Research Topics
| Benjamin A LipskySummaryCountry: USA Publications
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Publications
The value of a wound score for diabetic foot infections in predicting treatment outcome: a prospective analysis from the SIDESTEP trialBenjamin A Lipsky
Primary Care Clinic, Antibiotic Research, VA Puget Sound Health Care System, University of Washington School of Medicine, 1660 South Columbian Way, Seattle, WA 98108, USA
Wound Repair Regen 17:671-7. 2009..This easily performed wound score appears to be a reliable, valid, and useful tool for predicting clinical outcomes. Further validation studies in different patient populations should refine the items included...
Medical treatment of diabetic foot infectionsBenjamin A Lipsky
Department of Medicine, University of Washington School of Medicine, and General Internal Medicine Clinic, VA Puget Sound Health Care System, Seattle 98108 1597, USA
Clin Infect Dis 39:S104-14. 2004..Definitive therapy depends on culture results and the clinical response. Bone infection is particularly difficult to treat and often requires surgery. Several adjuvant agents may be beneficial in some cases...- Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trialBenjamin A Lipsky
University of Washington School of Medicine and Veterans Affairs Puget Sound Health Care System S 111 GIMC, 1660 S Columbian Way, Seattle, WA 98108, USA
Lancet 366:1695-703. 2005..Our aim was to assess the efficacy and safety of ertapenem versus piperacillin/tazobactam for foot infections... - Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanateBenjamin A Lipsky
VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA
J Antimicrob Chemother 60:370-6. 2007.... - Diagnosis and treatment of diabetic foot infectionsBenjamin A Lipsky
Medical Service, Veterans Affairs Puget Sound Health Care System, and Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108-9804, USA
Clin Infect Dis 39:885-910. 2004 - Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan creamBenjamin A Lipsky
Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98116 1597, USA
Clin Infect Dis 47:1537-45. 2008.... - A report from the international consensus on diagnosing and treating the infected diabetic footBenjamin A Lipsky
Diabetes Metab Res Rev 20:S68-77. 2004..Among the factors predisposing diabetic patients to foot infections are ill-defined immunological perturbations 56; foot anatomy may foster proximal spread of infection and ischemic necrosis 78... - Diagnosing and treating diabetic foot infectionsBenjamin A Lipsky
University of Washington and VA Puget Sound Health Care System, Seattle, Washington, USA
Diabetes Metab Res Rev 20:S56-64. 2004..This paper presents a summary of a minisymposium on infection of the diabetic foot that was held at the fourth International Symposium on the Diabetic Foot, in Noordwijkerhout, The Netherlands... - Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanateBenjamin A Lipsky
Antibiotic Research Clinic, Veterans Affairs Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle, Washington 98108 1597, USA
Clin Infect Dis 38:17-24. 2004..Linezolid was at least as effective as aminopenicillin/beta-lactamase inhibitors for treating foot infections in diabetic patients... - 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infectionsBenjamin A Lipsky
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
Clin Infect Dis 54:e132-73. 2012..Employing multidisciplinary foot teams improves outcomes. Clinicians and healthcare organizations should attempt to monitor, and thereby improve, their outcomes and processes in caring for DFIs... - Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trialBenjamin A Lipsky
Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108 1597, USA
Int Wound J 4:30-8. 2007..Increased white blood cell count and severe UT wound grade at baseline, but not other features, were significant independent and additive risk factors for clinical failure in patients treated for a diabetic foot infection... - 2012 infectious diseases society of america clinical practice guideline for the diagnosis and treatment of diabetic foot infectionsBenjamin A Lipsky
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle
J Am Podiatr Med Assoc 103:2-7. 2013..Employing multidisciplinary foot teams improves outcomes. Clinicians and healthcare organizations should attempt to monitor, and thereby improve, their outcomes and processes in caring for DFIs... - Executive summary: 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infectionsBenjamin A Lipsky
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Clin Infect Dis 54:1679-84. 2012..Employing multidisciplinary foot teams improves outcomes. Clinicians and healthcare organizations should attempt to monitor, and thereby improve, their outcomes and processes in caring for DFIs... 
