Research Topics
Species | Jean LoganSummaryCountry: USA Publications
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Publications
Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progressJean Logan
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 34:667-79. 2007..Quantification methods were determined from test/retest studies, and sensitivity to pharmacological blockade was tested with different doses of atomoxetine (ATX), a drug that binds to the NET with high affinity (K(i)=2-5 nM)...- Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxYu Shin Ding
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurochem 94:337-51. 2005..Thus, to our knowledge (S,S)-[11C]MRB remains by far the most promising NET ligand for PET studies... - Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokersJoanna S Fowler
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
J Nucl Med 46:1414-20. 2005..Because smoking exposes peripheral organs as well as the brain to MAO A-inhibitory compounds, we determined whether smokers would also have reduced MAO A in peripheral organs... - Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brainNora D Volkow
Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
Am J Psychiatry 161:1173-80. 2004..These findings support educational strategies that make schoolwork more interesting as nonpharmacological interventions to treat ADHD... - Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humansJoanna S Fowler
Brookhaven National Laboratory, Chemistry Department, Bldg 555, Upton, NY 11973, USA
Nucl Med Biol 31:313-9. 2004.... - Monoamine oxidase A imaging in peripheral organs in healthy human subjectsJoanna S Fowler
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 49:178-87. 2003.... - Brain dopamine is associated with eating behaviors in humansNora D Volkow
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Int J Eat Disord 33:136-42. 2003..We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables... 
Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozoleAnat Biegon
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 64:801-7. 2010..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...- Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PETAlicia E Reid
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 35:287-98. 2008.... - Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drugSung Won Kim
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 34:541-51. 2007..One of its two major demethylated metabolites, 4-OH-GTS-21, has been suggested to contribute to its therapeutic effects... - Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organsYu Shin Ding
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 50:345-52. 2003..These studies demonstrate that the use of (S,S)-[11C]MRB would allow a better understanding of the role that NET plays in living systems... - Low monoamine oxidase B in peripheral organs in smokersJoanna S Fowler
Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Proc Natl Acad Sci U S A 100:11600-5. 2003.... - Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaineJoanna S Fowler
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Neuroimage 43:756-63. 2008..The absence of significant differences between Caucasians and African Americans suggests that variables other than methamphetamine pharmacokinetics and bioavailability account for the lower abuse prevalence in African Americans... - Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasmaNora D Volkow
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Psychopharmacology (Berl) 166:264-70. 2003..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans... - The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effectsNora D Volkow
Brookhaven National Laboratory, Upton, NY 11973, USA
Biol Psychiatry 57:640-6. 2005..This study measures the potency and kinetics for DAT blockade by radafaxine in human brain... - Brain monoamine oxidase A activity predicts trait aggressionNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurosci 28:5099-104. 2008..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression... - Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primatesHelene Benveniste
Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
J Nucl Med 46:312-20. 2005..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus... - Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference regionJean Logan
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 32:531-42. 2005..The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated... - Synthesis and evaluation of inhaled [11C]butane and intravenously injected [11C]acetone as potential radiotracers for studying inhalant abuseMadina R Gerasimov
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 32:201-8. 2005..These data provide insight into the pharmacokinetic features possibly associated with the abuse liability of toluene, acetone and butane... - Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgylineJean Logan
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Cereb Blood Flow Metab 22:1367-76. 2002..This method should be generalizable to other tracers and should facilitate the analysis of group differences... - Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjectsJoanna S Fowler
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Biol Psychiatry 62:355-8. 2007..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects... - PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaineJoanna S Fowler
Brookhaven National Laboratory, Upton, New York, USA
J Nucl Med 48:1724-32. 2007.... - Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary studyNora D Volkow
Brookhaven National Laboratory, Upton, NY 11973, USA
Psychiatry Res 116:163-72. 2002..These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor... - "Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effectNora D Volkow
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 44:175-80. 2002..In addition it demonstrates the ability of methylphenidate to amplify weak dopamine signals... - Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboonsAnat Biegon
Brookhaven National Laboratory, Upton, New York, USA
Biol Psychiatry 67:774-7. 2010..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase... - Decreased brain dopaminergic transporters in HIV-associated dementia patientsGene-Jack Wang
Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
Brain 127:2452-8. 2004..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals... - PET imaging of monoamine oxidase B in peripheral organs in humansJoanna S Fowler
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Nucl Med 43:1331-8. 2002..The purpose of this study was to investigate the feasibility of imaging MAO B in peripheral organs in humans with PET... - The MAO-A genotype does not modulate resting brain metabolism in adultsNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
Psychiatry Res 164:73-6. 2008..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype... - 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matterYu-Shin Ding
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 53:184-9. 2004 - Translational neuroimaging: positron emission tomography studies of monoamine oxidaseJoanna S Fowler
Brookhaven National Laboratory, Upton, NY 11973, USA
Mol Imaging Biol 7:377-87. 2005..In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs... - PET imaging in clinical drug abuse researchS John Gatley
Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973, USA
Curr Pharm Des 11:3203-19. 2005.... - Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamineWynne K Schiffer
SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA
Neuropsychopharmacology 28:2192-8. 2003..5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA... - Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication studyNora D Volkow
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 46:79-82. 2002..These results replicate our previous findings and provide further evidence that striatal DA D2 receptors modulate reinforcing responses to stimulants in humans and may underlie predisposition for drug self-administration... - In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPETPanayotis K Thanos
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Nucl Med 43:1570-7. 2002..MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain neurochemistry in KO mice has not been demonstrated... - Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activityDavid L Alexoff
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Nucl Med 44:815-22. 2003..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability... - Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokersJean Logan
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 32:521-9. 2005.... - Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157Joanna S Fowler
Medical Department, Brookhaven National Laboratory, Upton, NY, USA
Neuropsychopharmacology 35:623-31. 2010..These data were used to establish the dosing regimen for a current clinical efficacy trial with CX157... - Simplifications in analyzing positron emission tomography data: effects on outcome measuresJean Logan
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 34:743-56. 2007..The ultimate solution to the problem of arterial sampling may be a wrist scanner, which acts as a small PET camera for imaging the arteries in the wrist. This is currently under development... - Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinenceGene Jack Wang
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Am J Psychiatry 161:242-8. 2004..In this study, the authors assessed whether metabolism recovers with protracted abstinence... - The use of alternative forms of graphical analysis to balance bias and precision in PET imagesJean Logan
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Cereb Blood Flow Metab 31:535-46. 2011..The variance of the four estimates can serve as a guide to the reliability of the median estimate. This may provide a general method for the generation of parametric images with little bias and good precision... - Monoamine oxidase and cigarette smokingJoanna S Fowler
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Neurotoxicology 24:75-82. 2003.... - Enhanced striatal dopamine release during food stimulation in binge eating disorderGene Jack Wang
Medical Department, Brookhaven National Laboratory, Upton, New York, USA
Obesity (Silver Spring) 19:1601-8. 2011..The lack of correlation between BMI and dopamine changes suggests that dopamine release per se does not predict BMI within a group of obese individuals but that it predicts binge eating... - Monoamine oxidase: radiotracer development and human studiesJoanna S Fowler
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Methods 27:263-77. 2002..PET studies have been carried out to measure the effects of age, MAO inhibitor drugs, tobacco smoke exposure, and other factors on MAO activity in the human brain... - Imaging dopamine receptors in the rat striatum with the MicroPET R4: kinetic analysis of [11C]raclopride binding using graphical methodsDavid L Alexoff
Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973, USA
Methods Enzymol 385:213-28. 2004 - PET imaging of norepinephrine transportersYu Shin Ding
Chemistry and Medical Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
Curr Pharm Des 12:3831-45. 2006..Thus, to our knowledge, (S, S)-[(11)C]MRB remains by far the most promising NET ligand for PET studies... - Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboonJean Logan
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Psychopharmacology (Berl) 223:447-55. 2012.... - Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implicationsNora D Volkow
Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 43:181-7. 2002.... - Effect of vehicle on brain uptake of [11C]tolueneMadina R Gerasimov
Brookhaven National Laboratory, Department of Chemistry, Upton, NY 11973, USA
Nucl Med Biol 29:607-12. 2002..Present results clearly demonstrate that the choice of a vehicle has a significant effect on tracer uptake and should be considered as a potential factor contributing to the pharmacokinetic measurements... - A review of graphical methods for tracer studies and strategies to reduce biasJean Logan
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Nucl Med Biol 30:833-44. 2003..One problem in the use of these methods particularly the method for reversible tracers is the bias generated due to the presence of statistical noise. Some recently proposed techniques for reducing the noise are considered... - Brain dopamine transporter levels in treatment and drug naïve adults with ADHDNora D Volkow
National Institute on Drug Abuse, Bethesda, MD 20892, USA
Neuroimage 34:1182-90. 2007..g., prefrontal or cingulostriatal pathways, noradrenergic neurotransmission) is necessary to account for the large differences in inattention observed between controls and ADHD subjects... - Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brainNora D Volkow
National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
J Neurosci 28:8454-61. 2008.... - Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imagingWynne K Schiffer
Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
J Neurosci Methods 144:25-34. 2005..0 and 3.5 pmol/ml, around which the measured BP can be compromised by system sensitivity, endogenous DA, or excessive competition with unlabeled compound... - Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive taskNora D Volkow
National Institute on Drug Abuse, Bethesda, Maryland, United States of America
PLoS ONE 3:e2017. 2008..This would explain why methylphenidate has beneficial effects in some individuals and contexts and detrimental effects in others... - Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cuesNora D Volkow
National Institute on Drug Abuse, Bethesda MD 20892, USA National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
Neuroimage 39:1266-73. 2008.... - Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvementNora D Volkow
National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
J Neurosci 27:12700-6. 2007.... - Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addictionNora D Volkow
National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
J Neurosci 26:6583-8. 2006..Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction... - Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorderNora D Volkow
National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:932-40. 2007..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed... - Consensus nomenclature for in vivo imaging of reversibly binding radioligandsRobert B Innis
National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
J Cereb Blood Flow Metab 27:1533-9. 2007..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands... - Seeing what Alzheimer sawMony J de Leon
Nat Med 13:129-31. 2007 - High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factorsNora D Volkow
National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
Arch Gen Psychiatry 63:999-1008. 2006..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...