Paul T Williams

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc The effects of changing exercise levels on weight and age-related weight gain
    P T Williams
    Lawrence Berkeley Laboratory, Donner Laboratory, Life Sciences Division, Berkeley, CA 94720, USA
    Int J Obes (Lond) 30:543-51. 2006
  2. doi request reprint Self-selection accounts for inverse association between weight and cardiorespiratory fitness
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, California, USA
    Obesity (Silver Spring) 16:102-6. 2008
  3. pmc Association between walking distance and percentiles of body mass index in older and younger men
    P T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Br J Sports Med 42:352-6. 2008
  4. pmc A cohort study of incident hypertension in relation to changes in vigorous physical activity in men and women
    Paul T Williams
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Hypertens 26:1085-93. 2008
  5. pmc Inadequate exercise as a risk factor for sepsis mortality
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e79344. 2013
  6. pmc Dose-response relationship of physical activity to premature and total all-cause and cardiovascular disease mortality in walkers
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e78777. 2013
  7. pmc Breast cancer mortality vs. exercise and breast size in runners and walkers
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e80616. 2013
  8. pmc Effects of running and walking on osteoarthritis and hip replacement risk
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Med Sci Sports Exerc 45:1292-7. 2013
  9. pmc Walking and running produce similar reductions in cause-specific disease mortality in hypertensives
    Paul T Williams
    Berkeley National Laboratory, Donner 464, 1 Cycloton Road, Berkeley, CA 94720, USA
    Hypertension 62:485-91. 2013
  10. pmc Reduced incidence of cardiac arrhythmias in walkers and runners
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e65302. 2013

Detail Information

Publications74

  1. pmc The effects of changing exercise levels on weight and age-related weight gain
    P T Williams
    Lawrence Berkeley Laboratory, Donner Laboratory, Life Sciences Division, Berkeley, CA 94720, USA
    Int J Obes (Lond) 30:543-51. 2006
    ..To determine prospectively whether physical activity can prevent age-related weight gain and whether changing levels of activity affect body weight...
  2. doi request reprint Self-selection accounts for inverse association between weight and cardiorespiratory fitness
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, California, USA
    Obesity (Silver Spring) 16:102-6. 2008
    ..Whether these results apply to maximum exercise performance (i.e., cardiorespiratory fitness) as well as to doses of vigorous exercise (metabolic equivalents >6) remains to be determined...
  3. pmc Association between walking distance and percentiles of body mass index in older and younger men
    P T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Br J Sports Med 42:352-6. 2008
    ....
  4. pmc A cohort study of incident hypertension in relation to changes in vigorous physical activity in men and women
    Paul T Williams
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Hypertens 26:1085-93. 2008
    ..To assess the dose-response relationship between changes in vigorous exercise (running distance, Deltakm per week) and physician-diagnosed hypertension...
  5. pmc Inadequate exercise as a risk factor for sepsis mortality
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e79344. 2013
    ..Test whether inadequate exercise is related to sepsis mortality...
  6. pmc Dose-response relationship of physical activity to premature and total all-cause and cardiovascular disease mortality in walkers
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e78777. 2013
    ..To assess the dose-response relationships between cause-specific mortality and exercise energy expenditure in a prospective epidemiological cohort of walkers...
  7. pmc Breast cancer mortality vs. exercise and breast size in runners and walkers
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e80616. 2013
    ..Identify predictors of breast cancer mortality in women who exercised below (<7.5 metabolic equivalent hours/week, MET-hours/wk), at (7.5 to 12.5 MET-hours/wk), or above (≥12.5 MET-hours/wk) recommended levels...
  8. pmc Effects of running and walking on osteoarthritis and hip replacement risk
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Med Sci Sports Exerc 45:1292-7. 2013
    ..Analyses were therefore performed to test whether running, walking, and other exercise affect OA and hip replacement risk and to assess the role of body mass index (BMI) in mediating these relationships...
  9. pmc Walking and running produce similar reductions in cause-specific disease mortality in hypertensives
    Paul T Williams
    Berkeley National Laboratory, Donner 464, 1 Cycloton Road, Berkeley, CA 94720, USA
    Hypertension 62:485-91. 2013
    ..Results did not differ between running and walking. Thus, walking and running produce similar reductions in mortality in hypertensives...
