Matthias M Falk

Summary

Affiliation: Lehigh University
Country: USA

Publications

  1. ncbi Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 20:3342-52. 2009
  2. ncbi Adherens junctions remain dynamic
    Matthias M Falk
    Department of Biology, Lehigh University, Bethlehem, PA, USA
    BMC Biol 8:34. 2010
  3. ncbi Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery
    Anna M Gumpert
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:2887-92. 2008
  4. ncbi Internalized gap junctions are degraded by autophagy
    John T Fong
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Autophagy 8:794-811. 2012
  5. ncbi Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation
    Susan M Baker
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, Bethlehem, PA 18015, USA
    FEBS Lett 582:4039-46. 2008
  6. ncbi Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes
    Susan M Baker
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    BMC Cell Biol 11:15. 2010
  7. ncbi Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process
    Michelle Piehl
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 18:337-47. 2007
  8. ncbi Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels
    M Kathryn Iovine
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:165-70. 2008
  9. ncbi Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: a perspective
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, D 218, Bethlehem, PA 18015, USA
    J Membr Biol 245:465-76. 2012
  10. ncbi Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes
    Stephen D Eastman
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca B-217, Bethlehem, PA 18015, USA
    Genomics 87:265-74. 2006

Collaborators

  • MARY IOVINE
  • Susan M Baker
  • Anna M Gumpert
  • Michelle Piehl
  • John T Fong
  • Dominique Segretain
  • Stephen D Eastman
  • Rachael M Kells
  • Michael W Davidson
  • Jutta Y Marzillier
  • Robert W Buckheit
  • Joseph S Varco
  • Namho Kim
  • Corinna Lehmann
  • Anna Gumpert
  • Jean Pierre Denizot
  • Jean-Pierre Denizot
  • Tamra C Mendelson
  • Tim H-P Chen

Detail Information

Publications10

  1. ncbi Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 20:3342-52. 2009
    ..Our observations may have implications for the process of endocytic vesicle budding in general...
  2. ncbi Adherens junctions remain dynamic
    Matthias M Falk
    Department of Biology, Lehigh University, Bethlehem, PA, USA
    BMC Biol 8:34. 2010
    ....
  3. ncbi Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery
    Anna M Gumpert
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:2887-92. 2008
    ..To our knowledge, we are first to report that the endocytic clathrin machinery can internalize double-membrane vesicles into cells...
  4. ncbi Internalized gap junctions are degraded by autophagy
    John T Fong
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Autophagy 8:794-811. 2012
    ..Its recent link to health and disease lends additional importance to this GJ degradation mechanism and to autophagy in general...
  5. ncbi Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation
    Susan M Baker
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, Bethlehem, PA 18015, USA
    FEBS Lett 582:4039-46. 2008
    ..These findings demonstrate that GJ internalization is an efficient mechanism for modulating GJIC in inflammatory response...
  6. ncbi Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes
    Susan M Baker
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    BMC Cell Biol 11:15. 2010
    ..Initial limitations to their use (due to their tetrameric nature) were overcome when monomeric variants, such as Dendra, mEos, and mKikGR were cloned/engineered...
  7. ncbi Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process
    Michelle Piehl
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 18:337-47. 2007
    ..These findings contribute to the understanding of clathrin's numerous emerging functions...
  8. ncbi Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels
    M Kathryn Iovine
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:165-70. 2008
    ..Functional assays reveal that the Cx23 gap junctions are capable of sharing neurobiotin, and further, that Cx23 connexins form hemichannels in vitro...
  9. ncbi Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: a perspective
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, D 218, Bethlehem, PA 18015, USA
    J Membr Biol 245:465-76. 2012
    ..Furthermore, we highlight and discuss structural criteria that seem required for an alternate degradation via the endo-/lysosomal pathway...
  10. ncbi Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes
    Stephen D Eastman
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca B-217, Bethlehem, PA 18015, USA
    Genomics 87:265-74. 2006
    ..The identification of a third complete connexin gene family provides novel insight into the evolution of connexins, and sheds light into the phenotypic evolution of intercellular communication via gap junctions...