int J Radiat Biol 89:26-35. 2013
    ..The major goal was to evaluate effects of various radiation regimens on leukocyte populations relatively long-term after whole-body irradiation...
  4. ncbi request reprint Effects of minocycline on hematopoietic recovery after whole-body irradiation
    Shalini Mehrotra
    Department of Basic Sciences, Divisions of Biochemistry and Microbiology, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 27:11-28. 2013
    ..In the current study we further determined the drug's effect on hematopoietic recovery...
  5. ncbi request reprint Analysis of minocycline as a countermeasure against acute radiation syndrome
    Shalini Mehrotra
    Department of Basic Sciences, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 26:743-58. 2012
    ..To evaluate the impact of an antibiotic, minocycline, on several immune parameters in response to radiation in a mouse model...
  6. doi request reprint Long-term changes in rat hematopoietic and other physiological systems after high-energy iron ion irradiation
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Int J Radiat Biol 84:549-59. 2008
    ..To assess the long-term consequences of high-linear energy transfer (LET) iron ion radiation on immune and other critical body systems in the context of assessing potential effects astronauts may experience during exploratory missions...
  7. doi request reprint Proton-beam therapy for tumors of the CNS
    Daila S Gridley
    Department of Radiation Medicine, Chan Shun Pavilion, 11175 Campus Street, Loma Linda University, Loma Linda, CA 92354, USA
    Expert Rev Neurother 10:319-30. 2010
    ..Recognition of these advantages has resulted in development of many new proton treatment facilities worldwide...
  8. doi request reprint A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model
    Adeola Y Makinde
    Department of Basic Sciences and, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    Radiat Res 173:441-52. 2010
    ..Overall, the findings suggest that administration of MnTE-2-PyP(5+) together with radiotherapy may enhance anti-tumor immune responsiveness and decrease the risk for radiation-induced normal tissue toxicities...
  9. ncbi request reprint Hypergravity-induced immunomodulation in a rodent model: lymphocytes and lymphoid organs
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine, Loma Linda, CA 92354 USA
    J Gravit Physiol 9:15-27. 2002
    ..In certain cases, the detected changes were similar to those observed after whole-body irradiation. In future investigations we hope to combine hypergravity with low-dose rate irradiation and immune challenge...
  10. ncbi request reprint Variable hematopoietic responses to acute photons, protons and simulated solar particle event protons
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    In Vivo 22:159-69. 2008
    ..The goal of this study was to evaluate, for the first time, the response of bone marrow-derived cell populations to protons mimicking a space radiation environment...
  11. ncbi request reprint Combining gene therapy and radiation against cancer
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Curr Gene Ther 4:231-48. 2004
    ..The evidence indicates that many of these innovative gene-based strategies have great potential to augment radiotherapy, as well as other established forms of cancer treatment, in the near future...
  12. ncbi request reprint Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for resectable but medically inoperable non-small-cell lung cancer
    Daila S Gridley
    Department of Radiation Medicine, School of Medicine, Loma Linda University and Medical Center, Chan Shuh Pavilion, 11175 Campus Street, Loma Linda, CA 92354, USA
    Int J Radiat Oncol Biol Phys 60:759-66. 2004
    ..These factors were quantified because they may be extremely important in the development of side effects, and the treated volume integral dose may be crucial in inducing them...
  13. doi request reprint Low-dose photons modify liver response to simulated solar particle event protons
    Daila S Gridley
    Department of Radiation Medicine, Molecular Radiation Biology Laboratories, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    Radiat Res 169:280-7. 2008
    ..The results demonstrate that whole-body irradiation with low-dose-rate photons, as well as time after exposure, had a great impact on liver response to a simulated solar particle event...
  14. pmc Spaceflight effects on T lymphocyte distribution, function and gene expression
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    J Appl Physiol (1985) 106:194-202. 2009
    ..Collectively, the data show that T cell distribution, function, and gene expression are significantly modified shortly after return from the spaceflight environment...
  15. ncbi request reprint Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model
    Daila S Gridley
    Departments of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Anticancer Res 27:3101-9. 2007
    ..The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tumor response to radiation and identify possible mechanisms of interaction...
  16. doi request reprint Low-dose, low-dose-rate proton radiation modulates CD4(+) T cell gene expression
    Daila S Gridley
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University, CA 92354, USA
    Int J Radiat Biol 85:250-61. 2009
    ..To evaluate cluster of differentiation 4(+) (CD4(+)) T cell gene expression and related parameters after whole-body exposure to proton radiation as it occurs in the spaceflight environment...
