Joseph Ramcharan

Summary

Affiliation: Locus Pharmaceuticals
Country: USA

Publications

  1. pmc Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody
    Joseph Ramcharan
    The Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Retrovirology 3:34. 2006
  2. pmc Oligonucleotide-based assays for integrase activity
    George Merkel
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Methods 47:243-8. 2009
  3. pmc Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    AIDS Res Ther 6:14. 2009

Collaborators

  • Xue Zhi Zhao
  • Mark D Andrake
  • George Merkel
  • Anna Marie Skalka
  • Terrence R Burke

Detail Information

Publications3

  1. pmc Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody
    Joseph Ramcharan
    The Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Retrovirology 3:34. 2006
    ..To gain additional insight into the mode of inhibition we also measured the DNA binding capacity and enzymatic activities of the Ala substituted proteins...
  2. pmc Oligonucleotide-based assays for integrase activity
    George Merkel
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Methods 47:243-8. 2009
    ..They can greatly facilitate further biochemical and structural analyses for HIV-1 and other IN proteins. The assays can also be adapted for moderate-high throughput testing of various inhibitory compounds...
  3. pmc Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution
    Mark D Andrake
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    AIDS Res Ther 6:14. 2009
    ..The assay is validated, and its utility demonstrated in a comparison of the metal-dependent activities of HIV-1 and ASV IN proteins...