Research Topics
| J R AsplinSummaryAffiliation: Litholink Corporation Country: USA Publications
Research Grants
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Detail Information
Publications
Hyperoxaluric calcium nephrolithiasisJohn R Asplin
University of Chicago and Litholink Corporation, 2250 W Campbell Park Drive, Chicago, IL 60612, USA
Endocrinol Metab Clin North Am 31:927-49. 2002..Recent studies of oxalate degrading bacteria and renewed interest in the role of diet calcium in oxalate absorption may lead to better therapeutic strategies for hyperoxaluric calcium nephrolithiasis...
Obesity and urolithiasisJohn R Asplin
Litholink Corporation, Chicago, IL 60612, USA
Adv Chronic Kidney Dis 16:11-20. 2009..The optimal approach to weight control that minimizes stone risk needs to be determined...
Thiosulfate reduces calcium phosphate nephrolithiasisJohn R Asplin
Litholink Corp, 2250 W Campbell Park Drive, Chicago, IL 60612, USA
J Am Soc Nephrol 20:1246-53. 2009..In summary, sodium thiosulfate reduces calcium phosphate stone formation in the genetic hypercalciuric rat. Controlled trials testing the efficacy and safety of sodium thiosulfate for recurrent kidney stones in humans are needed...- Evaluation of the kidney stone patientJohn R Asplin
Litholink Corporation, Chicago, IL 60612, USA
Semin Nephrol 28:99-110. 2008..For patients with multiple kidney stones 24-hour urine chemistries need to be measured to identify abnormalities that predispose to kidney stones, which guides dietary and pharmacologic therapy to prevent future stone events... - Hyperoxaluria in kidney stone formers treated with modern bariatric surgeryJohn R Asplin
Litholink Corporation and the Section of Nephrology, University of Chicago, Chicago, Illinois, USA
J Urol 177:565-9. 2007..Bariatric procedures currently in use have not been adequately evaluated for this complication... - Urine calcium excretion predicts bone loss in idiopathic hypercalciuriaJ R Asplin
Litholink Corporation, University of Chicago, Chicago, Illinois 60612, USA
Kidney Int 70:1463-7. 2006..It would appear that IHSF with the highest 24-h urine calcium excretion rates are at highest risk for loss of femoral neck bone mineral over a 3-year period... - Differences in urine volume and supersaturation in 2 physician networksF L Coe
University of Chicago and LithoLink Corp, Chicago, Illinois, USA
J Urol 166:423-8. 2001..Initial patient characteristics may vary significantly in the groups for reasons that are unknown to date, greatly affecting treatment outcome... - Proportional reduction of urine supersaturation during nephrolithiasis treatmentF L Coe
Nephrology Section, University of Chicago, Chicago, Illinois, USA
J Urol 166:1247-51. 2001..The mechanisms responsible for proportional reduction remain to be clarified... - Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallizationS N Pillay
Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol 275:F255-61. 1998..Given its urinary abundance and potency, calgranulin may contribute importantly to the normal urinary inhibition of crystal growth and aggregation and therefore to the renal defense against clinical stone disease... - Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugsF L Coe
University of Chicago and LithoLink Corp, Chicago, Illinois, USA
J Urol 166:688-93. 2001..This assay enables one to assess the level of drug effect and the need for a change in dosing... - Influence of gender and age on calcium oxalate crystal growth inhibition by urine from relatives of stone forming patientsKristin J Bergsland
University of Chicago and LithoLink Corp, Chicago, Illinois, USA
J Urol 167:2372-6. 2002..Further use of this assay in clinical investigations must take age and gender into proper account... - Patient adherence to long-term medical treatment of kidney stonesJ H Parks
University of Chicago and LithoLink Corp, Chicago, Illinois, USA
J Urol 166:2057-60. 2001..Timing of followup measurements can be close to that of the protocol in use... - Protein content of human apatite and brushite kidney stones: significant correlation with morphologic measuresRocky Pramanik