  17. ncbi request reprint Radiation and primary response to lipopolysaccharide: bone marrow-derived cells and susceptible organs
    Daila S Gridley
    Department of Radiation Medicine, Molecular Radiation Biology Laboratories, and Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 21:453-61. 2007
    ..The major goal of this study was to determine whether radiation significantly alters bone marrow-derived cell distribution and mass of sensitive organs after challenge with lipopolysaccharide (LPS)...
  18. ncbi request reprint Low dose, low dose rate photon radiation modifies leukocyte distribution and gene expression in CD4(+) T cells
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University and Medical Center, CA 92354, USA
    J Radiat Res 50:139-50. 2009
    ..1 Gy group (P < 0.1). The data show that protracted low dose photons had dose- and time-dependent effects on CD4(+) T cells after whole-body exposure...
  19. ncbi request reprint Acute effects of iron-particle radiation on immunity. Part II: Leukocyte activation, cytokines and adhesion
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University and Medical Center, CA 92354, USA
    Radiat Res 165:78-87. 2006
    ..The implications of the data are discussed in relation to low-LET radiation, altered gravity, and space flight...
  20. ncbi request reprint Low-dose photon and simulated solar particle event proton effects on Foxp3+ T regulatory cells and other leukocytes
    Daila S Gridley
    Department of Radiation Medicine, University and Medical Center, Loma Linda, CA 92354, USA
    Technol Cancer Res Treat 9:637-49. 2010
    ....
  21. doi request reprint Genetic background and lymphocyte populations after total-body exposure to iron ion radiation
    Daila S Gridley
    Department of Radiation Medicine, Radiation Research Laboratories, Divisions of Microbiology and Biochemistry, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    Int J Radiat Biol 87:8-23. 2011
    ....
  22. ncbi request reprint Strain-related differences and radiation quality effects on mouse leukocytes: gamma-rays and protons (with and without aluminum shielding)
    Daila S Gridley
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 25:871-80. 2011
    ....
  23. ncbi request reprint Dose and dose rate effects of whole-body gamma-irradiation: II. Hematological variables and cytokines
    D S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 15:209-16. 2001
    ....
  24. ncbi request reprint Lymphocyte activation with localized pGL1-TNF-alpha gene therapy in a glioma model
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Oncology 62:66-77. 2002
    ....
  25. ncbi request reprint Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: part I
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine and Medical Center, Chan Shun Pavilion, Room A 1010, 11175 Campus Street, Loma Linda, CA 92354, USA
    Immunol Lett 80:55-66. 2002
    ..Results from gamma- and proton-irradiated groups (both at 3 Gy HDR) were similar, although proton-irradiation gave consistently lower values in some measurements...
  26. ncbi request reprint Combination of pGL1-TNF-alpha gene and radiation (proton and gamma-ray) therapy against brain tumor
    D S Gridley
    Department of Radiation Medicine Radiobiology Program, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Anticancer Res 20:4195-203. 2000
    ....
  27. ncbi request reprint Whole-body irradiation and long-term modification of bone marrow-derived cell populations by low- and high-LET radiation
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 20:781-9. 2006
    ..The major aim of this study was to quantify long-term changes in bone marrow-derived cell populations after exposure to radiations of differing quality...
  28. ncbi request reprint TNF-alpha gene and proton radiotherapy in an orthotopic brain tumor model
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Int J Oncol 21:251-9. 2002
    ..Overall, the data indicate that pGL1-TNF-alpha/proton treatment results in a measurable antitumor effect and is safe under the conditions used...
  29. ncbi request reprint Proton radiation and TNF-alpha/Bax gene therapy for orthotopic C6 brain tumor in Wistar rats
    Daila S Gridley
    Department of Radiation Medicine, Loma Linda University and Medical Center, CA 92354 U S A
    Technol Cancer Res Treat 3:217-27. 2004
    ..The results demonstrate that treatment with pGL1-TNF-alpha/pGL1-Bax combined with proton hemibrain irradiation is safe under the conditions used. Overall, these data support further investigation of this unique combination therapy...
  30. ncbi request reprint Evaluation of TNF-alpha/Bax gene therapy and radiation against C6 glioma xenografts
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Technol Cancer Res Treat 2:41-50. 2003
    ..To our knowledge, this is the first report of bax gene therapy used together with radiation in an in vivo glioma model...
