Julie Anne Saugstad

Summary

Affiliation: Legacy Research
Country: USA

Publications

  1. pmc Interaction between metabotropic glutamate receptor 7 and alpha tubulin
    Julie A Saugstad
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA
    J Neurochem 80:980-8. 2002
  2. pmc MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration
    Julie A Saugstad
    Robert Stone Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Cereb Blood Flow Metab 30:1564-76. 2010
  3. pmc Analysis of the membrane topology of the acid-sensing ion channel 2a
    Julie A Saugstad
    Robert S Dow Neurobiology Laboratories, Legacy Research, 1225 N E 2nd Avenue, Portland, OR 97232, USA
    J Biol Chem 279:55514-9. 2004
  4. pmc Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance
    Robert Meller
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurosci 28:50-9. 2008
  5. pmc Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels
    Xiang Ping Chu
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurosci 24:8678-89. 2004
  6. pmc ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents
    Xiang Ping Chu
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurosci 26:5329-39. 2006
  7. pmc Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents
    Carol D Farr
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurochem 91:438-50. 2004
  8. pmc A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a
    Sunghee Chai
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Biol Chem 282:22668-77. 2007
  9. pmc Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex
    Theresa A Lusardi
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Cereb Blood Flow Metab 30:744-56. 2010
  10. pmc Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons
    Robert Meller
    Robert S Dow Neurobiology Laboratories, Legacy Clinical Research and Technology Center, 1225 NE 2nd Avenue, Portland, OR 97232, USA
    J Biol Chem 281:7429-36. 2006

Research Grants

  1. Role for MicroRNAs in Ischemic Tolerance
    Julie Anne Saugstad; Fiscal Year: 2010
  2. Neuroprotection by Novel Regulators of mGluR Signaling
    Julie Saugstad; Fiscal Year: 2009
  3. Role of MicroRNAs in Ischemic Tolerance
    Julie Saugstad; Fiscal Year: 2007
  4. Neuroprotection by Novel Regulators of mGluR Signaling
    Julie Saugstad; Fiscal Year: 2007
  5. Role of Acid-Sensing Ion Channels in Glaucoma
    Julie Saugstad; Fiscal Year: 2006
  6. Extracellular Modulation of Metabotropic GluRs
    Julie Saugstad; Fiscal Year: 2005
  7. REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR RESPONSES
    Julie Saugstad; Fiscal Year: 2002

Collaborators

Detail Information

Publications12

  1. pmc Interaction between metabotropic glutamate receptor 7 and alpha tubulin
    Julie A Saugstad
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA
    J Neurochem 80:980-8. 2002
    ....
  2. pmc MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration
    Julie A Saugstad
    Robert Stone Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Cereb Blood Flow Metab 30:1564-76. 2010
    ..This review discusses microRNA discovery, biogenesis, mechanisms of gene regulation, their expression and function in the brain, and their roles in brain ischemia and injury, neuroprotection, and neurodegeneration...
  3. pmc Analysis of the membrane topology of the acid-sensing ion channel 2a
    Julie A Saugstad
    Robert S Dow Neurobiology Laboratories, Legacy Research, 1225 N E 2nd Avenue, Portland, OR 97232, USA
    J Biol Chem 279:55514-9. 2004
    ..These data confirm the membrane topology prediction that the ASIC2a subtype consists of intracellular amino and carboxyl termini and two transmembrane domains connected by a large extracellular loop...
  4. pmc Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance
    Robert Meller
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurosci 28:50-9. 2008
    ..Together these data suggest that rapid tolerance results from changes to the postsynaptic density mediated by the ubiquitin-proteasome system, rendering neurons resistant to excitotoxicity...
  5. pmc Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels
    Xiang Ping Chu
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurosci 24:8678-89. 2004
    ..Our studies suggest that Zn2+ may play an important role in a negative feedback system for preventing overexcitation of neurons during normal synaptic transmission and ASIC1a-mediated excitotoxicity in pathological conditions...
  6. pmc ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents
    Xiang Ping Chu
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurosci 26:5329-39. 2006
    ..Our results suggest that redox state of the ASIC1a subunit is an important factor in determining the overall physiological function and the pathological role of ASICs in the CNS...
  7. pmc Proteomic analysis of native metabotropic glutamate receptor 5 protein complexes reveals novel molecular constituents
    Carol D Farr
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurochem 91:438-50. 2004
    ....
  8. pmc A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a
    Sunghee Chai
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Biol Chem 282:22668-77. 2007
    ....
  9. pmc Ischemic preconditioning regulates expression of microRNAs and a predicted target, MeCP2, in mouse cortex
    Theresa A Lusardi
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Cereb Blood Flow Metab 30:744-56. 2010
    ....
  10. pmc Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons
    Robert Meller
    Robert S Dow Neurobiology Laboratories, Legacy Clinical Research and Technology Center, 1225 NE 2nd Avenue, Portland, OR 97232, USA
    J Biol Chem 281:7429-36. 2006
    ..This suggests that the rapid degradation of cell death-promoting proteins by the ubiquitin-proteasome pathway may represent a novel therapeutic strategy to reduce cell damage following neuropathological insults, e.g. stroke...
  11. ncbi request reprint Interaction of 14-3-3 with Bid during seizure-induced neuronal death
    Sachiko Shinoda
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Neurochem 86:460-9. 2003
    ..These data suggest 14-3-3 proteins may target active as well as inactive conformations of pro-apoptotic Bcl-2 death agonists, highlighting novel targets for intervention in seizure-induced neuronal death...
  12. pmc Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function
    Scott D Sorensen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA
    Mol Pharmacol 61:1303-12. 2002
    ..Furthermore, our studies suggest that CaM binding is not required for mGluR7-mediated activation of GIRK current...

Research Grants11

  1. Role for MicroRNAs in Ischemic Tolerance
    Julie Anne Saugstad; Fiscal Year: 2010
    ....
  2. Neuroprotection by Novel Regulators of mGluR Signaling
    Julie Saugstad; Fiscal Year: 2009
    ..abstract_text> ..
  3. Role of MicroRNAs in Ischemic Tolerance
    Julie Saugstad; Fiscal Year: 2007
    ....
  4. Neuroprotection by Novel Regulators of mGluR Signaling
    Julie Saugstad; Fiscal Year: 2007
    ....
  5. Role of Acid-Sensing Ion Channels in Glaucoma
    Julie Saugstad; Fiscal Year: 2006
    ..abstract_text> ..
  6. Extracellular Modulation of Metabotropic GluRs
    Julie Saugstad; Fiscal Year: 2005
    ..abstract_text> ..
  7. REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR RESPONSES
    Julie Saugstad; Fiscal Year: 2002
    ..abstract_text> ..