James Leyden

Summary

Country: USA

Publications

  1. ncbi request reprint Effect of topical benzoyl peroxide/clindamycin versus topical clindamycin and vehicle in the reduction of Propionibacterium acnes
    James J Leyden
    Department of Dermatology, University of Pennsylvania School of Medicine and Hospital of the University of Pennsylvania, Philadelphia 19104 4283, USA
    Cutis 69:475-80. 2002
  2. ncbi request reprint Effect of wax epilation before hair removal with a long-pulsed alexandrite laser: a pilot study
    Michael S Lehrer
    Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA 19104, USA
    Dermatol Surg 29:118-22; discussion 122-3. 2003
  3. ncbi request reprint Facial tolerability of topical retinoid therapy
    James Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, PA 19104, USA
    J Drugs Dermatol 3:641-51. 2004
  4. ncbi request reprint Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study
    Warren Wallo
    Johnson and Johnson Consumer Companies, Inc, Skillman, NJ, USA
    J Drugs Dermatol 6:917-22. 2007
  5. ncbi request reprint In vivo antibacterial effects of tretinoin-clindamycin and clindamycin alone on Propionibacterium acnes with varying clindamycin minimum inhibitory
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    J Drugs Dermatol 11:1434-8. 2012
  6. doi request reprint Multicenter clinical trial of a home-use nonablative fractional laser device for wrinkle reduction
    James Leyden
    Skin Study Center, Broomall, Pennsylvania 19008, USA
    J Am Acad Dermatol 67:975-84. 2012
  7. ncbi request reprint The effect of benzoyl peroxide 9.8% emollient foam on reduction of Propionibacterium acnes on the back using a short contact therapy approach
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    J Drugs Dermatol 11:830-3. 2012
  8. ncbi request reprint Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gel
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, USA
    J Drugs Dermatol 9:998-1003. 2010
  9. ncbi request reprint Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessment
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Ther 27:216-24. 2005
  10. ncbi request reprint Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris
    James J Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
    J Am Acad Dermatol 54:73-81. 2006

