J R Asplin

Summary

Affiliation: Litholink Corporation
Country: USA

Publications

  1. ncbi request reprint Hyperoxaluric calcium nephrolithiasis
    John R Asplin
    University of Chicago and Litholink Corporation, 2250 W Campbell Park Drive, Chicago, IL 60612, USA
    Endocrinol Metab Clin North Am 31:927-49. 2002
  2. doi request reprint Obesity and urolithiasis
    John R Asplin
    Litholink Corporation, Chicago, IL 60612, USA
    Adv Chronic Kidney Dis 16:11-20. 2009
  3. pmc Thiosulfate reduces calcium phosphate nephrolithiasis
    John R Asplin
    Litholink Corp, 2250 W Campbell Park Drive, Chicago, IL 60612, USA
    J Am Soc Nephrol 20:1246-53. 2009
  4. doi request reprint Evaluation of the kidney stone patient
    John R Asplin
    Litholink Corporation, Chicago, IL 60612, USA
    Semin Nephrol 28:99-110. 2008
  5. ncbi request reprint Hyperoxaluria in kidney stone formers treated with modern bariatric surgery
    John R Asplin
    Litholink Corporation and the Section of Nephrology, University of Chicago, Chicago, Illinois, USA
    J Urol 177:565-9. 2007
  6. ncbi request reprint Urine calcium excretion predicts bone loss in idiopathic hypercalciuria
    J R Asplin
    Litholink Corporation, University of Chicago, Chicago, Illinois 60612, USA
    Kidney Int 70:1463-7. 2006
  7. ncbi request reprint Differences in urine volume and supersaturation in 2 physician networks
    F L Coe
    University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 166:423-8. 2001
  8. ncbi request reprint Proportional reduction of urine supersaturation during nephrolithiasis treatment
    F L Coe
    Nephrology Section, University of Chicago, Chicago, Illinois, USA
    J Urol 166:1247-51. 2001
  9. ncbi request reprint Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization
    S N Pillay
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 275:F255-61. 1998
  10. ncbi request reprint Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugs
    F L Coe
    University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 166:688-93. 2001

