Joseph B Muhlestein

Summary

Affiliation: LDS Hospital
Country: USA

Publications

  1. ncbi request reprint The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 48:396-401. 2006
  2. ncbi request reprint Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients
    Joseph B Muhlestein
    Cardiovascular Department, Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Thromb Haemost 103:71-82. 2010
  3. ncbi request reprint Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
  4. ncbi request reprint C-reactive protein predicts death in patients with non-ischemic cardiomyopathy
    Brianna S Ronnow
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 104:196-201. 2005
  5. ncbi request reprint Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing
    John F Carlquist
    Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    J Thromb Thrombolysis 26:1-7. 2008
  6. pmc Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 160:250-256.e3. 2010
  7. doi request reprint Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 156:1155-1162.e2. 2008
  8. doi request reprint Exceptional mortality prediction by risk scores from common laboratory tests
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84157, USA
    Am J Med 122:550-8. 2009
  9. doi request reprint The Intermountain Risk Score (including the red cell distribution width) predicts heart failure and other morbidity endpoints
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, 5121 S Cottonwood St, Salt Lake City, UT 84107, USA
    Eur J Heart Fail 12:1203-13. 2010
  10. ncbi request reprint Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
    Joseph B Muhlestein
    Intermountain Medical Center, Murray, Utah University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 106:764-9. 2010

Collaborators

Detail Information

Publications96

  1. ncbi request reprint The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 48:396-401. 2006
    ..The primary objective was to determine the effect of statin-fibrate combination therapy on inflammatory biomarkers in patients with diabetes...
  2. ncbi request reprint Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients
    Joseph B Muhlestein
    Cardiovascular Department, Intermountain Medical Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Thromb Haemost 103:71-82. 2010
    ..This review examines the evidence for and potential clinical relevance of the effects of antiplatelet therapy on inflammatory markers...
  3. ncbi request reprint Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  4. ncbi request reprint C-reactive protein predicts death in patients with non-ischemic cardiomyopathy
    Brianna S Ronnow
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 104:196-201. 2005
    ..0) significantly and independently predicted mortality. Even in the absence of coronary artery disease, patients with left ventricular dysfunction are at increased risk of mortality based on their baseline CRP concentrations...
  5. ncbi request reprint Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing
    John F Carlquist
    Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    J Thromb Thrombolysis 26:1-7. 2008
    ..99. Combined with a method for rapid buccal swab DNA extraction, genotyping results were obtained in a median of 59 min. These methods should facilitate genotype-driven warfarin dosing in "real-time" clinical practice...
  6. pmc Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 160:250-256.e3. 2010
    ....
  7. doi request reprint Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 156:1155-1162.e2. 2008
    ..Variants at the 9p21 locus have been associated with coronary heart disease, but their precise disease phenotype and utility for clinical risk assessment are uncertain...
  8. doi request reprint Exceptional mortality prediction by risk scores from common laboratory tests
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84157, USA
    Am J Med 122:550-8. 2009
    ..Many of their components are not commonly used, but they might contain independent risk information. This study tested the ability of a risk score combining all components to predict all-cause mortality...
  9. doi request reprint The Intermountain Risk Score (including the red cell distribution width) predicts heart failure and other morbidity endpoints
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, 5121 S Cottonwood St, Salt Lake City, UT 84107, USA
    Eur J Heart Fail 12:1203-13. 2010
    ..Mortality is the most definitive clinical endpoint, but medical care is more easily applied to modify morbidity and thereby prevent death. This study tested whether IMRS is associated with clinical morbidity endpoints...
  10. ncbi request reprint Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
    Joseph B Muhlestein
    Intermountain Medical Center, Murray, Utah University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 106:764-9. 2010
    ..In conclusion, elevated baseline PRA is associated with cardiac morbidity and mortality in patients with coronary artery disease but normal left ventricular function and no previous MI or HF...
  11. pmc Usefulness of routine periodic fasting to lower risk of coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 102:814-819. 2008
    ..In conclusion, not only proscription of tobacco, but also routine periodic fasting was associated with lower risk of CAD...
