Stefan Maas

Summary

Affiliation: Lehigh University
Country: USA

Publications

  1. pmc Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome
    Alekos Athanasiadis
    Department of Biological Sciences, Lehigh University Bethlehem, Pennsylvania, USA
    PLoS Biol 2:e391. 2004
  2. pmc A-to-I RNA editing and human disease
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    RNA Biol 3:1-9. 2006
  3. pmc Novel exon of mammalian ADAR2 extends open reading frame
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, United States of America
    PLoS ONE 4:e4225. 2009
  4. pmc A mammalian reporter system for fast and quantitative detection of intracellular A-to-I RNA editing levels
    Willemijn M Gommans
    Department of Biological Sciences, 111 Research Drive, Iacocca Hall D226, Bethlehem, PA 18015 4732, USA
    Anal Biochem 399:230-6. 2010
  5. doi request reprint IGFBP7's susceptibility to proteolysis is altered by A-to-I RNA editing of its transcript
    Christina Godfried Sie
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    FEBS Lett 586:2313-7. 2012
  6. doi request reprint MiRNA editing
    Dylan E Dupuis
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Methods Mol Biol 667:267-79. 2010
  7. pmc Identification of a selective nuclear import signal in adenosine deaminases acting on RNA
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Nucleic Acids Res 37:5822-9. 2009
  8. doi request reprint Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1
    Christina P Sie
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015 4732, USA
    FEBS Lett 583:1171-4. 2009
  9. pmc Screening of human SNP database identifies recoding sites of A-to-I RNA editing
    Willemijn M Gommans
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015 4732, USA
    RNA 14:2074-85. 2008
  10. doi request reprint Characterization of ADAR1-mediated modulation of gene expression
    Willemijn M Gommans
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015 4732, USA
    Biochem Biophys Res Commun 377:170-5. 2008

Collaborators

Detail Information

Publications18

  1. pmc Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome
    Alekos Athanasiadis
    Department of Biological Sciences, Lehigh University Bethlehem, Pennsylvania, USA
    PLoS Biol 2:e391. 2004
    ..The analysis suggests that modification of repetitive elements is a predominant activity for RNA editing with significant implications for cellular gene expression...
  2. pmc A-to-I RNA editing and human disease
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    RNA Biol 3:1-9. 2006
    ..Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes...
  3. pmc Novel exon of mammalian ADAR2 extends open reading frame
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, United States of America
    PLoS ONE 4:e4225. 2009
    ..Therefore, the characterization of ADAR expression and identification of alternative ADAR variants is an important prerequisite for understanding the mechanisms for regulation of RNA editing and the causes for deregulation in disease...
  4. pmc A mammalian reporter system for fast and quantitative detection of intracellular A-to-I RNA editing levels
    Willemijn M Gommans
    Department of Biological Sciences, 111 Research Drive, Iacocca Hall D226, Bethlehem, PA 18015 4732, USA
    Anal Biochem 399:230-6. 2010
    ..This reporter system therefore sets the stage for the effective screening of cDNA libraries or small molecules for strong modulators of intracellular editing to ultimately elucidate how A-to-I editing is regulated in vivo...
  5. doi request reprint IGFBP7's susceptibility to proteolysis is altered by A-to-I RNA editing of its transcript
    Christina Godfried Sie
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    FEBS Lett 586:2313-7. 2012
    ..Here we show that editing of IGFBP7 transcripts impacts the protein's susceptibility to proteolytic cleavage, thus providing a means for a cell to modulate its functionality through A-to-I RNA editing...
  6. doi request reprint MiRNA editing
    Dylan E Dupuis
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Methods Mol Biol 667:267-79. 2010
    ....
  7. pmc Identification of a selective nuclear import signal in adenosine deaminases acting on RNA
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Nucleic Acids Res 37:5822-9. 2009
    ..Thus, in vivo RNA editing might be regulated, in part, through controlled subcellular localization of ADARs, which in turn is governed by the coordinated local expression of importin alpha proteins and ADAR protein variants...
  8. doi request reprint Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1
    Christina P Sie
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015 4732, USA
    FEBS Lett 583:1171-4. 2009
    ..Remarkably, although editing of C1QL1 is conserved across vertebrate species, the predicted RNA secondary structure mediating editing involves different regions in zebrafish versus mammals...
  9. pmc Screening of human SNP database identifies recoding sites of A-to-I RNA editing
    Willemijn M Gommans
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015 4732, USA
    RNA 14:2074-85. 2008
    ..Our approach sets the stage for effective and comprehensive genome-wide screens for A-to-I editing targets...
  10. doi request reprint Characterization of ADAR1-mediated modulation of gene expression
    Willemijn M Gommans
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015 4732, USA
    Biochem Biophys Res Commun 377:170-5. 2008
    ..Our results suggest that a cellular, ADAR1-specific RNA editing substrate causes upregulation of plasmid-based gene expression...
  11. pmc RNA editing: a driving force for adaptive evolution?
    Willemijn M Gommans
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Bioessays 31:1137-45. 2009
    ..We propose that higher organisms have therefore evolved to systems with increasing RNA editing activity and, as a result, to more complex systems...
  12. doi request reprint Posttranscriptional recoding by RNA editing
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, USA
    Adv Protein Chem Struct Biol 86:193-224. 2012
    ..Here, I give an overview of the process of adenosine deamination RNA editing and describe its relationship to other RNA processing events and its currently established roles in gene regulation...
  13. pmc Molecular diversity through RNA editing: a balancing act
    Sanaz Farajollahi
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Trends Genet 26:221-30. 2010
    ..In particular, transcriptome instabilities in the form of too much or too little RNA editing activity, or misguided editing, manifest in several human disease phenotypes and can disrupt that balance...
  14. ncbi request reprint Gene regulation through RNA editing
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Discov Med 10:379-86. 2010
    ..Here, I am reviewing main features of this epigenetic phenomenon, its relevance for health and disease, as well as potential prospects for using RNA editing as a therapeutic tool...
  15. ncbi request reprint A-to-I RNA editing: recent news and residual mysteries
    Stefan Maas
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:1391-4. 2003
  16. pmc Modulation of ADAR1 editing activity by Z-RNA in vitro
    Michael Koeris
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nucleic Acids Res 33:5362-70. 2005
    ..These results suggest that the local conformation of dsRNA molecules might be an important feature for target selectivity by ADAR1 and other proteins with Z-RNA binding domains...
  17. pmc RNA editing of a miRNA precursor
    Daniel J Luciano
    RNA 10:1174-7. 2004
    ..The observed editing events are predicted to have significant implications for the biogenesis and function of miRNA22 and might point toward a more general role for RNA editing in the regulation of miRNA gene expression...
  18. pmc Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes
    Dama Laxminarayana
    Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunology 121:359-69. 2007
    ..Based on these results, it is proposed that altered transcript editing contributes to the modulation of gene expression and immune functions in SLE patients...