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Hyperoxaluric calcium nephrolithiasis
    John R Asplin
    University of Chicago and Litholink Corporation, 2250 W Campbell Park Drive, Chicago, IL 60612, USA
    Endocrinol Metab Clin North Am 31:927-49. 2002
    ..Recent studies of oxalate degrading bacteria and renewed interest in the role of diet calcium in oxalate absorption may lead to better therapeutic strategies for hyperoxaluric calcium nephrolithiasis...
  2. doi request reprint Obesity and urolithiasis
    John R Asplin
    Litholink Corporation, Chicago, IL 60612, USA
    Adv Chronic Kidney Dis 16:11-20. 2009
    ..The optimal approach to weight control that minimizes stone risk needs to be determined...
  3. pmc Thiosulfate reduces calcium phosphate nephrolithiasis
    John R Asplin
    Litholink Corp, 2250 W Campbell Park Drive, Chicago, IL 60612, USA
    J Am Soc Nephrol 20:1246-53. 2009
    ..In summary, sodium thiosulfate reduces calcium phosphate stone formation in the genetic hypercalciuric rat. Controlled trials testing the efficacy and safety of sodium thiosulfate for recurrent kidney stones in humans are needed...
  4. doi request reprint Evaluation of the kidney stone patient
    John R Asplin
    Litholink Corporation, Chicago, IL 60612, USA
    Semin Nephrol 28:99-110. 2008
    ..For patients with multiple kidney stones 24-hour urine chemistries need to be measured to identify abnormalities that predispose to kidney stones, which guides dietary and pharmacologic therapy to prevent future stone events...
  5. ncbi request reprint Hyperoxaluria in kidney stone formers treated with modern bariatric surgery
    John R Asplin
    Litholink Corporation and the Section of Nephrology, University of Chicago, Chicago, Illinois, USA
    J Urol 177:565-9. 2007
    ..Bariatric procedures currently in use have not been adequately evaluated for this complication...
  6. ncbi request reprint Urine calcium excretion predicts bone loss in idiopathic hypercalciuria
    J R Asplin
    Litholink Corporation, University of Chicago, Chicago, Illinois 60612, USA
    Kidney Int 70:1463-7. 2006
    ..It would appear that IHSF with the highest 24-h urine calcium excretion rates are at highest risk for loss of femoral neck bone mineral over a 3-year period...
  7. ncbi request reprint Differences in urine volume and supersaturation in 2 physician networks
    F L Coe
    University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 166:423-8. 2001
    ..Initial patient characteristics may vary significantly in the groups for reasons that are unknown to date, greatly affecting treatment outcome...
  8. ncbi request reprint Proportional reduction of urine supersaturation during nephrolithiasis treatment
    F L Coe
    Nephrology Section, University of Chicago, Chicago, Illinois, USA
    J Urol 166:1247-51. 2001
    ..The mechanisms responsible for proportional reduction remain to be clarified...
  9. ncbi request reprint Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization
    S N Pillay
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol 275:F255-61. 1998
    ..Given its urinary abundance and potency, calgranulin may contribute importantly to the normal urinary inhibition of crystal growth and aggregation and therefore to the renal defense against clinical stone disease...
  10. ncbi request reprint Solid phase assay of urine cystine supersaturation in the presence of cystine binding drugs
    F L Coe
    University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 166:688-93. 2001
    ..This assay enables one to assess the level of drug effect and the need for a change in dosing...
  11. ncbi request reprint Influence of gender and age on calcium oxalate crystal growth inhibition by urine from relatives of stone forming patients
    Kristin J Bergsland
    University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 167:2372-6. 2002
    ..We define the relationships between urine inhibition of calcium oxalate crystal growth and age, gender, urine chemistries and stone formation among relatives of calcium stone forming patients...
  12. ncbi request reprint Patient adherence to long-term medical treatment of kidney stones
    J H Parks
    University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 166:2057-60. 2001
    ..Timing of followup measurements can be close to that of the protocol in use...
  13. pmc Protein content of human apatite and brushite kidney stones: significant correlation with morphologic measures
    Rocky Pramanik
    Litholink Corporation, 2250 West Campbell Park Drive, Chicago, IL 60612, USA
    Urol Res 36:251-8. 2008
    ..Our results show that protein content of brushite and apatite stones is higher than that was previously thought, and also suggest that micro CT-visible void regions are related to the presence of protein...
  14. ncbi request reprint Bone mineral density and urine calcium excretion among subjects with and without nephrolithiasis
    John R Asplin
    Litholink Corporation, and Renal Section, University of Chicago, Chicago, Illinois 60612, USA
    Kidney Int 63:662-9. 2003
    ..To disentangle effects of diet, stone formation, and physiology upon BMD, we studied vertebral and femoral neck BMD among relatives of hypercalciuric stone formers, and contrasted those with to those without stones...
  15. ncbi request reprint Urinary stone risk factors in the siblings of patients with calcium renal stones
    Jennifer M Kinder
    Litholink Corp and Nephrology Section, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
    J Urol 167:1965-7. 2002
    ..We determined which, if any, urinary stone risk factors accurately discriminate stone forming and nonstone forming siblings of patients with calcium renal stones...
  16. ncbi request reprint Reduced crystallization inhibition by urine from women with nephrolithiasis
    John R Asplin
    Renal Section, University of Chicago, and Litholink Corporation, Chicago, Illinois 60637, USA
    Kidney Int 61:1821-9. 2002
    ..This study tested the hypothesis that low levels of inhibition are present in women with calcium oxalate stones and, therefore, could promote stone production...
  17. ncbi request reprint A single 24-hour urine collection is inadequate for the medical evaluation of nephrolithiasis
    Joan H Parks
    Nephrology Section, University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 167:1607-12. 2002
    ..We determined the adequacy of a single 24-hour urine sample for evaluating patients for medical renal stone prevention...
  18. ncbi request reprint Calcium oxalate stone formation in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Strong Memorial Hospital, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Kidney Int 61:975-87. 2002
    ....
  19. ncbi request reprint A randomized, controlled trial of lactic acid bacteria for idiopathic hyperoxaluria
    David S Goldfarb
    Nephrology Section, New York Harbor VA Medical Center and New York University School of Medicine, New York, NY 10010, USA
    Clin J Am Soc Nephrol 2:745-9. 2007
    ..Some lactic acid bacteria can degrade oxalate in vitro. This study sought to reduce urinary oxalate excretion in calcium stone formers with idiopathic hyperoxaluria...
  20. ncbi request reprint Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6
    Zhirong Jiang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 38:474-8. 2006
    ..We conclude that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis...
  21. ncbi request reprint Chitosan does not reduce post-prandial urinary oxalate excretion
    Joshua Wolf
    Nephrology Section, University of California at San Francisco Medical Center, San Francisco, CA, and Nephrology Section, New York Harbor VAMC, Department of Urology, St Vincents Hospital, New York, NY 10010, USA
    Urol Res 34:227-30. 2006
    ..3+/-16.9 mg/g creatinine (P=0.57, NS). We conclude that chitosan does not reduce acute intestinal oxalate absorption and therefore does not affect post-prandial urinary oxalate excretion...
  22. ncbi request reprint Thiazides reduce brushite, but not calcium oxalate, supersaturation, and stone formation in genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Strong Memorial Hospital, 601 Elmwood Avenue, Box 675, Rochester, NY 14642, USA
    J Am Soc Nephrol 16:417-24. 2005
    ....

Research Grants4

  1. Osteoporosis in Hypercalciuric Kidney Stone Formers
    John Asplin; Fiscal Year: 2003
    ..We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families. ..
  2. Urine Protein Predictors of Nephrolithiasis
    John Asplin; Fiscal Year: 2005
    ....
  3. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..New, more effective and better tolerated drugs are needed to reduce the recurrence of kidney stones in these patients. ..
  4. Urine Crystal Inhibition in Pediatric Nephrolithiasis
    John Asplin; Fiscal Year: 2007
    ..abstract_text> ..