Developing and validating a risk score for lower-extremity amputation in patients hospitalized for a diabetic foot infectionBenjamin A Lipsky
Department of Medicine, University of Washington, Seattle, WA, USA
Diabetes Care 34:1695-700. 2011..We sought to develop and validate a risk score to aid in the early identification of patients hospitalized for diabetic foot infection who are at highest risk of LEA...- The role of diabetes mellitus in the treatment of skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: results from three randomized controlled trialsBenjamin A Lipsky
Medical Service, VA Puget Sound Health Care System, 1880 S Columbian Way S 111 GIMC, Seattle, WA 98108 1587, USA
Int J Infect Dis 15:e140-6. 2011..To compare outcomes of treating complicated skin and skin structure infections (cSSSI) caused by methicillin-resistant Staphylococcus aureus (MRSA) with linezolid versus vancomycin in diabetic and non-diabetic patients... - The evaluation and treatment of complicated skin and skin structure infectionsPaul B Cornia
University of Washington School of Medicine, Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System and Department of Medicine, Seattle, WA 98108 1597, USA
Expert Opin Pharmacother 9:717-30. 2008..Skin and skin structure infections are frequently encountered in clinical practice. Fortunately, these infections usually produce only mild to moderate symptoms and signs. Some, however, are severe and may even be life-threatening... - Does this coughing adolescent or adult patient have pertussis?Paul B Cornia
Primary and Specialty Medical Care Service, Veterans Affairs Puget Sound Health Care System, and Department of Medicine, University of Washington School of Medicine, Seattle, USA
JAMA 304:890-6. 2010..Pertussis is often overlooked as a cause of chronic cough, especially in adolescents and adults. Several symptoms are classically thought to be suggestive of pertussis, but the diagnostic value of each of them is uncertain... - Topical application of a gentamicin-collagen sponge combined with systemic antibiotic therapy for the treatment of diabetic foot infections of moderate severity: a randomized, controlled, multicenter clinical trialBenjamin A Lipsky
Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA, USA
J Am Podiatr Med Assoc 102:223-32. 2012.... - Optimising antimicrobial therapy in diabetic foot infectionsNalini Rao
Division of Infectious Disease, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232 1381, USA
Drugs 67:195-214. 2007..Certain other organisms, such as Pseudomonas aeruginosa and Enterococcus spp., while potentially pathogenic, are often colonisers that do not require targeted therapy... - Clinical problem-solving. Red snapper or crab?Paul B Cornia
Primary and Specialty Medical Care Service, Veterans Affairs Puget Sound Health Care System, Seattle 98108 1597, USA
N Engl J Med 350:1443-8. 2004 - Computer-based order entry decreases duration of indwelling urinary catheterization in hospitalized patientsPaul B Cornia
Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System, and the Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Am J Med 114:404-7. 2003 - The microbiology of bacteriuria in men: a 5-year study at a Veterans' Affairs hospitalPaul B Cornia
Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108 1597, USA
Diagn Microbiol Infect Dis 56:25-30. 2006..1 for GNR). We conclude that the microorganisms causing bacteriuria in older male veterans are substantially different from those found in women, and the Gram-stained smear provides useful information on the causative organisms... - Skin, soft tissue, bone, and joint infections in hospitalized patients: epidemiology and microbiological, clinical, and economic outcomesBenjamin A Lipsky
VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Infect Control Hosp Epidemiol 28:1290-8. 2007..There are currently few published studies on the epidemiology and clinical and economic outcomes of these infections, whether acquired in the community or healthcare setting, in a large population... - Predicting bacteremia among patients hospitalized for skin and skin-structure infections: derivation and validation of a risk scoreBenjamin A Lipsky
General Medical Service, Veterans Affairs Puget Sound Health Care System, Department of Medicine, University of Washington, Seattle, Washington 98108, USA