  31. doi request reprint Comparison of proton and electron radiation effects on biological responses in liver, spleen and blood
    Daila S Gridley
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Int J Radiat Biol 87:1173-81. 2011
    ..To determine whether differences exist between proton and electron radiations on biological responses after total-body exposure...
  32. ncbi request reprint Low-dose vaccinia virus-mediated cytokine gene therapy of glioma
    B Chen
    Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, California 92350, USA
    J Immunother 24:46-57. 2001
    ..05). These results suggest that attenuated recombinant strains of VV at low doses may potentially be efficient vectors for cancer immunotherapy...
  33. ncbi request reprint Evaluation of cytokine toxicity induced by vaccinia virus-mediated IL-2 and IL-12 antitumour immunotherapy
    B Chen
    Center for Molecular Biology and Gene Therapy, Department of Microbiology and Molecular Genetics, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Cytokine 15:305-14. 2001
    ..Short-term effects induced by IL-2 and IL-12 could be critical for antitumour therapy that prolongs survival and protects from adverse side effects...
  34. ncbi request reprint Evaluation of polysaccharopeptide effects against C6 glioma in combination with radiation
    X W Mao
    Department of Radiation Medicine Radiobiology Program, Loma Linda University and Medical Center, Loma Linda, Calif 92354, USA
    Oncology 61:243-53. 2001
    ..Collectively, these results warrant further investigation to determine if PSP can be effectively utilized to upregulate immune responsiveness in case of neoplasia and other diseases in which immunosuppression is a prominent feature...
  35. ncbi request reprint Liposome-encapsulated tumor necrosis factor-alpha enhances the effects of radiation against human colon tumor xenografts
    D W Kim
    Department of Microbiology and Molecular Genetics, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Interferon Cytokine Res 21:885-97. 2001
    ....
  36. pmc Effects of spaceflight on innate immune function and antioxidant gene expression
    Farnaz P Baqai
    Department of Radiation Medicine, Loma Linda University, Loma Linda, CA 92354, USA
    J Appl Physiol (1985) 106:1935-42. 2009
    ..These data indicate that exposure to the spaceflight environment can increase anti-inflammatory mechanisms and change the ex vivo response to LPS, a bacterial product associated with septic shock and a prominent Th1 response...
  37. ncbi request reprint Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation
    Adeola Y Makinde
    Department of Biochemistry and Microbiology, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Anticancer Res 29:107-18. 2009
    ..The major objectives were to evaluate the effects of Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP) on tumor response to radiation and to explore mechanisms responsible for the observed effects...
  38. ncbi request reprint NK cell depletion results in accelerated tumor growth and attenuates the antitumor effect of total body irradiation
    Glen M Miller
    Department of Biochemistry and Microbiology, Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, CA 92345, USA
    Int J Oncol 23:1585-92. 2003
    ..These findings also support the premise that radiation exposure can activate NK and some T cytotoxic lymphocytes, thereby leading to tumor suppression...
  39. ncbi request reprint Analysis of a metalloporphyrin antioxidant mimetic (MnTE-2-PyP) as a radiomitigator: prostate tumor and immune status
    S Mehrotra
    Department of Basic Sciences, Divisions of Biochemistry and Microbiology, Loma Linda University and Medical Center, Loma Linda, CA, USA
    Technol Cancer Res Treat 11:447-57. 2012
    ..05). The results show that MnTE-2-PyP slowed RM-9 tumor progression and up-regulated immune parameters, but mitigation of the effects of 2 Gy total-body irradiation were minimal...
  40. ncbi request reprint Dose and dose rate effects of whole-body gamma-irradiation: I. Lymphocytes and lymphoid organs
    M J Pecaut
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 15:195-208. 2001
    ..The results also suggest that the response of lymphocytes in different body compartments may be variable...
  41. ncbi request reprint Radiation enhances the anti-tumor effects of vaccinia-p53 gene therapy in glioma
    Tatyana M Timiryasova
    Center for Molecular Biology and Gene Therapy, Loma Linda University and Medical Center, School of Medicine, 11085 Campus Street, Loma Linda, CA 92350, USA
    Technol Cancer Res Treat 2:223-35. 2003
    ..Furthermore, the results support the conclusion that the mechanisms underlying the enhanced anti-tumor effect of combination treatment include apoptosis/necrosis and upregulation of innate immune defenses...
  42. ncbi request reprint Changes in the activation and reconstitution of lymphocytes resulting from total-body irradiation correlate with slowed tumor growth
    Glen M Miller
    Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Oncology 65:229-41. 2003
    ..Taken together, the relative percentages and activation status of immune cell compartments support the conclusion that these TBI-induced changes function to slow tumor progression...
