CHARLES DUCSAY

Summary

Affiliation: Loma Linda University
Country: USA

Publications

  1. ncbi Extracellular signal-regulated kinases (ERK1/2) signaling pathway plays a role in cortisol secretion in the long-term hypoxic ovine fetal adrenal near term
    Vladimir E Vargas
    Center for Perinatal Biology, School of Medicine, Loma Linda Univ, Loma Linda, CA 92350
    Am J Physiol Regul Integr Comp Physiol 304:R636-43. 2013
  2. ncbi Leptin receptor antagonist treatment ameliorates the effects of long-term maternal hypoxia on adrenal expression of key steroidogenic genes in the ovine fetus
    Charles A Ducsay
    Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Am J Physiol Regul Integr Comp Physiol 304:R435-42. 2013
  3. ncbi eNOS activation and NO function: differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia
    Charles A Ducsay
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Endocrinol 210:259-69. 2011
  4. ncbi Long-term hypoxia enhances ACTH response to arginine vasopressin but not corticotropin-releasing hormone in the near-term ovine fetus
    Charles A Ducsay
    Center for Perinatal Biology, Loma Linda Univ School of Medicine, Loma Linda, CA, 92350, USA
    Am J Physiol Regul Integr Comp Physiol 297:R892-9. 2009
  5. ncbi Long-term hypoxia increases endothelial nitric oxide synthase expression in the ovine fetal adrenal
    Tshepo R Monau
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Reprod Sci 16:865-74. 2009
  6. ncbi Long-term hypoxia alters endocrine and physiologic responses to umbilical cord occlusion in the ovine fetus
    Toshiko Imamura
    Department of Physiology/Pharmacology, Center for Perinatal Biology, School of Medicine, Loma Linda University, California 92350, USA
    J Soc Gynecol Investig 11:131-40. 2004
  7. ncbi Long-term hypoxia alters ovine fetal endocrine and physiological responses to hypotension
    Keiichi Adachi
    Center for Perinatal Biology, School of Medicine, Loma Linda Univ, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 287:R209-17. 2004
  8. ncbi Long-term hypoxia increases leptin receptors and plasma leptin concentrations in the late-gestation ovine fetus
    Charles A Ducsay
    Center for Perinatal Biology, Loma Linda University, School of Medicine, CA, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1406-13. 2006
  9. ncbi Nitric oxide inhibits ACTH-induced cortisol production in near-term, long-term hypoxic ovine fetal adrenocortical cells
    Tshepo R Monau
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Reprod Sci 17:955-62. 2010
  10. ncbi Effect of long-term high-altitude hypoxia on fetal pulmonary vascular contractility
    Qin Xue
    Dept of Physiology and Pharmacology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    J Appl Physiol 104:1786-92. 2008