Infect Control Hosp Epidemiol 31:828-37. 2010..We used selected demographic and clinical characteristics easily assessable at initial evaluation to develop a model for the early identification of patients with SSSI who are at higher risk for bacteremia... - New developments in diagnosing and treating diabetic foot infectionsBenjamin A Lipsky
University of Washington, USA
Diabetes Metab Res Rev 24:S66-71. 2008.... - Are granulocyte colony-stimulating factors beneficial in treating diabetic foot infections?: A meta-analysisMario Cruciani
University of Washington, School of Medicine, Director, General Internal Medicine Clinic, VA Puget Sound Health Care System S 111 GIMC, 1660 South Columbian Way, Seattle, WA 98108 1597, USA
Diabetes Care 28:454-60. 2005..To assess the value of granulocyte colony-stimulating factor (G-CSF) as adjunctive therapy for diabetic foot infections... - Commentary: indwelling urinary catheters in hospitalized patients: when in doubt, pull it outPaul B Cornia
Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, Washington, USA
Infect Control Hosp Epidemiol 29:820-2. 2008 - Treatment of bacterial prostatitisBenjamin A Lipsky
General Internal Medicine Service, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
Clin Infect Dis 50:1641-52. 2010..We review recent pharmacological and clinical data on treating bacterial prostatitis... - Topical antimicrobial therapy for treating chronic woundsBenjamin A Lipsky
Veterans Affairs Puget Sound Health Care System and 2University of Washington, School of Medicine, Seattle, WA 98108, USA
Clin Infect Dis 49:1541-9. 2009..We provide clinically relevant information on currently available topical antimicrobial agents... - Which antimicrobial impregnated central venous catheter should we use? Modeling the costs and outcomes of antimicrobial catheter useKristin D Marciante
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle WA 98195, USA
Am J Infect Control 31:1-8. 2003..It remains unclear whether minocycline/rifampin catheters are cost-effective for all high-risk patients or only those requiring longer-term catheterization... - Clinical problem-solving. Nothing to cough at--a 73-year-old man presented to the emergency department with a 4-day history of nonproductive cough that worsened at nightPaul B Cornia
Primary and Specialty Medical Care Service, Veterans Affairs Puget Sound Health Care System, and the Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108-1597, USA
N Engl J Med 357:1432-7. 2007 - Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infectionsBenjamin A Lipsky
University of Washington School of Medicine, and General Internal Medicine Clinic, VA Puget Sound Health Care System S 111 GIMC, 1660 S Columbian Way, Seattle, WA 98108 1597, USA
J Antimicrob Chemother 55:240-5. 2005.... - Preventing foot ulcers in patients with diabetesNalini Singh
Department of Medicine, Division of Endocrinology, Veterans Affairs Puget Sound Healthcare System and University of Washington School of Medicine, Seattle 98108, USA
JAMA 293:217-28. 2005..0% to 4.1%, and the lifetime incidence may be as high as 25%. These ulcers frequently become infected, cause great morbidity, engender considerable financial costs, and are the usual first step to lower extremity amputation... - Influenza vaccination rates of children in households with high-risk adultsRu Chien Chi
Veterans Administration Puget Sound Health Care System, Seattle, WA, USA
Public Health Rep 125:192-8. 2010..We evaluated influenza vaccine coverage among children to determine whether or not living with a high-risk adult predicts the likelihood of being vaccinated... - Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodineNathorn Chaiyakunapruk
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, WA 98195-7630, USA
Clin Infect Dis 37:764-71. 2003..Use of chlorhexidine gluconate in place of the current standard solution for vascular catheter site care is a simple and cost-effective method of improving patient safety in the hospital setting... - Superior pulmonary sulcus tumor with Pancoast syndromeKier V Huehnergarth
General Internal Medicine Clinic, University of Washington, Seattle, USA
Mayo Clin Proc 79:1268. 2004 - Use of maximal sterile barriers during central venous catheter insertion: clinical and economic outcomesKent K Hu
Northwest Health Services Research and Development Program, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle 98108, USA