  43. ncbi request reprint Radiation-enhanced endostatin gene expression and effects of combination treatment
    Xian Luo
    Department of Radiation Medicine, Chan Shun Pavilion, Room A 1010, 11175 Campus Street, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Technol Cancer Res Treat 4:193-202. 2005
    ..05 or less compared to all other groups). No toxicity was observed. These findings are very promising and suggest that endostatin therapy with a plasmid vector, such as pXLG-mEndo, may enhance the efficacy of radiotherapy for lung cancer...
  44. ncbi request reprint Dose and timing of total-body irradiation mediate tumor progression and immunomodulation
    Glen M Miller
    Department of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, CA 92354, USA
    Oncol Res 13:9-18. 2002
    ..A selective radiation-induced depletion of CD8+ T lymphocytes and changes in NKT cell percentages, correlated with findings from cytotoxicity assays, were indicative of a protumoricidal immune environment...
  45. ncbi request reprint Protracted low-dose radiation priming and response of liver to acute gamma and proton radiation
    D S Gridley
    Division of Radiation Research, Department of Basic Sciences, Loma Linda University and Medical Center, Loma Linda, CA, USA
    Free Radic Res 47:811-20. 2013
    ..The data demonstrate that response to acute radiation is dependent on radiation quality and regimen and that some LDR γ-ray-induced modifications in liver response were still evident nearly 2 months after exposure...
  46. ncbi request reprint Radiation and endostatin gene therapy in a lung carcinoma model: pilot data on cells and cytokines that affect angiogenesis and immune status
    Xian Luo
    Department of Radiation Medicine, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Technol Cancer Res Treat 5:135-46. 2006
    ..The data demonstrate in the Lewis lung carcinoma model that tumor-localized endostatin gene therapy and radiation had significant effects on cells and cytokines that can influence angiogenesis, tumor growth, and immune status...
  47. ncbi request reprint Enhancement of radiation effects by pXLG-mEndo in a lung carcinoma model
    Xian Luo
    Department of Biochemistry and Microbiology, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Int J Radiat Oncol Biol Phys 63:553-64. 2005
    ..The major goal of this study was to evaluate the combination of radiation and endostatin gene therapy in a preclinical lung cancer model...
  48. doi request reprint Radioprotective effect of a metalloporphyrin compound in rat eye model
    X W Mao
    Department of Radiation Medicine, Molecular Radiation Biology Laboratories, Loma Linda University and Medical Center, Loma Linda, California, USA
    Curr Eye Res 34:62-72. 2009
    ..The purpose of this study was to evaluate the efficacy of the antioxidant Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP) in protecting ocular tissue and retinal microvasculature from radiation damage...
  49. ncbi request reprint Immunohistological analysis of immune cell infiltration of a human colon tumor xenograft after treatment with Stealth liposome-encapsulated tumor necrosis factor-alpha and radiation
    Dong W Kim
    Department of Radiation Medicine, Radiobiology Program, Chan Shun Pavilion, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Int J Oncol 21:973-9. 2002
    ..Overall, the data indicate that the mechanisms underlying the increased efficacy of SL-TNF-alpha compared to free TNF-alpha include a rapid and relatively sustained recruitment of NK cells, macrophages, and neutrophils...
  50. doi request reprint Response of extracellular matrix regulators in mouse lung after exposure to photons, protons and simulated solar particle event protons
    Jian Tian
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Radiat Res 172:30-41. 2009
    ..The greater perturbations after photon exposure compared to proton exposure have clinical implications and warrant further investigation...
  51. ncbi request reprint Research activities at the Loma Linda University and Proton Treatment Facility--an overview
    G A Nelson
    Loma Linda University Radiobiology Program, Loma Linda University, Loma Linda, California 92354, USA
    Phys Med 17:30-2. 2001
    ....
  52. ncbi request reprint IL-2 gene and antisense TGF-beta1 strategies counteract HSV-2 transformed tumor progression
    James D Kettering
    Dept of Biochemistry and Microbiology, Loma Linda University, Loma Linda, CA 92350, USA
    Technol Cancer Res Treat 2:211-21. 2003
    ....
