R V Skibbens

Summary

Affiliation: Lehigh University
Country: USA

Publications

  1. doi request reprint Sticking a fork in cohesin--it's not done yet!
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    Trends Genet 27:499-506. 2011
  2. doi request reprint Buck the establishment: reinventing sister chromatid cohesion
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    Trends Cell Biol 20:507-13. 2010
  3. pmc Cohesins coordinate gene transcriptions of related function within Saccharomyces cerevisiae
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Cell Cycle 9:1601-6. 2010
  4. pmc Positional analyses of BRCA1-dependent expression in Saccharomyces cerevisiae
    Robert V Skibbens
    Lehigh University, Department of Biological Sciences, Bethlehem, Pennsylvania 18015, USA
    Cell Cycle 7:3928-34. 2008
  5. ncbi request reprint Cell biology of cancer: BRCA1 and sister chromatid pairing reactions?
    Robert V Skibbens
    Lehigh University Department of Biological Sciences, Bethlehem, Pennsylvania 18015, USA
    Cell Cycle 7:449-52. 2008
  6. ncbi request reprint Fork it over: the cohesion establishment factor Ctf7p and DNA replication
    Robert V Skibbens
    Lehigh University, Department of Biological Sciences, 111 Research Drive, Bethlehem, PA 18015, USA
    J Cell Sci 120:2471-7. 2007
  7. pmc Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    J Cell Biol 169:841-6. 2005
  8. pmc Sister chromatid cohesion role for CDC28-CDK in Saccharomyces cerevisiae
    Alex Brands
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Genetics 180:7-16. 2008
  9. pmc Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Genetics 166:33-42. 2004
  10. ncbi request reprint The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion
    Lisa M Antoniacci
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    J Biol Chem 279:49542-50. 2004

