R E Shaddy

Summary

Affiliation: LDS Hospital
Country: USA

Publications

  1. ncbi request reprint Optimizing treatment for chronic congestive heart failure in children
    R E Shaddy
    University of Utah School of Medicine, and the Heart Transplant Program, Primary Children's Medical Center, Salt Lake City, UT, USA
    Crit Care Med 29:S237-40. 2001
  2. ncbi request reprint Evidence for lack of myocardial injury in children with acute rheumatic carditis
    Richard V Williams
    Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City UT 84113, USA
    Cardiol Young 12:519-23. 2002
  3. ncbi request reprint Spectrum of left ventricular dysfunction in potential pediatric heart transplant donors
    James J Paul
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113 1100, USA
    J Heart Lung Transplant 22:548-52. 2003
  4. ncbi request reprint Safety of endomyocardial biopsy in children
    Collin G Cowley
    Division of Pediatric Cardiology, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Cardiol Young 13:404-7. 2003
  5. ncbi request reprint Long-term, randomized comparison of balloon angioplasty and surgery for native coarctation of the aorta in childhood
    Collin G Cowley
    Department of Pediatrics, University of Utah and Primary Children s Medical Center, Salt Lake City, Utah, USA
    Circulation 111:3453-6. 2005
  6. ncbi request reprint Prospective randomized trial of azathioprine in cryopreserved valved allografts in children
    R E Shaddy
    Department of Pediatrics, Primary Children s Medical Center and University of Utah, Salt Lake City 84113, USA
    Ann Thorac Surg 71:43-7; discussion 47-8. 2001
  7. ncbi request reprint The Pediatric Randomized Carvedilol Trial in Children with Heart Failure: rationale and design
    Robert E Shaddy
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Am Heart J 144:383-9. 2002
  8. ncbi request reprint Immunology and failure of valved allografts in children
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA
    Ann Thorac Surg 74:1271-5. 2002
  9. ncbi request reprint Class I and class II anti-HLA antibodies after implantation of cryopreserved allograft material in pediatric patients
    J A Hawkins
    Department of Surgery, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    J Thorac Cardiovasc Surg 119:324-30. 2000
  10. ncbi request reprint Late results and reintervention after aortic valvotomy for critical aortic stenosis in neonates and infants
    J A Hawkins
    Department of Surgery, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    Ann Thorac Surg 65:1758-62; discussion 1763. 1998

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Optimizing treatment for chronic congestive heart failure in children
    R E Shaddy
    University of Utah School of Medicine, and the Heart Transplant Program, Primary Children's Medical Center, Salt Lake City, UT, USA
    Crit Care Med 29:S237-40. 2001
    ..Findings from these types of studies will provide critical information for developing guidelines for the appropriate treatment of children with chronic heart failure...
  2. ncbi request reprint Evidence for lack of myocardial injury in children with acute rheumatic carditis
    Richard V Williams
    Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City UT 84113, USA
    Cardiol Young 12:519-23. 2002
    ..This supports the concept that acute valvar regurgitation is the major hemodynamic abnormality in these patients...
  3. ncbi request reprint Spectrum of left ventricular dysfunction in potential pediatric heart transplant donors
    James J Paul
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84113 1100, USA
    J Heart Lung Transplant 22:548-52. 2003
    ..Therefore, the purpose of this study was to determine the spectrum of myocardial dysfunction in potential pediatric heart transplant donors...
  4. ncbi request reprint Safety of endomyocardial biopsy in children
    Collin G Cowley
    Division of Pediatric Cardiology, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Cardiol Young 13:404-7. 2003
    ..1%. No demographic or procedural factors were identified to be predictive of complications. In experienced hands, therefore, endomyocardial biopsy can be safely performed in children with very low morbidity...
  5. ncbi request reprint Long-term, randomized comparison of balloon angioplasty and surgery for native coarctation of the aorta in childhood
    Collin G Cowley
    Department of Pediatrics, University of Utah and Primary Children s Medical Center, Salt Lake City, Utah, USA
    Circulation 111:3453-6. 2005
    ..A prior randomized, short-term comparison of BA and surgery for native CoA in 36 children demonstrated equivalent relief of obstruction. The risk of aneurysm formation and possibly restenosis was higher among patients treated with BA...
  6. ncbi request reprint Prospective randomized trial of azathioprine in cryopreserved valved allografts in children
    R E Shaddy
    Department of Pediatrics, Primary Children s Medical Center and University of Utah, Salt Lake City 84113, USA
    Ann Thorac Surg 71:43-7; discussion 47-8. 2001
    ..The purpose of this study was to prospectively assess the effects of azathioprine on the humoral immune response to HLA alloantigens and allograft function in children receiving cryopreserved valved allografts...