  53. ncbi request reprint Modulation of innate immunological factors by STEALTH liposome-encapsulated tumor necrosis factor-alpha in a colon tumor xenograft model
    Dong W Kim
    Department of Radiation Medicine, Loma Linda University and Medical Center, CA 92354, USA
    Anticancer Res 22:777-88. 2002
    ..The aim of this study was to examine the effects of SL-TNF-alpha in the LS174T human colon tumor xenograft model and to correlate its administration with alterations in innate immune system parameters...
  54. ncbi request reprint "Out-of-field" effects of head-localized proton irradiation on peripheral immune parameters
    Michael J Pecaut
    Departments of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine and Medical Center, Chan Shun Pavilion, Room A 1010, 11175 Campus Street, Loma Linda, CA 92354, USA
    In Vivo 17:513-21. 2003
    ..The data also suggest that immune modulation induced by localized proton, as well as other forms of radiation, should be taken into consideration when evaluating adjunctive immunotherapies in patients receiving radiotherapy...
  55. ncbi request reprint Hypergravity-induced immunomodulation in a rodent model: hematological and lymphocyte function analyses
    Michael J Pecaut
    Department of Radiation Medicina, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    J Appl Physiol (1985) 97:29-38. 2004
    ....
  56. doi request reprint The impact of mouse strain on iron ion radio-immune response of leukocyte populations
    Michael J Pecaut
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    Int J Radiat Biol 86:409-19. 2010
    ..The major goal of this study was to compare leukocyte population responses in two strains of mice that differ in susceptibility to radiation: C57BL/6 (resistant) and CBA/Ca (susceptible)...
  57. ncbi request reprint Gene expression analysis of oxidative stress and apoptosis in proton-irradiated rat retina
    Xiao W Mao
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA 92350, USA
    In Vivo 24:425-30. 2010
    ..The aim of this study was to examine the induction of oxidative stress and apoptosis-associated gene expression profiles in retina after proton irradiation exposure at 0.5 to 4 Gy...
  58. ncbi request reprint Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions
    Michael J Pecaut
    Department of Radiation Medicine, Radiobiology Program, Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    J Appl Physiol (1985) 94:2085-94. 2003
    ..Many of the results are similar to those using other models. Clearly, spaceflight can influence immune parameters ranging from hematopoiesis to mature leukocyte mechanisms...
  59. ncbi request reprint Cytoskeletal and functional changes in bioreactor assembled thyroid tissue organoids exposed to gamma radiation
    Lora M Green
    Radiobiology Program, Loma Linda University Chan Shun Pavilion, Rm A1010, 11175 Campus Street, Loma Linda, CA 92354, USA
    J Radiat Res 43:S213-8. 2002
    ..Thus, the engineered tissue responses to radiation differed from those of conventional tissue culture making it a potentially better mimic of the in vivo situation...
  60. doi request reprint Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung
    Jian Tian
    Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda Univ, Loma Linda, CA 92354, USA
    J Appl Physiol (1985) 108:162-71. 2010
    ..Taken together, the data demonstrate that significant changes can be readily detected shortly after return from spaceflight in the expression of factors that can adversely influence lung function...
  61. ncbi request reprint Long-term effects of low-dose proton radiation on immunity in mice: shielded vs. unshielded
    Michael J Pecaut
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    Aviat Space Environ Med 74:115-24. 2003
    ..These fields and their biological risks are modified in complex ways by the presence of protective shielding...
  62. ncbi request reprint Acute effects of iron-particle radiation on immunity. Part I: Population distributions
    Michael J Pecaut
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University and Medical Center, CA 92354, USA
    Radiat Res 165:68-77. 2006
    ..The data are discussed in relation to our previous investigations with iron ions, other forms of radiation, and space flight in this same animal model...
  63. ncbi request reprint An improved mouse Sca-1+ cell-based bone marrow transplantation model for use in gene- and cell-based therapeutic studies
    Susan L Hall
    Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, Calif 92357, USA
    Acta Haematol 117:24-33. 2007
    ..In summary, this murine Sca-1+ cell-based strategy could be used in studies of HSC-based gene or cell therapies...
  64. ncbi request reprint Radiation and primary immune response to lipopolysaccharide: lymphocyte distribution and function
    Michael J Pecaut
    Department of Radiation Medicine, Molecular Radiation Biology Laboratories, Loma Linda University and Medical Center, Loma Linda, CA 92354, USA
    In Vivo 21:463-70. 2007
    ..The purpose of this study was to quantify the effects of whole-body irradiation on lymphocyte populations during response to challenge with LPS...