Detail Information

Publications48

  1. ncbi request reprint Effect of topical benzoyl peroxide/clindamycin versus topical clindamycin and vehicle in the reduction of Propionibacterium acnes
    James J Leyden
    Department of Dermatology, University of Pennsylvania School of Medicine and Hospital of the University of Pennsylvania, Philadelphia 19104 4283, USA
    Cutis 69:475-80. 2002
    ..This activity is likely responsible for the quick onset of clinical efficacy produced by this combination regimen...
  2. ncbi request reprint Effect of wax epilation before hair removal with a long-pulsed alexandrite laser: a pilot study
    Michael S Lehrer
    Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA 19104, USA
    Dermatol Surg 29:118-22; discussion 122-3. 2003
    ..Recent reports indicate that laser hair removal is most effective on anagen hairs. However, no published trials have examined laser epilation after hair cycle synchronization...
  3. ncbi request reprint Facial tolerability of topical retinoid therapy
    James Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, PA 19104, USA
    J Drugs Dermatol 3:641-51. 2004
    ..Retinoid concentration, vehicle, skin sensitivity, and retinoid can all affect facial tolerability. Skin vulnerability may be the most important factor...
  4. ncbi request reprint Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study
    Warren Wallo
    Johnson and Johnson Consumer Companies, Inc, Skillman, NJ, USA
    J Drugs Dermatol 6:917-22. 2007
    ..In this study, we found that a moisturizer containing stabilized soy extracts is safe and effective, and can be used to ameliorate overall skin tone and texture attributes of photoaging...
  5. ncbi request reprint In vivo antibacterial effects of tretinoin-clindamycin and clindamycin alone on Propionibacterium acnes with varying clindamycin minimum inhibitory
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    J Drugs Dermatol 11:1434-8. 2012
    ..DESIGn: Study 1 was an initial range-finding study that was neither blinded nor randomized. Study 2 was an open-label, randomized, splitface, single-center study. Both studies were conducted in Pennsylvania...
  6. doi request reprint Multicenter clinical trial of a home-use nonablative fractional laser device for wrinkle reduction
    James Leyden
    Skin Study Center, Broomall, Pennsylvania 19008, USA
    J Am Acad Dermatol 67:975-84. 2012
    ..Until now, nonablative fractional treatments could only be delivered in an office setting by trained professionals...
  7. ncbi request reprint The effect of benzoyl peroxide 9.8% emollient foam on reduction of Propionibacterium acnes on the back using a short contact therapy approach
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    J Drugs Dermatol 11:830-3. 2012
    ..8% emollient foam used once daily over a 2 week duration was highly effective in reducing the quantity of P acnes organisms on the back and provided comparable colony count reduction to "leave on" therapy using BP 5.3% emollient foam...
  8. ncbi request reprint Irritation potential of tretinoin gel microsphere pump versus adapalene plus benzoyl peroxide gel
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, USA
    J Drugs Dermatol 9:998-1003. 2010
    ..1%/2.5% gel. While both agents were well tolerated by most patients, TGM 0.04% pump demonstrated significantly better tolerance than ADA-BPO 0.1%/2.5% gel in both neurosensory parameters and signs of contact irritation...
  9. ncbi request reprint Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessment
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Ther 27:216-24. 2005
    ..Despite published data showing the efficacy of topical retinoids in treating inflammatory acne, in clinical practice topical retinoids tend to be used most commonly for noninflammatory acne...
  10. ncbi request reprint Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris
    James J Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
    J Am Acad Dermatol 54:73-81. 2006
    ..The development of a hydrogel to stabilize and solubilize clindamycin and tretinoin provides a single, once-daily treatment for acne vulgaris...
  11. ncbi request reprint Comparison of tazarotene and minocycline maintenance therapies in acne vulgaris: a multicenter, double-blind, randomized, parallel-group study
    James Leyden
    Skin Study Center, Broomall, PA, USA
    Arch Dermatol 142:605-12. 2006
    ..To evaluate the efficacy of 3 maintenance regimens (topical tazarotene, oral minocycline hydrochloride, or both) in sustaining improvement in acne...
  12. ncbi request reprint Cumulative irritation potential of topical retinoid formulations
    James J Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, PA, USA
    J Drugs Dermatol 7:s14-8. 2008
    ..The factors that influence irritant reactions have been shown to include individual skin sensitivity, the particular retinoid and concentration used, and the vehicle formulation...
  13. ncbi request reprint A novel gel formulation of clindamycin phosphate-tretinoin is not associated with acne flaring
    James J Leyden
    KGL, Inc, Broomall, Pennsylvania 19008, USA
    Cutis 82:151-6. 2008
    ..Lack of flaring may result from either the novel vehicle formulation or the antiinflammatory effects of CLIN...
  14. ncbi request reprint Efficacy of a novel rosacea treatment system: an investigator-blind, randomized, parallel-group study
    James J Leyden
    KGL, Inc, Broomall, PA 19008, USA
    J Drugs Dermatol 10:1179-85. 2011
    ..A rosacea treatment system (cleanser, metronidazole 0.75% gel, hydrating complexion corrector, and sunscreen SPF30) has been developed to treat rosacea...
  15. ncbi request reprint Antibiotic-resistant Propionibacterium acnes suppressed by a benzoyl peroxide cleanser 6%
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, USA
    Cutis 82:417-21. 2008