  10. pmc Reduced incidence of cardiac arrhythmias in walkers and runners
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e65302. 2013
    ..The purpose of these analyses is to compare incident self-reported physician-diagnosed cardiac arrhythmia to baseline energy expenditure (metabolic equivalent hours per day, METhr/d) from walking, running and other exercise...
  11. pmc Walking and running are associated with similar reductions in cataract risk
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 45:1089-96. 2013
    ..g., walking) provides as significant and equivalent reduction in cataract risk as vigorous exercise (e.g., running)...
  12. pmc Greater weight loss from running than walking during a 6.2-yr prospective follow-up
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 45:706-13. 2013
    ..This study aimed to test whether equivalent changes in moderate (walking) and vigorous exercise (running) produce equivalent weight loss under free-living, nonexperimental conditions...
  13. pmc Walking versus running for hypertension, cholesterol, and diabetes mellitus risk reduction
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Donner 464, 1 Cycloton Rd, Berkeley, CA 94720, USA
    Arterioscler Thromb Vasc Biol 33:1085-91. 2013
    ..To test whether equivalent energy expenditure by moderate-intensity (eg, walking) and vigorous-intensity exercise (eg, running) provides equivalent health benefits...
  14. pmc Fifty-three year follow-up of coronary heart disease versus HDL2 and other lipoproteins in Gofman's Livermore Cohort
    Paul T Williams
    Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 53:266-72. 2012
    ..01). Higher LDL-mass concentrations increased total CHD risk by 3.8% (P < 10(-9)) and premature CHD risk by 6.1% (P < 10(-7)) per 10 mg/dl increase in concentration. Thus, low HDL2 is associated with increased CHD risk...
  15. pmc Walking attenuates the relationships of high-meat, low-fruit dietary intake to total and regional adiposity in men and women
    Paul T Williams
    Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Obesity (Silver Spring) 20:1929-35. 2012
    ..The weaker results in men than women probably related to the smaller sample size, and reduced statistical power of the men...
  16. pmc Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height
    Paul T Williams
    Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 7:e28764. 2012
    ....
  17. pmc Distance walked and run as improved metrics over time-based energy estimation in epidemiological studies and prevention; evidence from medication use
    Paul T Williams
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California, USA
    PLoS ONE 7:e41906. 2012
    ....
  18. pmc Advantage of distance- versus time-based estimates of walking in predicting adiposity
    Paul T Williams
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 44:1728-37. 2012
    ..Analyses were therefore performed to test whether time or distance provides the best metric for relating walking volume to estimated total and regional adiposity...
  19. pmc Non-exchangeability of running vs. other exercise in their association with adiposity, and its implications for public health recommendations
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 7:e36360. 2012
    ..The validity of the exchangeability premise was assessed using data from the National Runners' Health Study...
  20. pmc Low high-density lipoprotein 3 reduces the odds of men surviving to age 85 during 53-year follow-up
    Paul T Williams
    Lawrence Berkeley Laboratory, Berkeley, California 94720, USA
    J Am Geriatr Soc 60:430-6. 2012
    ..To identify high-density lipoprotein (HDL) subfractions associated with longevity in men...
  21. pmc Attenuating effect of vigorous physical activity on the risk for inherited obesity: a study of 47,691 runners
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Donner Laboratory, Berkeley, California, United States of America
    PLoS ONE 7:e31436. 2012
    ..Such information is needed to best prescribe an exercise dose for obesity prevention in those at risk due to their family history...
  22. pmc Reduction in incident stroke risk with vigorous physical activity: evidence from 7.7-year follow-up of the national runners' health study
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Stroke 40:1921-3. 2009
    ..The purpose of this study was to assess the dose-response relationship between vigorous physical activity (running distance, km/d) and the participant-reported physician-diagnosed stroke...
  23. pmc Lower prevalence of hypertension, hypercholesterolemia, and diabetes in marathoners
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 41:523-9. 2009
    ..To test whether the prevalence of hypertension, hypercholesterolemia, and diabetes declines with marathon participation independent of annual running mileage...
