Research Topics
| W M BennettSummaryAffiliation: Legacy Health System Country: USA Publications
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Detail Information
Publications
Cyclosporine nephrotoxicityEmmanuel A Burdmann
Division of Nephrology, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, Brazil
Semin Nephrol 23:465-76. 2003..A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided...- Morbid obesity does not preclude successful renal transplantationWilliam M Bennett
Solid Organ and Cellular Transplantation, Legacy Good Samaritan Hospital, Portland, OR 97210 3025, USA
Clin Transplant 18:89-93. 2004..Based on our experience, morbid obesity should not be used to exclude patients arbitrarily from transplantation anymore than advanced age or diabetes should... - Renal transplantation for ADPKD patients: a 2007 updateWilliam M Bennett
Legacy Transplant Services, Portland, OR, USA
Nephrol News Issues 21:24-5, 27. 2007 - Reporting eGFRWilliam M Bennett
Northwest Renal Clinic, Portland, Oregon, USA
Clin J Am Soc Nephrol 3:1561-2. 2008 
Use of organs for transplantation from a donor with primary meningoencephalitis due to Naegleria fowleriW M Bennett
Northwest Renal Clinic, Legacy Transplant Services, Portland, OR, USA
Am J Transplant 8:1334-5. 2008..fowleri infection. Kidneys, pancreas, a lung and liver were used with no evidence of posttransplant infectious complications. This unusual cause of brain death does not preclude successful organ donation...- Disseminated intravascular coagulation (DIC) in a kidney donor associated with transient recipient DICWilliam M Bennett
Solid Organ and Cellular Transplantation, Legacy Good Samaritan Hospital, Portland, OR, USA
Am J Transplant 5:412-4. 2005.... - Kidney transplantation in the morbidly obese: complicated but still better than dialysisWilliam M Bennett
Legacy Good Samaritan Hospital, Portland, OR, USA
Clin Transplant 25:401-5. 2011..Thus, there is no a priori ethical reason for treating obese ESRD patients differently from those with other comorbidities... - Should dialysis patients ever receive warfarin and for what reasons?William M Bennett
Northwest Renal Clinic, Transplant Services, Legacy Good Samaritan Hospital, Portland, OR 97210, USA
Clin J Am Soc Nephrol 1:1357-9. 2006 - Surveillance and modification of immunosuppression minimizes BK virus nephropathyWilliam M Bennett
Transplant Services, Legacy Good Samaritan Medical Center, Portland, OR 97210, USA
Am J Nephrol 32:10-2. 2010..Infection of a transplanted kidney with the polyomavirus, BK, is associated with poor allograft survival... 
Autosomal dominant polycystic kidney disease: 2009 update for internistsWilliam M Bennett
Northwest Renal Clinic, Transplant Services Legacy Good Samaritan Hospital, Portland, OR 97210, USA
Korean J Intern Med 24:165-8. 2009..In the near future, therapies for this common genetic disease may be available to either prevent or stabilize the disease course for many affected individuals...- Chronic cyclosporine nephrotoxicityT F Andoh
Department of Medicine, Oregon Health Sciences University, Portland, USA
Curr Opin Nephrol Hypertens 7:265-70. 1998..Insights gained from experimental models of chronic nephrotoxicity associated with tubulointerstitial fibrosis are presented to elucidate the pathophysiology... - Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategiesA J Olyaei
Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University and Solid Organ and Cellular Transplantation, Legacy Good Samaritan Hospital, Portland, Oregon 97201, USA
Curr Opin Crit Care 7:384-9. 2001..New experiences with non-nephrotoxic agents and protocols including mycophenolate and sirolimus allow for early calcineurin inhibitor reduction or elimination without increasing the risk of allograft rejection... - Subclinical renal injury induced by transient cyclosporine exposure is associated with salt-sensitive hypertensionT F Andoh
Solid Organ Transplant Service, Legacy Good Samaritan Hospital, Portland, OR 97232, USA
Am J Transplant 1:222-7. 2001..One mechanism by which cyclosporine induces hypertension is the induction of subtle renal microvascular and tubulointerstitial disease. This mechanism is not dependent on GFR and may persist even after the cyclosporine is discontinued... - Use of basiliximab and daclizumab in kidney transplantationA J Olyaei
Oregon Health Sciences University, Portland, Ore, USA
Prog Transplant 11:33-7; quiz 38-9. 2001..Further studies are needed to evaluate the overall effect of these agents on long-term patient and allograft survival... - Increased vascular resistance and not salt retention characterizes cyclosporine A-induced hypertension: report in an anuric patientI M Wahba
Department of Medicine, Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR, USA
Am J Transplant 7:2042-6. 2007..We briefly discuss the possible mechanisms of CsA-induced hypertension in light of this information... - Drug-related renal dysfunction in the elderlyW M Bennett
Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland, USA
