Philipp Singer

Summary

Affiliation: Legacy Research
Country: USA

Publications

  1. pmc Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning
    Philipp Singer
    Laboratory of Behavioral Neurobiology, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Behav Brain Res 242:54-61. 2013
  2. pmc Reversal of scopolamine-induced disruption of prepulse inhibition by clozapine in mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Pharmacol Biochem Behav 101:107-14. 2012
  3. pmc Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?
    Philipp Singer
    Laboratory of Behavioural Neurobiology, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Behav Neurosci 123:1012-27. 2009
  4. pmc Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Eur Neuropsychopharmacol 21:401-13. 2011
  5. doi Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Federal Institute of Technology Zurich, Schorenstrasse 16, Schwerzenbach, Switzerland
    Psychopharmacology (Berl) 206:677-98. 2009
  6. pmc Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia
    Hai Ying Shen
    Robert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA
    J Clin Invest 122:2567-77. 2012
  7. pmc Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning
    Sylvain Dubroqua
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Switzerland
    Behav Neurosci 124:839-50. 2010
  8. doi Prepulse inhibition predicts working memory performance whilst startle habituation predicts spatial reference memory retention in C57BL/6 mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, CH 8063 Schwerzenbach, Switzerland
    Behav Brain Res 242:166-77. 2013
  9. doi Sensorimotor gating and vigilance-dependent choice accuracy: a within-subject correlative analysis in wild-type C57BL/6 mice
    Byron K Y Bitanihirwe
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland
    Behav Brain Res 217:178-87. 2011
  10. ncbi Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs
    Benjamin K Yee
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland
    Eur J Neurosci 26:3237-52. 2007

Collaborators

Detail Information

Publications17

  1. pmc Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning
    Philipp Singer
    Laboratory of Behavioral Neurobiology, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Behav Brain Res 242:54-61. 2013
    ....
  2. pmc Reversal of scopolamine-induced disruption of prepulse inhibition by clozapine in mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Pharmacol Biochem Behav 101:107-14. 2012
    ..In concert with previous data showing its sensitivity to haloperidol the present finding supports the predictive validity of the anti-muscarinic PPI disruption model for both typical and atypical antipsychotic drug action...
  3. pmc Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?
    Philipp Singer
    Laboratory of Behavioural Neurobiology, ETH Zurich, 8603 Schwerzenbach, Switzerland
    Behav Neurosci 123:1012-27. 2009
    ....
  4. pmc Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Eur Neuropsychopharmacol 21:401-13. 2011
    ..These results demonstrate in mice that depending on the regional and/or cell-type specificity, deletion of the GlyT1 gene could yield divergent effects on PPI...
  5. doi Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Federal Institute of Technology Zurich, Schorenstrasse 16, Schwerzenbach, Switzerland
    Psychopharmacology (Berl) 206:677-98. 2009
    ..In this study, we examined the robustness of the PPI deficit when this confound is fully taken into account...
  6. pmc Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia
    Hai Ying Shen
    Robert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA
    J Clin Invest 122:2567-77. 2012
    ....
  7. pmc Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning
    Sylvain Dubroqua
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Switzerland
    Behav Neurosci 124:839-50. 2010
    ..In addition, we revealed here for the first time a clear increase in the number of immature neurons in the hippocampus of the mutants, although the behavioral significance of this phenotype remains to be determined...
  8. doi Prepulse inhibition predicts working memory performance whilst startle habituation predicts spatial reference memory retention in C57BL/6 mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, CH 8063 Schwerzenbach, Switzerland
    Behav Brain Res 242:166-77. 2013
    ....
  9. doi Sensorimotor gating and vigilance-dependent choice accuracy: a within-subject correlative analysis in wild-type C57BL/6 mice
    Byron K Y Bitanihirwe
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland
    Behav Brain Res 217:178-87. 2011
    ....
  10. ncbi Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs
    Benjamin K Yee
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland
    Eur J Neurosci 26:3237-52. 2007
    ..The present findings are of relevance to current pathophysiological hypotheses of schizophrenia and its pharmacotherapy...
  11. doi The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex
    Susanna Pietropaolo
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Psychopharmacology (Berl) 197:613-28. 2008
    ..However, controversy exists over the precise behavioural profile and the robustness of some of the reported effects of social isolation rearing...
  12. doi Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour
    Philipp Singer
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Eur Neuropsychopharmacol 19:571-80. 2009
    ..The specificity of this action of SSR504734 will be highly relevant to its potential application as an antipsychotic agent...
  13. ncbi Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons
    Philipp Singer
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Switzerland
    Behav Neurosci 121:815-25. 2007
    ....
  14. pmc Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy
    Detlev Boison
    Robert Stone Dow Neurobiology Laboratories, Legacy Research Institute, 1225 NE 2nd Avenue, Portland, OR 97232, USA
    Neuropharmacology 62:1527-43. 2012
    ..Key preliminary clinical data and preclinical findings are reviewed...
  15. doi The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice
    Philipp Singer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Psychopharmacology (Berl) 202:371-84. 2009
    ....
  16. pmc Dysregulation of brain adenosine is detrimental to the expression of conditioned freezing but not general Pavlovian learning
    Philipp Singer
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Pharmacol Biochem Behav 104:80-9. 2013
    ....
  17. ncbi Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile
    Benjamin K Yee
    Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology, 8603 Schwerzenbach, Switzerland
    J Neurosci 26:3169-81. 2006
    ....