  24. pmc Changes in body weight and waist circumference affect incident hypercholesterolemia during 7 years of follow-up
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Obesity (Silver Spring) 16:2163-8. 2008
    ..To assess whether changes in total and regional adiposity affect the odds for becoming hypercholesterolemic...
  25. pmc Incident hypercholesterolemia in relation to changes in vigorous physical activity
    Paul T Williams
    Ernest Orlando Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 41:74-80. 2009
    ..Test whether changes in vigorous exercise affect the risk for hypercholesterolemia...
  26. pmc Relationship of running intensity to hypertension, hypercholesterolemia, and diabetes
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 40:1740-8. 2008
    ..To estimate the independent relationships of running intensity with antihypertensive, LDL-cholesterol-lowering, and antidiabetic medication use when adjusted for running volume (km x d(-1))...
  27. pmc Effects of running distance and performance on incident benign prostatic hyperplasia
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 40:1733-9. 2008
    ..Our goal is to assess whether running (a vigorous physical activity) and 10-km race performance (an indicator of cardiorespiratory fitness) reduce BPH risk...
  28. pmc Increases in weight and body size increase the odds for hypertension during 7 years of follow-up
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Obesity (Silver Spring) 16:2541-8. 2008
    ....
  29. pmc Incident diverticular disease is inversely related to vigorous physical activity
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 41:1042-7. 2009
    ..The purpose of this article was to assess whether this finding can be verified among older men and women of the National Runners' Health Study...
  30. pmc Optimal body weight for the prevention of coronary heart disease in normal-weight physically active men
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Obesity (Silver Spring) 17:1428-34. 2009
    ..These results suggest that the optimal BMI for minimizing CHD risk lies somewhere <22.5 kg/m(2), as suggested from our previous analyses of incident diabetes, hypertension, and hypercholesterolemia in these men...
  31. pmc Relationship of incident glaucoma versus physical activity and fitness in male runners
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 41:1566-72. 2009
    ..To assess the dose-response relationship of vigorous physical activity (running distance, km x d(-1)) or cardiorespiratory fitness (meters-per-second pace during a 10-km footrace) to the risk for incident glaucoma...
  32. pmc Usefulness of cardiorespiratory fitness to predict coronary heart disease risk independent of physical activity
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Donner Laboratory, Berkeley, California, USA
    Am J Cardiol 106:210-5. 2010
    ..In conclusion, the results suggest that cardiorespiratory fitness is a CHD risk factor, largely independent of physical activity, which warrants clinical screening...
  33. pmc Prospective study of coronary heart disease vs. HDL2, HDL3, and other lipoproteins in Gofman's Livermore Cohort
    Paul T Williams
    Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    Atherosclerosis 214:196-202. 2011
    ..To assess the relationship of lipoprotein subfractions to coronary heart disease (CHD)...
  34. pmc Dose-response relationship between walking and the attenuation of inherited weight
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Prev Med 52:293-9. 2011
    ..We sought to test whether moderate intensity physical activity affected parent-offspring relationships for body mass index and regional adiposity in 26,587 female and 6428 male walkers surveyed in the United States in 2000...
  35. pmc Exercise attenuates the association of body weight with diet in 106,737 runners
    Paul T Williams
    Lawrence Berkeley National Laboratory, Berkeley, CA 94556, USA
    Med Sci Sports Exerc 43:2120-6. 2011
    ..However, people have also become less active, and inactivity may have increased the risk for weight gain from poor dietary choices. Analyses were performed to test whether diet-weight relationships were attenuated by vigorous exercise...
  36. pmc Attenuated inheritance of body weight by running in monozygotic twins
    Paul T Williams
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 44:98-103. 2012
    ..The purpose of this study was to test whether exercise attenuates the inherited risk for excess body weight...
  37. pmc Relationship of adiposity to the population distribution of plasma triglyceride concentrations in vigorously active men and women
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Lawrence Berkeley Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Atherosclerosis 174:363-71. 2004
    ..It remains to be verified whether these relationship also apply to less active populations...