Geriatr Nephrol Urol 9:21-5. 1999..This paper reviews this issue with specific emphasis on drugs that are often used in elderly subjects such as nonsteroidal antiinflammatory agents, angiotension converting enzyme inhibitors, antibiotics, and immunosuppressive drugs... - Validation of an algorithm for predicting cardiac events in renal transplant candidatesMichael S Lewis
Division of Cardiology, Oregon Health Sciences University, Portland, Oregon 97201, USA
Am J Cardiol 89:847-50. 2002..Pretransplant risk stratification by clinical variables identified low-risk patients who may not require further cardiac evaluation and high-risk patients with normal SPECT imaging who may not require angiography... - Relationship between elevated serum troponin values in end-stage renal disease patients and abnormal isotopic cardiac scans following stressGeorge A Porter
Division of Nephrology, Hypertension and Clinical Pharmacology, PP 262 Department of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
Ren Fail 25:55-65. 2003..A cTnT > 0.1 microgram/L increases the likelihood of finding significant coronary artery disease three fold in high-risk ESRD patients being evaluated for renal transplantation... - Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney diseaseVicente E Torres
Mayo Clinic College of Medicine, Rochester, MN 55901, USA
Clin J Am Soc Nephrol 2:112-20. 2007..TKV and RBF were independent predictors of GFR decline (functional disease progression). In ADPKD, RBF reduction (1) parallels TKV increase, (2) precedes GFR decline, and (3) predicts structural and functional disease progression... - Comparison of methods for determining renal function decline in early autosomal dominant polycystic kidney disease: the consortium of radiologic imaging studies of polycystic kidney disease cohortAndrew D Rule
Division of Nephrology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, and University of Alabama, Birmingham, USA
J Am Soc Nephrol 17:854-62. 2006..Misclassification from changes in non-GFR factors (e.g., creatinine production, tubular secretion) conservatively biased associations with eGFR. Misclassification from method imprecision attenuated associations with creatinine clearance... - Pirfenidone treatment decreases transforming growth factor-beta1 and matrix proteins and ameliorates fibrosis in chronic cyclosporine nephrotoxicityFuad S Shihab
Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, USA
Am J Transplant 2:111-9. 2002..These experiments suggest that PFD can be clinically useful for preventing chronic CsA nephrotoxicity and may prove to be helpful in other progressive renal diseases... - Nitric oxide modulates vascular endothelial growth factor and receptors in chronic cyclosporine nephrotoxicityFuad S Shihab
Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Kidney Int 63:522-33. 2003..We examined the role of nitric oxide modulation on VEGF in this model... - Reversibility of chronic cyclosporine nephropathy in rats after withdrawal of cyclosporineCan Li
Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
Am J Physiol Renal Physiol 284:F389-98. 2003..01). These findings suggest that OPN expression and macrophage infiltration decrease after long-term CsA withdrawal in rats with established chronic CsA nephropathy, and this is closely associated with recovery from renal injury... - Immunosuppression with mycophenolic acid: one size does not fit allWilliam M Bennett
J Am Soc Nephrol 14:2414-6. 2003 - Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohortArlene B Chapman
Department of Medicine Renal Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
Kidney Int 64:1035-45. 2003.... - Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohortKyongtae T Bae
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Clin J Am Soc Nephrol 1:64-9. 2006..Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age... - Immunosuppression: practice and trendsJ Harold Helderman
Vanderbilt University, Nashville, TN, USA
Am J Transplant 3:41-52. 2003 - Combination therapy with sirolimus and mycophenolate mofetil: effects on the kidney and on transforming growth factor-beta1Fuad S Shihab
Division of Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA
Transplantation 77:683-6. 2004..The long-term consequence of increased TGF-beta in SRL-treated kidneys remains unknown. However, because MMF can reverse this trend, SRL and MMF combination therapy may be protective... - Sirolimus increases transforming growth factor-beta1 expression and potentiates chronic cyclosporine nephrotoxicityFuad S Shihab
Division of Nephrology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Kidney Int 65:1262-71. 2004..We investigated the effect of combining CsA and SRL on renal structure and function and on transforming growth factor-beta1 (TGF-beta1) and extracellular matrix (ECM) proteins in a model of chronic CsA nephrotoxicity... - Response to "Sustained improvement of renal graft function for two years in hypertensive renal transplant recipients treated with nifedipine as compared with lisinopril"Titte R Srinivas