    ..Benzoyl peroxide cleanser 6% effectively reduced resistant P acnes populations and offers a useful therapy for controlling antibiotic resistance in patients receiving antibiotics...
  16. ncbi request reprint Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel
    James Leyden
    Skin Study Center, Broomall, PA 19008, USA
    J Drugs Dermatol 8:383-8. 2009
    ..Recently, a gel containing crystalline clindamycin 1.2% and tretinoin 0.025% (CLIN/RA) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of treating mild-to-moderate acne...
  17. ncbi request reprint Treating photodamage of the d├ęcolletage area with a novel copper zinc malonate complex plus hydroquinone and tretinoin
    James J Leyden
    University of Pennsylvania, Philadelphia, PA, USA
    J Drugs Dermatol 9:220-6. 2010
    ..Treatment was generally well tolerated and 94% of subjects were satisfied or very satisfied with the overall improvement in their d├ęcolletage at week 24...
  18. ncbi request reprint Efficacy of benzoyl peroxide (5.3%) emollient foam and benzoyl peroxide (8%) wash in reducing Propionibacterium acnes on the back
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
    J Drugs Dermatol 9:622-5. 2010
    ..Prior to this trial, no data on Propionibacterium acnes (P. acnes) reduction on the back has existed for any benzoyl peroxide (BP) formulations or other acne treatments...
  19. ncbi request reprint Meta-analysis of topical tazarotene in the treatment of mild to moderate acne
    James J Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, USA
    Cutis 74:9-15. 2004
    ..These results indicate that topical tazarotene 0.1% gel and cream are efficacious and well-tolerated treatment options for clearing acne vulgaris across a broad range of patients...
  20. ncbi request reprint Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:11-7. 2004
    ..647 (BP/C) and 0.722 (vehicle) on the OGI scale (P < .001). These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea...
  21. ncbi request reprint New developments in topical antimicrobial therapy for acne
    James Leyden
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Drugs Dermatol 7:s8-11. 2008
    ..This new product exhibits enhanced follicular penetration of BPO, improved P acnes kill rates and clinical efficacy, and good consumer acceptance relative to existing formulations...
  22. ncbi request reprint A systemic type I 5 alpha-reductase inhibitor is ineffective in the treatment of acne vulgaris
    James Leyden
    University of Pennsylvania Hospital, 36th and Spruce Streets, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 50:443-7. 2004
    ..These results indicate the need for further work at the molecular level to better understand the action of androgens on sebaceous gland function...
  23. ncbi request reprint A double-blinded, randomized, vehicle-controlled, multicenter, parallel-group study to assess the safety and efficacy of tretinoin gel microsphere 0.04% in the treatment of acne vulgaris in adults
    Richard Berger
    Hill Top Research, Inc, East Brunswick, New Jersey, USA
    Cutis 80:152-7. 2007
    ..At week 12, there were no statistically significant differences between treatment groups for any measured tolerability parameter...
  24. ncbi request reprint Once-daily tazarotene 0.1 % gel versus once-daily tretinoin 0.1 % microsponge gel for the treatment of facial acne vulgaris: a double-blind randomized trial
    James J Leyden
    University of Pennsylvania Hospital, Philadelphia, USA
    Cutis 69:12-9. 2002
    ..24 per treatment success with tretinoin microsponge. Tazarotene was observed to have greater efficacy and comparable tolerability and to be a cost-effective alternative to tretinoin 0.1% microsponge gel...
  25. ncbi request reprint A review of the use of combination therapies for the treatment of acne vulgaris
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
    J Am Acad Dermatol 49:S200-10. 2003
    ..Retinoids can also be used alone for long-term maintenance to prevent the reemergence of comedones and inflammatory acne lesions and to spare the use of antibiotics, thus helping to reduce the risk of bacterial resistance...
  26. ncbi request reprint Mechanism-based selection of pharmacologic agents for rosacea
    Alan Shalita
    Department of Dermatology, State University of New York, Downstate Medical Center, Brooklyn, USA
    Cutis 73:15-8. 2004
    ..Future topical formulations may involve the combination of active pharmacologic agents and sunscreens or sun blocks to address the proposed etiologic role played by UV radiation in the pathophysiology of rosacea...
  27. ncbi request reprint Topical treatment for the inflamed lesion in acne, rosacea, and pseudofolliculitis barbae
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:4-5. 2004
  28. ncbi request reprint Antibiotic resistance in the topical treatment of acne vulgaris
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:6-10. 2004
    ....
  29. ncbi request reprint The treatment of rosacea
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 73:34-6. 2004
    ..A lively discussion centered on treatment options for the various subtypes of rosacea ensued...
  30. ncbi request reprint Guidelines of care for acne vulgaris management
    John S Strauss
    Department of Dermatology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    J Am Acad Dermatol 56:651-63. 2007
    ..The ultimate judgment regarding the propriety of any specific therapy must be made by the physician and the patient in light of all the circumstances presented by the individual patient...
  31. ncbi request reprint Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: focus on antibiotic resistance
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, USA
    Cutis 79:9-25. 2007
    ..By increasing our understanding of the multifaceted actions of antibiotics and the known clinical implications of antibiotic resistance, physicians can improve their decision making in prescribing these agents...
