PAUL I YASWEN

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. ncbi Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    Rituparna Mukhopadhyay
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Breast Cancer Res 12:R11. 2010
  2. ncbi Epigenetic changes accompanying human mammary epithelial cell immortalization
    P Yaswen
    Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Mammary Gland Biol Neoplasia 6:223-34. 2001
  3. ncbi Oncogene-induced senescence pathways weave an intricate tapestry
    Paul Yaswen
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    Cell 128:233-4. 2007
  4. ncbi Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors
    Alexey V Bazarov
    Division of Hematology Oncology, Department of Medicine, University of California, San Francisco, 94143, USA
    Breast Cancer Res 13:308. 2011
  5. ncbi Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells
    Paul Yaswen
    Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 70A 1118, Berkeley, CA 94720, USA
    Int J Biochem Cell Biol 34:1382-94. 2002
  6. ncbi Soothing the watchman: telomerase reduces the p53-dependent cellular stress response
    Alain Beliveau
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cell Cycle 6:1284-7. 2007
  7. ncbi Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells
    Tarlochan Nijjar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Oncogene 24:3369-76. 2005
  8. ncbi p53-dependent integration of telomere and growth factor deprivation signals
    Alain Beliveau
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:4431-6. 2007
  9. ncbi Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
    Martha R Stampfer
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA 94720, USA
    Oncogene 22:5238-51. 2003
  10. ncbi Multidimensional profiling of cell surface proteins and nuclear markers
    Ju Han
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    IEEE/ACM Trans Comput Biol Bioinform 7:80-90. 2010

Collaborators

Detail Information

Publications16

  1. ncbi Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    Rituparna Mukhopadhyay
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Breast Cancer Res 12:R11. 2010
    ..We investigated whether ionizing radiation, which increases breast cancer risk in women, affects the rate of vHMEC outgrowth...
  2. ncbi Epigenetic changes accompanying human mammary epithelial cell immortalization
    P Yaswen
    Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Mammary Gland Biol Neoplasia 6:223-34. 2001
    ..Characterization of the epigenetic mechanisms involved in immortalization may uncover additional factors that drive tumor progression, and that may be responsive to novel forms of intervention...
  3. ncbi Oncogene-induced senescence pathways weave an intricate tapestry
    Paul Yaswen
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    Cell 128:233-4. 2007
    ..They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53...
  4. ncbi Who is in the driver's seat in 8p12 amplifications? ZNF703 in luminal B breast tumors
    Alexey V Bazarov
    Division of Hematology Oncology, Department of Medicine, University of California, San Francisco, 94143, USA
    Breast Cancer Res 13:308. 2011
    ..Expression of the murine homolog of ZNF703 reduces cell adhesion and promotes metastasis. ZNF703 overexpression thus alters regulation of proliferation and differentiation in luminal B tumors...
  5. ncbi Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells
    Paul Yaswen
    Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 70A 1118, Berkeley, CA 94720, USA
    Int J Biochem Cell Biol 34:1382-94. 2002
    ..In the presence of active p53, conversion may represent a rate-limiting step in immortal transformation...
  6. ncbi Soothing the watchman: telomerase reduces the p53-dependent cellular stress response
    Alain Beliveau
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cell Cycle 6:1284-7. 2007
    ..These findings explain a number of observed effects of telomerase expression on cell growth and survival without postulating additional functions for telomerase...
  7. ncbi Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells
    Tarlochan Nijjar
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Oncogene 24:3369-76. 2005
    ..The process responsible for accumulation of TRF2 in immortalized HMEC and breast tumor-derived cell lines may promote tumorigenesis by contributing to the cells' ability to maintain an indefinite lifespan...
  8. ncbi p53-dependent integration of telomere and growth factor deprivation signals
    Alain Beliveau
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:4431-6. 2007
    ..Our findings provide a previously unrecognized mechanistic explanation for the observation that ectopically expressed hTERT conveys growth advantages to cells, without having to postulate nontelomeric functions for the enzyme...
  9. ncbi Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
    Martha R Stampfer
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA 94720, USA
    Oncogene 22:5238-51. 2003
    ..These studies also provide evidence that the function of p53 in suppression of telomerase activity is separable from its cell cycle checkpoint function...
  10. ncbi Multidimensional profiling of cell surface proteins and nuclear markers
    Ju Han
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    IEEE/ACM Trans Comput Biol Bioinform 7:80-90. 2010
    ..We demonstrate that multidimensional representations of cell-by-cell phenotypes improve predictive and visualization capabilities among different treatment groups, and identify hidden variables...
  11. ncbi Human epithelial cell immortalization as a step in carcinogenesis
    Martha R Stampfer
    Lawrence Berkeley National Laboratory, Life Sciences Division, University of California, 1 Cyclotron Road, 70A1118, Berkeley, CA 94720 8174, USA
    Cancer Lett 194:199-208. 2003
    ..Attainment of immortality and telomerase reactivation are crucial to human carcinoma development; the derangements responsible for attainment of immortality may be rate-limiting and permissive for further progression to malignancy...
  12. ncbi Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells
    Marcia V Fournier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 69:4545-52. 2009
    ..This interaction thus seems to be a critical integrator of proliferative and morphogenetic signaling in breast epithelial cells...
  13. ncbi Reversal of human cellular senescence: roles of the p53 and p16 pathways
    Christian M Beausejour
    Lawrence Berkeley National Laboratory, MS 84 171, 1 Cyclotron Road, Berkeley, CA 94720, USA
    EMBO J 22:4212-22. 2003
    ..Our results indicate that the senescence response to telomere dysfunction is reversible and is maintained primarily by p53. However, p16 provides a dominant second barrier to the unlimited growth of human cells...
  14. ncbi Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
    Catherine L Olsen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, CA 94720, USA
    Oncogene 21:6328-39. 2002
    ....
  15. ncbi Cancer and aging: the importance of telomeres in genome maintenance
    Francis Rodier
    Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    Int J Biochem Cell Biol 37:977-90. 2005
    ..Here, we review what is known about the structure and function of telomeres in mammalian cells, particularly human cells, and how telomere dysfunction may arise and contribute to cancer and aging phenotypes...
  16. ncbi Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer
    Marcia V Fournier
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 66:7095-102. 2006
    ..This study represents a novel unsupervised approach to identifying breast cancer markers that may be of use clinically...