  12. ncbi request reprint Comparison of effects of simvastatin alone versus fenofibrate alone versus simvastatin plus fenofibrate on lipoprotein subparticle profiles in diabetic patients with mixed dyslipidemia (from the Diabetes and Combined Lipid Therapy Regimen study)
    Heidi T May
    Intermountain Medical Center and LDS Hospital, Salt Lake City, Utah, USA
    Am J Cardiol 101:486-9. 2008
    ..In conclusion, in this trial of mixed dyslipidemic patients with diabetes, combination therapy was more effective in changing a variety of other cardiovascular risk markers...
  13. ncbi request reprint Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes
    Matthew J Kolek
    Cardiovascular Department, Division of Cardiology, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 148:1034-40. 2004
    ..We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is associated with reduced vascular inflammation (assessed by C-reactive protein [CRP]) and a decreased risk for CAD and diabetes...
  14. doi request reprint Trends in early and late mortality in patients undergoing coronary catheterization for myocardial infarction: implications on observation periods and risk factors to determine ICD candidacy
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 8:1460-6. 2011
    ..Survivors of acute myocardial infarction (MI) are at high risk for death from both sudden cardiac death and progressive heart failure...
  15. doi request reprint The intermountain risk score predicts incremental age-specific long-term survival and life expectancy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah, USA
    Transl Res 158:307-14. 2011
    ..IMRS may be used to stratify age-specific risk of mortality in research, clinical/preventive, and quality improvement applications. A web calculator is located at http://intermountainhealthcare.org/IMRS...
  16. pmc Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84157, USA
    Circ Cardiovasc Genet 1:85-92. 2008
    ..Using angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single-nucleotide polymorphisms predict ischemic events (eg, myocardial infarction [MI]) among CAD patients...
  17. ncbi request reprint The role of a common adenosine monophosphate deaminase (AMPD)-1 polymorphism in outcomes of ischemic and nonischemic heart failure
    Matthew J Kolek
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    J Card Fail 11:677-83. 2005
    ..A common variant of the adenosine monophosphate deaminase (AMPD)-1 gene (C34T) results in enzymatic inactivity and may increase adenosine in cardiac muscle and confer cardioprotection through ischemic preconditioning...
  18. ncbi request reprint Lipoprotein-associated phospholipase A2 independently predicts the angiographic diagnosis of coronary artery disease and coronary death
    Heidi T May
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 152:997-1003. 2006
    ..We evaluated the independent association of lipoprotein-associated phospholipase A2 (Lp-PLA2) to angiographic CAD and CV events adjusting for standard factors, lipids, and CRP...
  19. pmc Soluble CD40 ligand as a predictor of coronary artery disease and long-term clinical outcomes in stable patients undergoing coronary angiography
    Matthew T Rondina
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Cardiology 109:196-201. 2008
    ..We evaluated sCD40L levels and future cardiovascular events in patients not experiencing ACS...
  20. doi request reprint Relation of routine, periodic fasting to risk of diabetes mellitus, and coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 109:1558-62. 2012
    ..A reported fasting association with a lower CAD risk was also validated and fasting associations with lower glucose and BMI were found...
  21. ncbi request reprint Homocysteine levels are associated with increased risk of congestive heart failure in patients with and without coronary artery disease
    Heidi T May
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 107:178-84. 2007
    ..Whether HCY affects development of congestive heart failure (CHF) independent of coronary artery disease (CAD) is uncertain. We evaluated whether increased HCY predicts low ejection fraction or clinical CHF...
  22. doi request reprint Superior predictive ability for death of a basic metabolic profile risk score
    Heidi T May
    Intermountain Medical Center, Murray, UT 84157, USA
    Am Heart J 157:946-54. 2009
    ..Although individual variables are checked for cardiovascular health and risk, combining them into a total BMP-derived score, as to maximize BMP predictive ability, has not been previously attempted...
  23. ncbi request reprint Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:969-75. 2007
    ..In an independent but demographically similar population, this study tested 6 SNPs that were previously reported to be associated with MI...
