B Weigelt

Summary

Affiliation: Lawrence Berkeley National Laboratory
Country: USA

Publications

  1. pmc Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas
    Bas Kreike
    Division of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Breast Cancer Res 9:R65. 2007
  2. doi request reprint Refinement of breast cancer classification by molecular characterization of histological special types
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Pathol 216:141-50. 2008
  3. doi request reprint The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type
    Britta Weigelt
    The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Pathol 220:45-57. 2010
  4. doi request reprint Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis
    Britta Weigelt
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Breast Cancer Res Treat 117:273-80. 2009
  5. pmc Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
    Britta Weigelt
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Semin Cancer Biol 18:311-21. 2008
  6. pmc No common denominator for breast cancer lymph node metastasis
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Br J Cancer 93:924-32. 2005
  7. doi request reprint The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 and 70 years of age
    S Mook
    Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
    Ann Oncol 21:717-22. 2010
  8. pmc Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple mRNA markers
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Br J Cancer 90:1531-7. 2004
  9. ncbi request reprint Expression of a novel lacrimal gland gene lacritin in human breast tissues
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cancer Res Clin Oncol 129:735-6. 2003
  10. pmc Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
    Br J Cancer 88:1091-4. 2003

Collaborators

Detail Information

Publications22

  1. pmc Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas
    Bas Kreike
    Division of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Breast Cancer Res 9:R65. 2007
    ..We examined the histopathological and gene-expression profile of triple-negative tumors to define subgroups with specific characteristics, including risk of developing distant metastases...
  2. doi request reprint Refinement of breast cancer classification by molecular characterization of histological special types
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Pathol 216:141-50. 2008
    ....
  3. doi request reprint The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type
    Britta Weigelt
    The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Pathol 220:45-57. 2010
    ..However, classic ILCs and PLCs are remarkably similar at the molecular level and should be considered as part of a spectrum of lesions...
  4. doi request reprint Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis
    Britta Weigelt
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Breast Cancer Res Treat 117:273-80. 2009
    ..Previous histopathological and immunohistochemical analysis of MBCs suggested that these cancers would have a basal-like profile...
  5. pmc Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
    Britta Weigelt
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Semin Cancer Biol 18:311-21. 2008
    ....
  6. pmc No common denominator for breast cancer lymph node metastasis
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Br J Cancer 93:924-32. 2005
    ..Surprisingly, however, different sets of these genes are either up- or downregulated in lymph node metastases. Our data suggest that breast carcinomas do not use a shared gene set to accomplish lymph node metastasis...
  7. doi request reprint The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 and 70 years of age
    S Mook
    Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
    Ann Oncol 21:717-22. 2010
    ..The aim of this study was to evaluate the prognostic value of the 70-gene prognosis signature for early events in postmenopausal patients...
  8. pmc Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple mRNA markers
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Br J Cancer 90:1531-7. 2004
    ..The application of this technique may be of clinical relevance, as it is suggested that micrometastatic disease in SNs are associated with further nodal non-SN metastases in breast cancer...
  9. ncbi request reprint Expression of a novel lacrimal gland gene lacritin in human breast tissues
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cancer Res Clin Oncol 129:735-6. 2003
    ..The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland...
  10. pmc Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients
    B Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
    Br J Cancer 88:1091-4. 2003
    ..015 and 0.0053, respectively). Breast cancer patients with metastatic disease have a significantly worse progression-free and overall survival when circulating tumour cells can be detected in their peripheral blood...
  11. doi request reprint Mammosphere-derived gene set predicts outcome in patients with ER-positive breast cancer
    Marleen Kok
    Departments of Pathology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    J Pathol 218:316-26. 2009
    ....
  12. ncbi request reprint Detection of circulating breast tumor cells by differential expression of marker genes
    Astrid J Bosma
    Division of Experimental Therapy, Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Clin Cancer Res 8:1871-7. 2002
    ..We undertook a systematic approach to identify breast cancer (BC) marker genes with molecular assays and evaluated these marker genes for the detection of minimal residual disease in peripheral blood mononuclear cells (PBMCs)...
  13. pmc Gene expression profiles of primary breast tumors maintained in distant metastases
    Britta Weigelt
    Departments of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 100:15901-5. 2003
    ..Our findings suggest that metastatic capability in breast cancer is an inherent feature and is not based on clonal selection...
  14. doi request reprint Mucinous and neuroendocrine breast carcinomas are transcriptionally distinct from invasive ductal carcinomas of no special type
    Britta Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute NKI, Amsterdam, The Netherlands
    Mod Pathol 22:1401-14. 2009
    ..These findings support the contention that mucinous B and neuroendocrine carcinomas are part of a spectrum of lesions, whereas mucinous A is a discrete entity...
  15. ncbi request reprint Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
    Britta Weigelt
    Divisions of Experimental Therapy and Diagnostic Oncology, The Netherlands Cancer Institute, The Netherlands
    Cancer Res 65:9155-8. 2005
    ..Furthermore, our data imply that poor prognosis breast carcinomas classified either by the intrinsic gene set or the 70 prognosis genes represent distinct disease entities that seem sustained throughout the metastatic process...
  16. ncbi request reprint Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas
    Vassiliki Theodorou
    Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Oncogene 23:6047-55. 2004
    ..A survey of primary human breast carcinomas revealed strongly elevated Fgf10 mRNA levels in approximately 10% of the tumors tested, suggesting that Fgf10 may also be involved in oncogenicity of a subset of human breast cancers...
  17. ncbi request reprint Hard-wired genotype in metastatic breast cancer
    Britta Weigelt
    The Netherlands Cancer Institute, Department of Experimental Therapy, Amsterdam, The Netherlands
    Cell Cycle 3:756-7. 2004
    ..Our findings challenge this common theory and imply that the metastatic nature of 'poor prognosis profile' breast carcinomas is an inherent feature, and not reserved to advantageous subpopulations...
  18. ncbi request reprint A large-scale RNAi screen in human cells identifies new components of the p53 pathway
    Katrien Berns
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 428:431-7. 2004
    ..Furthermore, we describe siRNA bar-code screens to rapidly identify individual siRNA vectors associated with a specific phenotype. These new tools will greatly facilitate large-scale loss-of-function genetic screens in mammalian cells...
  19. ncbi request reprint Breast cancer metastasis: markers and models
    Britta Weigelt
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Nat Rev Cancer 5:591-602. 2005
    ..These data have important implications for prognosis prediction and our understanding of metastasis...
  20. pmc HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    Britta Weigelt
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California Berkeley, Mailstop 977R225A, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Breast Cancer Res Treat 122:35-43. 2010
    ....
  21. ncbi request reprint Road map to metastasis
    Laura J Van't Veer
    Nat Med 9:999-1000. 2003
  22. ncbi request reprint Concordance among gene-expression-based predictors for breast cancer
    Cheng Fan
    Department of Genetics, University of North Carolina at Chapel Hill and Lineberger Comprehensive Cancer Center, Chapel Hill 27599, USA
    N Engl J Med 355:560-9. 2006
    ..Gene-expression-profiling studies of primary breast tumors performed by different laboratories have resulted in the identification of a number of distinct prognostic profiles, or gene sets, with little overlap in terms of gene identity...