Transplantation 74:139; author reply 139-40. 2002 - Expression of apoptosis-related genes in chronic cyclosporine nephrotoxicity in miceChul Woo Yang
Division of Nephrology, Catholic University of Korea, Seoul, Korea
Am J Transplant 2:391-9. 2002..These findings suggest that local activation of the apoptosis-related genes is associated with CsA-induced apoptotic cell death... - Angiotensin II regulation of vascular endothelial growth factor and receptors Flt-1 and KDR/Flk-1 in cyclosporine nephrotoxicityFuad S Shihab
Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Kidney Int 62:422-33. 2002..We have previously shown that VEGF is up-regulated in a chronic cyclosporine (CsA) nephrotoxicity model. Our current study examined the role of angiotensin II (Ang II) blockade with enalapril (E) or losartan (L) on VEGF in this model... - Effect of cyclosporine and sirolimus on the expression of connective tissue growth factor in rat experimental chronic nephrotoxicityFuad S Shihab
Division of Nephrology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Am J Nephrol 26:400-7. 2006..However, CTGF regulation remains unknown. We tried to determine the effect of two commonly used immunosuppressants, cyclosporine (CsA) and sirolimus (SRL), on CTGF expression in a model of chronic nephrotoxicity... - Volume progression in polycystic kidney diseaseJared J Grantham
Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
N Engl J Med 354:2122-30. 2006..Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of cyst-filled kidneys... - Cyclosporin induces renal proto-oncogene RNA message and increased transforming growth factor-beta prior to renal fibrosis: Modification by calcium channel blockade in the salt replete ratSubodh J Saggi
Division of Nephrology, Staten Island University Hospital, Staten Island, New York, USA
Nephrology (Carlton) 9:58-64. 2004..CONCLUSION: These data are consistent with the notion that CsA induces protooncogenes, which may be, at least partially, responsible for long-term CsA nephrotoxicity... - Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipientsRami T Bustami
Scientific Registry of Transplant Recipients University Renal Research and Education Association, Ann Arbor, MI, USA
Am J Transplant 4:87-93. 2004..024). These new estimates of the magnitude of malignancy risk associated with induction therapy may be useful for clinical practice... - Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney diseaseBernard F King
Department of Medicine (Renal Division, University of Alabama, Birmingham, Alabama, USA
Kidney Int 64:2214-21. 2003.... - Iron sucrose in hemodialysis patients: safety of replacement and maintenance regimensGeorge R Aronoff
University of Louisville School of Medicine, Louisville, Kentucky, USA
Kidney Int 66:1193-8. 2004..There were no serious or life-threatening drug-related adverse events. CONCLUSION: Iron sucrose is safe when given as treatment for iron deficiency or for maintenance of iron stores... - Mycophenolate mofetil ameliorates arteriolopathy and decreases transforming growth factor-beta1 in chronic cyclosporine nephrotoxicityFuad S Shihab
Division of Nephrology, University of Utah School of Medicine, Salt Lake City, USA
Am J Transplant 3:1550-9. 2003..While this drug combination may be useful clinically, long-term studies are needed to determine if MMF has a lasting benefit... - Cardiovascular complications of immunosuppressive agents in renal transplant recipientsAli J Olyaei
Oregon Health Sciences University, Division of Nephrology, Hypertension, 3181 SW Sam Jackson Park Road, Mail Code CR9 4 Portland, Oregon 97201, USA
Expert Opin Drug Saf 4:29-44. 2005..Adverse reactions and drug-drug interactions should not be neglected when selecting an agent for treatment of cardiovascular risk factors in transplant recipients... - Effect of pirfenidone on apoptosis-regulatory genes in chronic cyclosporine nephrotoxicityFuad S Shihab
Division of Nephrology, University of Utah School of Medicine, 30 N. 1900 E, Salt Lake City, UT 84132, USA
Transplantation 79:419-26. 2005..Because apoptosis can partly explain the loss of cells associated with fibrosis, the influence of PFD on apoptosis-regulatory genes in a manner that reduces apoptosis may explain some of its antifibrotic properties... - Current status of kidney and pancreas transplantation in the United States, 1994-2003Gabriel M Danovitch
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Am J Transplant 5:904-15. 2005..The percentage of Hispanic/Latino recipients increased from 5% to 9% over the same period... - The failed renal transplant: in or out?William M Bennett
Semin Dial 18:188-9. 2005..The author's personal approach is presented... - Administration of tobramycin in the beginning of the hemodialysis session: a novel intradialytic dosing regimenOsama Hussein Kamel Mohamed
Faculty of Pharmacy, Pharmaceutics Department, Cairo University, Cairo, Egypt
Clin J Am Soc Nephrol 2:694-9. 2007....