Research Topics
Species | J LiuSummaryCountry: USA Publications
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Publications
Physical interaction between p53 and primary response gene Egr-1J Liu
VA CT Healthcare System, Cancer Center 111D, 950 Campbell Avenue, West Haven, CT 06516, USA
Int J Oncol 18:863-70. 2001..The interaction of these regulatory proteins may alter multiple features of their biological activity especially with regard to the specificity of transcriptional control...- Translational regulation as a novel mechanism for the development of cellular drug resistanceJ C Schmitz
Department of Medicine and Pharmacology, Yale Cancer Center, Yale University School of Medicine and VA CT Cancer Center, VA CT Healthcare System, New Haven 06516, USA
Cancer Metastasis Rev 20:33-41. 2001.... - Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophagesD L Coleman
Infectious Disease Section, Yale University School of Medicine, West Haven, CT
J Immunol 149:3045-51. 1992..In addition, these findings support further study of the potential role of Egr-1 in mediating the effects of LPS in peritoneal macrophages... - A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and functionJ Liu
Developmental Biology Program, Division of Pediatric Surgery, Childrens Hospital Los Angeles, University of Southern California, Keek School of Medicine, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
Biochem Biophys Res Commun 273:1042-7. 2000.... - Activation of Arp2/3 complex-mediated actin polymerization by cortactinT Uruno
Department of Experimental Pathology, Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way, Rockville, Maryland 20855, USA
Nat Cell Biol 3:259-66. 2001..Our data indicate a new mechanism for activation of actin polymerization involving an enhanced interaction between the Arp2/3 complex and actin filaments... - Defective interplay of activators and repressors with TFIH in xeroderma pigmentosumJ Liu
Gene Regulation Section, Laboratory of Pathology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
Cell 104:353-63. 2001..Mutations in TFIIH that impair regulation by FBP and FIR affect proper regulation of c-myc expression and have implications in the development of malignancy... - Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2J Liu
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center 915 Camino de Salud, NE Albuquerque, New Mexico, NM 87131, USA
Oncogene 20:336-45. 2001..These results suggest that BCCIPalpha is an important cofactor for BRCA2 in tumor suppression... - Alterations in the flow of one-carbon units affect KinB-dependent sporulation in Bacillus subtilisV Dartois
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Mol Microbiol 25:39-51. 1997..Our results indicate that lrpA-lrpB together with the biosynthetic glyA gene lie on a common signalling pathway meant to activate the KinB sensor kinase... - A cellular gene up-regulated by hepatitis B virus-encoded X antigen promotes hepatocellular growth and survivalZ Lian
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
Hepatology 34:146-57. 2001..This factor may contribute to the persistence of infected hepatocytes during chronic infection, which is important for the later development of hepatocellular carcinoma (HCC)... 
Tbx19, a tissue-selective regulator of POMC gene expressionJ Liu
Howard Hughes Medical Institute, School and Department of Medicine, University of California at San Diego, 9500 Gilman Drive, Cellular and Molecular Medicine West, Room 345, La Jolla, CA 92093 0648, USA
Proc Natl Acad Sci U S A 98:8674-9. 2001..It is suggested that Tbx19, depending on the presence of synergizing transcription factors, can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters...- Inhibition of NFATx activation by an oligopeptide: disrupting the interaction of NFATx with calcineurinJ Liu
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
J Immunol 167:2677-87. 2001..This approach may provide an opportunity for pharmacological targeting of Ca(2+)-dependent signaling events... - Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamilyG Steele-Perkins
The Burnham Institute, La Jolla, California 92037, USA
Genes Dev 15:2250-62. 2001..These data suggest a direct link between tumor formation and the MTase domain of RIZ1 and describe for the first time a tumor susceptibility gene among methyltransferases... - Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformationS Xie
Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 20:6188-95. 2001..In summary, these findings provide strong evidence that the Jak2 tyrosine kinase is a critical factor in Bcr-Abl malignant transformation... - The delayed activation of the prostaglandin G/H synthase-2 promoter in bovine granulosa cells is associated with down-regulation of truncated upstream stimulatory factor-2J Liu
Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, C P 5000, Saint Hyacinthe, Quebec J2S 7C6, Canada