  24. ncbi request reprint Statin therapy interacts with cytomegalovirus seropositivity and high C-reactive protein in reducing mortality among patients with angiographically significant coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Circulation 107:258-63. 2003
    ..This study prospectively evaluated the effect of statins on CMV-and CRP-associated death among patients with significant, angiographically defined CAD...
  25. ncbi request reprint Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 153:67-73. 2007
    ....
  26. doi request reprint A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II)
    Jeffrey L Anderson
    Intermountain Medical Center, Cardiovascular Department, Murray, UT 84107 5701, USA
    Circulation 125:1997-2005. 2012
    ..Warfarin is characterized by marked variations in individual dose requirements and a narrow therapeutic window. Pharmacogenetics (PG) could improve dosing efficiency and safety, but clinical trials evidence is meager...
  27. pmc Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:751-8. 2007
    ..Furthermore, differentiation of predictive ability by end point (MI vs CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3...
  28. ncbi request reprint Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors?
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107 5701, USA
    Am Heart J 162:331-339.e2. 2011
    ..We tested whether elevated PTH is associated with CV disease and whether risk associations depend on Vit D status and renal function...
  29. ncbi request reprint Risk of nephropathy is not increased by the administration of larger volume of contrast during coronary angiography
    Troy E Madsen
    Division of Emergency Medicine, University of Utah, Salt Lake City, UT, USA
    Crit Pathw Cardiol 8:167-71. 2009
    ..The apparent inverse relation of risk with volume in the overall population is likely explained by clinical practice bias. If confirmed, these results may have important clinical implications...
  30. ncbi request reprint Relation of serum total cholesterol, C-reactive protein levels, and statin therapy to survival in heart failure
    Heidi T May
    LDS Hospital, Salt Lake City, Utah, USA
    Am J Cardiol 98:653-8. 2006
    ..In conclusion, elevated TC appears to be associated with improved survival. The effect was stronger in patients receiving statin therapy, but the cause of this differential effect is uncertain...
  31. ncbi request reprint Effect of fasting glucose levels on mortality rate in patients with and without diabetes mellitus and coronary artery disease undergoing percutaneous coronary intervention
    Joseph B Muhlestein
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 146:351-8. 2003
    ..Diabetes mellitus (DM) is predictive of increased mortality for patients with coronary artery disease (CAD). To what extent this risk extends below the diabetic threshold (fasting glucose level [FG] <126 mg/dL) is uncertain...
  32. ncbi request reprint Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:169-74. 2007
    ..A total CBC score is an important new addition to risk prediction, and it can be easily generated by computer for clinical use at negligible incremental cost...
  33. ncbi request reprint Surgical revascularization is associated with improved long-term outcomes compared with percutaneous stenting in most subgroups of patients with multivessel coronary artery disease: results from the Intermountain Heart Registry
    Tami L Bair
    Cardiovascular Department, University of Utah, Salt Lake City, USA
    Circulation 116:I226-31. 2007
    ..In this study, we examined the outcomes of major adverse cardiovascular events and death for subgroups of typical "real-world" patients undergoing coronary revascularization in the modern era...
  34. ncbi request reprint Less affluent area of residence and lesser-insured status predict an increased risk of death or myocardial infarction after angiographic diagnosis of coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Ann Epidemiol 14:143-50. 2004
    ..Low socioeconomic status (SES) predicts coronary artery disease (CAD) onset, but its value among patients with CAD is uncertain. Geographic measures (e.g., residential neighborhood) may predict risk, but this requires further evaluation...
  35. ncbi request reprint Early effects of statins in patients with coronary artery disease and high C-reactive protein
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 94:1107-12. 2004
    ..This provides further evidence of an anti-inflammatory effect of statins...
  36. ncbi request reprint Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study
    John F Carlquist
    Department of Medicine, Division of Cardiology, University of Utah School of Medicine, Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    J Thromb Thrombolysis 22:191-7. 2006
    ..vitamin K epoxide reductase complex subunit 1-VKORC1). We hypothesized that variants in these two genes explain a substantial proportion of variability in stable warfarin dose and could be used as a basis for improved dosing algorithms...