Clin Infect Dis 39:1441-5. 2004..Use of MSBs when placing CVCs may reduce the risk of infections but is more cumbersome, time-consuming, and expensive than other techniques... - Using maximal sterile barriers to prevent central venous catheter-related infection: a systematic evidence-based reviewKent K Hu
Northwest Health Services Research and Development Program, Department of Medicine, University of Washington and VA Puget Sound HCS, 1660 South Columbian Way, HSR and D (152, Seattle, WA 98108, USA
Am J Infect Control 32:142-6. 2004..While we believe the available evidence does support the use of maximal sterile barriers during routine insertion of central venous catheters, prospective studies and economic analyses would better clarify its value... - "Are we there yet?"LISA H WILLIAMS
Primary and Specialty Medicine Service, Veterans Affairs Puget Sound Health Care System, Department of Medicine, and the University of Washington School of Medicine, Seattle, Washington 98108, USA
J Hosp Med 2:181-8. 2007 - Treatment for diabetic foot ulcersPeter R Cavanagh
Diabetic Foot Care Program, Department of Biomedical Engineering, and the Orthopaedic Research Center, Cleveland Clinic Foundation, Cleveland 44195, OH, USA
Lancet 366:1725-35. 2005..Ulcer recurrence rates are high, but appropriate education for patients, the provision of posthealing footwear, and regular foot care can reduce rates of re-ulceration... - Risk factors for nosocomial urinary tract-related bacteremia: a case-control studySanjay Saint
Center for Practice Management and Outcomes Research, Ann Arbor VA Health Services Research and Development Center of Excellence, Ann Arbor, MI, USA
Am J Infect Control 34:401-7. 2006..Risk factors for bacteremia in patients with hospital-acquired bacteriuria are largely unknown. Given the morbidity and costs associated with nosocomial bacteremia, determining risk factors could enhance the safety of hospitalized patients... - Condom versus indwelling urinary catheters: a randomized trialSanjay Saint
Center for Practice Management and Outcomes Research, Ann Arbor Department of Veterans Affairs Health Services Research and Development Center of Excellence, Ann Arbor, Michigan, USA
J Am Geriatr Soc 54:1055-61. 2006..To compare condom and indwelling urinary catheters in terms of infection risk and patient satisfaction... - Does dermal thermometry predict clinical outcome in diabetic foot infection? Analysis of data from the SIDESTEP* trialDavid G Armstrong
Rosalind Franklin University, Chicago, IL, USA
Int Wound J 3:302-7. 2006..While there was no overall relationship between skin temperature and poor clinical outcome, there may be a threshold effect in DT (<10 degrees F versus >10 degrees F) between the limbs at baseline that predicts outcome of therapy... - Advances in the treatment of diabetic foot infectionsDavid G Armstrong
Podiatry Section, Department of Surgery, Southern Arizona Veterans Affairs Medical Center, and University of Arizona, Tucson, Arizona 85750, USA
Diabetes Technol Ther 6:167-77. 2004..g., antibiotic beads, impregnated sponges) and novel antibiotics (e.g., levofloxacin, linezolid) are providing possible solutions to the challenges posed by this physically, emotionally, and financially devastating condition... - Managing skin and soft tissue infections: expert panel recommendations on key decision pointsLawrence J Eron
University of Hawaii, John A. Burns Medical School, Honolulu, HI, USA
J Antimicrob Chemother 52:i3-17. 2003 - What is the shelf life of physician-mixed antibiotic-impregnated calcium sulfate pellets?David G Armstrong
Department of Surgery, Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA
J Foot Ankle Surg 42:302-4. 2003.... - Diabetic foot infections: stepwise medical and surgical managementDavid G Armstrong
Dr William M Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, Chicago IL, USA
Int Wound J 1:123-32. 2004..Most foot ulcers occur on the plantar surface of the foot, thus requiring a plantar incision for any drainage procedure... - Indwelling urinary catheters: a one-point restraint?Sanjay Saint
Ann Intern Med 137:125-7. 2002 - Complicated infections of skin and skin structures: when the infection is more than skin deepMark J DiNubile
Merck Research Laboratories, BL 3 4, PO Box 4, West Point, PA 19486, USA