  7. ncbi request reprint The Pediatric Randomized Carvedilol Trial in Children with Heart Failure: rationale and design
    Robert E Shaddy
    University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Am Heart J 144:383-9. 2002
    ..Little is known about its safety, efficacy, pharmacokinetics, and dosing profile in children...
  8. ncbi request reprint Immunology and failure of valved allografts in children
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA
    Ann Thorac Surg 74:1271-5. 2002
    ..This review presents data on the immunologic and nonimmunologic risk factors implicated in valved allograft failure, in addition to ongoing investigation into the improvement of allograft function...
  9. ncbi request reprint Class I and class II anti-HLA antibodies after implantation of cryopreserved allograft material in pediatric patients
    J A Hawkins
    Department of Surgery, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    J Thorac Cardiovasc Surg 119:324-30. 2000
    ..Very little is known regarding the immune response to cryopreserved allograft valves and patch material used in the surgical repair of congenital heart defects...
  10. ncbi request reprint Late results and reintervention after aortic valvotomy for critical aortic stenosis in neonates and infants
    J A Hawkins
    Department of Surgery, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    Ann Thorac Surg 65:1758-62; discussion 1763. 1998
    ..We evaluated our results with open aortic valvotomy over the past decade, specifically examining factors influencing survival and reintervention in the current era...
  11. ncbi request reprint Prospective analysis of HLA immunogenicity of cryopreserved valved allografts used in pediatric heart surgery
    R E Shaddy
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA
    Circulation 94:1063-7. 1996
    ..The HLA immunogenicity of cryopreserved valved allografts used in the surgical repair of congenital heart defects is unknown...
  12. ncbi request reprint Influence of left ventricular cavity size on interventricular shunt timing and outcome in neonates with coarctation of the aorta and ventricular septal defect
    L Y Tani
    Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    Am J Cardiol 84:750-2, A9. 1999
    ..We found smaller left heart structures (initial mitral and aortic annular diameters) to be associated with diastolic interventricular shunting and to be predictive of the development of mitral or aortic and/or subaortic stenosis...
  13. ncbi request reprint Pulmonary vascular resistance of children treated with nitrogen during early infancy
    R W Day
    Division of Pediatric Cardiology, Primary Children s Medical Center, University of Utah, Salt Lake City 84113, USA
    Ann Thorac Surg 65:1400-4. 1998
    ..Thus, we reviewed patient outcome to determine whether adverse pulmonary vascular effects may be associated with this therapy...
  14. ncbi request reprint Spectrum and influence of hypoplasia of the left heart in neonatal aortic coarctation
    L Y Tani
    Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    Cardiol Young 10:90-7. 2000
    ..Minimal sizes, and the score for adequacy used for critical aortic stenosis, are not applicable to neonates with coarctation...
  15. ncbi request reprint Complete follow-up echocardiograms are needed to detect stenosis of normally connecting pulmonary veins
    L L Minich
    Primary Children s Medical Center, 100 North Medical Drive, Suite 1500, Salt Lake City, Utah 84113, USA
    Echocardiography 18:589-92. 2001
    ..Complete follow-up examinations might be warranted to diagnose this lesion. This may be an important consideration when formulating reimbursement policies...
  16. ncbi request reprint Outcome of cardiac transplantation in children. Survival in a contemporary multi-institutional experience. Pediatric Heart Transplant Study
    R E Shaddy
    Division of Cardiology, Primary Children s Medical Center, Salt Lake City, UT 84113, USA
    Circulation 94:II69-73. 1996
    ..Meaningful analysis of survival and risk factors for death in children who undergo heart transplantation is problematic because of the small number of heart transplantations performed at individual institutions...
  17. ncbi request reprint B-type natriuretic peptide levels in congenital heart disease
    C G Cowley
    Division of Pediatric Cardiology, Primary Children s Medical Center, University of Utah, Salt Lake City, UT 84113, USA
    Pediatr Cardiol 25:336-40. 2004
    ..661; p = 0.001). This study suggests that with additional research, BNP concentration may prove to be a useful clinical tool in managing children and adults with congenital heart disease...
  18. ncbi request reprint Intra-aortic balloon pumping in children with dilated cardiomyopathy as a bridge to transplantation
    L L Minich
    Departments of Pediatrics and Cardiothoracic Surgery, University of Utah, Salt Lake City, Utah 84113, USA
    J Heart Lung Transplant 20:750-4. 2001
    ..Intra-aortic balloon pumping timed precisely with M-mode echocardiographic markers offers a relatively simple and safe intermediate level of mechanical support for children with dilated cardiomyopathy who fail pharmacologic support...
