Research Topics
Genomes and Genes | Stefan MaasSummaryAffiliation: Lehigh University Country: USA Publications
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Publications
Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptomeAlekos Athanasiadis
Department of Biological Sciences, Lehigh University Bethlehem, Pennsylvania, USA
PLoS Biol 2:e391. 2004..The analysis suggests that modification of repetitive elements is a predominant activity for RNA editing with significant implications for cellular gene expression...- A-to-I RNA editing and human diseaseStefan Maas
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
RNA Biol 3:1-9. 2006..Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes... - Novel exon of mammalian ADAR2 extends open reading frameStefan Maas
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, United States of America
PLoS ONE 4:e4225. 2009..Therefore, the characterization of ADAR expression and identification of alternative ADAR variants is an important prerequisite for understanding the mechanisms for regulation of RNA editing and the causes for deregulation in disease... - A mammalian reporter system for fast and quantitative detection of intracellular A-to-I RNA editing levelsWillemijn M Gommans
Department of Biological Sciences, 111 Research Drive, Iacocca Hall D226, Bethlehem, PA 18015 4732, USA
Anal Biochem 399:230-6. 2010..This reporter system therefore sets the stage for the effective screening of cDNA libraries or small molecules for strong modulators of intracellular editing to ultimately elucidate how A-to-I editing is regulated in vivo... 
IGFBP7's susceptibility to proteolysis is altered by A-to-I RNA editing of its transcriptChristina Godfried Sie
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
FEBS Lett 586:2313-7. 2012..Here we show that editing of IGFBP7 transcripts impacts the protein's susceptibility to proteolytic cleavage, thus providing a means for a cell to modulate its functionality through A-to-I RNA editing...- MiRNA editingDylan E Dupuis
Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
Methods Mol Biol 667:267-79. 2010.... - Identification of a selective nuclear import signal in adenosine deaminases acting on RNAStefan Maas
Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
Nucleic Acids Res 37:5822-9. 2009..Thus, in vivo RNA editing might be regulated, in part, through controlled subcellular localization of ADARs, which in turn is governed by the coordinated local expression of importin alpha proteins and ADAR protein variants... - Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1Christina P Sie
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015 4732, USA
FEBS Lett 583:1171-4. 2009..Remarkably, although editing of C1QL1 is conserved across vertebrate species, the predicted RNA secondary structure mediating editing involves different regions in zebrafish versus mammals... - Screening of human SNP database identifies recoding sites of A-to-I RNA editingWillemijn M Gommans
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015 4732, USA
RNA 14:2074-85. 2008..Our approach sets the stage for effective and comprehensive genome-wide screens for A-to-I editing targets... - Characterization of ADAR1-mediated modulation of gene expressionWillemijn M Gommans
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015 4732, USA
Biochem Biophys Res Commun 377:170-5. 2008..Our results suggest that a cellular, ADAR1-specific RNA editing substrate causes upregulation of plasmid-based gene expression... - RNA editing: a driving force for adaptive evolution?Willemijn M Gommans
Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
Bioessays 31:1137-45. 2009..We propose that higher organisms have therefore evolved to systems with increasing RNA editing activity and, as a result, to more complex systems... - Posttranscriptional recoding by RNA editingStefan Maas
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, USA
Adv Protein Chem Struct Biol 86:193-224. 2012..Here, I give an overview of the process of adenosine deamination RNA editing and describe its relationship to other RNA processing events and its currently established roles in gene regulation... - Molecular diversity through RNA editing: a balancing actSanaz Farajollahi
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
Trends Genet 26:221-30. 2010..In particular, transcriptome instabilities in the form of too much or too little RNA editing activity, or misguided editing, manifest in several human disease phenotypes and can disrupt that balance... 
Gene regulation through RNA editingStefan Maas
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
Discov Med 10:379-86. 2010..Here, I am reviewing main features of this epigenetic phenomenon, its relevance for health and disease, as well as potential prospects for using RNA editing as a therapeutic tool...- A-to-I RNA editing: recent news and residual mysteriesStefan Maas
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Biol Chem 278:1391-4. 2003 - Modulation of ADAR1 editing activity by Z-RNA in vitroMichael Koeris
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Nucleic Acids Res 33:5362-70. 2005..These results suggest that the local conformation of dsRNA molecules might be an important feature for target selectivity by ADAR1 and other proteins with Z-RNA binding domains... - RNA editing of a miRNA precursorDaniel J Luciano
RNA 10:1174-7. 2004..The observed editing events are predicted to have significant implications for the biogenesis and function of miRNA22 and might point toward a more general role for RNA editing in the regulation of miRNA gene expression... - Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytesDama Laxminarayana
Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Immunology 121:359-69. 2007..Based on these results, it is proposed that altered transcript editing contributes to the modulation of gene expression and immune functions in SLE patients...