  37. ncbi request reprint Early postoperative use of unfractionated heparin or enoxaparin is associated with increased surgical re-exploration for bleeding
    Heath U Jones
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    Ann Thorac Surg 80:518-22. 2005
    ..exist for the use of unfractionated heparin (UFH) and enoxaparin (ENOX) in the early postoperative period following open-heart surgery. However, the overall postoperative risk for hemorrhage from the use of UFH and ENOX are not known...
  38. pmc Repeated measurement of the intermountain risk score enhances prognostication for mortality
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    PLoS ONE 8:e69160. 2013
    ..Whether longitudinal repeated measurement of IMRS is useful for prognostication is an important question for its clinical applicability...
  39. doi request reprint A strategy of rapid cardioversion minimizes the significance of early recurrent atrial tachyarrhythmias after ablation for atrial fibrillation
    Gangadhar Malasana
    University of Utah, Salt Lake City, Utah, USA
    J Cardiovasc Electrophysiol 22:761-6. 2011
    ..Aggressive attempts to restore sinus rhythm in the temporal period of healing after ablation might improve outcomes...
  40. doi request reprint Atrial fibrillation hospitalization is not increased with short-term elevations in exposure to fine particulate air pollution
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Pacing Clin Electrophysiol 34:1475-9. 2011
    ..This study explored the potential associations between short-term elevations in PM exposure and atrial fibrillation (AF)...
  41. ncbi request reprint Patients treated with catheter ablation for atrial fibrillation have long-term rates of death, stroke, and dementia similar to patients without atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists Department of Cardiology, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Electrophysiol 22:839-45. 2011
    ..AF ablation eliminates AF in most patients. We evaluated the long-term impact of AF ablation on mortality, heart failure (HF), stroke, and dementia in a large system-wide patient population...
  42. ncbi request reprint The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease
    John F Carlquist
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 146:1007-14. 2003
    ..We studied CETP Taq1B genotype, plasma HDL, and clinical events among all patients and patients stratified by statin treatment...
  43. ncbi request reprint Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Intermountain Healthcare, Salt Lake City, UT, USA
    Circulation 116:2563-70. 2007
    ..Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials...
  44. ncbi request reprint Which features of the metabolic syndrome predict the prevalence and clinical outcomes of angiographic coronary artery disease?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital and University of Utah, Salt Lake City, Utah, USA
    Cardiology 101:185-93. 2004
    ..The prevalence of the metabolic syndrome (MS) is growing. The Adult Treatment Panel (ATP) III provided a uniform definition of MS but no information on its predictive ability...
  45. doi request reprint Association of vitamin D levels with incident depression among a general cardiovascular population
    Heidi T May
    Intermountain Medical Center, Murray, UT 84157, USA
    Am Heart J 159:1037-43. 2010
    ..Therefore, we evaluated whether there is an association between vitD and incident depression among a CV population...
  46. ncbi request reprint Comparison of effects of high (80 mg) versus low (20 mg) dose of simvastatin on C-reactive protein and lipoproteins in patients with angiographic evidence of coronary arterial narrowing
    Kent G Meredith
    Cardiovascular Department, LDS Hospital, Division of Cardiology, University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:149-53. 2007
    ..In conclusion, this randomized trial in patients with chronic stable coronary artery disease showed a strong dose response for simvastatin for total and low-density lipoprotein cholesterol lowering but not for hs-CRP...
  47. ncbi request reprint Sex- and age-related differences in the prognostic value of C-reactive protein in patients with angiographic coronary artery disease
    Lillian L C Khor
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Am J Med 117:657-64. 2004
    ..To determine whether sex and age affect serum C-reactive protein level and its prognostic value in patients with coronary artery disease...