  65. ncbi request reprint Dose and dose rate effects of whole-body proton-irradiation on lymphocyte blastogenesis and hematological variables: part II
    Michael J Pecaut
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University School of Medicine and Medical Center, Chan Shun Pavilion, Room A 1010, 11175 Campus Street, Loma Linda, CA 92354, USA
    Immunol Lett 80:67-73. 2002
    ..A difference, however, was found between protons and gamma-rays in the degree of change induced in some of the measurements...
  66. doi request reprint A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status
    Jerry R Williams
    Molecular Radiation Biology Laboratory, Department of Radiation Medicine, Loma Linda Medical Center, 11175 Campus Street, Room A 1010, Loma Linda CA 92350 1700, USA
    Int J Radiat Biol 84:253-64. 2008
    ..We now establish a global, quantitative description of human tumor cells based on genotype-dependent radiosensitivity across histological types...
  67. doi request reprint Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation
    Jerry R Williams
    Molecular Radiation Biology Program, Department of Radiation Medicine, Loma Linda Medical Center, Loma Linda, CA, USA
    Int J Radiat Oncol Biol Phys 72:909-17. 2008
    ..We measured susceptibility to LDR-induced redistribution in the cell cycle in eight of these cell lines...
  68. ncbi request reprint Attenuation of a vaccine strain of vaccinia virus via inactivation of interferon viroceptor
    Bela Denes
    Center for Molecular Biology and Gene Therapy, Loma Linda University, 11085 Campus St, Loma Linda, CA 92354, USA
    J Gene Med 8:814-23. 2006
    ..Here, we explore an attenuation strategy with a vaccine strain of VV lacking a virus-encoded IFN-gamma receptor homolog (viroceptor)...
  69. doi request reprint Stem cell antigen-1+ cell-based bone morphogenetic protein-4 gene transfer strategy in mice failed to promote endosteal bone formation
    Susan L Hall
    Musculoskeletal Disease Center 151, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, California 92357, USA
    J Gene Med 11:877-88. 2009
    ....
  70. ncbi request reprint Biological and metabolic response in STS-135 space-flown mouse skin
    X W Mao
    Division of Radiation Research, Department of Basic Sciences, Loma Linda University and Medical Center, Loma Linda, CA, USA
    Free Radic Res 48:890-7. 2014
    ..This indicates that astronauts may be at increased risk for pathophysiologic damage or carcinogenesis in cutaneous tissue. ..
  71. pmc Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo
    Jerry R Williams
    Radiation Research Laboratories, Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA
    Radiat Oncol 5:71. 2010
    ..We reduce these data into a simple analytical structure that defines the relationship between tumor response and total dose based on two coefficients that are specific to tumor cell genotype, fraction size and total dose...
  72. ncbi request reprint Sca-1(+) hematopoietic cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice
    Susan L Hall
    Musculoskeletal Disease Center, Jerry L Pettis Memorial V A Medical Center, Loma Linda, California 92357, USA
    Mol Ther 15:1881-9. 2007
    ..In conclusion, this study provided compelling test-of-principle evidence for the feasibility of using an Sca-1(+) cell-based ex vivo systemic FGF-2 gene therapy strategy to promote endosteal bone formation...
  73. doi request reprint Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution
    Jerry R Williams
    Molecular Radiation Biology Laboratory, Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California, USA
    Int J Radiat Biol 84:151-64. 2008
    ..We describe variations of three radiation-induced endpoints on the basis of cell genotype: Clonogenic survival, expression of apoptosis and cell-cycle redistribution...
  74. ncbi request reprint Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets
    Daila S Gridley
    Department of Radiation Medicine, Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    J Appl Physiol 94:2095-103. 2003
    ..05) and were consistent with dehydration. These data indicate that relatively short exposure to the spaceflight environment can induce profound changes that may become significant during long-term space missions...
  75. ncbi request reprint Total-body irradiation with high-LET particles: acute and chronic effects on the immune system
    Daila S Gridley
    Department of Radiation Medicine, Radiobiology Program, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    Am J Physiol Regul Integr Comp Physiol 282:R677-88. 2002
    ..Thus simultaneous exposure to multiple radiation sources could lead to a broader spectrum of immune dysfunction than currently anticipated...
  76. doi request reprint Long-term dose response of trabecular bone in mice to proton radiation
    Eric R Bandstra
    Department of Bioengineering, Clemson University, Clemson, SC 29631, USA
    Radiat Res 169:607-14. 2008
    ..Trabecular bone loss 4 months after exposure to 1 Gy highlights the importance of further examination of how space radiation affects bone...