Research Topics
Species | David J LeeheySummaryCountry: USA Publications
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Publications
Aerobic exercise in obese diabetic patients with chronic kidney disease: a randomized and controlled pilot studyDavid J Leehey
Veterans Affairs Hospital, Hines, IL, USA
Cardiovasc Diabetol 8:62. 2009..Patients with obesity, diabetes, and chronic kidney disease (CKD) are generally physically inactive, have a high mortality rate, and may benefit from an exercise program...
Glomerular renin angiotensin system in streptozotocin diabetic and Zucker diabetic fatty ratsDavid J Leehey
Department of Medicine, Veterans Affairs Hospital, Hines, IL 60141, USA
Transl Res 151:208-16. 2008..The mechanism of nephropathy in the ZDF rat may involve factors other than hyperglycemia and RAS activation, such as hypertension and hyperlipidemia...
A novel mechanism for angiotensin II formation in streptozotocin-diabetic rat glomeruliRekha Singh
Department of Medicine, Veterans Affairs Hospital, 111-L, Hines, IL 60141, USA
Am J Physiol Renal Physiol 288:F1183-90. 2005..Thus this study demonstrates that in diabetic rats, glomerular ANG II levels are increased due to an increase in angiotensinogen and an increase in the formation of ANG II...- Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trialRajiv Agarwal
Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Clin J Am Soc Nephrol 6:114-21. 2011..This study examined differences in proteinuria between two intravenous iron preparations after multiple doses... - Progression of kidney disease in type 2 diabetes - beyond blood pressure control: an observational studyDavid J Leehey
Department of Medicine Veterans Affairs Hospital Hines, IL and Loyola University Medical Center Maywood, IL, USA
BMC Nephrol 6:8. 2005..Although uncontrolled blood pressure (BP) is known to be deleterious, other factors may become more important once BP is treated... - A comparison of aerobic exercise and resistance training in patients with and without chronic kidney diseaseIrfan Moinuddin
Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
Adv Chronic Kidney Dis 15:83-96. 2008.... - Inhibition of intracellular angiotensin II formation blocks high glucose effect on mesangial matrixRekha Singh
Hines VA Hospital, Hines, IL 60141, USA
Regul Pept 158:103-9. 2009..These data suggest that intracellular Ang II may play an important role in the mediation of the high glucose effect on matrix and that ACE inhibitors may not be effective in blocking intracellular Ang II formation in mesangial cells... - Effect of high glucose on superoxide in human mesangial cells: role of angiotensin IIDavid J Leehey
Veterans Affairs Hospital, Hines, IL 60141, USA
Nephron Exp Nephrol 100:e46-53. 2005..This study was designed to investigate the effects of high glucose (HG) on O2* accumulation and SOD activity in human mesangial cells (HMC) and to determine if these effects are mediated by angiotensin II (Ang II)... - Effect of ACE inhibitors on angiotensin II in rat mesangial cells cultured in high glucoseRekha Singh
Veterans Affairs Hospital, Hines, IL 60141, USA
Biochem Biophys Res Commun 357:1040-5. 2007..Addition of captopril to cell lysates was indeed able to inhibit Ang I conversion to Ang II but only partially. These findings suggest the involvement of non-ACE mechanisms in Ang II formation from Ang I in mesangial cells... - Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceusMohammed S Ahmed
Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA
Am J Kidney Dis 50:1028-32. 2007..The clinical course of this patient suggests that Astragalus may have beneficial effects in patients with idiopathic membranous nephropathy... - Albuminuria in acute tubular necrosisBradford Lee West
Department of Medicine, Loyola University Medical Center, 2160 S 1st Avenue, Maywood, IL 60153, USA
Nephrol Dial Transplant 21:2953-6. 2006 - Sodium ferric gluconate causes oxidative stress but not acute renal injury in patients with chronic kidney disease: a pilot studyDavid J Leehey
Division of Nephrology, Department of Medicine, Loyola University School of Medicine and Edward Hines Jr VA Medical Center, Hines, IL 60141, USA
Nephrol Dial Transplant 20:135-40. 2005..Intravenous (i.v) iron is widely used to treat anaemia in patients with chronic kidney disease (CKD). Although beneficial and usually well tolerated, concerns have been raised about its ability to cause oxidative stress and renal injury... - Simultaneous transjugular renal biopsy and hemodialysis catheter placement in patients with ARFMohammed S Ahmed
Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL, USA
Am J Kidney Dis 44:429-36. 2004..CONCLUSION: Simultaneous transjugular renal biopsy/HD catheter placement should be considered in patients with ARF requiring HD therapy for whom knowledge of the renal histological diagnosis may alter patient management... - Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucoseRekha Singh
Department of Medicine, Veterans Affairs Hospital, Hines, Illinois, and Loyola University Stritch School of Medicine, Maywood, Illinois 60141, USA
J Am Soc Nephrol 14:873-80. 2003..In addition, this study provides new information that Ang(1-9) is produced by mesangial cells, can be converted to AngII, and that this conversion is also stimulated under high-glucose conditions...