  48. ncbi request reprint High-resolution characterization of linkage disequilibrium structure and selection of tagging single nucleotide polymorphisms: application to the cholesteryl ester transfer protein gene
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Ann Hum Genet 70:524-34. 2006
    ..This study provides an optimal set of tSNPs for association analyses of CETP. The observed complexity of LD structure highlights the importance of using methods, such as PCA, that allow for multiple dynamics in intragenic LD structure...
  49. doi request reprint Intracardiac ultrasound for esophageal anatomic assessment and localization during left atrial ablation for atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Electrophysiol 24:33-9. 2013
    ..Intracardiac ultrasound (ICE) can provide a real-time assessment of the esophagus during ablation. We hypothesized that ICE can accurately define esophageal anatomy and location to enhance avoidance strategies during ablation...
  50. doi request reprint Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Pacing Clin Electrophysiol 34:1600-6. 2011
    ..Ranolazine may be an option for recurrent AAD-refractory ICD shocks secondary to VT, but its efficacy, outcomes, and tolerance are unknown...
  51. ncbi request reprint Do statins increase the risk of idiopathic polyneuropathy?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Cardiology Division, Intermountain Health Care, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:1097-9. 2005
    ..It was found that statin use before diagnosis was not significantly greater in patients than controls (odds ratio 1.30, 95% confidence interval 0.3 to 2.1, p = 0.27), nor were doses different between patients and controls...
  52. ncbi request reprint Improved long-term survival associated with stent deployment during percutaneous coronary interventions: results from a registry of 3399 patients
    Joseph B Muhlestein
    Division of Cardiology, Department of Cardiovascular Medicine, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 150:182-7. 2005
    ..However, few studies have had a sufficient sample size or adequate follow-up to determine whether this advantage results in a positive effect on mortality...
  53. ncbi request reprint Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?
    James S Zebrack
    Divisions of Cardiology and Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Am Coll Cardiol 42:57-63. 2003
    ..We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI)...
  54. ncbi request reprint Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control study
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Pharmacol Ther 14:170-5. 2009
    ..This large epidemiologic study failed to confirm a reported large event differential for tegaserod that was noted incidentally in a clinical trials database, suggesting that the prior observation may have been due to chance...
  55. ncbi request reprint Frequency of elevation of C-reactive protein in atrial fibrillation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, University of Utah, Salt Lake City 84143, USA
    Am J Cardiol 94:1255-9. 2004
    ..Increased CRP is a new risk marker for AF propensity, and testing therapies that target inflammation should be considered...
  56. doi request reprint Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 7:433-7. 2010
    ..Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia...
  57. ncbi request reprint Beta-blockers reduce the incidence of clinical restenosis: prospective study of 4840 patients undergoing percutaneous coronary revascularization
    Jeffrey D Jackson
    Division of Cardiology, Department of Medicine, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 145:875-81. 2003
    ..Although beta-adrenergic receptor blockers (BBs) effectively reduce many cardiac events, no large prospective studies have examined the association of BBs with restenosis...
  58. ncbi request reprint A common variant of the AMPD1 gene predicts improved survival in patients with ischemic left ventricular dysfunction
    Yoshikazu Yazaki
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Card Fail 10:316-20. 2004
    ..This variant might lead to ischemic preconditioning by increasing tissue adenosine. We tested whether the survival benefit of C34T occurs preferentially in the setting of ischemic left ventricular dysfunction...
  59. pmc A new ratio for better predicting future death/myocardial infarction than standard lipid measurements in women >50 years undergoing coronary angiography: the apolipoprotein A1 remnant ratio (Apo A1/ [VLDL₃+IDL])
    Heidi T May
    Intermountain Medical Center, Cardiovascular Department, 5121 S Cottonwood Street, Murray, UT 84157, USA
    Lipids Health Dis 12:55. 2013
    ..Our objective was to evaluate standard- and sub-lipid parameters and the apo A1 remnant ratio: (apo A1/[VLDL₃-C+IDL-C]) for their associations with death/myocardial infarction among peri- and post-menopausal women...