Collaborators

Detail Information

Publications22

  1. doi request reprint Sticking a fork in cohesin--it's not done yet!
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    Trends Genet 27:499-506. 2011
    ..I discuss these challenges and then offer alternative views that include cohesin-independent mechanisms for replication-fork destabilization and transcription-based effects on S-phase progression...
  2. doi request reprint Buck the establishment: reinventing sister chromatid cohesion
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    Trends Cell Biol 20:507-13. 2010
    ..Here, new models are presented in which replication-coupled cohesin deposition is followed by conversion to a pairing-competent C-clamp structure that does not require DNA entrapment...
  3. pmc Cohesins coordinate gene transcriptions of related function within Saccharomyces cerevisiae
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Cell Cycle 9:1601-6. 2010
    ..Prior studies indicate that defects in rRNA maturation/ribosome biogenesis produce developmental maladies in humans. Thus, the identification of genes critical for rRNA maturation in this study is of particular interest...
  4. pmc Positional analyses of BRCA1-dependent expression in Saccharomyces cerevisiae
    Robert V Skibbens
    Lehigh University, Department of Biological Sciences, Bethlehem, Pennsylvania 18015, USA
    Cell Cycle 7:3928-34. 2008
    ..Cluster-functional analysis reveals that these repressed factors are required for mitotic stability and provide a novel molecular explanation for the conditional lethality observed between BRCA1 and chromosome segregation genes...
  5. ncbi request reprint Cell biology of cancer: BRCA1 and sister chromatid pairing reactions?
    Robert V Skibbens
    Lehigh University Department of Biological Sciences, Bethlehem, Pennsylvania 18015, USA
    Cell Cycle 7:449-52. 2008
    ..Future research into sister chromatid pairing mechanisms are likely to provide critical new insights into the underlying causes of cancer...
  6. ncbi request reprint Fork it over: the cohesion establishment factor Ctf7p and DNA replication
    Robert V Skibbens
    Lehigh University, Department of Biological Sciences, 111 Research Drive, Bethlehem, PA 18015, USA
    J Cell Sci 120:2471-7. 2007
    ..The recent findings that the establishment factor Ctf7p/Eco1p is recruited to DNA and binds both a DNA polymerase processivity factor (PCNA) and the cohesin regulator Pds5p test current models of sister chromatid pairing...
  7. pmc Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    J Cell Biol 169:841-6. 2005
    ..The identification of both replication factor C and DNA helicases as critical for sister chromatid pairing has brought new insights into this fundamental process...
  8. pmc Sister chromatid cohesion role for CDC28-CDK in Saccharomyces cerevisiae
    Alex Brands
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Genetics 180:7-16. 2008
    ..These and other results reveal that Ctf7p regulation is more complicated than previously envisioned and suggest that CDK acts in sister chromatid cohesion parallel to Ctf7p reactions...
  9. pmc Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Genetics 166:33-42. 2004
    ..Our findings document a novel role for Chl1p in sister-chromatid cohesion and provide new insights into the possible mechanisms through which DNA helicases may contribute to cancer progression when mutated...
  10. ncbi request reprint The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion
    Lisa M Antoniacci
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    J Biol Chem 279:49542-50. 2004
    ..These findings document a new role for Mps3p in sister chromatid cohesion and provide novel insights into the mechanism by which a spindle pole body component, when mutated, contributes to aneuploidy...
  11. ncbi request reprint Sister-chromatid telomere cohesion is nonredundant and resists both spindle forces and telomere motility
    Lisa M Antoniacci
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Curr Biol 16:902-6. 2006
    ..These findings are consistent with numerous studies that telomeres translocate along the nuclear periphery and provide new evidence that telomere dynamics can contribute to sister-chromatid separation, independent of centromere motility...
  12. pmc Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes
    Margaret A Kenna
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Mol Cell Biol 23:2999-3007. 2003
    ..Furthermore, the association of Ctf7p/Eco1p with each of three RFC complexes supplies new insights into the functional redundancy of RFC complexes in cohesion establishment...
  13. pmc Epitope tag-induced synthetic lethality between cohesin subunits and Ctf7/Eco1 acetyltransferase
    Marie E Maradeo
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    FEBS Lett 584:4037-40. 2010
    ..We further demonstrate that mutation in ELG1 or RFC5 anti-establishment genes suppress tag-induced lethality, consistent with the notion that the replication fork regulates Ctf7/Eco1...
  14. doi request reprint Mechanisms of sister chromatid pairing
    Robert V Skibbens
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Int Rev Cell Mol Biol 269:283-339. 2008
    ....
  15. pmc Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains
    Aaron M Bellows
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    Nucleic Acids Res 31:6334-43. 2003
    ..These findings document the first characterization of a novel human acetyltransferase, hEFO1p, that is comprised of both linker histone and Ctf7p/Eco1p domains...
  16. ncbi request reprint Regulated assembly of the mitotic spindle: a perspective from two ends
    Lynne Cassimeris
    Dept of Biological Sciences, 111 Research Dr, Lehigh University, Bethlehem, PA 18015, USA
    Curr Issues Mol Biol 5:99-112. 2003
    ..In this review, we discuss current models of how centrosomes and chromosomes organize the spindle for their equal distribution to each daughter cell...
  17. ncbi request reprint The nuclear envelope and spindle pole body-associated Mps3 protein bind telomere regulators and function in telomere clustering
    Lisa M Antoniacci
    Lehigh University, Department of Biological Sciences, Bethlehem, Pennsylvania 18015, USA
    Cell Cycle 6:75-9. 2007
    ..Findings that Mps3p and the nuclear envelope recruit/sequester soluble chromatin metabolism factors such as Ctf7p and Est1p describe, at the molecular level, a new mechanism of nuclear envelope-dependent chromatin regulation...
  18. pmc The Elg1-RFC clamp-loading complex performs a role in sister chromatid cohesion
    Marie E Maradeo
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, USA
    PLoS ONE 4:e4707. 2009
    ..In combination, these findings challenge current views and document new and distinct roles for RFC complexes in cohesion and for Ctf7p(Eco1p) in DNA repair...
  19. ncbi request reprint Intersection between the regulators of sister chromatid cohesion establishment and maintenance in budding yeast indicates a multi-step mechanism
    Daniel Noble
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cell Cycle 5:2528-36. 2006
    ..We propose a model whereby Ctf7p and Pds5p cooperate to facilitate efficient establishment by mediating changes in cohesin complex on chromosomes after its deposition...
  20. pmc A multi-step pathway for the establishment of sister chromatid cohesion
    Mark Milutinovich
    Howard Hughes Medical Institute, Carnegie Institution, Baltimore, Maryland, United States of America
    PLoS Genet 3:e12. 2007
    ....
  21. ncbi request reprint Role of chromosome segregation genes in BRCA1-dependent lethality
    Robert V Skibbens
    Cell Cycle 7:2071-2. 2008
  22. ncbi request reprint Ctf7p/Eco1p exhibits acetyltransferase activity--but does it matter?
    Alex Brands
    Curr Biol 15:R50-1. 2005