J Antimicrob Chemother 53:ii37-50. 2004..Surgical debridement is important for many complicated infections, and is the critical element in managing necrotizing fasciitis and myonecrosis... - Bone of contention: diagnosing diabetic foot osteomyelitisBenjamin A Lipsky
Clin Infect Dis 47:528-30. 2008 - Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agentsDiane M Citron
R M Alden Research Laboratory, 2001 Santa Monica Blvd, Suite 685W, Santa Monica CA 90404, USA
J Clin Microbiol 45:2819-28. 2007..Moderate-to-severe DFIs are typically polymicrobial, and almost half include anaerobes. Our antibiotic susceptibility results can help to inform therapeutic choices... - Diabetic foot infections: microbiology made modern? Array of hopeBenjamin A Lipsky
Diabetes Care 30:2171-2. 2007 - Comparative costs of ertapenem and piperacillin-tazobactam in the treatment of diabetic foot infectionsAlan D Tice
John A Burns School of Medicine, University of Hawaii, Honolulu, USA
Am J Health Syst Pharm 64:1080-6. 2007..To evaluate potential cost savings, trial data were used to determine the clinical outcomes for i.v. ertapenem given once daily and i.v. piperacillin-tazobactam given every six hours daily in treating diabetic foot infections... - Probe-to-bone test for diagnosing diabetic foot osteomyelitis: reliable or relic?Lawrence A Lavery
Department of Surgery, Scott and White Hospital, 703 Highland Spring Lane, Georgetown, TX 78628, USA
Diabetes Care 30:270-4. 2007..We sought to assess the accuracy of the probe-to-bone (PTB) test in diagnosing foot osteomyelitis in a cohort of diabetic patients with bone culture proven disease... - Clinical management of diabetic foot infection: diagnostics, therapeutics and the futurePhilippa C Matthews
Bone Infection Unit, Nuffield Orthopaedic Centre NHS Trust, Windmill Road, Headington, Oxford OX3 7LD, UK
Expert Rev Anti Infect Ther 5:117-27. 2007..We discuss this complex group of infections with a particular emphasis on medical management of osteomyelitis, while also highlighting the importance of a broad multidisciplinary approach to eradicating infection... - Risk factors for foot infections in individuals with diabetesLawrence A Lavery
Department of Surgery, Scott and White Hospital, Texas A and M University Health Science Center College of Medicine, Temple, TX, USA
Diabetes Care 29:1288-93. 2006..To prospectively determine risk factors for foot infection in a cohort of people with diabetes... - Nothing to cough atPerrianne Lurie
N Engl J Med 358:857; author reply 857. 2008 - Controversies in diagnosing and managing osteomyelitis of the foot in diabetesWilliam J Jeffcoate
Department of Diabetes and Endocrinology, City Hospital, Nottingham, United Kingdom
Clin Infect Dis 39:S115-22. 2004..We review the microbiology of osteomyelitis of the foot in diabetes, the benefits and limitations of various diagnostic procedures, and the evidence for the effectiveness of both surgical and nonsurgical approaches to management... - The Biogun: a novel way of eradicating methicillin-resistant Staphylococcus aureus colonization in diabetic foot ulcers. Response to Dang et alBenjamin A Lipsky
Diabetes Care 29:2181; author reply 2181-2. 2006 - Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysisNathorn Chaiyakunapruk
Department of Pharmacy Practice, School of Pharmacy, Naresuan University, Pitsanuloak 65000, Thailand
Ann Intern Med 136:792-801. 2002..Use of chlorhexidine gluconate is a simple and effective means of reducing vascular catheter-related infections... - Validation of the Infectious Diseases Society of America's diabetic foot infection classification systemLawrence A Lavery
Department of Surgery, Scott and White Hospital, Texas A and M University Health Science Center College of Medicine, Temple, Texas, USA
Clin Infect Dis 44:562-5. 2007..6; P<.001) with increasing infection severity. The Infectious Diseases Society of America's foot infection classification system may be a useful tool for grading foot infections... - Antibiotic treatment of osteomyelitis: what have we learned from 30 years of clinical trials?Luca Lazzarini
Department of Infectious Diseases and Tropical Medicine, S Bortolo Hospital, 36100 Vicenza, Italy
Int J Infect Dis 9:127-38. 2005..To determine the most appropriate approach to antibiotic therapy for osteomyelitis, the medical literature for articles published from 1968 to 2000 was reviewed...