Litholink Corporation, 2250 West Campbell Park Drive, Chicago, IL 60612, USA
Urol Res 36:251-8. 2008..Our results show that protein content of brushite and apatite stones is higher than that was previously thought, and also suggest that micro CT-visible void regions are related to the presence of protein... - Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasisJohn R Asplin
Litholink Corporation, and Renal Section, University of Chicago, Chicago, Illinois 60612, USA
Kidney Int 63:662-9. 2003..Lowered calcium consumption in IH, perhaps in response to stone formation, alters bone responses in a direction that can predispose to mineral loss and eventual fracture... - Urinary stone risk factors in the siblings of patients with calcium renal stonesJennifer M Kinder
Litholink Corp. and Nephrology Section, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
J Urol 167:1965-7. 2002..To determine whether these measurements can be used to predict new stone onset may require years of observation of our current cohort... - Reduced crystallization inhibition by urine from women with nephrolithiasisJohn R Asplin
Renal Section, University of Chicago, and Litholink Corporation, Chicago, Illinois 60637, USA
Kidney Int 61:1821-9. 2002..This defect could promote stones by facilitating crystal nucleation. Abnormal inhibition may well be a very important cause of human nephrolithiasis... - A single 24-hour urine collection is inadequate for the medical evaluation of nephrolithiasisJoan H Parks
Nephrology Section, University of Chicago and LithoLink Corp, Chicago, Illinois, USA
J Urol 167:1607-12. 2002..CONCLUSIONS: A single 24-hour sample is not sufficient for evaluating patients before metabolic treatment for stone prevention because misdiagnosis is common, leading to inappropriate treatment... - Calcium oxalate stone formation in genetic hypercalciuric stone-forming ratsDavid A Bushinsky
Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Strong Memorial Hospital, 601 Elmwood Avenue, Rochester, NY 14642, USA
Kidney Int 61:975-87. 2002.... - A randomized, controlled trial of lactic acid bacteria for idiopathic hyperoxaluriaDavid S Goldfarb
Nephrology Section, New York Harbor VA Medical Center and New York University School of Medicine, New York, NY 10010, USA
Clin J Am Soc Nephrol 2:745-9. 2007..Some lactic acid bacteria can degrade oxalate in vitro. This study sought to reduce urinary oxalate excretion in calcium stone formers with idiopathic hyperoxaluria... - Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6Zhirong Jiang
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nat Genet 38:474-8. 2006..We conclude that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis... - Chitosan does not reduce post-prandial urinary oxalate excretionJoshua Wolf
Nephrology Section, University of California at San Francisco Medical Center, San Francisco, CA, and Nephrology Section, New York Harbor VAMC, Department of Urology, St. Vincents Hospital, New York, NY 10010, USA
Urol Res 34:227-30. 2006..3+/-16.9 mg/g creatinine (P=0.57, NS). We conclude that chitosan does not reduce acute intestinal oxalate absorption and therefore does not affect post-prandial urinary oxalate excretion... - Thiazides reduce brushite, but not calcium oxalate, supersaturation, and stone formation in genetic hypercalciuric stone-forming ratsDavid A Bushinsky
Department of Medicine, University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
J Am Soc Nephrol 16:417-24. 2005....
Research Grants
- Osteoporosis in Hypercalciuric Kidney Stone FormersJohn Asplin; Fiscal Year: 2003..We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families. ..
- Urine Protein Predictors of NephrolithiasisJohn Asplin; Fiscal Year: 2005....
- Treatment of Calcium Nephrolithiasis Sodium ThiosulfateJohn Asplin; Fiscal Year: 2006..New, more effective and better tolerated drugs are needed to reduce the recurrence of kidney stones in these patients. ..
- Urine Crystal Inhibition in Pediatric NephrolithiasisJohn Asplin; Fiscal Year: 2007..abstract_text> ..