Matthias M Falk

Summary

Affiliation: Lehigh University
Country: USA

Publications

  1. pmc Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 20:3342-52. 2009
  2. pmc Adherens junctions remain dynamic
    Matthias M Falk
    Department of Biology, Lehigh University, Bethlehem, PA, USA
    BMC Biol 8:34. 2010
  3. pmc Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery
    Anna M Gumpert
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:2887-92. 2008
  4. pmc Internalized gap junctions are degraded by autophagy
    John T Fong
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Autophagy 8:794-811. 2012
  5. pmc Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation
    Susan M Baker
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, Bethlehem, PA 18015, USA
    FEBS Lett 582:4039-46. 2008
  6. doi request reprint Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation
    Anastasia F Thévenin
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, USA
    Physiology (Bethesda) 28:93-116. 2013
  7. pmc Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: a perspective
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, D 218, Bethlehem, PA 18015, USA
    J Membr Biol 245:465-76. 2012
  8. pmc Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes
    Susan M Baker
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    BMC Cell Biol 11:15. 2010
  9. pmc Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process
    Michelle Piehl
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 18:337-47. 2007
  10. pmc Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels
    M Kathryn Iovine
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:165-70. 2008

Collaborators

  • MARY IOVINE
  • John T Fong
  • Susan M Baker
  • Anna M Gumpert
  • Rachael M Kells
  • Michelle Piehl
  • Anastasia F Thévenin
  • Tia J Kowal
  • Shaojie Wang
  • Dominique Segretain
  • Stephen D Eastman
  • Himanshu Jain
  • Charles G Fisher
  • Mona K Marei
  • Jutta Y Marzillier
  • Michael W Davidson
  • Robert W Buckheit
  • Joseph S Varco
  • Namho Kim
  • Jean Pierre Denizot
  • Corinna Lehmann
  • Anna Gumpert
  • Tamra C Mendelson
  • Tim H P Chen

Detail Information

Publications13

  1. pmc Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 20:3342-52. 2009
    ..Our observations may have implications for the process of endocytic vesicle budding in general...
  2. pmc Adherens junctions remain dynamic
    Matthias M Falk
    Department of Biology, Lehigh University, Bethlehem, PA, USA
    BMC Biol 8:34. 2010
    ....
  3. pmc Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery
    Anna M Gumpert
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:2887-92. 2008
    ..To our knowledge, we are first to report that the endocytic clathrin machinery can internalize double-membrane vesicles into cells...
  4. pmc Internalized gap junctions are degraded by autophagy
    John T Fong
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Autophagy 8:794-811. 2012
    ..Its recent link to health and disease lends additional importance to this GJ degradation mechanism and to autophagy in general...
  5. pmc Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation
    Susan M Baker
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, Bethlehem, PA 18015, USA
    FEBS Lett 582:4039-46. 2008
    ..These findings demonstrate that GJ internalization is an efficient mechanism for modulating GJIC in inflammatory response...
  6. doi request reprint Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation
    Anastasia F Thévenin
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, USA
    Physiology (Bethesda) 28:93-116. 2013
    ..We also look closely at the atomic resolution structure of a GJ channel, since the structure harbors vital cues relevant to GJ biosynthesis and turnover...
  7. pmc Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: a perspective
    Matthias M Falk
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, D 218, Bethlehem, PA 18015, USA
    J Membr Biol 245:465-76. 2012
    ..Furthermore, we highlight and discuss structural criteria that seem required for an alternate degradation via the endo-/lysosomal pathway...
  8. pmc Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes
    Susan M Baker
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    BMC Cell Biol 11:15. 2010
    ..Initial limitations to their use (due to their tetrameric nature) were overcome when monomeric variants, such as Dendra, mEos, and mKikGR were cloned/engineered...
  9. pmc Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process
    Michelle Piehl
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Mol Biol Cell 18:337-47. 2007
    ..These findings contribute to the understanding of clathrin's numerous emerging functions...
  10. pmc Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels
    M Kathryn Iovine
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA
    FEBS Lett 582:165-70. 2008
    ..Functional assays reveal that the Cx23 gap junctions are capable of sharing neurobiotin, and further, that Cx23 connexins form hemichannels in vitro...
  11. pmc Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis
    John T Fong
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015
    Mol Biol Cell 24:2834-48. 2013
    ..Our analyses provide a mechanistic model for clathrin's efficient internalization of large plasma membrane structures, such as GJs. ..
  12. pmc Nanoporosity significantly enhances the biological performance of engineered glass tissue scaffolds
    Shaojie Wang
    Department of Materials Science and Engineering, Lehigh University, Bethlehem, PA 18015, USA
    Tissue Eng Part A 19:1632-40. 2013
    ....
  13. ncbi request reprint Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes
    Stephen D Eastman
    Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca B 217, Bethlehem, PA 18015, USA
    Genomics 87:265-74. 2006
    ..The identification of a third complete connexin gene family provides novel insight into the evolution of connexins, and sheds light into the phenotypic evolution of intercellular communication via gap junctions...