Research Topics
Species | B WeigeltSummaryAffiliation: Lawrence Berkeley National Laboratory Country: USA Publications
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Detail Information
Publications
Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomasBas Kreike
Division of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Breast Cancer Res 9:R65. 2007..We examined the histopathological and gene-expression profile of triple-negative tumors to define subgroups with specific characteristics, including risk of developing distant metastases...
Refinement of breast cancer classification by molecular characterization of histological special typesB Weigelt
Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
J Pathol 216:141-50. 2008....- The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special typeBritta Weigelt
The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
J Pathol 220:45-57. 2010..However, classic ILCs and PLCs are remarkably similar at the molecular level and should be considered as part of a spectrum of lesions... - Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysisBritta Weigelt
Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
Breast Cancer Res Treat 117:273-80. 2009..Previous histopathological and immunohistochemical analysis of MBCs suggested that these cancers would have a basal-like profile... - Unraveling the microenvironmental influences on the normal mammary gland and breast cancerBritta Weigelt
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
Semin Cancer Biol 18:311-21. 2008.... - No common denominator for breast cancer lymph node metastasisB Weigelt
Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
Br J Cancer 93:924-32. 2005..Surprisingly, however, different sets of these genes are either up- or downregulated in lymph node metastases. Our data suggest that breast carcinomas do not use a shared gene set to accomplish lymph node metastasis... - The 70-gene prognosis signature predicts early metastasis in breast cancer patients between 55 and 70 years of ageS Mook
Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
Ann Oncol 21:717-22. 2010..The aim of this study was to evaluate the prognostic value of the 70-gene prognosis signature for early events in postmenopausal patients... - Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple mRNA markersB Weigelt
Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Br J Cancer 90:1531-7. 2004..The application of this technique may be of clinical relevance, as it is suggested that micrometastatic disease in SNs are associated with further nodal non-SN metastases in breast cancer... 
Expression of a novel lacrimal gland gene lacritin in human breast tissuesB Weigelt
Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Cancer Res Clin Oncol 129:735-6. 2003..The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland...- Marker genes for circulating tumour cells predict survival in metastasized breast cancer patientsB Weigelt
Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
Br J Cancer 88:1091-4. 2003..015 and 0.0053, respectively). Breast cancer patients with metastatic disease have a significantly worse progression-free and overall survival when circulating tumour cells can be detected in their peripheral blood... - Mammosphere-derived gene set predicts outcome in patients with ER-positive breast cancerMarleen Kok
Departments of Pathology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
J Pathol 218:316-26. 2009.... - Detection of circulating breast tumor cells by differential expression of marker genesAstrid J Bosma
Division of Experimental Therapy, Department of Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Clin Cancer Res 8:1871-7. 2002..CONCLUSIONS: Real-time PCR for the simultaneous expression of multiple cancer-specific genes may ensure the specificity required for the clinical application of mRNA expression-based assays for occult tumor cells... - Gene expression profiles of primary breast tumors maintained in distant metastasesBritta Weigelt
Departments of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Proc Natl Acad Sci U S A 100:15901-5. 2003..Our findings suggest that metastatic capability in breast cancer is an inherent feature and is not based on clonal selection... - Mucinous and neuroendocrine breast carcinomas are transcriptionally distinct from invasive ductal carcinomas of no special typeBritta Weigelt
Division of Experimental Therapy, The Netherlands Cancer Institute NKI, Amsterdam, The Netherlands
Mod Pathol 22:1401-14. 2009..These findings support the contention that mucinous B and neuroendocrine carcinomas are part of a spectrum of lesions, whereas mucinous A is a discrete entity... - Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancerBritta Weigelt
Divisions of Experimental Therapy and Diagnostic Oncology, The Netherlands Cancer Institute, The Netherlands
Cancer Res 65:9155-8. 2005..Furthermore, our data imply that poor prognosis breast carcinomas classified either by the intrinsic gene set or the 70 prognosis genes represent distinct disease entities that seem sustained throughout the metastatic process... - Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomasVassiliki Theodorou
Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Oncogene 23:6047-55. 2004..A survey of primary human breast carcinomas revealed strongly elevated Fgf10 mRNA levels in approximately 10% of the tumors tested, suggesting that Fgf10 may also be involved in oncogenicity of a subset of human breast cancers... - Hard-wired genotype in metastatic breast cancerBritta Weigelt
The Netherlands Cancer Institute, Department of Experimental Therapy, Amsterdam, The Netherlands
Cell Cycle 3:756-7. 2004..Our findings challenge this common theory and imply that the metastatic nature of 'poor prognosis profile' breast carcinomas is an inherent feature, and not reserved to advantageous subpopulations... - A large-scale RNAi screen in human cells identifies new components of the p53 pathwayKatrien Berns
Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Nature 428:431-7. 2004..Furthermore, we describe siRNA bar-code screens to rapidly identify individual siRNA vectors associated with a specific phenotype. These new tools will greatly facilitate large-scale loss-of-function genetic screens in mammalian cells... - Breast cancer metastasis: markers and modelsBritta Weigelt
Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Nat Rev Cancer 5:591-602. 2005..These data have important implications for prognosis prediction and our understanding of metastasis... - HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironmentBritta Weigelt
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California Berkeley, Mailstop 977R225A, 1 Cyclotron Road, Berkeley, CA 94720, USA
Breast Cancer Res Treat 122:35-43. 2010.... - Road map to metastasisBritta Weigelt
Nat Med 9:999-1000. 2003 - Concordance among gene-expression-based predictors for breast cancerCheng Fan
Department of Genetics, University of North Carolina at Chapel Hill and Lineberger Comprehensive Cancer Center, Chapel Hill 27599, USA
N Engl J Med 355:560-9. 2006....