Research Grants

  1. Leptin and hypothalamo-pituitary-adrenal function in the long-term hypoxic fetus
    Charles A Ducsay; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Extracellular signal-regulated kinases (ERK1/2) signaling pathway plays a role in cortisol secretion in the long-term hypoxic ovine fetal adrenal near term
    Vladimir E Vargas
    Center for Perinatal Biology, School of Medicine, Loma Linda Univ, Loma Linda, CA 92350
    Am J Physiol Regul Integr Comp Physiol 304:R636-43. 2013
    ..UO126 pretreatment virtually eliminated pERK1/2 expression. We conclude that basal ERK signaling in FACs is necessary for normal cortisol production and sustained pERK in LTH adrenals enhances cortisol production...
  2. ncbi Leptin receptor antagonist treatment ameliorates the effects of long-term maternal hypoxia on adrenal expression of key steroidogenic genes in the ovine fetus
    Charles A Ducsay
    Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Am J Physiol Regul Integr Comp Physiol 304:R435-42. 2013
    ..We speculate that while leptin plays a role in governing expression of key enzymes and StAR in response to LTH, other factors play a role in modulating cortisol synthesis in these fetuses...
  3. ncbi eNOS activation and NO function: differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia
    Charles A Ducsay
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Endocrinol 210:259-69. 2011
    ..The effects of hypoxia on generation of NO and subsequent effects on steroid biosynthesis will also be examined. Finally, a potential model for the interaction of hypoxia on NO synthesis and steroid production is proposed...
  4. ncbi Long-term hypoxia enhances ACTH response to arginine vasopressin but not corticotropin-releasing hormone in the near-term ovine fetus
    Charles A Ducsay
    Center for Perinatal Biology, Loma Linda Univ School of Medicine, Loma Linda, CA, 92350, USA
    Am J Physiol Regul Integr Comp Physiol 297:R892-9. 2009
    ..LTH significantly increases pituitary sensitivity to AVP. This enhanced sensitivity may be a mechanism of our previously observed enhanced corticotrope function...
  5. ncbi Long-term hypoxia increases endothelial nitric oxide synthase expression in the ovine fetal adrenal
    Tshepo R Monau
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Reprod Sci 16:865-74. 2009
    ..We conclude that LTH enhances eNOS expression in the inner adrenal cortex which may play a role in regulation of cortisol biosynthesis in the LTH fetus...
  6. ncbi Long-term hypoxia alters endocrine and physiologic responses to umbilical cord occlusion in the ovine fetus
    Toshiko Imamura
    Department of Physiology/Pharmacology, Center for Perinatal Biology, School of Medicine, Loma Linda University, California 92350, USA
    J Soc Gynecol Investig 11:131-40. 2004
    ..LTH appears to result in enhanced adrenal sensitivity to a secondary stressor or altered cortisol metabolism...
  7. ncbi Long-term hypoxia alters ovine fetal endocrine and physiological responses to hypotension
    Keiichi Adachi
    Center for Perinatal Biology, School of Medicine, Loma Linda Univ, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 287:R209-17. 2004
    ..These results demonstrate an enhanced cortisol response to hypotension in LTH fetuses that does not appear to be the result of an increase in negative feedback sensitivity of the hypothalamic-pituitary-adrenal axis...
  8. ncbi Long-term hypoxia increases leptin receptors and plasma leptin concentrations in the late-gestation ovine fetus
    Charles A Ducsay
    Center for Perinatal Biology, Loma Linda University, School of Medicine, CA, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1406-13. 2006
    ..These changes may be responsible in part, for our previously observed alterations in fetal hypothalamic-pituitary-adrenal function following LTH...
  9. ncbi Nitric oxide inhibits ACTH-induced cortisol production in near-term, long-term hypoxic ovine fetal adrenocortical cells
    Tshepo R Monau
    Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Reprod Sci 17:955-62. 2010
    ..Nitric oxide may, therefore, play an important role in regulating ACTH-induced cortisol production in the LTH fetal adrenal...
  10. ncbi Effect of long-term high-altitude hypoxia on fetal pulmonary vascular contractility
    Qin Xue
    Dept of Physiology and Pharmacology, Loma Linda Univ School of Medicine, Loma Linda, CA 92350, USA
    J Appl Physiol 104:1786-92. 2008
    ....
  11. ncbi Long-term hypoxia modulates expression of key genes regulating adrenomedullary function in the late gestation ovine fetus
    Charles A Ducsay
    Center for Perinatal Biology, Loma Linda University, California, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1997-2005. 2007
    ..These findings have important implications regarding fetal cardiovascular and metabolic responses to stress in the LTH fetus...
  12. ncbi Cortisol-mediated regulation of uterine artery contractility: effect of chronic hypoxia
    Daliao Xiao
    Center for Perinatal Biology, Dept. of Physiology and Pharmacology, Loma Linda Univ. School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Heart Circ Physiol 286:H716-22. 2004
    ..Chronic hypoxia suppresses uterine artery sensitivity to cortisol, which may play an important role in the adaptation of uterine vascular tone and blood flow in response to chronic stress of hypoxia during pregnancy...
  13. ncbi Cortisol-mediated potentiation of uterine artery contractility: effect of pregnancy
    Daliao Xiao
    Center for Perinatal Biology, Department of Pharmacology and Physiology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Heart Circ Physiol 283:H238-46. 2002
    ..Pregnancy attenuates UA sensitivity to cortisol, which may be mediated by increasing type-2 11-beta HSD activity in UA...

Research Grants2

  1. Leptin and hypothalamo-pituitary-adrenal function in the long-term hypoxic fetus
    Charles A Ducsay; Fiscal Year: 2010
    ....