  60. doi request reprint An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction
    John F Carlquist
    Cardiovascular Department, Intermountain Medical Center, 5121 South Cottonwood Street, Murray, UT 84157, USA
    J Thromb Thrombolysis 30:358-64. 2010
    ..Addition of VKORC1 SNP -1639 to a model eliminated the association of VKORC1 3730 with warfarin dose (P-trend = 0.74), but -1639 remained highly significant. No impact on dose was observed for the other tested genetic variants...
  61. ncbi request reprint Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, Salt Lake City, UT 84108 1266, USA
    Am Heart J 152:305-11. 2006
    ..This study evaluated deaths caused by CAD, MI, hypertensive heart disease (HtnHD), and congestive heart failure (CHF) among close and distant relatives...
  62. ncbi request reprint Which white blood cell subtypes predict increased cardiovascular risk?
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 45:1638-43. 2005
    ..We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI)...
  63. ncbi request reprint Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment
    Jessica L Clarke
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:155-8. 2005
    ..This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank...
  64. ncbi request reprint Risk factor analysis of plasma cytokines in patients with coronary artery disease by a multiplexed fluorescent immunoassay
    Thomas B Martins
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
    Am J Clin Pathol 125:906-13. 2006
    ..017), and CRP (P pound .001). Cytokine profiles may have a role in differentiating patients with CAD with MI from those with chest pain due to other disorders and in deciphering the role of inflammation in the pathogenesis of CAD...
  65. ncbi request reprint Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients
    Chloe A Allen Maycock
    Cardiology Research, LDS Hospital, 8th Avenue and C Street, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 40:1777-85. 2002
    ..This study evaluated the effect of statin therapy on mortality in individuals with significant coronary artery disease (CAD) stratified by age...
  66. ncbi request reprint Relation of bisphosphonate therapies and risk of developing atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, UT, USA
    Am J Cardiol 103:824-8. 2009
    ..However, patients who received bisphosphonates were older and had more cardiovascular disease that we suspect accounts for the increased arrhythmia risk reported in other trials...
  67. doi request reprint Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 106:963-8. 2010
    ..Given the ease of vitamin D measurement and replacement, prospective studies of vitamin D supplementation to prevent and treat CV disease are urgently needed...
  68. pmc Antibiotic trials for coronary heart disease
    Jeffrey L Anderson
    University of Utah School of Medicine, Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Tex Heart Inst J 31:33-8. 2004
    ..New and innovative experimental approaches, in addition to traditionally designed antibiotic trials, should be welcome in our attempts to gain adequate insight into the role of infection in atherosclerosis and its therapy...
  69. ncbi request reprint Improvements in 1-year cardiovascular clinical outcomes associated with a hospital-based discharge medication program
    Jason M Lappe
    Intermountain Health Care, LDS Hospital, Salt Lake City, Utah 84143, USA
    Ann Intern Med 141:446-53. 2004
    ..Despite recent advances in the treatment and prevention of cardiovascular disease, a treatment gap for secondary prevention medications still exists...
  70. ncbi request reprint Elective coronary angiography and percutaneous coronary intervention during uninterrupted warfarin therapy
    David B Jessup
    Division of Cardiology, University of Utah, Salt Lake City, Utah 84132, USA
    Catheter Cardiovasc Interv 60:180-4. 2003
    ..We conclude that cardiac catheterization and percutaneous coronary intervention may be considered in the setting of uninterrupted warfarin therapy...
  71. doi request reprint Incremental survival benefit with adherence to standardized heart failure core measures: a performance evaluation study of 2958 patients
    Abdallah G Kfoury
    Heart Failure Prevention and Treatment Program, Intermountain Medical Center and Intermountain Healthcare, 5121 S Cottonwood Street, Murray, UT 84107, USA
    J Card Fail 14:95-102. 2008
    ..Although adherence to these HF care processes may be improving, their collective impact on survival is not yet settled...