  38. pmc Prospective study of incident age-related macular degeneration in relation to vigorous physical activity during a 7-year follow-up
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Invest Ophthalmol Vis Sci 50:101-6. 2009
    ..To test whether the risk of age-related macular degeneration (AMD) decreases with vigorous physical activity...
  39. pmc Effects of diet, physical activity and performance, and body weight on incident gout in ostensibly healthy, vigorously active men
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Am J Clin Nutr 87:1480-7. 2008
    ..Physical activity and cardiorespiratory fitness are not currently recognized as factors related to preventing gout, nor are risk factors for gout in physically active men well understood...
  40. pmc Nonlinear relationships between weekly walking distance and adiposity in 27,596 women
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, CA 94720, USA
    Med Sci Sports Exerc 37:1893-901. 2005
    ..The purpose of the current study is to assess the cross-sectional relationship between the amount of moderate-intensity physical activity (walking distance) and indicators of adiposity...
  41. ncbi request reprint Relationships of age and weekly running distance to BMI and circumferences in 41,582 physically active women
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    Obes Res 13:1370-80. 2005
    ..To assess in women whether age-related increases in adiposity are dependent on exercise, and, contrariwise, whether exercise-related declines in adiposity are dependent on age...
  42. ncbi request reprint Cross-sectional relationships of exercise and age to adiposity in 60,617 male runners
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 37:1329-37. 2005
    ..To assess in men whether exercise affects the estimated age-related increase in adiposity, and contrariwise, whether age affects the estimated exercise-related decrease in adiposity...
  43. ncbi request reprint Behavioral versus genetic correlates of lipoproteins and adiposity in identical twins discordant for exercise
    Paul T Williams
    Lawrence Berkeley National Laboratory, Donner Laboratory, One Cyclotron Rd, Berkeley, CA 94720, USA
    Circulation 112:350-6. 2005
    ....
  44. ncbi request reprint Concordant lipoprotein and weight responses to dietary fat change in identical twins with divergent exercise levels 1
    Paul T Williams
    Lawrence Berkeley National Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Am J Clin Nutr 82:181-7. 2005
    ..Individuals vary greatly in their lipoprotein responses to low-fat diets, with some of this variation being attributable to genes...
  45. pmc The illusion of improved physical fitness and reduced mortality
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 35:736-40. 2003
    ..g., physical fitness or activity) at baseline...
  46. ncbi request reprint Health effects resulting from exercise versus those from body fat loss
    P T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 33:S611-21; discussion S640-1. 2001
    ..The purpose of this review was to assess whether body weight confounds the relationships between physical activity and its health benefits...
  47. pmc Physical fitness and activity as separate heart disease risk factors: a meta-analysis
    P T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 33:754-61. 2001
    ....
  48. ncbi request reprint Relationships of heart disease risk factors to exercise quantity and intensity
    P T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Calif, USA
    Arch Intern Med 158:237-45. 1998
    ..To assess the relationships of exercise amount and exercise intensity to coronary heart disease risk factors measured cross-sectionally in runners...
  49. ncbi request reprint Interactive effects of exercise, alcohol, and vegetarian diet on coronary artery disease risk factors in 9242 runners: the National Runners' Health Study
    P T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Am J Clin Nutr 66:1197-206. 1997
    ..Also, vigorous exercise provides important health benefits beyond those obtained by diet...
  50. ncbi request reprint Evidence for the incompatibility of age-neutral overweight and age-neutral physical activity standards from runners
    P T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Am J Clin Nutr 65:1391-6. 1997
    ....
  51. ncbi request reprint Self-selection contributes significantly to the lower adiposity of faster, longer-distanced, male and female walkers
    P T Williams
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Int J Obes (Lond) 31:652-62. 2007
    ..The purpose of this paper is to determine the extent that this is due to self-selection bias, specifically to initially leaner men and women choosing to exercise longer and more intensely...
  52. ncbi request reprint Dose-dependent effects of training and detraining on weight in 6406 runners during 7.4 years
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Obesity (Silver Spring) 14:1975-84. 2006
    ..The objectives of this study were to determine whether exercise reduces body weight and to examine the dose-response relationships between changes in exercise and changes in total and regional adiposity...