  32. doi request reprint New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, USA
    J Am Acad Dermatol 60:S1-50. 2009
    ..As in the original supplement, the authors have based recommendations on published evidence as much as possible...
  33. ncbi request reprint Efficacy of a low-dose oral contraceptive containing 20 microg of ethinyl estradiol and 100 microg of levonorgestrel for the treatment of moderate acne: A randomized, placebo-controlled trial
    James Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, USA
    J Am Acad Dermatol 47:399-409. 2002
    ..A low-dose oral contraceptive containing 20 microg of ethinyl estradiol and 100 microg of levonorgestrel (EE/LNG) has been shown to improve biochemical markers of androgenicity. Lowering bioavailable androgens may improve acne...
  34. ncbi request reprint A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight-week, double-blind, vehicle-controlled study
    Samantha Tucker-Samaras
    Johnson and Johnson Consumer Companies, Inc, Skillman, NJ 08558, USA
    J Drugs Dermatol 8:932-6. 2009
    ..This study demonstrates that a formulation containing stabilized retinol is safe and effective to ameliorate the appearance of photoaged skin...
  35. ncbi request reprint Introduction. Contemporary perspectives on topical retinoids
    James J Leyden
    Department of Dermatology, University of Pennsylvania Hospital, Philadelphia, USA
    Cutis 75:4. 2005
  36. doi request reprint Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: a status report
    James J Leyden
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Dermatol Clin 27:1-15. 2009
    ..It concludes that there are treatment strategies that can effectively minimize the potential for development of resistant P. acnes organisms...
  37. ncbi request reprint Antibiotic use in acne vulgaris and rosacea: clinical considerations and resistance issues of significance to dermatologists
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 82:5-12. 2008
    ....
  38. ncbi request reprint Effect of antibiotics on the oropharyngeal flora in patients with acne
    Ross M Levy
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Dermatol 139:467-71. 2003
    ..To estimate the prevalence and resistance patterns of Streptococcus pyogenes and Staphylococcus aureus in the oropharynx of individuals with acne who were using or not using antibiotic therapy...
  39. doi request reprint The mechanism of action and clinical benefits of soy for the treatment of hyperpigmentation
    James Leyden
    The University of Pennsylvania, Philadelphia, PA, USA
    Int J Dermatol 50:470-7. 2011
    ..The most commonly used treatments for hyperpigmentation include topical agents, such as hydroquinone, retinoids and azelaic acid...
  40. ncbi request reprint Body dysmorphic disorder symptoms among patients with acne vulgaris
    Whitney P Bowe
    Department of Dermatology, The Children s Hospital of Philadelphia, USA
    J Am Acad Dermatol 57:222-30. 2007
    ....
  41. ncbi request reprint Effects of tazarotene 0.1 % cream in the treatment of facial acne vulgaris: pooled results from two multicenter, double-blind, randomized, vehicle-controlled, parallel-group trials
    Alan R Shalita
    State University of New York Health Sciences Center, Brooklyn, New York, USA
    Clin Ther 26:1865-73. 2004
    ..The effects of the gel formulation of the topical retinoid tazarotene have been widely reported, but few data on the cream formulation are available...
  42. ncbi request reprint Bacterial resistance and therapeutic outcome following three months of topical acne therapy with 2% erythromycin gel versus its vehicle
    Otto Mills
    Hill Top Research, East Brunswick, New Jersey, USA
    Acta Derm Venereol 82:260-5. 2002
    ..Nearly all of the resistant isolates were highly resistant (minimal inhibitory concentrations > 128 microg/ml). Resistance development was confined to the macrolide class of antibiotics. No anti-acne efficacy was observed...
  43. ncbi request reprint Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial
    Tania J Phillips
    Boston University School of Medicine, Boston, MA 02118, USA
    Arch Dermatol 138:1486-93. 2002
    ..To determine the efficacy and safety of 0.1% tazarotene cream for the treatment of photodamage...
  44. ncbi request reprint Safety of doxycycline and minocycline: a systematic review
    Kelly Smith
    Warner Chilcott Laboratories, Rockaway, NJ 07866, USA
    Clin Ther 27:1329-42. 2005
    ..The goal of this review was to summarize the available literature covering the safety profiles of oral doxycycline and minocycline...
  45. ncbi request reprint Acne vulgaris is a multifactorial disease
    James J Leyden
    J Am Acad Dermatol 49:S199. 2003
  46. ncbi request reprint Management of acne: a report from a Global Alliance to Improve Outcomes in Acne
    Harald Gollnick
    American Academy of Dermatology, Inc
    J Am Acad Dermatol 49:S1-37. 2003
  47. ncbi request reprint Current concepts in the treatment of acne: report from a clinical roundtable
    Diane S Berson
    Cornell University Medical College, New York, New York, USA
    Cutis 72:5-13. 2003
    ..Clinical experience has shown that combination therapies, which affect multiple aspects of pathophysiology, are most likely to achieve this goal and help in its long-term management and resolution...
  48. ncbi request reprint Status report on antibiotic resistance: implications for the dermatologist
    James Q Del Rosso
    Valley Hospital Medical Center, PMB 531, 3230 E Flamingo Rad 8, Las Vegas, NV 89121, USA
    Dermatol Clin 25:127-32, v. 2007
    ..The common use of systemic antibiotic therapy in dermatology warrants a closer look at how prescribing patterns impact on the development of antibiotic resistant bacteria and outcomes in clinical practice...