  72. ncbi request reprint Lipoprotein-associated phospholipase A2: a new biomarker for cardiovascular risk assessment and potential therapeutic target
    John F Carlquist
    LDS Hospital, Cardiology Department, 8th Avenue and C Street, Salt Lake City, UT 84143, USA
    Expert Rev Mol Diagn 7:511-7. 2007
    ..Considering the large number of biomarkers currently under evaluation, it is probable that useful additions to existing risk models may be found in combinatorial models...
  73. ncbi request reprint C-reactive protein and angiographic coronary artery disease: independent and additive predictors of risk in subjects with angina
    James S Zebrack
    Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Am Coll Cardiol 39:632-7. 2002
    ..The objective of this study was to determine the prognostic value of C-reactive protein (CRP) independent of coronary angiographic findings...
  74. ncbi request reprint Effects of statins on six-month survival and clinical restenosis frequency after coronary stent deployment
    T Jared Bunch
    Cardiovascular Department, LDS Hospital and University of Utah, Salt Lake City 84143, USA
    Am J Cardiol 90:299-302. 2002
  75. ncbi request reprint Cardiovascular pharmacogenomics: current status, future prospects
    Jeffrey L Anderson
    Intermountain Heart Collaborative Research Group, LDS Hospital Cardiovascular Department, and University of Utah School of Medicine, Salt Lake City, Utah 84143, USA
    J Cardiovasc Pharmacol Ther 8:71-83. 2003
    ..Rapid research progress and initial clinical applications with pharmacogenomics are foreseen in the near future...
  76. ncbi request reprint Preoperative use of enoxaparin compared with unfractionated heparin increases the incidence of re-exploration for postoperative bleeding after open-heart surgery in patients who present with an acute coronary syndrome: clinical investigation and reports
    Heath U Jones
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Circulation 106:I19-22. 2002
    ....
  77. pmc Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, UT, USA
    Ann Hum Genet 73:551-8. 2009
    ..Genetic risk conferred by some of these genes may be modified by smoking. Future CAD association studies of these and other genes should evaluate effect modification by smoking...
  78. ncbi request reprint Evidence for a heritable component in death resulting from aortic and mitral valve diseases
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1266, USA
    Circulation 110:3143-8. 2004
    ..This study evaluated the familiality of death resulting from aortic, mitral, and all valvular diseases using a population-based genealogy linked to death records...
  79. ncbi request reprint Antibiotic treatment of atherosclerosis
    Joseph B Muhlestein
    Division of Cardiology, LDS Hospital, 8th Avenue and C Street, Salt Lake City, Utah 84143, USA
    Curr Opin Lipidol 14:605-14. 2003
    ..The purpose of this review is to summarize the results of these studies and comment on their implications for the treatment of atherosclerosis...
  80. ncbi request reprint Greater pathogen burden but not elevated C-reactive protein increases the risk of clinical restenosis after percutaneous coronary intervention
    Benjamin D Horne
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 144:491-500. 2002
    ....
  81. ncbi request reprint Strategies to increase HMG-CoA reductase inhibitor use after acute myocardial infarction
    Joseph B Muhlestein
    Cardiovascular Department, Division of Cardiology, LDS Hospital, Salt Lake City, Utah 84143, USA
    Drugs Aging 21:583-95. 2004
    ..Based on these preliminary studies, it is recommended that the implementation of these strategies be considered by most healthcare institutions...
  82. ncbi request reprint Effect of folic acid fortification of food on homocysteine-related mortality
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah 84143, USA
    Am J Med 116:158-64. 2004
    ..In 1998, the Food and Drug Administration mandated the fortification of food products with folic acid. The effect of this rule on mortality associated with homocysteine levels in patients with coronary artery disease is unknown...
  83. ncbi request reprint Left ventricular assist device malfunction: an approach to diagnosis by echocardiography
    Steven C Horton
    Department of Cardiology, LDS Hospital, Salt Lake City, Utah, USA
    J Am Coll Cardiol 45:1435-40. 2005
    ..A protocol using transthoracic echocardiography was designed to diagnose the common malfunctions of patients on chronic support with a left ventricular assist device (LVAD)...