  53. pmc Relationship of distance run per week to coronary heart disease risk factors in 8283 male runners. The National Runners' Health Study
    P T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, Calif, USA
    Arch Intern Med 157:191-8. 1997
    ....
  54. pmc Reduced diabetic, hypertensive, and cholesterol medication use with walking
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 40:433-43. 2008
    ..To assess the relationships of walking distance, frequency, and intensity to the prevalence of antidiabetic, antihypertensive, and LDL cholesterol-lowering medications use...
  55. pmc Vigorous exercise and diabetic, hypertensive, and hypercholesterolemia medication use
    Paul T Williams
    Ernest Orlando Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 39:1933-41. 2007
    ..Whether these reductions extend beyond contemporary guideline activity levels and whether fitness affects medication use independent of activity, remains unclear...
  56. ncbi request reprint Changes in vigorous physical activity and incident diabetes in male runners
    Paul T Williams
    Ernest Orlando Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    Diabetes Care 30:2838-42. 2007
    ..We examined the relationship between changes in reported vigorous exercise and self-reported physician-diagnosed diabetes in 25,988 active men...
  57. pmc Prospective epidemiological cohort study of reduced risk for incident cataract with vigorous physical activity and cardiorespiratory fitness during a 7-year follow-up
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Invest Ophthalmol Vis Sci 50:95-100. 2009
    ..To test whether greater vigorous physical activity (kilometers per week run) and greater cardiorespiratory fitness (10-km race performance in meters per second) reduce the incidence of clinically diagnosed cataract...
  58. ncbi request reprint Weight-related increases in hypertension, hypercholesterolemia, and diabetes risk in normal weight male and female runners
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Arterioscler Thromb Vasc Biol 27:1811-9. 2007
    ..Although 36% of US men and 42% of US women are of normal weight, the health implications of greater weight in ostensibly normal-weight individuals are seldom acknowledged...
  59. pmc Maintaining vigorous activity attenuates 7-yr weight gain in 8340 runners
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 39:801-9. 2007
    ..Specifically, prior studies have not tested whether the maintenance of physical activity, in the absence of any change in activity, prevents weight gain...
  60. pmc Vigorous exercise, fitness and incident hypertension, high cholesterol, and diabetes
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 40:998-1006. 2008
    ..Analyses were undertaken to determine the dose-response relationships of fitness to incident hypertension, hypercholesterolemia, and diabetes independent of activity...
  61. pmc Evidence that obesity risk factor potencies are weight dependent, a phenomenon that may explain accelerated weight gain in western societies
    Paul T Williams
    Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 6:e27657. 2011
    ..The purpose of the current analyses was to assess whether recent, accelerated increases in obesity could potentially be due to increased vulnerability to obesity risk factors as the population has become more overweight...
  62. pmc The relationship of walking intensity to total and cause-specific mortality. Results from the National Walkers' Health Study
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e81098. 2013
    ..Test whether: 1) walking intensity predicts mortality when adjusted for walking energy expenditure, and 2) slow walking pace (≥24-minute mile) identifies subjects at substantially elevated risk for mortality...
  63. ncbi request reprint The relationships of vigorous exercise, alcohol, and adiposity to low and high high-density lipoprotein-cholesterol levels
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA, USA
    Metabolism 53:700-9. 2004
    ....
  64. pmc Independent effects of cardiorespiratory fitness, vigorous physical activity, and body mass index on clinical gallbladder disease risk
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Am J Gastroenterol 103:2239-47. 2008
    ....
  65. pmc Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS)
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, California, United States of America
    PLoS ONE 8:e56782. 2013
    ....
  66. pmc Reversal of small, dense LDL subclass phenotype by normalization of adiposity
    Patty W Siri-Tarino
    Atherosclerosis Research, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Obesity (Silver Spring) 17:1768-75. 2009
    ..Conversion of LDL subclass pattern B to pattern A and reversal of ALP can be achieved in a high proportion of overweight men by normalization of adiposity...
  67. pmc Reductions in incident coronary heart disease risk above guideline physical activity levels in men
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Donner Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, United States
    Atherosclerosis 209:524-7. 2010
    ..One-half of Americans currently meet guideline physical activity levels. For these individuals, exceeding guideline levels may provide additional health benefits...