  19. ncbi request reprint Beta-adrenergic receptor blockers as therapy in pediatric chronic heart failure
    R E Shaddy
    Primary Children s Medical Center, Salt Lake City, Utah, USA
    Minerva Pediatr 53:297-304. 2001
    ..Large prospective, randomized trials in children are currently underway in order to attempt to determine the indications, dosages, and optimal use of beta-blockers in children with chronic congestive heart failure...
  20. ncbi request reprint Cholelithiasis in infants receiving furosemide: a prospective study of the incidence and one-year follow-up
    L H Randall
    Primary Children s Medical Center, Salt Lake City, Utah
    J Perinatol 12:107-11. 1992
    ..Thus, furosemide, either independently or in conjunction with the use of TPN, predisposes infants to the development of cholelithiasis...
  21. ncbi request reprint Cardiomyopathies in adolescents: dilated, hypertrophic, and restrictive
    R E Shaddy
    Department of Pediatrics, University of Utah School of Medicine, Heart Transplant Program, Primary Children's Medical Center, 100 North Medical Drive, Salt Lake City, Utah 84113, USA
    Adolesc Med 12:35-45. 2001
    ..For those in whom medical management fails, heart transplantation is a therapeutic option with an excellent intermediate-term success rate...
  22. ncbi request reprint Evidence for early vessel involvement in the dysfunctional myocardium of Takayasu's arteritis
    J P Breinholt
    Department of Pediatrics, Primary Children's Medical Center and the University of Utah, 100 N. Medical Drive, Suite 1500, Salt Lake City, UT 84113, USA
    Pediatr Cardiol 22:74-6. 2001
    ..These results indicate that the inflammatory, vasculitic process affecting the large vessels in Takayasu's arteritis may also involve the endomyocardium and its small vessels resulting in ventricular dysfunction...
  23. ncbi request reprint Carvedilol for children and adolescents with heart failure: a randomized controlled trial
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, USA
    JAMA 298:1171-9. 2007
    ..Although beta-blockers improve symptoms and survival in adults with heart failure, little is known about these medications in children and adolescents...
  24. ncbi request reprint Rheumatic Fever in children under 5 years
    Lloyd Y Tani
    Pediatrics 114:906. 2004
  25. ncbi request reprint Early failure of a tricuspid valve replacement with a mitral valve homograft in a heart transplant recipient
    Rami Alharethi
    Utah Transplantation Affiliated Hospitals UTAH Cardiac Transplant Program, LDS Hospital, Primary Children s Medical Center, Salt Lake City, Utah 84143, USA
    J Heart Lung Transplant 23:1460-2. 2004
    ..Tricuspid valve replacement was repeated with a porcine bioprosthesis with excellent recovery and function for >2 years. The mitral valve homograft displayed inflammatory features consistent with humoral immune-mediated destruction...
  26. ncbi request reprint Panel-reactive antibodies late after allograft implantation in children
    David K Hooper
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Ann Thorac Surg 79:641-4; discussion 645. 2005
    ..The purpose of this study was to prospectively determine the level of HLA sensitization several years after implantation of cryopreserved allografts in children...
  27. ncbi request reprint The sensitized pediatric heart transplant candidate: causes, consequences, and treatment options
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, UT, USA
    Pediatr Transplant 9:208-14. 2005
    ..Improved methods of diagnosing, preventing, and treating this problem can only lead to better outcomes for children who require heart transplantation...
  28. ncbi request reprint The impact and outcome of transplant coronary artery disease in a pediatric population: a 9-year multi-institutional study
    Elfriede Pahl
    Children s Memorial Hospital, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Heart Lung Transplant 24:645-51. 2005
    ..The purpose of this study was to determine the angiographic incidence of TCAD, potential risk factors, and outcomes in a large pediatric cohort...
  29. ncbi request reprint Two-year reduction of panel reactive human leukocyte antigen antibodies in children receiving mycophenolate mofetil after valved allograft placement
    Jeffrey B Anderson
    Department of Pediatrics, University of North Carolina School of Medicine, North Carolina Children s Hospital, Chapel Hill, NC, USA
    Transplantation 80:414-6. 2005
    ..This study demonstrates the ability to persistently alter the HLA class I antibody response using 3 months of MMF following allograft implantation in children...
  30. ncbi request reprint Ventricular remodeling in children with left ventricular dysfunction secondary to various cardiomyopathies
    Lloyd Y Tani
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Cardiol 96:1157-61. 2005
    ..In conclusion, LV remodeling occurs in children with LV dysfunction. The reversal of this remodeling with a decrease in the degree of MR and the size of the mitral annulus occurs as systolic function improves...