  84. ncbi request reprint Real-world safety and efficacy of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention
    Peter J Casterella
    Utah Heart Clinic and LDS Hospital, 324 Tenth Avenue, Suite 206, Salt Lake City, UT, 84143, USA
    J Invasive Cardiol 20:94-8. 2008
    ..Large randomized clinical trials have demonstrated differences in the efficacy and safety of glycoprotein (GP) IIb/IIIa inhibitors, but little has been published regarding comparisons of these agents in a "real-world" setting...
  85. ncbi request reprint Early initiation of statin therapy in acute coronary syndromes: a review of the evidence
    Matthew T Rondina
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA
    J Interv Cardiol 18:55-63. 2005
    ..We recommend the initiation of statin therapy in all ACS patients prior to hospital discharge...
  86. ncbi request reprint Impact of renal failure on the risk of myocardial infarction and death
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 62:1776-83. 2002
    ..We examined whether renal failure independently increases the risk of myocardial infarction and death...
  87. ncbi request reprint Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease
    David Aguilar
    Cardiology Division, Baylor College of Medicine, Houston, TX 77030, USA
    Am Heart J 152:298-304. 2006
    ..The prognosis associated with metabolic syndrome and high-sensitivity C-reactive protein (hs-CRP) in patients with stable coronary artery disease has not been well established...
  88. ncbi request reprint Azithromycin for the secondary prevention of coronary events
    J Thomas Grayston
    Department of Epidemiology, University of Washington, Seattle 98195, USA
    N Engl J Med 352:1637-45. 2005
    ..We evaluated the efficacy of one year of azithromycin treatment for the secondary prevention of coronary events...
  89. ncbi request reprint Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease
    Olaimatu S Mahdi
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, USA
    Circulation 106:1659-63. 2002
    ..Our aim was to determine if chlamydial Hsp (cHsp) antibody responses are predictive of CAD...
  90. ncbi request reprint Serum uric acid independently predicts mortality in patients with significant, angiographically defined coronary disease
    Troy E Madsen
    Ohio State University Medical Center, Columbus, OH 43210, USA
    Am J Nephrol 25:45-9. 2005
    ..This study prospectively evaluated the predictive value of serum uric acid (SUA) levels for mortality after angiographic diagnosis of CAD...
  91. ncbi request reprint Lack of association of Helicobacter pylori infection with coronary artery disease and frequency of acute myocardial infarction or death
    Jianhui Zhu
    Cardiovascular Research Institute of the MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Am J Cardiol 89:155-8. 2002
    ..pylori seropositivity was 1.12 (95% confidence interval 0.81 to 1.54). Our data suggest that prior infection with H. pylori is not a major factor determining either risk of CAD, AMI, or death in patients with CAD...
  92. ncbi request reprint Restenosis after coronary intervention: narrowing C-reactive protein's prognostic potential?
    Jeffrey L Anderson
    Am J Med 115:147-9. 2003
  93. ncbi request reprint Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution
    C Arden Pope
    Brigham Young University, Provo, UT 84602 2363, USA
    Circulation 114:2443-8. 2006
    ..These findings are inconclusive and controversial and require further study. This study evaluates the role of short-term particulate exposure in triggering acute ischemic heart disease events...
  94. ncbi request reprint Infectious serology and atherosclerosis: how burdensome is the risk?
    Joseph B Muhlestein
    Circulation 107:220-2. 2003
  95. ncbi request reprint Azithromycin for the secondary prevention of coronary heart disease events: the WIZARD study: a randomized controlled trial
    CHRISTOPHER M O'CONNOR
    Duke University, Durham NC, USA
    JAMA 290:1459-66. 2003
    ..Several lines of evidence have implied an association between Chlamydia pneumoniae infection and atherogenesis...
  96. ncbi request reprint Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol
    Amy J Sehnert
    CardioDx, Inc, Palo Alto, California 94303, USA
    J Am Coll Cardiol 52:644-51. 2008
    ..This study investigated the role of adrenergic receptor genetics on transplant-free survival in heart failure (HF)...