J Biol Chem 274:35037-45. 1999.... - Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterizationJ Liu
Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Japan
Mol Biol Cell 8:157-70. 1997..These results provide the first evidence for the requirement of calcineurin in the control of mNFATx imported from the cytoplasm to the nucleus and implies that mNFATx may possibly be a substrate of calcineurin in vivo... - Inhibition of HIV-1 gp120-induced apoptosis in neuroblastoma SK-N-SH cells by an antisense oligodeoxynucleotide against p53M C Yeung
Department of Pediatrics, University of California, San Francisco, USA
AIDS 12:349-54. 1998..This study examines the cytotoxicity potential and the mechanism of toxicity of the HIV-1 gp120 on human neuroblastoma cells... - Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulationJ Liu
Department of Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA
Mol Cell Biol 19:4918-26. 1999..Because of the tissue and cell type distribution of SATB1 and CDP, we propose that the SATB1-to-CDP ratio in different tissues is a novel mechanism for homeoproteins to control gene expression and differentiation in mammals... - Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domainE S Masuda
Department of Cell Signaling, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
Mol Cell Biol 17:2066-75. 1997.... - Obesity reduced the gene expressions of leptin receptors in hypothalamus and liverZ J Liu
Department of Pediatrics, the Second Affiliated Hospital Dalian Medical University, Dalian, PR China
Horm Metab Res 39:489-94. 2007..The results suggest that a leptin downregulated OB-R expression is one of leptin resistant mechanisms for maintaining obesity... - Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functionsB Song
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Virology 290:320-8. 2001..Finally, these results show that HSV-1 ICP27 and vhs act jointly to reduce host mRNA levels in infected cells... - Construction of a yeast one-hybrid system with the xylanase2 promoter from Trichoderma reesei to isolate transcriptional activatorsJ Liu
State Key Laboratory of Microbial Technology, Shandong University, Shanda Nanlu, Jinan, China
Lett Appl Microbiol 38:277-82. 2004..ACE II is a main and universal transcriptional activator that controls cellulase and hemicellulase transcription regulation in T. reesei... - Atrial tachycardia induces remodelling of muscarinic receptors and their coupled potassium currents in canine left atrial and pulmonary vein cardiomyocytesY H Yeh
Department of Medicine, Université de Montréal and Research Center, Montreal Heart Institute, Quebec, Canada
Br J Pharmacol 152:1021-32. 2007..This study investigated AT-induced remodelling of mAChR subtypes and K+-currents in left-atrial (LA) and PV cardiomyocytes... - U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasiaW Xiao
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Oncogene 27:1536-44. 2008..The U19/Eaf2 knockout mouse also provides a unique animal model for three important cancers: lung adenocarcinoma, B-cell lymphoma and hepatocellular carcinoma... - Systems biology of the neurospora biological clockW Dong
Genetics Department, University of Georgia, Athens, GA 30602, USA
IET Syst Biol 1:257-65. 2007..A promising genetic network for the clock mechanism is identified... - Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosisW Qian
Department of Hematology, Institute of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, Hangzhou, PR China
Leukemia 22:361-9. 2008.... - The critical role of the PE21 element in oncostatin M-mediated transcriptional repression of the p53 tumor suppressor gene in breast cancer cellsC Li
Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
Oncogene 20:8193-202. 2001..Taken together, we demonstrate that OM inhibits the transcription of the p53 gene through the PE21 element. Thus, the PE21 element is functionally involved in p53 transcription regulated by UV-induction and OM suppression... - [Establishment and biologic characterization of human hepatocellular carcinoma cell line HCC-9903]J Liu
Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China
Zhonghua Wai Ke Za Zhi 39:872-4. 2001..CONCLUSION: According to the rules of establishing a cell line in vitro, HCC-9903 has been proved to be a new cell line of human HCC carcinoma, and more experimental methods have been used to study its biological characteristics... - Adaptation to chronic PCP results in hyperfunctional NMDA and hypofunctional GABA(A) synaptic receptorsB Yu
Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1031, USA
Neuroscience 113:1-10. 2002..Our data support a reconsideration of NMDA and GABA(A) receptor responsiveness following a chronic, not acute, exposure to PCP and the adaptations that persist after such a regimen... - Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti-larval immunityA J MacDonald
Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, NY 10021, USA
Parasite Immunol 26:53-62. 2004..Ov-ASP-1 is potentially secreted based on its localization in the secretory granules of L3... - Characterization and utilization of two novel anti-erbB-2 monoclonal antibodies in detection of soluble ErbB-2 for breast cancer prognosisP Li
School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China
Cancer Lett 193:139-48. 2003..Based on our preliminary clinical data, we came to the conclusion that both A18 and A21 could possibly be used in the prognosis of breast cancer... - Transcription factors GATA-4 and GATA-6 in human adrenocortical tumorsS Kiiveri
Children s Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
Endocr Res 30:919-23. 2004..In contrast, both cell lines expressed GATA-6. GATA expression patterns similar to the animal models can thus be observed in human adrenocortical tumors, but the pathophysiological significance of these findings remains to be elucidated... - [Determination of human PDGF-B promoter binding nuclear protein by capillary electrophoresis]X J Fan
State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031, China
Se Pu 19:170-2. 2001..This technique can provide one of the rapid and accurate separation methods in the studying of the formation and repression behavior of DNA binding protein based on PDGF gene as the target... - Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD studySamer Karamohamed
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Mov Disord 20:1188-91. 2005..None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study... - Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical developmentS Kiiveri
Children s Hospital, P O Box 63, 00014, University of Helsinki, Finland
Endocr Res 28:647-50. 2002..Our findings suggest that GATA-6 expression is hormonally controlled, and required throughout adrenal development from fetal to adult age. GATA-4, on the other hand, may serve a role in fetal adrenal gene regulation... - G-CSF-primed haploidentical marrow transplantation without ex vivo T cell depletion: an excellent alternative for high-risk leukemiaS-Q Ji
Research Center for Hematology, The General Hospital of Air Force, PLA, Beijing, PR China
Bone Marrow Transplant 30:861-6. 2002..In conclusion, using G-CSF priming marrow grafts along with sequential immunosuppressants provided an excellent alternative for the treatment of high-risk hematological malignancy in patients who lack matched donors... - A point mutation (R192H) in the C-terminus of human cardiac troponin I causes diastolic dysfunction in transgenic miceJ Du
Department of Biomedical Science and Center for Molecular Biology and Biotechnology, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
Arch Biochem Biophys 456:143-50. 2006..This mouse model provides us with a tool to further investigate the pathophysiology and the development of RCM... - Study of heat shock response of human umbilical vein endothelial cells (HUVECs) using cDNA microarrayM Zhou
Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, P R China
Int J Hyperthermia 23:225-58. 2007..It has been shown that a large number of genes were regulated indicating global response to heat treatment at the genetic level... - Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cellsJ Liu
Department of Pathology, PO Box 21, University of Helsinki, FIN 00014 Helsinki, Finland
Mol Hum Reprod 8:992-7. 2002..Taken together, previous and our present data suggest that protein kinase C and A signal transduction pathways differently regulate the expression of FLRG and follistatin genes in human ovarian granulosa-luteal cells... - Analysis of hypermutation of the 5' noncoding region in the BCL-6 geneL Wang
Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Chin Med J (Engl) 114:286-90. 2001..CONCLUSIONS: The 5' regulatory region of the BCL-6 gene undergoes frequent somatic hypermutation during lymphomagenesis and the identification of BCL-6 gene hypermutations provides a molecular marker for confirmatory diagnosis of B-NHL... - [The dynamic change in the expression of interleukin 18 mRNA in the tissue of scalded rats after delayed resuscitation]J Liu
Burn Institute, 304th Hospital of PLA, Beijing, 100037, P. R. China
Zhonghua Shao Shang Za Zhi 17:286-8. 2001..And the expression of tissue IL-18 mRNA in a variety of body tissue was significantly affected by post-traumatic endotoxemia... - Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatmentM Ikeguchi
First Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
Apoptosis 7:23-9. 2002..1 or 1 microg/ml of CDDP was 3 to 6.5 fold higher than that of the survivin protein of untreated cells. These results indicate that survivin expression may correlate with the chemo-resistance of malignant cells... 
ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrinD D Chang
Department of Medicine, and Department of Microbiology and Immunology, University of California, Los Angeles, California 90095, USA
J Cell Biol 138:1149-57. 1997..The regulation of ICAP-1alpha phosphorylation by the cell-matrix interaction suggests an important role of ICAP-1 during integrin-dependent cell adhesion...- Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfateM Kobayashi
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Biol Chem 274:10474-80. 1999.... - Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferaseJ Liu
Department of Microbiology, Umea University, S 901 87 Umea, Sweden and Shanghai Research Centre of Life Sciences, Academia Sinica, 200031 Shanghai, China
Nucleic Acids Res 26:5102-8. 1998.... - Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagusJ Motoyama
Programs in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Nat Genet 20:54-7. 1998..These results indicate that Gli2 and Gli3 possess specific and overlapping functions in Shh signalling during foregut development, and suggest that mutations in GLI genes may be involved in human foregut malformations... - Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligandsY Ghendler
Laboratory of Immunobiology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 95:10061-6. 1998..Based on these finding and the recent structural elucidation of the N15-VSV8/Kb complex, moreover, it appears that the germ-line Valpha repertoire contributes in a significant way to positive selection... - Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogasterJ Liu
Section of Genetics and Development, Cornell University, Ithaca, New York 14853 2703, USA
Mol Cell Biol 18:188-97. 1998..Finally, we showed that the C-terminal 179 amino acids of YA are necessary to target, or retain, YA in the nuclear envelope... - Molecular sites of regulation of expression of the rat cationic amino acid transporter geneK S Aulak
Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Biol Chem 271:29799-806. 1996.... - Frizzled gene expression and development of tissue polarity in the Drosophila wingW J Park
Biology Department, University of Virginia, Charlottesville 22903
Dev Genet 15:383-9. 1994..We have also found that fz function is not required for normal fz expression. We have further found that mutations in several other tissue polarity genes do not noticeably alter the expression or the modification state of the Fz protein... - Activation of the dephosphorylation of nitrogen regulator I-phosphate of Escherichia coliJ Liu
Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139
J Bacteriol 177:926-31. 1995..This effect of glutamate appears to be a backup control that becomes effective when the normal regulation of PII activity is disabled... - Two modes of PriA binding to DNAP Nurse
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
J Biol Chem 274:25026-32. 1999..The D loop DNA binding activity of PriA can be accounted for by the second mode, where the enzyme binds bent DNA at three strand junctions... - Cloning and characterization of human oncostatin M promoterY Ma
Department of Veterans Affairs Medical Center, Boise, ID 83702, USA
Nucleic Acids Res 27:4649-57. 1999.... - The FBP interacting repressor targets TFIIH to inhibit activated transcriptionJ Liu
Gene Regulation Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell 5:331-41. 2000..Thus, FIR locks TFIIH in an activation-resistant configuration that still supports basal transcription... - Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosisS H Lee
Molecular Therapy Research Center, College of Medicine, Sung Kyun Kwan University, Samsung Medical Center, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Korea
Oncogene 20:6700-6. 2001..Thus, because loss of thymosin beta-10 expression may contribute to the development of a subset of ovarian cancers, restoration of thymosin beta-10 expression may be a new strategy for ovarian cancer treatment... - Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient miceJ Liu
Department of Bio Research Technologies and Proteins, Eli Lilly and Company, Indianapolis, IN 46285, USA
Immunity 15:23-34. 2001..DR6, therefore, functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses... - Oncostatin M-induced growth inhibition and morphological changes of MDA-MB231 breast cancer cells are abolished by blocking the MEK/ERK signaling pathwayC Li
Department of Veterans Affairs Palo Alto Health Care System, CA 94304, USA
Breast Cancer Res Treat 66:111-21. 2001.... - Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli proteinJ Liu
Department of Oncological Sciences, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Mol Cell 7:927-36. 2001..These results indicate that APC and Siah-1 mediate a novel beta-catenin degradation pathway linking p53 activation to cell cycle control... - Isolation of a CONSTANS ortholog from Pharbitis nil and its role in floweringJ Liu
Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824-1312, USA
Plant Physiol 125:1821-30. 2001..A major portion of the PnCO transcripts contained an unspliced intron. Only the intron-free PnCO was able to complement the co mutant of Arabidopsis by shortening the time to flower... - Role of retinoid receptor coactivator pockets in cofactor recruitment and transcriptional regulationC Leo
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Biol Chem 276:23127-34. 2001..These results indicate a differential role for each retinoid receptor to the overall binding of cofactors and regulation of transcription by the retinoid receptor heterodimer... - Requirement of Sp1 and estrogen receptor alpha interaction in 17beta-estradiol-mediated transcriptional activation of the low density lipoprotein receptor gene expressionC Li
Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
Endocrinology 142:1546-53. 2001..This study for the first time provides a molecular basis for an understanding of the regulation of LDLR transcription by estrogens... - Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complexS Otte
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Cell Biol 152:503-18. 2001..A cell-free assay that reproduces transport between the ER and Golgi indicates that deletion of the Erv41p-Erv46p complex influences the membrane fusion stage of transport... - The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 geneJ Liu
Department of Microbiology, Umea University, S 90187 Umea, Sweden
Nucleic Acids Res 28:3445-51. 2000..A deletion of these 90 C-terminal amino acids left the modification activity in vitro intact. Among point mutations in the hTRM1 gene, only those located in conserved regions of hTRM1p completely eliminated modification activity... - The PML gene encodes a phosphoprotein associated with the nuclear matrixK S Chang
Department of Hematology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Blood 85:3646-53. 1995..Our study showed that PML has many similar properties compared with the tumor suppressor, eg, Rb. These findings further support the important role of PML in APL pathogenesis...