  68. pmc Asymmetric weight gain and loss from increasing and decreasing exercise
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA
    Med Sci Sports Exerc 40:296-302. 2008
    ..Unequal (asymmetric) weight changes could contribute to overall weight gain or loss among individuals with seasonal or irregular activity...
  69. ncbi request reprint Vigorous exercise and the population distribution of body weight
    P T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Int J Obes Relat Metab Disord 28:120-8. 2004
    ..The impact of exercise on the more extreme body weights and body circumferences is clinically important because these values represent individuals at greatest health risk...
  70. ncbi request reprint Smallest LDL particles are most strongly related to coronary disease progression in men
    Paul T Williams
    Life Sciences Division, E O Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
    Arterioscler Thromb Vasc Biol 23:314-21. 2003
    ..2 to 24.7 nm), LDL-IVa (23.3 to 24.2 nm), and LDL-IVb (22.0 to 23.3 nm in diameter). We hypothesized that the association between smaller LDL particles and coronary artery disease (CAD) risk might involve specific LDL subclasses...
  71. ncbi request reprint Gemfibrozil reduces small low-density lipoprotein more in normolipemic subjects classified as low-density lipoprotein pattern B compared with pattern A
    H Robert Superko
    Fuqua Heart Center Piedmont Hospital, Atlanta, Georgia, USA
    Am J Cardiol 96:1266-72. 2005
    ..Thus, treatment with gemfibrozil may have additional antiatherogenic effects in those with LDL pattern B by decreasing small dense LDL that is not apparent in those with pattern A...
  72. ncbi request reprint Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia
    Ronald M Krauss
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 83:1025-31; quiz 1205. 2006
    ..Low-carbohydrate diets have been used to manage obesity and its metabolic consequences...
  73. ncbi request reprint Polyacrylamide gradient gel electrophoresis of lipoprotein subclasses
    G Russell Warnick
    Berkeley HeartLab Inc, 960 Atlantic Avenue, Suite 100 Alameda, CA 94501, USA
    Clin Lab Med 26:803-46. 2006
    ....
  74. ncbi request reprint Longitudinal changes in cardiorespiratory fitness: measurement error or true change?
    Paul T Williams
    Med Sci Sports Exerc 37:877-8; author reply 879. 2005

Research Grants15

  1. Cross-sectional and prospective cohort data analysis of physical activity and hea
    Paul T Williams; Fiscal Year: 2010
    ..This application is concerned exclusively with the interpretation of actual data and not the collection of new data. The major objective is to better define the dose and intensity of physical activity for optimal health. ..
  2. Cross-sectional and prospective cohort data analysis of physical activity and hea
    Paul Williams; Fiscal Year: 2009
    ..This application is concerned exclusively with the interpretation of actual data and not the collection of new data. The major objective is to better define the dose and intensity of physical activity for optimal health. ..
  3. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2007
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  4. Long-Term Exercise Maintenance via Internet Support
    Paul Williams; Fiscal Year: 2006
    ..We estimate that we will be able to detect differences in exercise cessation rates between the intervention and control group of 0.45% in runners and walkers separately (alpha=0.05, 80% statistical power). ..
  5. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2006
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  6. Long-Term Exercise Maintenance via Internet Support
    Paul Williams; Fiscal Year: 2005
    ..We estimate that we will be able to detect differences in exercise cessation rates between the intervention and control group of 0.45% in runners and walkers separately (alpha=0.05, 80% statistical power). ..
  7. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2005
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  8. Long-Term Exercise Maintenance via Internet Support
    Paul Williams; Fiscal Year: 2004
    ..We estimate that we will be able to detect differences in exercise cessation rates between the intervention and control group of 0.45% in runners and walkers separately (alpha=0.05, 80% statistical power). ..
  9. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2004
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  10. Long-Term Exercise Maintenance via Internet Support
    Paul Williams; Fiscal Year: 2003
    ..We estimate that we will be able to detect differences in exercise cessation rates between the intervention and control group of 0.45% in runners and walkers separately (alpha=0.05, 80% statistical power). ..
  11. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2002
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..
  12. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2001
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..
  13. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2000
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..
  14. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 1999
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..