  31. doi request reprint Applying heart failure guidelines to adult congenital heart disease patients
    Robert E Shaddy
    Division of Cardiology, The Children s Hospital of Philadelphia, and University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
    Expert Rev Cardiovasc Ther 6:165-74. 2008
    ..For those patients without a systemic left ventricle (e.g., a systemic right ventricle or single ventricle), there is currently no foundation for evidence-based therapy...
  32. ncbi request reprint Immune response to allograft implantation in children with congenital heart defects
    Cammon B Arrington
    University of Utah, Department of Pediatrics, Division of Pediatric Cardiology, 100 N Medical Drive, Salt Lake City, UT 84132, USA
    Expert Rev Cardiovasc Ther 4:695-701. 2006
    ..The aim of this review is to discuss the immunogenicity of cryopreserved allograft tissue and measures that may minimize the deleterious effect of the immune system on allograft function and durability...
  33. ncbi request reprint Mycophenolic mofetil reduces the HLA antibody response of children to valved allograft implantation
    Robert E Shaddy
    Department of Pediatrics, University of Utah School of Medicine and Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Ann Thorac Surg 77:1734-9; discussion 1739. 2004
    ..Mycophenolic mofetil (MMF) is a powerful immunosuppressant that inhibits the proliferation of both T cells and B cells and has been reported to possibly reduce HLA panel reactive antibody (PRA) in sensitized transplant recipients...
  34. ncbi request reprint Comparison of Doppler echocardiography with angiography for determining the severity of pulmonary regurgitation
    Richard V Williams
    Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City, Utah 84113, USA
    Am J Cardiol 89:1438-41. 2002
  35. ncbi request reprint Intermediate effects of treatment with metoprolol or carvedilol in children with left ventricular systolic dysfunction
    Richard V Williams
    Division of Cardiology, Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City 84113, USA
    J Heart Lung Transplant 21:906-9. 2002
    ..When added to conventional therapy, beta-blocker therapy resulted in an increase in ejection-phase indices of left ventricular systolic performance at intermediate follow-up in pediatric patients with systolic dysfunction...
  36. ncbi request reprint Is Doppler an accurate predictor of catheterization gradients for postoperative branch pulmonary stenosis?
    Deborah U Frank
    Department of Pediatrics, Primary Children s Medical Center and the University of Utah, Salt Lake City, USA
    J Am Soc Echocardiogr 15:1140-4. 2002
    ..These findings suggest that Doppler gradients should be interpreted cautiously in this setting...
  37. ncbi request reprint Transcatheter treatment of a large traumatic ventricular septal defect
    Collin G Cowley
    Division of Pediatric Cardiology, University of Utah, Primary Children s Medical Center, Salt Lake City, Utah 84113, USA
    Catheter Cardiovasc Interv 61:144-6. 2004
    ..The risks of standard open heart repair using cardiopulmonary bypass were felt to be prohibitive due to coexistent injuries. This case demonstrates the feasibility of transcatheter therapy for traumatic ventricular septal defects...
  38. ncbi request reprint QT dispersion after beta-blocker therapy (carvedilol or metoprolol) in children with heart failure
    Susan P Etheridge
    Division of Cardiology, Department of Pediatrics, University of Utah and Primary Children s Medical Center, 100 North Medical Drive, Salt Lake City, UT 84113, USA
    Am J Cardiol 91:1497-500, A8. 2003
  39. ncbi request reprint Immunogenicity of decellularized cryopreserved allografts in pediatric cardiac surgery: comparison with standard cryopreserved allografts
    John A Hawkins
    Department of Pediatric Cardiothoracic Surgery, University of Utah Hospital, Salt Lake City 84113, USA
    J Thorac Cardiovasc Surg 126:247-52; discussion 252-3. 2003
    ..This preliminary study examined the HLA antibody response to these decellularized allografts and compared it with the response to standard allograft material...
  40. ncbi request reprint Rheumatic fever in children younger than 5 years: is the presentation different?
    Lloyd Y Tani
    Department of Pediatrics, University of Utah, and Primary Children s Medical Center, Salt Lake City, UT 84113, USA
    Pediatrics 112:1065-8. 2003
    ..To review our experience with children who presented with rheumatic fever (RF) before 5 years of age and to compare their presentation with that of older children...
  41. ncbi request reprint Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Su
    Charles E Canter
    St Louis Children s Hospital, USA
    Circulation 115:658-76. 2007
    ..These events justify a reevaluation of the indications for heart transplantation in congenital heart disease and other causes of pediatric heart failure...
  42. ncbi request reprint Paediatric heart failure trials...and tribulations
    Robert E Shaddy
    Primary Children s Medical Center, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA
    Cardiol Young 17:354-5. 2007